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Items: 41

1.

Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.

Peleli M, Bibli SI, Li Z, Chatzianastasiou A, Varela A, Katsouda A, Zukunft S, Bucci M, Vellecco V, Davos CH, Nagahara N, Cirino G, Fleming I, Lefer DJ, Papapetropoulos A.

Biochem Pharmacol. 2020 Feb 4:113833. doi: 10.1016/j.bcp.2020.113833. [Epub ahead of print]

PMID:
32027885
2.

Functional contribution of sphingosine-1-phosphate to airway pathology in cigarette smoke-exposed mice.

De Cunto G, Brancaleone V, Riemma MA, Cerqua I, Vellecco V, Spaziano G, Cavarra E, Bartalesi B, D'Agostino B, Lungarella G, Cirino G, Lucattelli M, Roviezzo F.

Br J Pharmacol. 2020 Jan;177(2):267-281. doi: 10.1111/bph.14861. Epub 2019 Nov 6.

PMID:
31499592
3.

Investigating the properties of TBA variants with twin thrombin binding domains.

Amato T, Virgilio A, Pirone L, Vellecco V, Bucci M, Pedone E, Esposito V, Galeone A.

Sci Rep. 2019 Jun 24;9(1):9184. doi: 10.1038/s41598-019-45526-z.

4.

Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle.

Vellecco V, Martelli A, Bibli IS, Vallifuoco M, Manzo OL, Panza E, Citi V, Calderone V, de Dominicis G, Cozzolino C, Basso EM, Mariniello M, Fleming I, Mancini A, Bucci M, Cirino G.

Br J Pharmacol. 2019 May 3. doi: 10.1111/bph.14700. [Epub ahead of print]

PMID:
31051045
5.

Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis.

Carino A, Marchianò S, Biagioli M, Bucci M, Vellecco V, Brancaleone V, Fiorucci C, Zampella A, Monti MC, Distrutti E, Fiorucci S.

FASEB J. 2019 Feb;33(2):2809-2822. doi: 10.1096/fj.201801373RR. Epub 2018 Oct 10.

PMID:
30303744
6.

Thrombin binding aptamer analogues containing inversion of polarity sites endowed with antiproliferative and anti-motility properties against Calu-6 cells.

Esposito V, Russo A, Vellecco V, Bucci M, Russo G, Mayol L, Virgilio A, Galeone A.

Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2645-2650. doi: 10.1016/j.bbagen.2018.07.031. Epub 2018 Jul 31.

PMID:
30071274
7.

Hydrogen sulfide pathway and skeletal muscle: an introductory review.

Vellecco V, Armogida C, Bucci M.

Br J Pharmacol. 2018 Aug;175(15):3090-3099. doi: 10.1111/bph.14358. Epub 2018 Jun 15. Review.

8.

The "Janus face" of the thrombin binding aptamer: Investigating the anticoagulant and antiproliferative properties through straightforward chemical modifications.

Esposito V, Russo A, Amato T, Vellecco V, Bucci M, Mayol L, Russo G, Virgilio A, Galeone A.

Bioorg Chem. 2018 Feb;76:202-209. doi: 10.1016/j.bioorg.2017.11.005. Epub 2017 Nov 15.

PMID:
29190476
9.

1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors.

Severino B, Corvino A, Fiorino F, Luciano P, Frecentese F, Magli E, Saccone I, Di Vaio P, Citi V, Calderone V, Servillo L, Casale R, Cirino G, Vellecco V, Bucci M, Perissutti E, Santagada V, Caliendo G.

Eur J Med Chem. 2018 Jan 1;143:1677-1686. doi: 10.1016/j.ejmech.2017.10.068. Epub 2017 Nov 11.

PMID:
29133036
10.

Nitric oxide and hydrogen sulfide: the gasotransmitter paradigm of the vascular system.

Cirino G, Vellecco V, Bucci M.

Br J Pharmacol. 2017 Nov;174(22):4021-4031. doi: 10.1111/bph.13815. Epub 2017 May 16. Review.

11.

Backbone modified TBA analogues endowed with antiproliferative activity.

Esposito V, Russo A, Amato T, Varra M, Vellecco V, Bucci M, Russo G, Virgilio A, Galeone A.

Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1213-1221. doi: 10.1016/j.bbagen.2016.09.019. Epub 2016 Sep 20.

PMID:
27663232
12.

Proteinase activated receptor-2 counterbalances the vascular effects of endothelin-1 in fibrotic tight-skin mice.

Roviezzo F, Brancaleone V, Mattera Iacono V, Bertolino A, De Cunto G, Vellecco V, Lungarella G, Lucattelli M, Cirino G.

Br J Pharmacol. 2017 Nov;174(22):4032-4042. doi: 10.1111/bph.13618. Epub 2016 Oct 5.

13.

Vascular effects of linagliptin in non-obese diabetic mice are glucose-independent and involve positive modulation of the endothelial nitric oxide synthase (eNOS)/caveolin-1 (CAV-1) pathway.

Vellecco V, Mitidieri E, Gargiulo A, Brancaleone V, Matassa D, Klein T, Esposito F, Cirino G, Bucci M.

Diabetes Obes Metab. 2016 Dec;18(12):1236-1243. doi: 10.1111/dom.12750. Epub 2016 Aug 30.

PMID:
27460695
14.

D-Penicillamine modulates hydrogen sulfide (H2S) pathway through selective inhibition of cystathionine-γ-lyase.

Brancaleone V, Esposito I, Gargiulo A, Vellecco V, Asimakopoulou A, Citi V, Calderone V, Gobbetti T, Perretti M, Papapetropoulos A, Bucci M, Cirino G.

Br J Pharmacol. 2016 May;173(9):1556-65. doi: 10.1111/bph.13459. Epub 2016 Mar 23.

15.

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity.

Virgilio A, Petraccone L, Vellecco V, Bucci M, Varra M, Irace C, Santamaria R, Pepe A, Mayol L, Esposito V, Galeone A.

Nucleic Acids Res. 2015 Dec 15;43(22):10602-11. doi: 10.1093/nar/gkv1224. Epub 2015 Nov 17.

16.

Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia.

Vellecco V, Mancini A, Ianaro A, Calderone V, Attanasio C, Cantalupo A, Andria B, Savoia G, Panza E, Di Martino A, Cirino G, Bucci M.

Clin Sci (Lond). 2016 Jan;130(1):35-44. doi: 10.1042/CS20150521. Epub 2015 Oct 12.

PMID:
26460077
17.

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative.

Scuotto M, Rivieccio E, Varone A, Corda D, Bucci M, Vellecco V, Cirino G, Virgilio A, Esposito V, Galeone A, Borbone N, Varra M, Mayol L.

Nucleic Acids Res. 2015 Sep 18;43(16):7702-16. doi: 10.1093/nar/gkv789. Epub 2015 Aug 6.

18.

Characterization of zofenoprilat as an inducer of functional angiogenesis through increased H2 S availability.

Terzuoli E, Monti M, Vellecco V, Bucci M, Cirino G, Ziche M, Morbidelli L.

Br J Pharmacol. 2015 Jun;172(12):2961-73. doi: 10.1111/bph.13101. Epub 2015 Mar 27.

19.

5-Hydroxymethyl-2'-deoxyuridine residues in the thrombin binding aptamer: investigating anticoagulant activity by making a tiny chemical modification.

Virgilio A, Petraccone L, Scuotto M, Vellecco V, Bucci M, Mayol L, Varra M, Esposito V, Galeone A.

Chembiochem. 2014 Nov 3;15(16):2427-34. doi: 10.1002/cbic.201402355. Epub 2014 Sep 11.

PMID:
25214456
20.

Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue.

Scuotto M, Persico M, Bucci M, Vellecco V, Borbone N, Morelli E, Oliviero G, Novellino E, Piccialli G, Cirino G, Varra M, Fattorusso C, Mayol L.

Org Biomol Chem. 2014 Jul 28;12(28):5235-42. doi: 10.1039/c4ob00149d.

PMID:
24920241
21.

Crucial role of androgen receptor in vascular H2S biosynthesis induced by testosterone.

Brancaleone V, Vellecco V, Matassa DS, d'Emmanuele di Villa Bianca R, Sorrentino R, Ianaro A, Bucci M, Esposito F, Cirino G.

Br J Pharmacol. 2015 Mar;172(6):1505-15. doi: 10.1111/bph.12740. Epub 2014 Jul 2.

22.

Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.

Bucci M, Vellecco V, Cantalupo A, Brancaleone V, Zhou Z, Evangelista S, Calderone V, Papapetropoulos A, Cirino G.

Cardiovasc Res. 2014 Apr 1;102(1):138-47. doi: 10.1093/cvr/cvu026. Epub 2014 Feb 5.

PMID:
24501330
23.

Perthamide C inhibits eNOS and iNOS expression and has immunomodulating activity in vivo.

Bucci M, Cantalupo A, Vellecco V, Panza E, Monti MC, Zampella A, Ianaro A, Cirino G.

PLoS One. 2013;8(3):e57801. doi: 10.1371/journal.pone.0057801. Epub 2013 Mar 12. Retraction in: PLoS One. 2019 Aug 30;14(8):e0222175.

24.

cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation.

Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Zaid A, Giannogonas P, Cantalupo A, Dhayade S, Karalis KP, Wang R, Feil R, Cirino G.

PLoS One. 2012;7(12):e53319. doi: 10.1371/journal.pone.0053319. Epub 2012 Dec 28.

25.

Investigating the role of T7 and T12 residues on the biological properties of thrombin-binding aptamer: enhancement of anticoagulant activity by a single nucleobase modification.

Borbone N, Bucci M, Oliviero G, Morelli E, Amato J, D'Atri V, D'Errico S, Vellecco V, Cirino G, Piccialli G, Fattorusso C, Varra M, Mayol L, Persico M, Scuotto M.

J Med Chem. 2012 Dec 13;55(23):10716-28. doi: 10.1021/jm301414f. Epub 2012 Nov 19.

PMID:
23126678
26.

Cross-talk between toll-like receptor 4 (TLR4) and proteinase-activated receptor 2 (PAR(2) ) is involved in vascular function.

Bucci M, Vellecco V, Harrington L, Brancaleone V, Roviezzo F, Mattace Raso G, Ianaro A, Lungarella G, De Palma R, Meli R, Cirino G.

Br J Pharmacol. 2013 Jan;168(2):411-20. doi: 10.1111/j.1476-5381.2012.02205.x.

27.

Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo.

Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G.

J Pharmacol Exp Ther. 2012 Mar;340(3):716-22. doi: 10.1124/jpet.111.189308. Epub 2011 Dec 13.

PMID:
22171091
28.

Inhibition of nitric oxide-stimulated vasorelaxation by carbon monoxide-releasing molecules.

Marazioti A, Bucci M, Coletta C, Vellecco V, Baskaran P, Szabó C, Cirino G, Marques AR, Guerreiro B, Gonçalves AM, Seixas JD, Beuve A, Romão CC, Papapetropoulos A.

Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2570-6. doi: 10.1161/ATVBAHA.111.229039.

PMID:
21836072
29.

Sphingosine-1-phosphate modulates vascular permeability and cell recruitment in acute inflammation in vivo.

Roviezzo F, Brancaleone V, De Gruttola L, Vellecco V, Bucci M, D'Agostino B, Cooper D, Sorrentino R, Perretti M, Cirino G.

J Pharmacol Exp Ther. 2011 Jun;337(3):830-7. doi: 10.1124/jpet.111.179168. Epub 2011 Mar 18.

PMID:
21421740
30.

Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei.

Festa C, De Marino S, Sepe V, D'Auria MV, Bifulco G, Débitus C, Bucci M, Vellecco V, Zampella A.

Org Lett. 2011 Mar 18;13(6):1532-5. doi: 10.1021/ol200221n. Epub 2011 Feb 22.

PMID:
21341715
31.

Hydrogen sulfide-induced dual vascular effect involves arachidonic acid cascade in rat mesenteric arterial bed.

d'Emmanuele di Villa Bianca R, Sorrentino R, Coletta C, Mitidieri E, Rossi A, Vellecco V, Pinto A, Cirino G, Sorrentino R.

J Pharmacol Exp Ther. 2011 Apr;337(1):59-64. doi: 10.1124/jpet.110.176016. Epub 2011 Jan 12.

PMID:
21228064
32.

Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity.

Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Pyriochou A, Roussos C, Roviezzo F, Brancaleone V, Cirino G.

Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1998-2004. doi: 10.1161/ATVBAHA.110.209783. Epub 2010 Jul 15.

PMID:
20634473
33.

Synthesis, structural studies and biological properties of new TBA analogues containing an acyclic nucleotide.

Coppola T, Varra M, Oliviero G, Galeone A, D'Isa G, Mayol L, Morelli E, Bucci MR, Vellecco V, Cirino G, Borbone N.

Bioorg Med Chem. 2008 Sep 1;16(17):8244-53. doi: 10.1016/j.bmc.2008.07.040. Epub 2008 Jul 20.

PMID:
18752966
34.

Biosynthesis of H2S is impaired in non-obese diabetic (NOD) mice.

Brancaleone V, Roviezzo F, Vellecco V, De Gruttola L, Bucci M, Cirino G.

Br J Pharmacol. 2008 Nov;155(5):673-80. doi: 10.1038/bjp.2008.296. Epub 2008 Jul 21.

35.

Hydrogen sulphide is involved in testosterone vascular effect.

Bucci M, Mirone V, Di Lorenzo A, Vellecco V, Roviezzo F, Brancaleone V, Ciro I, Cirino G.

Eur Urol. 2009 Aug;56(2):378-83. doi: 10.1016/j.eururo.2008.05.014. Epub 2008 May 22.

PMID:
18511180
36.

Haemostatic imbalance following carrageenan-induced rat paw oedema.

Cicala C, Morello S, Alfieri A, Vellecco V, Marzocco S, Autore G.

Eur J Pharmacol. 2007 Dec 22;577(1-3):156-61. Epub 2007 Aug 14.

PMID:
17850787
37.

Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness.

Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, Cirino G.

Am J Respir Cell Mol Biol. 2007 Jun;36(6):757-62. Epub 2007 Feb 22.

PMID:
17322125
38.

Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.

Posadas I, Vellecco V, Santos P, Prieto-Lloret J, Ceña V.

Br J Pharmacol. 2007 Mar;150(5):577-85. Epub 2007 Jan 22.

39.

A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats.

Morello S, Vellecco V, Roviezzo F, Maffia P, Cuzzocrea S, Cirino G, Cicala C.

Biochem Pharmacol. 2005 Dec 19;71(1-2):223-30. Epub 2005 Nov 21.

PMID:
16300746
40.

Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta.

Morello S, Vellecco V, Alfieri A, Mascolo N, Cicala C.

Life Sci. 2006 Jan 18;78(8):825-30. Epub 2005 Sep 15.

PMID:
16169019
41.

Basal nitric oxide modulates vascular effects of a peptide activating protease-activated receptor 2.

Cicala C, Morello S, Vellecco V, Severino B, Sorrentino L, Cirino G.

Cardiovasc Res. 2003 Nov 1;60(2):431-7.

PMID:
14613873

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