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Items: 1 to 50 of 130


AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms.

He L, Wei Q, Liu J, Yi M, Liu Y, Liu H, Sun L, Peng Y, Liu F, Venkatachalam MA, Dong Z.

Kidney Int. 2017 Nov;92(5):1071-1083. doi: 10.1016/j.kint.2017.06.030. Epub 2017 Sep 8. Review.


Pericytes Preserve Capillary Integrity to Prevent Kidney Hypoxia.

Venkatachalam MA, Weinberg JM.

J Am Soc Nephrol. 2017 Mar;28(3):717-719. doi: 10.1681/ASN.2016111157. Epub 2016 Dec 15. No abstract available.


Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI.

Lan R, Geng H, Singha PK, Saikumar P, Bottinger EP, Weinberg JM, Venkatachalam MA.

J Am Soc Nephrol. 2016 Nov;27(11):3356-3367. Epub 2016 Mar 21.


Renoprotective approaches and strategies in acute kidney injury.

Yang Y, Song M, Liu Y, Liu H, Sun L, Peng Y, Liu F, Venkatachalam MA, Dong Z.

Pharmacol Ther. 2016 Jul;163:58-73. doi: 10.1016/j.pharmthera.2016.03.015. Epub 2016 Apr 22. Review.


The role of glycine in regulated cell death.

Weinberg JM, Bienholz A, Venkatachalam MA.

Cell Mol Life Sci. 2016 Jun;73(11-12):2285-308. doi: 10.1007/s00018-016-2201-6. Epub 2016 Apr 11. Review.


Fibrosis without fibroblast TGF-β receptors?

Venkatachalam MA, Weinberg JM.

Kidney Int. 2015 Sep;88(3):434-7. doi: 10.1038/ki.2015.170.


Long-term response to renal ischaemia in the human kidney after partial nephrectomy: results from a prospective clinical trial.

Kallingal GJ, Weinberg JM, Reis IM, Nehra A, Venkatachalam MA, Parekh DJ.

BJU Int. 2016 May;117(5):766-74. doi: 10.1111/bju.13192. Epub 2015 Jul 18.


Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression.

Venkatachalam MA, Weinberg JM, Kriz W, Bidani AK.

J Am Soc Nephrol. 2015 Aug;26(8):1765-76. doi: 10.1681/ASN.2015010006. Epub 2015 Mar 25. Review.


Could Autophagic Exhaustion Be a Final Common Pathway for Podocytopathy in FSGS?

Venkatachalam MA.

J Am Soc Nephrol. 2015 May;26(5):999-1001. doi: 10.1681/ASN.2014090919. Epub 2014 Nov 18. No abstract available.


Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model.

Griffin KA, Polichnowski A, Litbarg N, Picken M, Venkatachalam MA, Bidani AK.

Hypertension. 2014 Oct;64(4):801-7. doi: 10.1161/HYPERTENSIONAHA.114.03609. Epub 2014 Jun 23.


Severe renal mass reduction impairs recovery and promotes fibrosis after AKI.

Polichnowski AJ, Lan R, Geng H, Griffin KA, Venkatachalam MA, Bidani AK.

J Am Soc Nephrol. 2014 Jul;25(7):1496-507. doi: 10.1681/ASN.2013040359. Epub 2014 Feb 7.


The conundrum of protection from AKI by adenosine in rodent clamp ischemia models.

Venkatachalam MA, Weinberg JM.

Kidney Int. 2013 Jul;84(1):16-9. doi: 10.1038/ki.2013.101.


New wrinkles in old receptors: core fucosylation is yet another target to inhibit TGF-β signaling.

Venkatachalam MA, Weinberg JM.

Kidney Int. 2013 Jul;84(1):11-4. doi: 10.1038/ki.2013.95.


Tolerance of the human kidney to isolated controlled ischemia.

Parekh DJ, Weinberg JM, Ercole B, Torkko KC, Hilton W, Bennett M, Devarajan P, Venkatachalam MA.

J Am Soc Nephrol. 2013 Feb;24(3):506-17. doi: 10.1681/ASN.2012080786. Epub 2013 Feb 14.


Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death.

Singha PK, Pandeswara S, Venkatachalam MA, Saikumar P.

Cell Death Dis. 2013 Jan 17;4:e457. doi: 10.1038/cddis.2012.192.


Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.

Geng H, Lan R, Singha PK, Gilchrist A, Weinreb PH, Violette SM, Weinberg JM, Saikumar P, Venkatachalam MA.

Am J Pathol. 2012 Oct;181(4):1236-49. doi: 10.1016/j.ajpath.2012.06.035. Epub 2012 Aug 10.


PI3K regulation of the SKP-2/p27 axis through mTORC2.

Shanmugasundaram K, Block K, Nayak BK, Livi CB, Venkatachalam MA, Sudarshan S.

Oncogene. 2013 Apr 18;32(16):2027-36. doi: 10.1038/onc.2012.226. Epub 2012 Jun 25.


PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.

Lan R, Geng H, Polichnowski AJ, Singha PK, Saikumar P, McEwen DG, Griffin KA, Koesters R, Weinberg JM, Bidani AK, Kriz W, Venkatachalam MA.

Am J Physiol Renal Physiol. 2012 May 1;302(9):F1210-23. doi: 10.1152/ajprenal.00660.2011. Epub 2012 Feb 1.


The tubule pathology of septic acute kidney injury: a neglected area of research comes of age.

Venkatachalam MA, Weinberg JM.

Kidney Int. 2012 Feb;81(4):338-40. doi: 10.1038/ki.2011.401.


Preserving postischemic reperfusion in the kidney: a role for extracellular adenosine.

Weinberg JM, Venkatachalam MA.

J Clin Invest. 2012 Feb;122(2):493-6. doi: 10.1172/JCI60957. Epub 2012 Jan 24.


Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1.

Kar R, Mishra N, Singha PK, Venkatachalam MA, Saikumar P.

Biochem Biophys Res Commun. 2010 Sep 3;399(4):548-54. doi: 10.1016/j.bbrc.2010.07.108. Epub 2010 Aug 1.


Transforming growth factor-beta (TGF-beta)-inducible gene TMEPAI converts TGF-beta from a tumor suppressor to a tumor promoter in breast cancer.

Singha PK, Yeh IT, Venkatachalam MA, Saikumar P.

Cancer Res. 2010 Aug 1;70(15):6377-83. doi: 10.1158/0008-5472.CAN-10-1180. Epub 2010 Jul 7.


Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2.

Mishra N, Kar R, Singha PK, Venkatachalam MA, McEwen DG, Saikumar P.

Biochem Biophys Res Commun. 2010 Apr 23;395(1):17-24. doi: 10.1016/j.bbrc.2010.03.093. Epub 2010 Mar 20.


Acute kidney injury: a springboard for progression in chronic kidney disease.

Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P, Bidani AK.

Am J Physiol Renal Physiol. 2010 May;298(5):F1078-94. doi: 10.1152/ajprenal.00017.2010. Epub 2010 Mar 3. Review.


Regulation of the mitochondrial permeability transition in kidney proximal tubules and its alteration during hypoxia-reoxygenation.

Feldkamp T, Park JS, Pasupulati R, Amora D, Roeser NF, Venkatachalam MA, Weinberg JM.

Am J Physiol Renal Physiol. 2009 Dec;297(6):F1632-46. doi: 10.1152/ajprenal.00422.2009. Epub 2009 Sep 9.


A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells.

Kar R, Singha PK, Venkatachalam MA, Saikumar P.

Oncogene. 2009 Jul 16;28(28):2556-68. doi: 10.1038/onc.2009.118. Epub 2009 May 18.


Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia.

Geng H, Lan R, Wang G, Siddiqi AR, Naski MC, Brooks AI, Barnes JL, Saikumar P, Weinberg JM, Venkatachalam MA.

Am J Pathol. 2009 Apr;174(4):1291-308. doi: 10.2353/ajpath.2009.080295.


Calcium in cell injury and death.

Dong Z, Saikumar P, Weinberg JM, Venkatachalam MA.

Annu Rev Pathol. 2006;1:405-34. Review.


Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules.

Feldkamp T, Kribben A, Roeser NF, Senter RA, Kemner S, Venkatachalam MA, Nissim I, Weinberg JM.

Am J Physiol Renal Physiol. 2004 Apr;286(4):F749-59. Epub 2003 Dec 9.


Role of apoptosis in hypoxic/ischemic damage in the kidney.

Saikumar P, Venkatachalam MA.

Semin Nephrol. 2003 Nov;23(6):511-21. Review.


Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2.

Dong Z, Wang JZ, Yu F, Venkatachalam MA.

Am J Pathol. 2003 Aug;163(2):663-71.


Glycine protection of PC-12 cells against injury by ATP-depletion.

Zhang K, Weinberg JM, Venkatachalam MA, Dong Z.

Neurochem Res. 2003 Jun;28(6):893-901.


Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release.

Mikhailov V, Mikhailova M, Degenhardt K, Venkatachalam MA, White E, Saikumar P.

J Biol Chem. 2003 Feb 14;278(7):5367-76. Epub 2002 Nov 25.


Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia.

Dong Z, Nishiyama J, Yi X, Venkatachalam MA, Denton M, Gu S, Li S, Qiang M.

Biochem J. 2002 Jun 1;364(Pt 2):413-21.


Guanine nucleotides and acute renal failure.

Weinberg JM, Venkatachalam MA.

J Clin Invest. 2001 Nov;108(9):1279-81. No abstract available.


cDNA cloning and promoter analysis of rat caspase-9.

Nishiyama J, Yi X, Venkatachalam MA, Dong Z.

Biochem J. 2001 Nov 15;360(Pt 1):49-56.


Energetic determinants of tyrosine phosphorylation of focal adhesion proteins during hypoxia/reoxygenation of kidney proximal tubules.

Weinberg JM, Venkatachalam MA, Roeser NF, Senter RA, Nissim I.

Am J Pathol. 2001 Jun;158(6):2153-64.


Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation.

Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM.

J Am Soc Nephrol. 2001 Jun;12(6):1315-25. No abstract available.


Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane.

Mikhailov V, Mikhailova M, Pulkrabek DJ, Dong Z, Venkatachalam MA, Saikumar P.

J Biol Chem. 2001 May 25;276(21):18361-74. Epub 2001 Feb 20.


Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms.

Dong Z, Venkatachalam MA, Wang J, Patel Y, Saikumar P, Semenza GL, Force T, Nishiyama J.

J Biol Chem. 2001 Jun 1;276(22):18702-9. Epub 2001 Mar 12.


Protection of ATP-depleted cells by impermeant strychnine derivatives: implications for glycine cytoprotection.

Dong Z, Venkatachalam MA, Weinberg JM, Saikumar P, Patel Y.

Am J Pathol. 2001 Mar;158(3):1021-8.


Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury.

Weinberg JM, Venkatachalam MA, Roeser NF, Saikumar P, Dong Z, Senter RA, Nissim I.

Am J Physiol Renal Physiol. 2000 Nov;279(5):F927-43.


Heme oxygenase-1 in tissue pathology: the Yin and Yang.

Dong Z, Lavrovsky Y, Venkatachalam MA, Roy AK.

Am J Pathol. 2000 May;156(5):1485-8. No abstract available.


Serine protease inhibitors suppress cytochrome c-mediatedcaspase-9 activation and apoptosis during hypoxia-reoxygenation.

Dong Z, Saikumar P, Patel Y, Weinberg JM, Venkatachalam MA.

Biochem J. 2000 May 1;347 Pt 3:669-77.


Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of citric acid cycle intermediates.

Weinberg JM, Venkatachalam MA, Roeser NF, Nissim I.

Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2826-31.


Apoptosis: definition, mechanisms, and relevance to disease.

Saikumar P, Dong Z, Mikhailov V, Denton M, Weinberg JM, Venkatachalam MA.

Am J Med. 1999 Nov;107(5):489-506. Review. No abstract available.


Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury.

Saikumar P, Dong Z, Patel Y, Hall K, Hopfer U, Weinberg JM, Venkatachalam MA.

Oncogene. 1998 Dec 31;17(26):3401-15.


Mechanisms of cell death in hypoxia/reoxygenation injury.

Saikumar P, Dong Z, Weinberg JM, Venkatachalam MA.

Oncogene. 1998 Dec 24;17(25):3341-9. Review.


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