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Items: 1 to 50 of 66

1.

Transcriptomics investigation of thyroid hormone disruption in the olfactory system of the Rana [Lithobates] catesbeiana tadpole.

Jackman KW, Veldhoen N, Miliano RC, Robert BJ, Li L, Khojasteh A, Zheng X, Zaborniak TSM, van Aggelen G, Lesperance M, Parker WJ, Hall ER, Pyle GG, Helbing CC.

Aquat Toxicol. 2018 Sep;202:46-56. doi: 10.1016/j.aquatox.2018.06.015. Epub 2018 Jun 30.

PMID:
30007154
2.

The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA.

Hammond SA, Warren RL, Vandervalk BP, Kucuk E, Khan H, Gibb EA, Pandoh P, Kirk H, Zhao Y, Jones M, Mungall AJ, Coope R, Pleasance S, Moore RA, Holt RA, Round JM, Ohora S, Walle BV, Veldhoen N, Helbing CC, Birol I.

Nat Commun. 2017 Nov 10;8(1):1433. doi: 10.1038/s41467-017-01316-7.

3.

Behavioral and molecular analyses of olfaction-mediated avoidance responses of Rana (Lithobates) catesbeiana tadpoles: Sensitivity to thyroid hormones, estrogen, and treated municipal wastewater effluent.

Heerema JL, Jackman KW, Miliano RC, Li L, Zaborniak TSM, Veldhoen N, van Aggelen G, Parker WJ, Pyle GG, Helbing CC.

Horm Behav. 2018 May;101:85-93. doi: 10.1016/j.yhbeh.2017.09.016. Epub 2017 Oct 4.

PMID:
28964734
4.

De novo assembly of the ringed seal (Pusa hispida) blubber transcriptome: A tool that enables identification of molecular health indicators associated with PCB exposure.

Brown TM, Hammond SA, Behsaz B, Veldhoen N, Birol I, Helbing CC.

Aquat Toxicol. 2017 Apr;185:48-57. doi: 10.1016/j.aquatox.2017.02.004. Epub 2017 Feb 3.

PMID:
28187360
5.

A multi-omic approach to elucidate low-dose effects of xenobiotics in zebrafish (Danio rerio) larvae.

Huang SSY, Benskin JP, Veldhoen N, Chandramouli B, Butler H, Helbing CC, Cosgrove JR.

Aquat Toxicol. 2017 Jan;182:102-112. doi: 10.1016/j.aquatox.2016.11.016. Epub 2016 Nov 18.

PMID:
27886581
6.

Implementation of Novel Design Features for qPCR-Based eDNA Assessment.

Veldhoen N, Hobbs J, Ikonomou G, Hii M, Lesperance M, Helbing CC.

PLoS One. 2016 Nov 1;11(11):e0164907. doi: 10.1371/journal.pone.0164907. eCollection 2016.

7.

Rethinking the biological relationships of the thyroid hormones, l-thyroxine and 3,5,3'-triiodothyronine.

Maher SK, Wojnarowicz P, Ichu TA, Veldhoen N, Lu L, Lesperance M, Propper CR, Helbing CC.

Comp Biochem Physiol Part D Genomics Proteomics. 2016 Jun;18:44-53. doi: 10.1016/j.cbd.2016.04.002. Epub 2016 Apr 7.

PMID:
27085304
8.

Identification of organ-autonomous constituents of the molecular memory conferred by thyroid hormone exposure in cold temperature-arrested metamorphosing Rana (Lithobates) catesbeiana tadpoles.

Austin Hammond S, Jackman KW, Partovi SH, Veldhoen N, Helbing CC.

Comp Biochem Physiol Part D Genomics Proteomics. 2016 Mar;17:58-65. doi: 10.1016/j.cbd.2016.01.002. Epub 2016 Jan 7.

PMID:
26795672
9.

Cadmium-induced olfactory dysfunction in rainbow trout: Effects of binary and quaternary metal mixtures.

Dew WA, Veldhoen N, Carew AC, Helbing CC, Pyle GG.

Aquat Toxicol. 2016 Mar;172:86-94. doi: 10.1016/j.aquatox.2015.12.018. Epub 2015 Dec 31.

PMID:
26775207
10.

Comparison of thyroid hormone-dependent gene responses in vivo and in organ culture of the American bullfrog (Rana (Lithobates) catesbeiana) lung.

Veldhoen N, Stevenson MR, Helbing CC.

Comp Biochem Physiol Part D Genomics Proteomics. 2015 Dec;16:99-105. doi: 10.1016/j.cbd.2015.09.001. Epub 2015 Oct 9.

PMID:
26462067
11.

De novo Transcriptome Assemblies of Rana (Lithobates) catesbeiana and Xenopus laevis Tadpole Livers for Comparative Genomics without Reference Genomes.

Birol I, Behsaz B, Hammond SA, Kucuk E, Veldhoen N, Helbing CC.

PLoS One. 2015 Jun 29;10(6):e0130720. doi: 10.1371/journal.pone.0130720. eCollection 2015.

12.

Estrogenic environmental contaminants alter the mRNA abundance profiles of genes involved in gonadal differentiation of the American bullfrog.

Wolff SE, Veldhoen N, Helbing CC, Ramirez CA, Malpas JM, Propper CR.

Sci Total Environ. 2015 Jul 15;521-522:380-7. doi: 10.1016/j.scitotenv.2015.02.033. Epub 2015 Apr 6.

13.

Influence of temperature on thyroid hormone signaling and endocrine disruptor action in Rana (Lithobates) catesbeiana tadpoles.

Hammond SA, Veldhoen N, Helbing CC.

Gen Comp Endocrinol. 2015 Aug 1;219:6-15. doi: 10.1016/j.ygcen.2014.12.001. Epub 2015 Jan 9.

PMID:
25583582
14.

PCB related effects thresholds as derived through gene transcript profiles in locally contaminated ringed seals (Pusa hispida).

Brown TM, Ross PS, Reimer KJ, Veldhoen N, Dangerfield NJ, Fisk AT, Helbing CC.

Environ Sci Technol. 2014 Nov 4;48(21):12952-61. doi: 10.1021/es5032294. Epub 2014 Oct 27.

PMID:
25286162
15.

Distinctive metabolite profiles in in-migrating Sockeye salmon suggest sex-linked endocrine perturbation.

Benskin JP, Ikonomou MG, Liu J, Veldhoen N, Dubetz C, Helbing CC, Cosgrove JR.

Environ Sci Technol. 2014 Oct 7;48(19):11670-8. doi: 10.1021/es503266x. Epub 2014 Sep 24.

PMID:
25198612
16.

Effects of acute exposure to the non-steroidal anti-inflammatory drug ibuprofen on the developing North American Bullfrog (Rana catesbeiana) tadpole.

Veldhoen N, Skirrow RC, Brown LL, van Aggelen G, Helbing CC.

Environ Sci Technol. 2014 Sep 2;48(17):10439-47. doi: 10.1021/es502539g. Epub 2014 Aug 15.

PMID:
25111458
17.

Development of a non-lethal method for evaluating transcriptomic endpoints in Arctic grayling (Thymallus arcticus).

Veldhoen N, Beckerton JE, Mackenzie-Grieve J, Stevenson MR, Truelson RL, Helbing CC.

Ecotoxicol Environ Saf. 2014 Jul;105:43-50. doi: 10.1016/j.ecoenv.2014.03.030. Epub 2014 May 7.

PMID:
24780232
18.
19.

PCBs are associated with altered gene transcript profiles in arctic Beluga Whales (Delphinapterus leucas).

Noël M, Loseto LL, Helbing CC, Veldhoen N, Dangerfield NJ, Ross PS.

Environ Sci Technol. 2014;48(5):2942-51. doi: 10.1021/es403217r. Epub 2014 Feb 19.

PMID:
24490950
20.
21.

Minimally invasive transcriptome profiling in salmon: detection of biological response in rainbow trout caudal fin following exposure to environmental chemical contaminants.

Veldhoen N, Stevenson MR, Skirrow RC, Rieberger KJ, van Aggelen G, Meays CL, Helbing CC.

Aquat Toxicol. 2013 Oct 15;142-143:239-47. doi: 10.1016/j.aquatox.2013.08.016. Epub 2013 Sep 4.

PMID:
24055988
22.

Characterization of gene expression endpoints during postembryonic development of the northern green frog (Rana clamitans melanota).

Hammond SA, Veldhoen N, Kobylarz M, Webber NR, Jordan J, Rehaume V, Boone MD, Helbing CC.

Zoolog Sci. 2013 May;30(5):392-401. doi: 10.2108/zsj.30.392.

PMID:
23647014
23.

Specific time of exposure during tadpole development influences biological effects of the insecticide carbaryl in green frogs (Lithobates clamitans).

Boone MD, Hammond SA, Veldhoen N, Youngquist M, Helbing CC.

Aquat Toxicol. 2013 Apr 15;130-131:139-48. doi: 10.1016/j.aquatox.2012.12.022. Epub 2013 Jan 8.

PMID:
23399446
24.

Triclosan exposure alters postembryonic development in a Pacific tree frog (Pseudacris regilla) Amphibian Metamorphosis Assay (TREEMA).

Marlatt VL, Veldhoen N, Lo BP, Bakker D, Rehaume V, Vallée K, Haberl M, Shang D, van Aggelen GC, Skirrow RC, Elphick JR, Helbing CC.

Aquat Toxicol. 2013 Jan 15;126:85-94. doi: 10.1016/j.aquatox.2012.10.010. Epub 2012 Oct 29.

PMID:
23159728
25.

Evidence of disruption in estrogen-associated signaling in the liver transcriptome of in-migrating sockeye salmon of British Columbia, Canada.

Veldhoen N, Ikonomou MG, Rehaume V, Dubetz C, Patterson DA, Helbing CC.

Comp Biochem Physiol C Toxicol Pharmacol. 2013 Mar;157(2):150-61. doi: 10.1016/j.cbpc.2012.10.007. Epub 2012 Oct 25.

PMID:
23103762
26.

Thyroid hormone-dependent development in Xenopus laevis: a sensitive screen of thyroid hormone signaling disruption by municipal wastewater treatment plant effluent.

Searcy BT, Beckstrom-Sternberg SM, Beckstrom-Sternberg JS, Stafford P, Schwendiman AL, Soto-Pena J, Owen MC, Ramirez C, Phillips J, Veldhoen N, Helbing CC, Propper CR.

Gen Comp Endocrinol. 2012 May 1;176(3):481-92. doi: 10.1016/j.ygcen.2011.12.036. Epub 2012 Jan 11.

PMID:
22248444
27.

Modulation of thyroid hormone-dependent gene expression in Xenopus laevis by INhibitor of Growth (ING) proteins.

Helbing CC, Wagner MJ, Pettem K, Johnston J, Heimeier RA, Veldhoen N, Jirik FR, Shi YB, Browder LW.

PLoS One. 2011;6(12):e28658. doi: 10.1371/journal.pone.0028658. Epub 2011 Dec 5.

28.

Biological effects of the anti-parasitic chemotherapeutant emamectin benzoate on a non-target crustacean, the spot prawn (Pandalus platyceros Brandt, 1851) under laboratory conditions.

Veldhoen N, Ikonomou MG, Buday C, Jordan J, Rehaume V, Cabecinha M, Dubetz C, Chamberlain J, Pittroff S, Vallée K, van Aggelen G, Helbing CC.

Aquat Toxicol. 2012 Feb;108:94-105. doi: 10.1016/j.aquatox.2011.10.015. Epub 2011 Oct 28.

PMID:
22088864
29.

Molecular profiling of marine fauna: integration of omics with environmental assessment of the world's oceans.

Veldhoen N, Ikonomou MG, Helbing CC.

Ecotoxicol Environ Saf. 2012 Feb;76(2):23-38. doi: 10.1016/j.ecoenv.2011.10.005. Epub 2011 Oct 28. Review.

PMID:
22036265
30.

PCB-associated changes in mRNA expression in killer whales (Orcinus orca) from the NE Pacific Ocean.

Buckman AH, Veldhoen N, Ellis G, Ford JK, Helbing CC, Ross PS.

Environ Sci Technol. 2011 Dec 1;45(23):10194-202. doi: 10.1021/es201541j. Epub 2011 Nov 2.

PMID:
21985468
31.

Triclosan affects the thyroid axis of amphibians.

Helbing CC, Propper CR, Veldhoen N.

Toxicol Sci. 2011 Oct;123(2):601-2; author reply 603-5. doi: 10.1093/toxsci/kfr127. Epub 2011 Aug 18. No abstract available.

PMID:
21852691
32.

Relationship between mRNA biomarker candidates and location near a marine municipal wastewater outfall in the benthic indicator species Modiolus modiolus (L.).

Veldhoen N, Kobylarz M, Lowe CJ, Meloche L, deBruyn AM, Helbing CC.

Aquat Toxicol. 2011 Sep;105(1-2):119-26. doi: 10.1016/j.aquatox.2011.05.020. Epub 2011 Jun 6.

PMID:
21703980
33.

Effect of low dose exposure to the herbicide atrazine and its metabolite on cytochrome P450 aromatase and steroidogenic factor-1 mRNA levels in the brain of premetamorphic bullfrog tadpoles (Rana catesbeiana).

Gunderson MP, Veldhoen N, Skirrow RC, Macnab MK, Ding W, van Aggelen G, Helbing CC.

Aquat Toxicol. 2011 Mar;102(1-2):31-8. doi: 10.1016/j.aquatox.2010.12.019. Epub 2011 Jan 4.

34.

Triclosan affects thyroid hormone-dependent metamorphosis in anurans.

Helbing CC, van Aggelen G, Veldhoen N.

Toxicol Sci. 2011 Feb;119(2):417-8; author reply 419-22. doi: 10.1093/toxsci/kfq343. Epub 2010 Nov 11. No abstract available.

PMID:
21071727
35.

Nanometals induce stress and alter thyroid hormone action in amphibia at or below North American water quality guidelines.

Hinther A, Vawda S, Skirrow RC, Veldhoen N, Collins P, Cullen JT, van Aggelen G, Helbing CC.

Environ Sci Technol. 2010 Nov 1;44(21):8314-21. doi: 10.1021/es101902n.

PMID:
20929207
36.

Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates.

Dryhurst D, Ishibashi T, Rose KL, Eirín-López JM, McDonald D, Silva-Moreno B, Veldhoen N, Helbing CC, Hendzel MJ, Shabanowitz J, Hunt DF, Ausió J.

BMC Biol. 2009 Dec 14;7:86. doi: 10.1186/1741-7007-7-86.

37.

Gene expression profiling and environmental contaminant assessment of migrating Pacific salmon in the Fraser River watershed of British Columbia.

Veldhoen N, Ikonomou MG, Dubetz C, Macpherson N, Sampson T, Kelly BC, Helbing CC.

Aquat Toxicol. 2010 May 5;97(3):212-25. doi: 10.1016/j.aquatox.2009.09.009. Epub 2009 Sep 18.

PMID:
19811841
38.

Characterization of vtg-1 mRNA expression during ontogeny in Oreochromis mossambicus (PETERS).

Esterhuyse MM, Venter M, Veldhoen N, Helbing CC, van Wyk JH.

J Steroid Biochem Mol Biol. 2009 Oct;117(1-3):42-9. doi: 10.1016/j.jsbmb.2009.07.001. Epub 2009 Jul 15.

PMID:
19615445
39.

Gene expression profiling in the deep water horse mussel Modiolus modiolus (L.) located near a marine municipal wastewater outfall.

Veldhoen N, Lowe CJ, Davis C, Mazumder A, Helbing CC.

Aquat Toxicol. 2009 Jun 28;93(2-3):116-24. doi: 10.1016/j.aquatox.2009.04.002. Epub 2009 Apr 17.

PMID:
19450888
40.

Ontogenetic changes in photoreceptor opsin gene expression in coho salmon (Oncorhynchus kisutch, Walbaum).

Temple SE, Veldhoen KM, Phelan JT, Veldhoen NJ, Hawryshyn CW.

J Exp Biol. 2008 Dec;211(Pt 24):3879-88. doi: 10.1242/jeb.020289.

41.
42.

Effects of exogenous thyroid hormones on visual pigment composition in coho salmon (Oncorhynchus kisutch).

Temple SE, Ramsden SD, Haimberger TJ, Veldhoen KM, Veldhoen NJ, Carter NL, Roth WM, Hawryshyn CW.

J Exp Biol. 2008 Jul;211(Pt 13):2134-43. doi: 10.1242/jeb.009365.

43.

Expression profiles of mRNA transcript variants encoding the human inhibitor of growth tumor suppressor gene family in normal and neoplastic tissues.

Walzak AA, Veldhoen N, Feng X, Riabowol K, Helbing CC.

Exp Cell Res. 2008 Jan 15;314(2):273-85. Epub 2007 Aug 2.

PMID:
17720155
44.

Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 1. Effects on the brain.

Helbing CC, Bailey CM, Ji L, Gunderson MP, Zhang F, Veldhoen N, Skirrow RC, Mu R, Lesperance M, Holcombe GW, Kosian PA, Tietge J, Korte JJ, Degitz SJ.

Aquat Toxicol. 2007 May 31;82(4):227-41. Epub 2007 Feb 23.

PMID:
17403546
45.

Identification of gene expression indicators for thyroid axis disruption in a Xenopus laevis metamorphosis screening assay. Part 2. Effects on the tail and hindlimb.

Helbing CC, Ji L, Bailey CM, Veldhoen N, Zhang F, Holcombe GW, Kosian PA, Tietge J, Korte JJ, Degitz SJ.

Aquat Toxicol. 2007 May 31;82(4):215-26. Epub 2007 Feb 23.

PMID:
17399805
46.

Characterization of Inhibitor of Growth 2 tumor suppressor in Alligator mississippiensis, its conservation in Archosauria, and response to thyroid stimulating hormone.

Helbing CC, Crump K, Bailey CM, Kohno S, Veldhoen N, Song Y, Bryan T, Bermudez DS, Ausió J, Guillette LJ Jr.

Comp Biochem Physiol B Biochem Mol Biol. 2007 Feb;146(2):279-88. Epub 2006 Nov 30.

PMID:
17208481
47.

The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development.

Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC.

Aquat Toxicol. 2006 Dec 1;80(3):217-27. Epub 2006 Sep 29. Erratum in: Aquat Toxicol. 2007 Jun 5;83(1):84.

PMID:
17011055
48.

Isolation of the alligator (Alligator mississippiensis) thyroid hormone receptor alpha and beta transcripts and their responsiveness to thyroid stimulating hormone.

Helbing CC, Crump K, Bailey CM, Kohno S, Veldhoen N, Bryan T, Bermudez D, Guillette LJ Jr.

Gen Comp Endocrinol. 2006 Nov;149(2):141-50. Epub 2006 Aug 1.

PMID:
16884722
49.

PCB-related alteration of thyroid hormones and thyroid hormone receptor gene expression in free-ranging harbor seals (Phoca vitulina).

Tabuchi M, Veldhoen N, Dangerfield N, Jeffries S, Helbing CC, Ross PS.

Environ Health Perspect. 2006 Jul;114(7):1024-31.

50.

Use of heterologous cDNA arrays and organ culture in the detection of thyroid hormone-dependent responses in a sentinel frog, Rana catesbeiana.

Veldhoen N, Skirrow RC, Ji L, Domanski D, Bonfield ER, Bailey CM, Helbing CC.

Comp Biochem Physiol Part D Genomics Proteomics. 2006 Jun;1(2):187-99. doi: 10.1016/j.cbd.2005.10.005. Epub 2005 Dec 12.

PMID:
20483250

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