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Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa.

Han ML, Zhu Y, Creek DJ, Lin YW, Gutu AD, Hertzog P, Purcell T, Shen HH, Moskowitz SM, Velkov T, Li J.

mSystems. 2019 Jan 8;4(1). pii: e00149-18. doi: 10.1128/mSystems.00149-18. eCollection 2019 Jan-Feb.


Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa.

Hussein M, Han ML, Zhu Y, Schneider-Futschik EK, Hu X, Zhou QT, Lin YW, Anderson D, Creek DJ, Hoyer D, Li J, Velkov T.

Comput Struct Biotechnol J. 2018 Nov 10;16:587-599. doi: 10.1016/j.csbj.2018.11.001. eCollection 2018.


Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii.

Han ML, Liu X, Velkov T, Lin YW, Zhu Y, Li M, Yu HH, Zhou Z, Creek DJ, Zhang J, Li J.

Front Microbiol. 2018 Nov 16;9:2776. doi: 10.3389/fmicb.2018.02776. eCollection 2018.


Contemporary anti-Ebola drug discovery approaches and platforms.

Schneider-Futschik EK, Hoyer D, Khromykh A, Baell JB, Marsh G, Baker MA, Li J, Velkov T.

ACS Infect Dis. 2018 Dec 5. doi: 10.1021/acsinfecdis.8b00285. [Epub ahead of print]


Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.

Dai C, Xiao X, Li D, Tun S, Wang Y, Velkov T, Tang S.

Cell Death Dis. 2018 Nov 26;9(12):1164. doi: 10.1038/s41419-018-1136-2.


Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention.

Dai C, Xiao X, Li J, Ciccotosto GD, Cappai R, Tang S, Schneider-Futschik EK, Hoyer D, Velkov T, Shen J.

ACS Chem Neurosci. 2018 Nov 7. doi: 10.1021/acschemneuro.8b00300. [Epub ahead of print]


Exploiting Macromolecular Design To Optimize the Antibacterial Activity of Alkylated Cationic Oligomers.

Grace JL, Schneider-Futschik EK, Elliott AG, Amado M, Truong NP, Cooper MA, Li J, Davis TP, Quinn JF, Velkov T, Whittaker MR.

Biomacromolecules. 2018 Nov 6. doi: 10.1021/acs.biomac.8b01317. [Epub ahead of print]


Intracellular localization of polymyxins in human alveolar epithelial cells.

Ahmed MU, Velkov T, Zhou QT, Fulcher AJ, Callaghan J, Zhou F, Chan K, Azad MAK, Li J.

J Antimicrob Chemother. 2019 Jan 1;74(1):48-57. doi: 10.1093/jac/dky409.


A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains.

Jasim R, Baker MA, Zhu Y, Han M, Schneider-Futschik EK, Hussein M, Hoyer D, Li J, Velkov T.

ACS Infect Dis. 2018 Oct 5. doi: 10.1021/acsinfecdis.8b00174. [Epub ahead of print]


Lipidomic Analysis of the Outer Membrane Vesicles from Paired Polymyxin-Susceptible and -Resistant Klebsiella pneumoniae Clinical Isolates.

Jasim R, Han ML, Zhu Y, Hu X, Hussein MH, Lin YW, Zhou QT, Dong CYD, Li J, Velkov T.

Int J Mol Sci. 2018 Aug 10;19(8). pii: E2356. doi: 10.3390/ijms19082356.


Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation.

Mangal S, Park H, Zeng L, Yu HH, Lin YW, Velkov T, Denman JA, Zemlyanov D, Li J, Zhou QT.

Int J Pharm. 2018 Sep 5;548(1):443-453. doi: 10.1016/j.ijpharm.2018.07.010. Epub 2018 Jul 3.


Correction to: Polymyxin B causes DNA damage in HK-2 cells and mice.

Yun B, Zhang T, Azad MAK, Wang J, Nowell CJ, Kalitsis P, Velkov T, Hudson DF, Li J.

Arch Toxicol. 2018 Jun 18. doi: 10.1007/s00204-018-2233-9. [Epub ahead of print]


Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study.

Tran TB, Bergen PJ, Creek DJ, Velkov T, Li J.

Front Pharmacol. 2018 Apr 16;9:359. doi: 10.3389/fphar.2018.00359. eCollection 2018.


Novel Polymyxin Combination With Antineoplastic Mitotane Improved the Bacterial Killing Against Polymyxin-Resistant Multidrug-Resistant Gram-Negative Pathogens.

Tran TB, Wang J, Doi Y, Velkov T, Bergen PJ, Li J.

Front Microbiol. 2018 Apr 12;9:721. doi: 10.3389/fmicb.2018.00721. eCollection 2018.


Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa.

Zhu Y, Czauderna T, Zhao J, Klapperstueck M, Maifiah MHM, Han ML, Lu J, Sommer B, Velkov T, Lithgow T, Song J, Schreiber F, Li J.

Gigascience. 2018 Apr 1;7(4). doi: 10.1093/gigascience/giy021.


Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa.

Han ML, Zhu Y, Creek DJ, Lin YW, Anderson D, Shen HH, Tsuji B, Gutu AD, Moskowitz SM, Velkov T, Li J.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02656-17. doi: 10.1128/AAC.02656-17. Print 2018 Jun.


Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing against Extensively Drug-Resistant Pseudomonas aeruginosa.

Lin YW, Yu HH, Zhao J, Han ML, Zhu Y, Akter J, Wickremasinghe H, Walpola H, Wirth V, Rao GG, Forrest A, Velkov T, Li J.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00028-18. doi: 10.1128/AAC.00028-18. Print 2018 Jun.


Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules.

Schneider-Futschik EK, Paulin OKA, Hoyer D, Roberts KD, Ziogas J, Baker MA, Karas J, Li J, Velkov T.

ACS Infect Dis. 2018 May 11;4(5):646-655. doi: 10.1021/acsinfecdis.7b00238. Epub 2018 Apr 2.


The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites.

Schneider EK, McQuade RM, Carbone VC, Reyes-Ortega F, Wilson JW, Button B, Saito A, Poole DP, Hoyer D, Li J, Velkov T.

ERJ Open Res. 2018 Mar 13;4(1). pii: 00127-2017. doi: 10.1183/23120541.00127-2017. eCollection 2018 Jan. Erratum in: ERJ Open Res. 2018 Dec 21;4(4):.


Polymyxin B causes DNA damage in HK-2 cells and mice.

Yun B, Zhang T, Azad MAK, Wang J, Nowell CJ, Kalitsis P, Velkov T, Hudson DF, Li J.

Arch Toxicol. 2018 Jul;92(7):2259-2271. doi: 10.1007/s00204-018-2192-1. Epub 2018 Mar 20. Erratum in: Arch Toxicol. 2018 Jun 18;:.


Fitness cost of mcr-1-mediated polymyxin resistance in Klebsiella pneumoniae.

Nang SC, Morris FC, McDonald MJ, Han ML, Wang J, Strugnell RA, Velkov T, Li J.

J Antimicrob Chemother. 2018 Jun 1;73(6):1604-1610. doi: 10.1093/jac/dky061.


A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens.

Lin YW, Chen K, Wang J, Velkov T, Zhou QT, Li J.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02527-17. doi: 10.1128/AAC.02527-17. Print 2018 May.


T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.

Zhang X, Wang Y, Velkov T, Tang S, Dai C.

Food Chem Toxicol. 2018 Apr;114:88-97. doi: 10.1016/j.fct.2018.02.010. Epub 2018 Feb 9.


Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.

Velkov T, Gallardo-Godoy A, Swarbrick JD, Blaskovich MAT, Elliott AG, Han M, Thompson PE, Roberts KD, Huang JX, Becker B, Butler MS, Lash LH, Henriques ST, Nation RL, Sivanesan S, Sani MA, Separovic F, Mertens H, Bulach D, Seemann T, Owen J, Li J, Cooper MA.

Cell Chem Biol. 2018 Apr 19;25(4):380-391.e5. doi: 10.1016/j.chembiol.2018.01.005. Epub 2018 Feb 3.


A Fresh Shine onCystic Fibrosis Inhalation Therapy: Antimicrobial Synergy of Polymyxin B in Combination with Silver Nanoparticles.

Jasim R, Schneider EK, Han M, Azad MAK, Hussein M, Nowell C, Baker MA, Wang J, Li J, Velkov T.

J Biomed Nanotechnol. 2017 Apr;13(4):447-57.


The inhibitory effects of eighteen front-line antibiotics on the substrate uptake mediated by human Organic anion/cation transporters, Organic anion transporting polypeptides and Oligopeptide transporters in in vitro models.

Lu X, Chan T, Zhu L, Bao X, Velkov T, Zhou QT, Li J, Chan HK, Zhou F.

Eur J Pharm Sci. 2018 Mar 30;115:132-143. doi: 10.1016/j.ejps.2018.01.002. Epub 2018 Jan 5.


Comparative analysis of phosphoethanolamine transferases involved in polymyxin resistance across 10 clinically relevant Gram-negative bacteria.

Huang J, Zhu Y, Han ML, Li M, Song J, Velkov T, Li C, Li J.

Int J Antimicrob Agents. 2018 Apr;51(4):586-593. doi: 10.1016/j.ijantimicag.2017.12.016. Epub 2017 Dec 27.


Broad activity of diphenyleneiodonium analogues against Mycobacterium tuberculosis, malaria parasites and bacterial pathogens.

Nguyen N, Wilson DW, Nagalingam G, Triccas JA, Schneider EK, Li J, Velkov T, Baell J.

Eur J Med Chem. 2018 Mar 25;148:507-518. doi: 10.1016/j.ejmech.2017.10.010. Epub 2017 Oct 6.


Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.

Dai C, Ciccotosto GD, Cappai R, Wang Y, Tang S, Hoyer D, Schneider EK, Velkov T, Xiao X.

ACS Chem Neurosci. 2018 Apr 18;9(4):824-837. doi: 10.1021/acschemneuro.7b00323. Epub 2018 Jan 5.


A Portrait of the Sialyl Glycan Receptor Specificity of the H10 Influenza Virus Hemagglutinin-A Picture of an Avian Virus on the Verge of Becoming a Pandemic?

Schneider EK, Li J, Velkov T.

Vaccines (Basel). 2017 Dec 13;5(4). pii: E51. doi: 10.3390/vaccines5040051. Review.


Proteomic analysis of good- and poor-quality human sperm demonstrates that several proteins are routinely aberrantly regulated.

Netherton JK, Hetherington L, Ogle RA, Velkov T, Baker MA.

Biol Reprod. 2018 Aug 1;99(2):395-408. doi: 10.1093/biolre/iox166.


Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance.

Han ML, Velkov T, Zhu Y, Roberts KD, Le Brun AP, Chow SH, Gutu AD, Moskowitz SM, Shen HH, Li J.

ACS Chem Biol. 2018 Jan 19;13(1):121-130. doi: 10.1021/acschembio.7b00836. Epub 2017 Dec 11.


Design and Evaluation of Novel Polymyxin Fluorescent Probes.

Yun B, Roberts KD, Thompson PE, Nation RL, Velkov T, Li J.

Sensors (Basel). 2017 Nov 11;17(11). pii: E2598. doi: 10.3390/s17112598.


Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress.

Azad MAK, Sivanesan S, Wang J, Chen K, Nation RL, Thompson PE, Roberts KD, Velkov T, Li J.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01254-17. doi: 10.1128/AAC.01254-17. Print 2018 Jan.


Cationic Acrylate Oligomers Comprising Amino Acid Mimic Moieties Demonstrate Improved Antibacterial Killing Efficiency.

Grace JL, Elliott AG, Huang JX, Schneider EK, Truong NP, Cooper MA, Li J, Davis TP, Quinn JF, Velkov T, Whittaker MR.

J Mater Chem B. 2017 Jan 21;5(3):531-536. doi: 10.1039/C6TB02787C. Epub 2016 Dec 13.


Gelofusine Ameliorates Colistin-Induced Nephrotoxicity.

Sivanesan SS, Azad MAK, Schneider EK, Ahmed MU, Huang J, Wang J, Li J, Nation RL, Velkov T.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e00985-17. doi: 10.1128/AAC.00985-17. Print 2017 Dec.


Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling.

Yadav R, Bulitta JB, Schneider EK, Shin BS, Velkov T, Nation RL, Landersdorfer CB.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e00722-17. doi: 10.1128/AAC.00722-17. Print 2017 Dec.


The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity.

Mountford SJ, Mohanty B, Roberts KD, Yu HH, Scanlon MJ, Nation RL, Velkov T, Li J, Thompson PE.

Org Biomol Chem. 2017 Aug 30;15(34):7173-7180. doi: 10.1039/c7ob01493g.


Polymyxins for CNS infections: Pharmacology and neurotoxicity.

Velkov T, Dai C, Ciccotosto GD, Cappai R, Hoyer D, Li J.

Pharmacol Ther. 2018 Jan;181:85-90. doi: 10.1016/j.pharmthera.2017.07.012. Epub 2017 Jul 25. Review.


Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes.

Han ML, Shen HH, Hansford KA, Schneider EK, Sivanesan S, Roberts KD, Thompson PE, Le Brun AP, Zhu Y, Sani MA, Separovic F, Blaskovich MAT, Baker MA, Moskowitz SM, Cooper MA, Li J, Velkov T.

ACS Infect Dis. 2017 Aug 11;3(8):606-619. doi: 10.1021/acsinfecdis.7b00065. Epub 2017 Jul 11.


Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization.

Zhu C, Schneider EK, Nikolaou V, Klein T, Li J, Davis TP, Whittaker MR, Wilson P, Kempe K, Velkov T, Haddleton DM.

Bioconjug Chem. 2017 Jul 19;28(7):1916-1924. doi: 10.1021/acs.bioconjchem.7b00242. Epub 2017 Jul 7.


Deficiency in outer dense fiber 1 is a marker and potential driver of idiopathic male infertility.

Hetherington L, Schneider EK, Scott C, DeKretser D, Muller CH, Hondermarck H, Velkov T, Baker MA.

Mol Cell Proteomics. 2017 Jun;16(6):1172. doi: 10.1074/mcp.A116.060343. No abstract available.


Pulsed-voltage atom probe tomography of low conductivity and insulator materials by application of ultrathin metallic coating on nanoscale specimen geometry.

Adineh VR, Marceau RKW, Chen Y, Si KJ, Velkov T, Cheng W, Li J, Fu J.

Ultramicroscopy. 2017 Oct;181:150-159. doi: 10.1016/j.ultramic.2017.05.002. Epub 2017 May 13.


Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.

Galea CA, Han M, Zhu Y, Roberts K, Wang J, Thompson PE, L J, Velkov T.

J Nat Prod. 2017 May 26;80(5):1264-1274. doi: 10.1021/acs.jnatprod.6b00807. Epub 2017 May 2.


Pharmacokinetics and relative bioavailability of an oral amoxicillin-apramycin combination in pigs.

Dai C, Zhao T, Yang X, Xiao X, Velkov T, Tang S.

PLoS One. 2017 Apr 20;12(4):e0176149. doi: 10.1371/journal.pone.0176149. eCollection 2017.


Potential Toxicity of Polymyxins in Human Lung Epithelial Cells.

Ahmed MU, Velkov T, Lin YW, Yun B, Nowell CJ, Zhou F, Zhou QT, Chan K, Azad MAK, Li J.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02690-16. doi: 10.1128/AAC.02690-16. Print 2017 Jun.


Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii.

Maifiah MH, Creek DJ, Nation RL, Forrest A, Tsuji BT, Velkov T, Li J.

Sci Rep. 2017 Mar 30;7:45527. doi: 10.1038/srep45527.


Antibiotic-non-antibiotic combinations for combating extremely drug-resistant Gram-negative 'superbugs'.

Schneider EK, Reyes-Ortega F, Velkov T, Li J.

Essays Biochem. 2017 Mar 3;61(1):115-125. doi: 10.1042/EBC20160058. Print 2017 Feb 28. Review.


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