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Diagnosis and Monitoring of Acute Infections with Emphasis on the Novel Biomarker Human Neutrophil Lipocalin.

Venge P, Xu S.

J Appl Lab Med. 2019 Jan;3(4):664-674. doi: 10.1373/jalm.2018.026369. Epub 2018 Dec 7. Review.


Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma.

George L, Taylor AR, Esteve-Codina A, Soler Artigas M, Thun GA, Bates S, Pavlidis S, Wagers S, Boland A, Prasse A, Boschetto P, Parr DG, Nowinski A, Barta I, Hohlfeld J, Greulich T, van den Berge M, Hiemstra PS, Timens W, Hinks T, Wenzel S, Siddiqui S, Richardson M, Venge P, Heath S, Gut I, Tobin MD, Edwards L, Riley JH, Djukanovic R, Auffray C, De-Meulder B, Erik-Dahlen S, Adcock IM, Chung KF, Ziegler-Heitbrock L, Sterk PJ, Singh D, Brightling CE; U-BIOPRED and the EvA study teams.

Allergy. 2019 Sep 10. doi: 10.1111/all.14016. [Epub ahead of print]


Performance of plasma measurement of neutrophil gelatinase-associated lipocalin as a biomarker of bacterial infections in the intensive care unit.

Jonsson N, Gille-Johnson P, Martling CR, Xu S, Venge P, Mårtensson J.

J Crit Care. 2019 Oct;53:264-270. doi: 10.1016/j.jcrc.2019.07.001. Epub 2019 Jul 2.


HNL (Human Neutrophil Lipocalin) and a multimarker approach to the distinction between bacterial and viral infections.

Venge P, Eriksson AK, Holmgren S, Douhan-Håkansson L, Peterson C, Xu S, Eriksson S, Garwicz D, Larsson A, Pauksen K.

J Immunol Methods. 2019 Nov;474:112627. doi: 10.1016/j.jim.2019.06.018. Epub 2019 Jun 23.


Fixed airflow obstruction relates to eosinophil activation in asthmatics.

Mogensen I, Alving K, Dahlen SE, James A, Forsberg B, Ono J, Ohta S, Venge P, Borres MP, Izuhara K, Janson C, Malinovschi A.

Clin Exp Allergy. 2019 Feb;49(2):155-162. doi: 10.1111/cea.13302. Epub 2018 Nov 25.


Prolyl carboxypeptidase activity in the circulation and its correlation with body weight and adipose tissue in lean and obese subjects.

Kehoe K, Noels H, Theelen W, De Hert E, Xu S, Verrijken A, Arnould T, Fransen E, Hermans N, Lambeir AM, Venge P, Van Gaal L, De Meester I.

PLoS One. 2018 May 17;13(5):e0197603. doi: 10.1371/journal.pone.0197603. eCollection 2018.


Predictors of 10-year changes in levels of N-terminal pro B-type natriuretic peptide and cardiac troponin I in the elderly.

Eggers KM, Lindahl B, Venge P, Lind L.

Int J Cardiol. 2018 Apr 15;257:300-305. doi: 10.1016/j.ijcard.2017.10.095.


Human neutrophil lipocalin (HNL) as a biomarker of acute infections.

Venge P.

Ups J Med Sci. 2018 Mar;123(1):1-8. doi: 10.1080/03009734.2017.1420112. Epub 2018 Feb 23. Review.


The genetically determined production of the alarmin eosinophil-derived neurotoxin is reduced in visceral leishmaniasis.

Blom K, Elshafie AI, Jönsson UB, Rönnelid J, Håkansson LD, Venge P.

APMIS. 2018 Jan;126(1):85-91. doi: 10.1111/apm.12780. Epub 2017 Nov 29.


Human Neutrophil Lipocalin in Activated Whole Blood Is a Specific and Rapid Diagnostic Biomarker of Bacterial Infections in the Respiratory Tract.

Venge P, Eriksson AK, Douhan-Håkansson L, Pauksen K.

Clin Vaccine Immunol. 2017 Jul 5;24(7). pii: e00064-17. doi: 10.1128/CVI.00064-17. Print 2017 Jul.


Equal clinical performance of a novel point-of-care cardiac troponin I (cTnI) assay with a commonly used high-sensitivity cTnI assay.

Venge P, van Lippen L, Blaschke S, Christ M, Geier F, Giannitsis E, Hagström E, Hausfater P, Khellaf M, Mair J, Pariente D, Scharnhorst V, Semjonow V.

Clin Chim Acta. 2017 Jun;469:119-125. doi: 10.1016/j.cca.2017.03.023. Epub 2017 Mar 25.


Early invasive versus non-invasive treatment in patients with non-ST-elevation acute coronary syndrome (FRISC-II): 15 year follow-up of a prospective, randomised, multicentre study.

Wallentin L, Lindhagen L, Ärnström E, Husted S, Janzon M, Johnsen SP, Kontny F, Kempf T, Levin LÅ, Lindahl B, Stridsberg M, Ståhle E, Venge P, Wollert KC, Swahn E, Lagerqvist B; FRISC-II study group.

Lancet. 2016 Oct 15;388(10054):1903-1911. doi: 10.1016/S0140-6736(16)31276-4. Epub 2016 Aug 29.


NT-proBNP is a powerful predictor for incident atrial fibrillation - Validation of a multimarker approach.

Svennberg E, Lindahl B, Berglund L, Eggers KM, Venge P, Zethelius B, Rosenqvist M, Lind L, Hijazi Z.

Int J Cardiol. 2016 Nov 15;223:74-81. doi: 10.1016/j.ijcard.2016.08.001. Epub 2016 Aug 4.


High-Sensitivity Cardiac Troponin I Is a Strong Predictor of Cardiovascular Events and Mortality in the AGES-Reykjavik Community-Based Cohort of Older Individuals.

Thorsteinsdottir I, Aspelund T, Gudmundsson E, Eiriksdottir G, Harris TB, Launer LJ, Gudnason V, Venge P.

Clin Chem. 2016 Apr;62(4):623-30. doi: 10.1373/clinchem.2015.250811. Epub 2016 Mar 2.


Distinction between bacterial and viral infections by serum measurement of human neutrophil lipocalin (HNL) and the impact of antibody selection.

Yu Z, Jing H, Hongtao P, Furong J, Yuting J, Xu S, Venge P.

J Immunol Methods. 2016 May;432:82-6. doi: 10.1016/j.jim.2016.02.014. Epub 2016 Feb 17.


Evaluation of Temporal Changes in Cardiovascular Biomarker Concentrations Improves Risk Prediction in an Elderly Population from the Community.

Eggers KM, Kempf T, Larsson A, Lindahl B, Venge P, Wallentin L, Wollert KC, Lind L.

Clin Chem. 2016 Mar;62(3):485-93. doi: 10.1373/clinchem.2015.246876. Epub 2016 Jan 14.


Human Neutrophil Lipocalin as a Superior Diagnostic Means To Distinguish between Acute Bacterial and Viral Infections.

Venge P, Douhan-Håkansson L, Garwicz D, Peterson C, Xu S, Pauksen K.

Clin Vaccine Immunol. 2015 Sep;22(9):1025-32. doi: 10.1128/CVI.00347-15. Epub 2015 Jul 1.


Elevation of cardiac troponins measured after recreational resistance training.

Savukoski T, Mehtälä L, Lindahl B, Venge P, Pettersson K.

Clin Biochem. 2015 Aug;48(12):803-6. doi: 10.1016/j.clinbiochem.2015.06.015. Epub 2015 Jun 25.


Human neutrophil lipocalin in fMLP-activated whole blood as a diagnostic means to distinguish between acute bacterial and viral infections.

Venge P, Håkansson LD, Garwicz D, Peterson C, Xu S, Pauksen K.

J Immunol Methods. 2015 Sep;424:85-90. doi: 10.1016/j.jim.2015.05.004. Epub 2015 May 20.


Cardiac troponin I levels in an elderly population from the community--The implications of sex.

Eggers KM, Johnston N, Lind L, Venge P, Lindahl B.

Clin Biochem. 2015 Aug;48(12):751-6. doi: 10.1016/j.clinbiochem.2015.04.013. Epub 2015 Apr 24.


Assessment of cell-cycle arrest biomarkers to predict early and delayed acute kidney injury.

Bell M, Larsson A, Venge P, Bellomo R, Mårtensson J.

Dis Markers. 2015;2015:158658. doi: 10.1155/2015/158658. Epub 2015 Mar 18.


High-sensitive cardiac troponin, NT-proBNP, hFABP and copeptin levels in relation to glomerular filtration rates and a medical record of cardiovascular disease.

Bjurman C, Petzold M, Venge P, Farbemo J, Fu ML, Hammarsten O.

Clin Biochem. 2015 Mar;48(4-5):302-7. doi: 10.1016/j.clinbiochem.2015.01.008. Epub 2015 Jan 28.


Urinary neutrophil gelatinase-associated lipocalin to hepcidin ratio as a biomarker of acute kidney injury in intensive care unit patients.

Mårtensson J, Glassford NJ, Jones S, Eastwood GM, Young H, Peck L, Ostland V, Westerman M, Venge P, Bellomo R.

Minerva Anestesiol. 2015 Nov;81(11):1192-200. Epub 2014 Dec 5.


Relation between cardiovascular disease risk markers and brain infarcts detected by magnetic resonance imaging in an elderly population.

Nylander R, Lind L, Wikström J, Lindahl B, Venge P, Larsson A, Ärnlöv J, Berglund L, Ahlström H, Johansson L, Larsson EM.

J Stroke Cerebrovasc Dis. 2015 Feb;24(2):312-8. doi: 10.1016/j.jstrokecerebrovasdis.2014.08.027. Epub 2014 Nov 22.


Protein post-translational modification in host defense: the antimicrobial mechanism of action of human eosinophil cationic protein native forms.

Salazar VA, Rubin J, Moussaoui M, Pulido D, Nogués MV, Venge P, Boix E.

FEBS J. 2014 Dec;281(24):5432-46. doi: 10.1111/febs.13082. Epub 2014 Oct 20.


Cardiac troponin I levels in patients with non-ST-elevation acute coronary syndrome-the importance of gender.

Eggers KM, Johnston N, James S, Lindahl B, Venge P.

Am Heart J. 2014 Sep;168(3):317-324.e1. doi: 10.1016/j.ahj.2014.06.006. Epub 2014 Jun 9.


Excellence in acute cardiac care: an overview of the seminar proceedings.

Acute Cardiovascular Care Association of the European Society of Cardiology, Thygesen K, Jaffe A, Apple F, Mockel M, Venge P, Plebani M, deFillipi C, Frye B, Wallseth A, Lindenau Stokfisch V.

Eur Heart J Acute Cardiovasc Care. 2014 Sep;3(1 Suppl):1-16. doi: 10.1177/2048872614541905. Epub 2014 Aug 11. Review. No abstract available.


Cardiac troponin I associated with the development of unrecognized myocardial infarctions detected with MRI.

Barbier CE, Themudo R, Bjerner T, Johansson L, Lindahl B, Venge P, Lind L, Ahlström H.

Clin Chem. 2014 Oct;60(10):1327-35. doi: 10.1373/clinchem.2014.222430. Epub 2014 Jul 25.


Recurrent pyoderma gangrenosum and cystic acne associated with leucocyte adhesion deficiency due to novel mutations in ITGB2: successful treatment with infliximab and adalimumab.

Vahlquist A, Håkansson LD, Rönnblom L, Karawajczyk M, Fasth A, van Gijn ME, Roos D, Venge P.

Acta Derm Venereol. 2015 Mar;95(3):349-51. doi: 10.2340/00015555-1929. No abstract available.


The production of the eosinophil proteins ECP and EPX/EDN are regulated in a reciprocal manner.

Jönsson UB, Blom K, Stålenheim G, Håkansson LD, Venge P.

APMIS. 2014 Apr;122(4):283-91. doi: 10.1111/apm.12142.


Novel sensitive cardiac troponin I immunoassay free from troponin I-specific autoantibody interference.

Savukoski T, Jacobino J, Laitinen P, Lindahl B, Venge P, Ristiniemi N, Wittfooth S, Pettersson K.

Clin Chem Lab Med. 2014 Jul;52(7):1041-8. doi: 10.1515/cclm-2013-1044.


Is it time to do away with the 99th percentile for cardiac troponin in the diagnosis of acute coronary syndrome and the assessment of cardiac risk?

Hickman PE, Lindahl B, Potter JM, Venge P, Koerbin G, Eggers KM.

Clin Chem. 2014 May;60(5):734-6. doi: 10.1373/clinchem.2013.217711. Epub 2014 Feb 21. No abstract available.


How to use C-reactive protein in acute coronary care.

Biasucci LM, Koenig W, Mair J, Mueller C, Plebani M, Lindahl B, Rifai N, Venge P, Hamm C, Giannitsis E, Huber K, Galvani M, Tubaro M, Collinson P, Alpert JS, Hasin Y, Katus H, Jaffe AS, Thygesen K; Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association of the European Society of Cardiology.

Eur Heart J. 2013 Dec;34(48):3687-90. doi: 10.1093/eurheartj/eht435. Epub 2013 Nov 7. No abstract available.


Measurement of natriuretic peptides at the point of care in the emergency and ambulatory setting: current status and future perspectives.

Bingisser R, Cairns CB, Christ M, Collinson P, Hausfater P, Lindahl B, Mair J, Price C, Venge P.

Am Heart J. 2013 Oct;166(4):614-621.e1. doi: 10.1016/j.ahj.2013.06.012. Epub 2013 Aug 15. Review.


Increase in net activity of serine proteinases but not gelatinases after local endotoxin exposure in the peripheral airways of healthy subjects.

Smith ME, Bozinovski S, Malmhäll C, Sjöstrand M, Glader P, Venge P, Hiemstra PS, Anderson GP, Lindén A, Qvarfordt I.

PLoS One. 2013 Sep 23;8(9):e75032. doi: 10.1371/journal.pone.0075032. eCollection 2013.


Prognostic implications of changes in cardiac troponin I levels in patients with non-ST elevation acute coronary syndrome.

Eggers KM, James S, Venge P, Lindahl B.

Biomarkers. 2013 Dec;18(8):668-72. doi: 10.3109/1354750X.2013.843023. Epub 2013 Oct 1.


Clinical and prognostic implications of circulating pentraxin 3 levels in non ST-elevation acute coronary syndrome.

Eggers KM, Armstrong PW, Califf RM, Johnston N, Simoons ML, Venge P, James SK.

Clin Biochem. 2013 Nov;46(16-17):1655-9. doi: 10.1016/j.clinbiochem.2013.08.014. Epub 2013 Sep 5.


The nature and discriminatory value of urinary neutrophil gelatinase-associated lipocalin in critically ill patients at risk of acute kidney injury.

Glassford NJ, Schneider AG, Xu S, Eastwood GM, Young H, Peck L, Venge P, Bellomo R.

Intensive Care Med. 2013 Oct;39(10):1714-24. doi: 10.1007/s00134-013-3040-7. Epub 2013 Aug 6.


Associations of mid-regional pro-adrenomedullin levels to cardiovascular and metabolic abnormalities, and mortality in an elderly population from the community.

Eggers KM, Venge P, Lindahl B, Lind L.

Int J Cardiol. 2013 Oct 9;168(4):3537-42. doi: 10.1016/j.ijcard.2013.05.005. Epub 2013 May 27.


Serum lysozyme - a surrogate marker of pulmonary microvascular injury in smokers?

Schmekel B, Blomstrand P, Venge P.

Clin Physiol Funct Imaging. 2013 Jul;33(4):307-12. doi: 10.1111/cpf.12029. Epub 2013 Feb 15.


Association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with sepsis and acute kidney dysfunction.

Mårtensson J, Bell M, Xu S, Bottai M, Ravn B, Venge P, Martling CR.

Biomarkers. 2013 Jun;18(4):349-56. doi: 10.3109/1354750X.2013.787460. Epub 2013 Apr 29.


Evaluation of four sensitive troponin assays for risk assessment in acute coronary syndromes using a new clinically oriented approach for comparison of assays.

Lindahl B, Eggers KM, Venge P, James S.

Clin Chem Lab Med. 2013 Sep;51(9):1859-64. doi: 10.1515/cclm-2013-0023.


Asparagine-linked glycans determine the cytotoxic capacity of eosinophil cationic protein (ECP).

Rubin J, Venge P.

Mol Immunol. 2013 Oct;55(3-4):372-80. doi: 10.1016/j.molimm.2013.03.016. Epub 2013 Apr 15.


Short- and long-term individual variation in NT-proBNP levels in patients with stable coronary artery disease.

Nordenskjöld AM, Ahlström H, Eggers KM, Fröbert O, Venge P, Lindahl B.

Clin Chim Acta. 2013 Jun 25;422:15-20. doi: 10.1016/j.cca.2013.03.025. Epub 2013 Apr 6.


Cardiac troponin I levels measured with a high-sensitive assay increase over time and are strong predictors of mortality in an elderly population.

Eggers KM, Venge P, Lindahl B, Lind L.

J Am Coll Cardiol. 2013 May 7;61(18):1906-13. doi: 10.1016/j.jacc.2012.12.048. Epub 2013 Mar 6.


Cardiac troponin assay classification by both clinical and analytical performance characteristics: a study on outcome prediction.

Venge P, Lindahl B.

Clin Chem. 2013 Jun;59(6):976-81. doi: 10.1373/clinchem.2012.194928. Epub 2013 Mar 12.


Factors influencing the 99th percentile of cardiac troponin I evaluated in community-dwelling individuals at 70 and 75 years of age.

Eggers KM, Lind L, Venge P, Lindahl B.

Clin Chem. 2013 Jul;59(7):1068-73. doi: 10.1373/clinchem.2012.196634. Epub 2013 Mar 5.


Mid-regional pro-atrial natriuretic peptide levels in the elderly: clinical and prognostic implications, and comparison to B-type natriuretic peptides.

Eggers KM, Venge P, Lind L.

Clin Chim Acta. 2013 Apr 18;419:62-6. doi: 10.1016/j.cca.2013.01.020. Epub 2013 Feb 13.


Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with mortality in a community-based cohort of older Swedish men.

Helmersson-Karlqvist J, Larsson A, Carlsson AC, Venge P, Sundström J, Ingelsson E, Lind L, Arnlöv J.

Atherosclerosis. 2013 Apr;227(2):408-13. doi: 10.1016/j.atherosclerosis.2013.01.009. Epub 2013 Jan 18.


Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed.

Blom K, Rubin J, Halfvarson J, Törkvist L, Rönnblom A, Sangfelt P, Lördal M, Jönsson UB, Sjöqvist U, Håkansson LD, Venge P, Carlson M.

World J Gastroenterol. 2012 Nov 28;18(44):6409-19; discussion p. 6417-8. doi: 10.3748/wjg.v18.i44.6409.

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