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Items: 1 to 50 of 78

1.

Alcohol and Pain: A Translational Review of Preclinical and Clinical Findings to Inform Future Treatment Strategies.

Edwards S, Vendruscolo LF, Gilpin NW, Wojnar M, Witkiewitz K.

Alcohol Clin Exp Res. 2020 Feb;44(2):368-383. doi: 10.1111/acer.14260. Epub 2020 Jan 6. Review.

PMID:
31840821
2.

PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease.

Lee JS, Mukhopadhyay P, Matyas C, Trojnar E, Paloczi J, Yang YR, Blank BA, Savage C, Sorokin AV, Mehta NN, Vendruscolo JCM, Koob GF, Vendruscolo LF, Pacher P, Lohoff FW.

Sci Rep. 2019 Nov 20;9(1):17167. doi: 10.1038/s41598-019-53603-6.

3.

Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder?

Tunstall BJ, Lorrai I, McConnell SA, Gazo KL, Zallar LJ, de Guglielmo G, Hoang I, Haass-Koffler CL, Repunte-Canonigo V, Koob GF, Vendruscolo LF, Sanna PP.

Alcohol Alcohol. 2019 Jan 9;54(5):497-502. doi: 10.1093/alcalc/agz054.

4.

Utility of fentanyl vaccines: unique challenges posed by preventing opioid overdose and treating opioid use disorder.

Tunstall BJ, Vendruscolo LF.

Neuropsychopharmacology. 2019 Sep;44(10):1675-1676. doi: 10.1038/s41386-019-0418-4. Epub 2019 May 24. No abstract available.

PMID:
31127167
5.

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala.

Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF.

PLoS Biol. 2019 Apr 16;17(4):e2006421. doi: 10.1371/journal.pbio.2006421. eCollection 2019 Apr.

6.

Heroin addiction engages negative emotional learning brain circuits in rats.

Carmack SA, Keeley RJ, Vendruscolo JCM, Lowery-Gionta EG, Lu H, Koob GF, Stein EA, Vendruscolo LF.

J Clin Invest. 2019 Mar 26;129(6):2480-2484. doi: 10.1172/JCI125534.

7.

Male and female mice develop escalation of heroin intake and dependence following extended access.

Towers EB, Tunstall BJ, McCracken ML, Vendruscolo LF, Koob GF.

Neuropharmacology. 2019 Jun;151:189-194. doi: 10.1016/j.neuropharm.2019.03.019. Epub 2019 Mar 14.

PMID:
30880124
8.

Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding.

Tyler RE, Kim SW, Guo M, Jang YJ, Damadzic R, Stodden T, Vendruscolo LF, Koob GF, Wang GJ, Wiers CE, Volkow ND.

Eur J Neurosci. 2019 Jul;50(1):1831-1842. doi: 10.1111/ejn.14392. Epub 2019 Mar 25.

PMID:
30803059
9.

Ghrelin Receptor Influence on Cocaine Reward is Not Directly Dependent on Peripheral Acyl-Ghrelin.

Wenthur CJ, Gautam R, Zhou B, Vendruscolo LF, Leggio L, Janda KD.

Sci Rep. 2019 Feb 12;9(1):1841. doi: 10.1038/s41598-019-38549-z.

10.

Ghrelin receptor deletion reduces binge-like alcohol drinking in rats.

Zallar LJ, Beurmann S, Tunstall BJ, Fraser CM, Koob GF, Vendruscolo LF, Leggio L.

J Neuroendocrinol. 2019 Jul;31(7):e12663. doi: 10.1111/jne.12663. Epub 2019 Jan 16.

PMID:
30456835
11.

Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents.

Kim SW, Wiers CE, Tyler R, Shokri-Kojori E, Jang YJ, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Cabrera EA, Stodden T, Guo M, Demiral ŞB, Diazgranados N, Park L, Liow JS, Pike V, Morse C, Vendruscolo LF, Innis RB, Koob GF, Tomasi D, Wang GJ, Volkow ND.

Neuropsychopharmacology. 2018 Aug;43(9):1832-1839. doi: 10.1038/s41386-018-0085-x. Epub 2018 May 3.

12.

Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats.

Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C.

Neuropsychopharmacology. 2018 Nov;43(12):2373-2382. doi: 10.1038/s41386-018-0054-4. Epub 2018 Apr 6.

13.

Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood.

Gueye AB, Vendruscolo LF, de Ávila C, Le Moine C, Darnaudéry M, Cador M.

Neuropsychopharmacology. 2018 Dec;43(13):2627-2635. doi: 10.1038/s41386-018-0025-9. Epub 2018 Feb 27.

14.

Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model.

Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendruscolo LF, Harvey BK, Leggio L.

Int J Obes (Lond). 2019 Feb;43(2):344-354. doi: 10.1038/s41366-018-0013-5. Epub 2018 Jan 30.

15.

Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice.

Juarez B, Morel C, Ku SM, Liu Y, Zhang H, Montgomery S, Gregoire H, Ribeiro E, Crumiller M, Roman-Ortiz C, Walsh JJ, Jackson K, Croote DE, Zhu Y, Zhang S, Vendruscolo LF, Edwards S, Roberts A, Hodes GE, Lu Y, Calipari ES, Chaudhury D, Friedman AK, Han MH.

Nat Commun. 2018 Feb 8;9(1):653. doi: 10.1038/s41467-018-02921-w.

16.

Midbrain circuit regulation of individual alcohol drinking behaviors in mice.

Juarez B, Morel C, Ku SM, Liu Y, Zhang H, Montgomery S, Gregoire H, Ribeiro E, Crumiller M, Roman-Ortiz C, Walsh JJ, Jackson K, Croote DE, Zhu Y, Zhang S, Vendruscolo LF, Edwards S, Roberts A, Hodes GE, Lu Y, Calipari ES, Chaudhury D, Friedman AK, Han MH.

Nat Commun. 2017 Dec 20;8(1):2220. doi: 10.1038/s41467-017-02365-8. Erratum in: Nat Commun. 2018 Feb 8;9(1):653.

17.

Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.

Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF.

Neuropharmacology. 2018 Mar 15;131:96-103. doi: 10.1016/j.neuropharm.2017.12.006. Epub 2017 Dec 5.

18.

The Role of the Ghrelin System in Drug Addiction.

Zallar LJ, Farokhnia M, Tunstall BJ, Vendruscolo LF, Leggio L.

Int Rev Neurobiol. 2017;136:89-119. doi: 10.1016/bs.irn.2017.08.002. Epub 2017 Sep 18. Review.

PMID:
29056157
19.

Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST).

Francesconi W, Szücs A, Berton F, Koob GF, Vendruscolo LF, Sanna PP.

Psychopharmacology (Berl). 2017 Dec;234(23-24):3485-3498. doi: 10.1007/s00213-017-4732-4. Epub 2017 Oct 6.

20.

Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder.

Lohoff FW, Sorcher JL, Rosen AD, Mauro KL, Fanelli RR, Momenan R, Hodgkinson CA, Vendruscolo LF, Koob GF, Schwandt M, George DT, Jones IS, Holmes A, Zhou Z, Xu MJ, Gao B, Sun H, Phillips MJ, Muench C, Kaminsky ZA.

Mol Psychiatry. 2018 Sep;23(9):1900-1910. doi: 10.1038/mp.2017.168. Epub 2017 Aug 29.

21.

Compulsive-Like Sufentanil Vapor Self-Administration in Rats.

Vendruscolo JCM, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater SA, Taffe MA, Koob GF, Vendruscolo LF.

Neuropsychopharmacology. 2018 Mar;43(4):801-809. doi: 10.1038/npp.2017.172. Epub 2017 Aug 16.

22.

Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors.

Somkuwar SS, Vendruscolo LF, Fannon MJ, Schmeichel BE, Nguyen TB, Guevara J, Sidhu H, Contet C, Zorrilla EP, Mandyam CD.

Psychoneuroendocrinology. 2017 Oct;84:17-31. doi: 10.1016/j.psyneuen.2017.06.006. Epub 2017 Jun 12.

23.

Dysregulation of Brain Stress Systems Mediates Compulsive Alcohol Drinking.

Tunstall BJ, Carmack SA, Koob GF, Vendruscolo LF.

Curr Opin Behav Sci. 2017 Feb;13:85-90. doi: 10.1016/j.cobeha.2016.10.006. Epub 2016 Nov 19.

24.

Effects of physical exercise and social isolation on anxiety-related behaviors in two inbred rat strains.

Mazur FG, Oliveira LFG, Cunha MP, Rodrigues ALS, Pértile RAN, Vendruscolo LF, Izídio GS.

Behav Processes. 2017 Sep;142:70-78. doi: 10.1016/j.beproc.2017.06.001. Epub 2017 Jun 8.

PMID:
28602748
25.

A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans.

Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L.

Mol Psychiatry. 2018 Jun;23(6):1466-1473. doi: 10.1038/mp.2017.97. Epub 2017 May 2.

26.

Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE.

J Neurosci. 2017 Feb 1;37(5):1139-1155. doi: 10.1523/JNEUROSCI.2002-16.2016. Epub 2016 Dec 16.

27.

Prior Exposure to Alcohol Has No Effect on Cocaine Self-Administration and Relapse in Rats: Evidence from a Rat Model that Does Not Support the Gateway Hypothesis.

Fredriksson I, Adhikary S, Steensland P, Vendruscolo LF, Bonci A, Shaham Y, Bossert JM.

Neuropsychopharmacology. 2017 Apr;42(5):1001-1011. doi: 10.1038/npp.2016.209. Epub 2016 Sep 21.

28.

Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence.

de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O.

J Neurosci. 2016 Sep 7;36(36):9446-53. doi: 10.1523/JNEUROSCI.1395-16.2016.

29.

Sex, strain, and estrous cycle influences on alcohol drinking in rats.

Priddy BM, Carmack SA, Thomas LC, Vendruscolo JC, Koob GF, Vendruscolo LF.

Pharmacol Biochem Behav. 2017 Jan;152:61-67. doi: 10.1016/j.pbb.2016.08.001. Epub 2016 Aug 4.

30.

Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex.

Verheij MM, Vendruscolo LF, Caffino L, Giannotti G, Cazorla M, Fumagalli F, Riva MA, Homberg JR, Koob GF, Contet C.

J Neurosci. 2016 Aug 3;36(31):8149-59. doi: 10.1523/JNEUROSCI.2711-14.2016.

31.

11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse.

Sanna PP, Kawamura T, Chen J, Koob GF, Roberts AJ, Vendruscolo LF, Repunte-Canonigo V.

Transl Psychiatry. 2016 Mar 15;6:e760. doi: 10.1038/tp.2016.13.

32.

Binge-like ingestion of a combination of an energy drink and alcohol leads to cognitive deficits and motivational changes.

Takahashi TT, Vendruscolo LF, Takahashi RN.

Pharmacol Biochem Behav. 2015 Sep;136:82-6. doi: 10.1016/j.pbb.2015.07.007. Epub 2015 Jul 15.

33.

Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals.

Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ.

J Clin Invest. 2015 Aug 3;125(8):3193-7. doi: 10.1172/JCI79828. Epub 2015 Jun 29.

34.

Divergent regulation of distinct glucocorticoid systems in alcohol dependence.

Edwards S, Little HJ, Richardson HN, Vendruscolo LF.

Alcohol. 2015 Dec;49(8):811-6. doi: 10.1016/j.alcohol.2015.04.004. Epub 2015 Apr 30. Review.

35.

Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks.

Repunte-Canonigo V, Shin W, Vendruscolo LF, Lefebvre C, van der Stap L, Kawamura T, Schlosburg JE, Alvarez M, Koob GF, Califano A, Sanna PP.

Genome Biol. 2015 Feb 2;16:68. doi: 10.1186/s13059-015-0593-5.

36.

Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking.

Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O.

J Neurosci. 2015 Apr 15;35(15):6241-53. doi: 10.1523/JNEUROSCI.3302-14.2015. Erratum in: J Neurosci. 2015 Aug 5;35(31):11169.

37.

DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity.

Barbier E, Tapocik JD, Juergens N, Pitcairn C, Borich A, Schank JR, Sun H, Schuebel K, Zhou Z, Yuan Q, Vendruscolo LF, Goldman D, Heilig M.

J Neurosci. 2015 Apr 15;35(15):6153-64. doi: 10.1523/JNEUROSCI.4571-14.2015.

38.

κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake.

Whitfield TW Jr, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF.

J Neurosci. 2015 Mar 11;35(10):4296-305. doi: 10.1523/JNEUROSCI.1978-13.2015.

39.

Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats.

Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF.

Neuropsychopharmacology. 2015 Mar 13;40(5):1123-9. doi: 10.1038/npp.2014.293.

40.

Compulsive-like responding for opioid analgesics in rats with extended access.

Wade CL, Vendruscolo LF, Schlosburg JE, Hernandez DO, Koob GF.

Neuropsychopharmacology. 2015 Jan;40(2):421-8. doi: 10.1038/npp.2014.188. Epub 2014 Jul 25.

41.

Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction.

George O, Koob GF, Vendruscolo LF.

Psychopharmacology (Berl). 2014 Oct;231(19):3911-7. doi: 10.1007/s00213-014-3623-1. Epub 2014 Jun 13. No abstract available.

PMID:
24923982
42.

Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats.

Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF.

Behav Brain Res. 2014 Sep 1;271:171-6. doi: 10.1016/j.bbr.2014.06.003. Epub 2014 Jun 7.

43.

Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats.

Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP.

Neuropsychopharmacology. 2014 Jun;39(7):1722-31. doi: 10.1038/npp.2014.20. Epub 2014 Jan 29.

44.

Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.

Park PE, Schlosburg JE, Vendruscolo LF, Schulteis G, Edwards S, Koob GF.

Addict Biol. 2015 Mar;20(2):275-84. doi: 10.1111/adb.12120. Epub 2013 Dec 13.

45.

Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake.

Schlosburg JE, Whitfield TW Jr, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF.

J Neurosci. 2013 Dec 4;33(49):19384-92. doi: 10.1523/JNEUROSCI.1979-13.2013.

46.

Operant alcohol self-administration in dependent rats: focus on the vapor model.

Vendruscolo LF, Roberts AJ.

Alcohol. 2014 May;48(3):277-86. doi: 10.1016/j.alcohol.2013.08.006. Epub 2013 Nov 1. Review.

47.

Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats.

Buck CL, Vendruscolo LF, Koob GF, George O.

Psychopharmacology (Berl). 2014 Mar;231(5):929-37. doi: 10.1007/s00213-013-3307-2. Epub 2013 Nov 13.

48.

Addiction as a stress surfeit disorder.

Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW Jr, George O.

Neuropharmacology. 2014 Jan;76 Pt B:370-82. doi: 10.1016/j.neuropharm.2013.05.024. Epub 2013 Jun 6. Review.

49.

Dynamic vaccine blocks relapse to compulsive intake of heroin.

Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):9036-41. doi: 10.1073/pnas.1219159110. Epub 2013 May 6.

50.

Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats.

Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW.

Addict Biol. 2014 Sep;19(5):755-7. doi: 10.1111/adb.12059. Epub 2013 May 3.

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