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Chicken CATH-2 increases antigen presentation markers on chicken monocytes and macrophages.

Kraaij MD, van Dijk A, Scheenstra MR, van Harten RM, Haagsman HP, Veldhuizen EJA.

Protein Pept Lett. 2019 Jul 30. doi: 10.2174/0929866526666190730125525. [Epub ahead of print]


Effects of human antimicrobial cryptides identified in apolipoprotein B depend on specific features of bacterial strains.

Gaglione R, Cesaro A, Dell'Olmo E, Della Ventura B, Casillo A, Di Girolamo R, Velotta R, Notomista E, Veldhuizen EJA, Corsaro MM, De Rosa C, Arciello A.

Sci Rep. 2019 Apr 30;9(1):6728. doi: 10.1038/s41598-019-43063-3.


Avian pathogenic Escherichia coli infection of a chicken lung epithelial cell line.

Mol N, Peng L, Esnault E, Quéré P, Haagsman HP, Veldhuizen EJA.

Vet Immunol Immunopathol. 2019 Apr;210:55-59. doi: 10.1016/j.vetimm.2019.03.007. Epub 2019 Mar 19.


Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action.

Scheenstra MR, van den Belt M, Tjeerdsma-van Bokhoven JLM, Schneider VAF, Ordonez SR, van Dijk A, Veldhuizen EJA, Haagsman HP.

Sci Rep. 2019 Mar 18;9(1):4780. doi: 10.1038/s41598-019-41246-6.


The wet bridge transfer system: a novel tool to assess exogenous surfactant as a vehicle for intrapulmonary drug delivery.

Baer B, Veldhuizen EJA, Possmayer F, Yamashita C, Veldhuizen R.

Discov Med. 2018 Nov;26(144):207-218.


Antifungal activities of surfactant protein D in an environment closely mimicking the lung lining.

Ordonez SR, van Eijk M, Escobar Salazar N, de Cock H, Veldhuizen EJA, Haagsman HP.

Mol Immunol. 2019 Jan;105:260-269. doi: 10.1016/j.molimm.2018.12.003. Epub 2018 Dec 15.


A canine keratinocyte cell line expresses antimicrobial peptide and cytokine genes upon stimulation with bacteria, microbial ligands and recombinant cytokines.

Chermprapai S, Broere F, Schlotter YM, Veldhuizen EJA, Rutten VPMG.

Vet Immunol Immunopathol. 2018 Dec;206:35-40. doi: 10.1016/j.vetimm.2018.11.009. Epub 2018 Nov 13.


Inhibition and Eradication of Pseudomonas aeruginosa Biofilms by Host Defence Peptides.

Chen H, Wubbolts RW, Haagsman HP, Veldhuizen EJA.

Sci Rep. 2018 Jul 11;8(1):10446. doi: 10.1038/s41598-018-28842-8.


Avian pathogenic Escherichia coli-induced activation of chicken macrophage HD11 cells.

Peng L, Matthijs MGR, Haagsman HP, Veldhuizen EJA.

Dev Comp Immunol. 2018 Oct;87:75-83. doi: 10.1016/j.dci.2018.05.019. Epub 2018 May 23.


A new and efficient culture method for porcine bone marrow-derived M1- and M2-polarized macrophages.

Gao J, Scheenstra MR, van Dijk A, Veldhuizen EJA, Haagsman HP.

Vet Immunol Immunopathol. 2018 Jun;200:7-15. doi: 10.1016/j.vetimm.2018.04.002. Epub 2018 Apr 14.


Role of Soluble Innate Effector Molecules in Pulmonary Defense against Fungal Pathogens.

Ordonez SR, Veldhuizen EJA, van Eijk M, Haagsman HP.

Front Microbiol. 2017 Oct 31;8:2098. doi: 10.3389/fmicb.2017.02098. eCollection 2017. Review.


The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens.

Banaschewski BJH, Baer B, Arsenault C, Jazey T, Veldhuizen EJA, Delport J, Gooyers T, Lewis JF, Haagsman HP, Veldhuizen RAW, Yamashita C.

Sci Rep. 2017 Nov 14;7(1):15545. doi: 10.1038/s41598-017-15558-4.


Imaging the Antistaphylococcal Activity of CATH-2: Mechanism of Attack and Regulation of Inflammatory Response.

Schneider VAF, Coorens M, Tjeerdsma-van Bokhoven JLM, Posthuma G, van Dijk A, Veldhuizen EJA, Haagsman HP.

mSphere. 2017 Nov 1;2(6). pii: e00370-17. doi: 10.1128/mSphere.00370-17. eCollection 2017 Nov-Dec.


Killing of Pseudomonas aeruginosa by Chicken Cathelicidin-2 Is Immunogenically Silent, Preventing Lung Inflammation In Vivo.

Coorens M, Banaschewski BJH, Baer BJ, Yamashita C, van Dijk A, Haagsman HP, Veldhuizen RAW, Veldhuizen EJA.

Infect Immun. 2017 Nov 17;85(12). pii: e00546-17. doi: 10.1128/IAI.00546-17. Print 2017 Dec.


Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner.

Coorens M, Schneider VAF, de Groot AM, van Dijk A, Meijerink M, Wells JM, Scheenstra MR, Veldhuizen EJA, Haagsman HP.

J Immunol. 2017 Aug 15;199(4):1418-1428. doi: 10.4049/jimmunol.1602164. Epub 2017 Jul 14.


Chicken mannose binding lectin has antiviral activity towards infectious bronchitis virus.

Zhang W, Bouwman KM, van Beurden SJ, Ordonez SR, van Eijk M, Haagsman HP, Verheije MH, Veldhuizen EJA.

Virology. 2017 Sep;509:252-259. doi: 10.1016/j.virol.2017.06.028. Epub 2017 Jul 4.


Antimicrobial and Immunomodulatory Activity of PMAP-23 Derived Peptides.

Veldhuizen EJA, Scheenstra MR, Tjeerdsma-van Bokhoven JLM, Coorens M, Schneider VAF, Bikker FJ, van Dijk A, Haagsman HP.

Protein Pept Lett. 2017;24(7):609-616. doi: 10.2174/0929866524666170428150925.


A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence.

Bosso A, Pirone L, Gaglione R, Pane K, Del Gatto A, Zaccaro L, Di Gaetano S, Diana D, Fattorusso R, Pedone E, Cafaro V, Haagsman HP, van Dijk A, Scheenstra MR, Zanfardino A, Crescenzi O, Arciello A, Varcamonti M, Veldhuizen EJA, Di Donato A, Notomista E, Pizzo E.

Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2342-2353. doi: 10.1016/j.bbagen.2017.04.009. Epub 2017 Apr 26.


Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential.

Gaglione R, Dell'Olmo E, Bosso A, Chino M, Pane K, Ascione F, Itri F, Caserta S, Amoresano A, Lombardi A, Haagsman HP, Piccoli R, Pizzo E, Veldhuizen EJA, Notomista E, Arciello A.

Biochem Pharmacol. 2017 Apr 15;130:34-50. doi: 10.1016/j.bcp.2017.01.009. Epub 2017 Jan 25.


Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis.

Coorens M, Scheenstra MR, Veldhuizen EJ, Haagsman HP.

Sci Rep. 2017 Jan 19;7:40874. doi: 10.1038/srep40874.


Expression and characterization of recombinant chicken mannose binding lectin.

Zhang W, van Eijk M, Guo H, van Dijk A, Bleijerveld OB, Verheije MH, Wang G, Haagsman HP, Veldhuizen EJ.

Immunobiology. 2017 Mar;222(3):518-528. doi: 10.1016/j.imbio.2016.10.019. Epub 2016 Oct 29.


Imaging the antimicrobial mechanism(s) of cathelicidin-2.

Schneider VA, Coorens M, Ordonez SR, Tjeerdsma-van Bokhoven JL, Posthuma G, van Dijk A, Haagsman HP, Veldhuizen EJ.

Sci Rep. 2016 Sep 14;6:32948. doi: 10.1038/srep32948.


N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa.

Bluhm ME, Schneider VA, Schäfer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R.

Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. eCollection 2016.


Protective effect of in ovo treatment with the chicken cathelicidin analog D-CATH-2 against avian pathogenic E. coli.

Cuperus T, van Dijk A, Matthijs MG, Veldhuizen EJ, Haagsman HP.

Sci Rep. 2016 May 27;6:26622. doi: 10.1038/srep26622.


Developmental regulation of chicken surfactant protein A and its localization in lung.

Zhang W, Cuperus T, van Dijk A, Skjødt K, Hansen S, Haagsman HP, Veldhuizen EJ.

Dev Comp Immunol. 2016 Aug;61:80-7. doi: 10.1016/j.dci.2016.03.010. Epub 2016 Mar 11.


Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity.

Schneider VA, van Dijk A, van der Sar AM, Kraaij MD, Veldhuizen EJ, Haagsman HP.

Dev Comp Immunol. 2016 Jul;60:108-14. doi: 10.1016/j.dci.2016.02.023. Epub 2016 Feb 23.


Immunomodulatory and Anti-Inflammatory Activities of Chicken Cathelicidin-2 Derived Peptides.

van Dijk A, van Eldik M, Veldhuizen EJ, Tjeerdsma-van Bokhoven HL, de Zoete MR, Bikker FJ, Haagsman HP.

PLoS One. 2016 Feb 5;11(2):e0147919. doi: 10.1371/journal.pone.0147919. eCollection 2016.


Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation.

Coorens M, van Dijk A, Bikker F, Veldhuizen EJ, Haagsman HP.

J Immunol. 2015 Oct 15;195(8):3970-7. doi: 10.4049/jimmunol.1501242. Epub 2015 Sep 16.


Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia.

Banaschewski BJ, Veldhuizen EJ, Keating E, Haagsman HP, Zuo YY, Yamashita CM, Veldhuizen RA.

Antimicrob Agents Chemother. 2015;59(6):3075-83. doi: 10.1128/AAC.04937-14. Epub 2015 Mar 9.


Antimicrobial and immunomodulatory activities of PR-39 derived peptides.

Veldhuizen EJ, Schneider VA, Agustiandari H, van Dijk A, Tjeerdsma-van Bokhoven JL, Bikker FJ, Haagsman HP.

PLoS One. 2014 Apr 22;9(4):e95939. doi: 10.1371/journal.pone.0095939. eCollection 2014.


The natural antimicrobial carvacrol inhibits quorum sensing in Chromobacterium violaceum and reduces bacterial biofilm formation at sub-lethal concentrations.

Burt SA, Ojo-Fakunle VT, Woertman J, Veldhuizen EJ.

PLoS One. 2014 Apr 1;9(4):e93414. doi: 10.1371/journal.pone.0093414. eCollection 2014.


Fungicidal mechanisms of cathelicidins LL-37 and CATH-2 revealed by live-cell imaging.

Ordonez SR, Amarullah IH, Wubbolts RW, Veldhuizen EJ, Haagsman HP.

Antimicrob Agents Chemother. 2014;58(4):2240-8. doi: 10.1128/AAC.01670-13. Epub 2014 Feb 3.


Chicken cathelicidins display antimicrobial activity against multiresistant bacteria without inducing strong resistance.

Veldhuizen EJ, Brouwer EC, Schneider VA, Fluit AC.

PLoS One. 2013 Apr 22;8(4):e61964. doi: 10.1371/journal.pone.0061964. Print 2013.


Synergy between essential oil components and antibiotics: a review.

Langeveld WT, Veldhuizen EJ, Burt SA.

Crit Rev Microbiol. 2014 Feb;40(1):76-94. doi: 10.3109/1040841X.2013.763219. Epub 2013 Feb 28. Review.


Campylobacter jejuni is highly susceptible to killing by chicken host defense peptide cathelicidin-2 and suppresses intestinal cathelicidin-2 expression in young broilers.

van Dijk A, Herrebout M, Tersteeg-Zijderveld MH, Tjeerdsma-van Bokhoven JL, Bleumink-Pluym N, Jansman AJ, Veldhuizen EJ, Haagsman HP.

Vet Microbiol. 2012 Dec 7;160(3-4):347-54. doi: 10.1016/j.vetmic.2012.05.034. Epub 2012 Jun 7.


Sub-lethal levels of carvacrol reduce Salmonella Typhimurium motility and invasion of porcine epithelial cells.

Inamuco J, Veenendaal AK, Burt SA, Post JA, Tjeerdsma-van Bokhoven JL, Haagsman HP, Veldhuizen EJ.

Vet Microbiol. 2012 May 25;157(1-2):200-7. doi: 10.1016/j.vetmic.2011.12.021. Epub 2011 Dec 24.


The carbohydrate recognition domain of collectins.

Veldhuizen EJ, van Eijk M, Haagsman HP.

FEBS J. 2011 Oct;278(20):3930-41. doi: 10.1111/j.1742-4658.2011.08206.x. Epub 2011 Jul 1. Review.


Avian cathelicidins: paradigms for the development of anti-infectives.

van Dijk A, Molhoek EM, Bikker FJ, Yu PL, Veldhuizen EJ, Haagsman HP.

Vet Microbiol. 2011 Nov 21;153(1-2):27-36. doi: 10.1016/j.vetmic.2011.03.028. Epub 2011 Mar 30. Review.


A cathelicidin-2-derived peptide effectively impairs Staphylococcus epidermidis biofilms.

Molhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ.

Int J Antimicrob Agents. 2011 May;37(5):476-9. doi: 10.1016/j.ijantimicag.2010.12.020. Epub 2011 Mar 3.


Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization.

Molhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ.

Peptides. 2011 May;32(5):875-80. doi: 10.1016/j.peptides.2011.02.017. Epub 2011 Mar 2.


Identification and characterisation of the BPI/LBP/PLUNC-like gene repertoire in chickens reveals the absence of a LBP gene.

Chiang SC, Veldhuizen EJ, Barnes FA, Craven CJ, Haagsman HP, Bingle CD.

Dev Comp Immunol. 2011 Mar;35(3):285-95. doi: 10.1016/j.dci.2010.09.013. Epub 2010 Oct 16.


Chicken cathelicidin-2-derived peptides with enhanced immunomodulatory and antibacterial activities against biological warfare agents.

Molhoek EM, van Dijk A, Veldhuizen EJ, Dijk-Knijnenburg H, Mars-Groenendijk RH, Boele LC, Kaman-van Zanten WE, Haagsman HP, Bikker FJ.

Int J Antimicrob Agents. 2010 Sep;36(3):271-4. doi: 10.1016/j.ijantimicag.2010.06.001. Epub 2010 Jul 14.


Recent advances in alveolar biology: evolution and function of alveolar proteins.

Orgeig S, Hiemstra PS, Veldhuizen EJ, Casals C, Clark HW, Haczku A, Knudsen L, Possmayer F.

Respir Physiol Neurobiol. 2010 Aug 31;173 Suppl:S43-54. doi: 10.1016/j.resp.2010.04.023. Epub 2010 Apr 28. Review.


Transcriptional expression levels of chicken collectins are affected by avian influenza A virus inoculation.

Reemers SS, Veldhuizen EJ, Fleming C, van Haarlem DA, Haagsman H, Vervelde L.

Vet Microbiol. 2010 Mar 24;141(3-4):379-84. doi: 10.1016/j.vetmic.2009.09.026. Epub 2009 Sep 26.


Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis.

van Damme CM, Willemse T, van Dijk A, Haagsman HP, Veldhuizen EJ.

Mol Immunol. 2009 Aug;46(13):2449-55. doi: 10.1016/j.molimm.2009.05.028. Epub 2009 Jul 2.


Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities.

van Dijk A, Molhoek EM, Veldhuizen EJ, Bokhoven JL, Wagendorp E, Bikker F, Haagsman HP.

Mol Immunol. 2009 Aug;46(13):2465-73. doi: 10.1016/j.molimm.2009.05.019. Epub 2009 Jun 12.


Chicken heterophils are recruited to the site of Salmonella infection and release antibacterial mature Cathelicidin-2 upon stimulation with LPS.

van Dijk A, Tersteeg-Zijderveld MH, Tjeerdsma-van Bokhoven JL, Jansman AJ, Veldhuizen EJ, Haagsman HP.

Mol Immunol. 2009 Apr;46(7):1517-26. doi: 10.1016/j.molimm.2008.12.015. Epub 2009 Feb 1.


Phosphate analysis of natural sausage casings preserved in brines with phosphate additives as inactivating agent - Method validation.

Wijnker JJ, Tjeerdsma-van Bokhoven JL, Veldhuizen EJ.

Meat Sci. 2009 Jan;81(1):245-8. doi: 10.1016/j.meatsci.2008.07.027. Epub 2008 Aug 7.


Salmonella serovar specific upregulation of porcine defensins 1 and 2 in a jejunal epithelial cell line.

Veldhuizen EJ, Koomen I, Ultee T, van Dijk A, Haagsman HP.

Vet Microbiol. 2009 Apr 14;136(1-2):69-75. doi: 10.1016/j.vetmic.2008.09.072. Epub 2008 Sep 30.


Surfactant collectins and innate immunity.

Haagsman HP, Hogenkamp A, van Eijk M, Veldhuizen EJ.

Neonatology. 2008;93(4):288-94. doi: 10.1159/000121454. Epub 2008 Jun 5. Review.


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