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Items: 34


The Cell Wall Lipid PDIM Contributes to Phagosomal Escape and Host Cell Exit of Mycobacterium tuberculosis.

Quigley J, Hughitt VK, Velikovsky CA, Mariuzza RA, El-Sayed NM, Briken V.

MBio. 2017 Mar 7;8(2). pii: e00148-17. doi: 10.1128/mBio.00148-17.


Recognition of the Thomsen-Friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor.

Luo M, Velikovsky CA, Yang X, Siddiqui MA, Hong X, Barchi JJ Jr, Gildersleeve JC, Pancer Z, Mariuzza RA.

J Biol Chem. 2013 Aug 9;288(32):23597-606. doi: 10.1074/jbc.M113.480467. Epub 2013 Jun 19.


A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey.

Deng L, Velikovsky CA, Xu G, Iyer LM, Tasumi S, Kerzic MC, Flajnik MF, Aravind L, Pancer Z, Mariuzza RA.

Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13408-13. doi: 10.1073/pnas.1005475107. Epub 2010 Jul 8.


Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates.

Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z.

Biol Chem. 2010 Jul;391(7):753-60. doi: 10.1515/BC.2010.091. Review.


High-affinity lamprey VLRA and VLRB monoclonal antibodies.

Tasumi S, Velikovsky CA, Xu G, Gai SA, Wittrup KD, Flajnik MF, Mariuzza RA, Pancer Z.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12891-6. doi: 10.1073/pnas.0904443106. Epub 2009 Jul 22.


Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen.

Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA.

Nat Struct Mol Biol. 2009 Jul;16(7):725-30. doi: 10.1038/nsmb.1619. Epub 2009 Jun 21.


Molecular basis of the dual functions of 2B4 (CD244).

Chlewicki LK, Velikovsky CA, Balakrishnan V, Mariuzza RA, Kumar V.

J Immunol. 2008 Jun 15;180(12):8159-67.


Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.

Velikovsky CA, Deng L, Chlewicki LK, Fernández MM, Kumar V, Mariuzza RA.

Immunity. 2007 Oct;27(4):572-84. Epub 2007 Oct 18.


A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination.

Cassataro J, Pasquevich KA, Estein SM, Laplagne DA, Velikovsky CA, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH, Goldbaum FA.

Vaccine. 2007 May 30;25(22):4437-46. Epub 2007 Apr 2.


Improved immunogenicity of a vaccination regimen combining a DNA vaccine encoding Brucella melitensis outer membrane protein 31 (Omp31) and recombinant Omp31 boosting.

Cassataro J, Velikovsky CA, Bruno L, Estein SM, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH.

Clin Vaccine Immunol. 2007 Jul;14(7):869-74. Epub 2007 Apr 11.


Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection.

Cassataro J, Estein SM, Pasquevich KA, Velikovsky CA, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH.

Infect Immun. 2005 Dec;73(12):8079-88.


A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response.

Cassataro J, Velikovsky CA, de la Barrera S, Estein SM, Bruno L, Bowden R, Pasquevich KA, Fossati CA, Giambartolomei GH.

Infect Immun. 2005 Oct;73(10):6537-46.


Structural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1.

Deng L, Velikovsky CA, Swaminathan CP, Cho S, Mariuzza RA.

J Mol Biol. 2005 Sep 9;352(1):1-10.


Sedimentation velocity analysis of heterogeneous protein-protein interactions: Lamm equation modeling and sedimentation coefficient distributions c(s).

Dam J, Velikovsky CA, Mariuzza RA, Urbanke C, Schuck P.

Biophys J. 2005 Jul;89(1):619-34. Epub 2005 Apr 29.


Studying multiprotein complexes by multisignal sedimentation velocity analytical ultracentrifugation.

Balbo A, Minor KH, Velikovsky CA, Mariuzza RA, Peterson CB, Schuck P.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):81-6. Epub 2004 Dec 21.


Entropically assisted carbohydrate recognition by a natural killer cell-surface receptor.

Swaminathan CP, Wais N, Vyas VV, Velikovsky CA, Moretta A, Moretta L, Biassoni R, Mariuzza RA, Dimasi N.

Chembiochem. 2004 Nov 5;5(11):1571-5. No abstract available.


Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.

Cho S, Velikovsky CA, Swaminathan CP, Houtman JC, Samelson LE, Mariuzza RA.

EMBO J. 2004 Apr 7;23(7):1441-51. Epub 2004 Mar 18.


Brucella lumazine synthase elicits a mixed Th1-Th2 immune response and reduces infection in mice challenged with Brucella abortus 544 independently of the adjuvant formulation used.

Velikovsky CA, Goldbaum FA, Cassataro J, Estein S, Bowden RA, Bruno L, Fossati CA, Giambartolomei GH.

Infect Immun. 2003 Oct;71(10):5750-5.


Diminished production of T helper 1 cytokines correlates with T cell unresponsiveness to Brucella cytoplasmic proteins in chronic human brucellosis.

Giambartolomei GH, Delpino MV, Cahanovich ME, Wallach JC, Baldi PC, Velikovsky CA, Fossati CA.

J Infect Dis. 2002 Jul 15;186(2):252-9. Epub 2002 Jun 17.


[Adjuvant factors in DNA vaccines].

Spitz M, Velikovsky CA, Cassataro J, Giambartolomei GH.

Medicina (B Aires). 2002;62(1):99-102. Spanish. No abstract available.


A DNA vaccine encoding lumazine synthase from Brucella abortus induces protective immunity in BALB/c mice.

Velikovsky CA, Cassataro J, Giambartolomei GH, Goldbaum FA, Estein S, Bowden RA, Bruno L, Fossati CA, Spitz M.

Infect Immun. 2002 May;70(5):2507-11.


Diagnostic usefulness of antibodies against ribosome recycling factor from Brucella melitensis in human or canine brucellosis.

Cassataro J, Delpino MV, Velikovsky CA, Bruno L, Fossati CA, Baldi PC.

Clin Diagn Lab Immunol. 2002 Mar;9(2):366-9.


Immunogenicity of the Brucella melitensis recombinant ribosome recycling factor-homologous protein and its cDNA.

Cassataro J, Velikovsky CA, Giambartolomei GH, Estein S, Bruno L, Cloeckaert A, Bowden RA, Spitz M, Fossati CA.

Vaccine. 2002 Feb 22;20(11-12):1660-9.


Limited diagnostic usefulness of antibodies to cytoplasmic proteins of Brucella in early-treated human brucellosis.

Baldi PC, Giambartolomei GH, Wallach JC, Velikovsky CA, Fossati CA.

Scand J Infect Dis. 2001;33(3):200-5.


Single-shot plasmid DNA intrasplenic immunization for the production of monoclonal antibodies. Persistent expression of DNA.

Velikovsky CA, Cassataro J, Sanchez M, Fossati CA, Fainboim L, Spitz M.

J Immunol Methods. 2000 Oct 20;244(1-2):1-7.


Structural, functional and immunological studies on a polymeric bacterial protein.

Baldi PC, Velikovsky CA, Braden BC, Giambartolomei GH, Fossati CA, Goldbaum FA.

Braz J Med Biol Res. 2000 Jul;33(7):741-7.


Divergence in macromolecular assembly: X-ray crystallographic structure analysis of lumazine synthase from Brucella abortus.

Braden BC, Velikovsky CA, Cauerhff AA, Polikarpov I, Goldbaum FA.

J Mol Biol. 2000 Apr 14;297(5):1031-6.


[Determination of antiprotein antibodies for the diagnosis of brucellosis in animals].

Baldi PC, Goldbaum FA, Velikovsky CA, Wallach JC, Fossati CA.

Rev Argent Microbiol. 1999;31 Suppl 1:49-51. Review. Spanish. No abstract available.


[Diagnosis and progress analysis of human brucellosis via new serological methods].

Wallach JC, Baldi PC, Goldbaum FA, Velikovsky CA, Fossati CA.

Rev Argent Microbiol. 1999;31 Suppl 1:46-8. Review. Spanish. No abstract available.


The 18-kDa cytoplasmic protein of Brucella species --an antigen useful for diagnosis--is a lumazine synthase.

Goldbaum FA, Velikovsky CA, Baldi PC, Mörtl S, Bacher A, Fossati CA.

J Med Microbiol. 1999 Sep;48(9):833-9.


Lack of significant differences in association rates and affinities of antibodies from short-term and long-term responses to hen egg lysozyme.

Goldbaum FA, Cauerhff A, Velikovsky CA, Llera AS, Riottot MM, Poljak RJ.

J Immunol. 1999 May 15;162(10):6040-5.


Crystallization and preliminary x-ray diffraction analysis of the lumazine synthase from Brucella abortus.

Goldbaum FA, Polikarpov I, Cauerhff AA, Velikovsky CA, Braden BC, Poljak RJ.

J Struct Biol. 1998 Oct;123(2):175-8.


Characterization of anti-anti-idiotypic antibodies that bind antigen and an anti-idiotype.

Goldbaum FA, Velikovsky CA, Dall'Acqua W, Fossati CA, Fields BA, Braden BC, Poljak RJ, Mariuzza RA.

Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8697-701.


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