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Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.

Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Roedel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML.

Sci Transl Med. 2019 Nov 27;11(520). pii: eaaw3521. doi: 10.1126/scitranslmed.aaw3521.


MUC2 mucin deficiency alters inflammatory and metabolic pathways in the mouse intestinal mucosa.

Tadesse S, Corner G, Dhima E, Houston M, Guha C, Augenlicht L, Velcich A.

Oncotarget. 2017 Apr 6;8(42):71456-71470. doi: 10.18632/oncotarget.16886. eCollection 2017 Sep 22.


A Model for Precise and Uniform Pelvic- and Limb-Sparing Abdominal Irradiation to Study the Radiation-Induced Gastrointestinal Syndrome in Mice Using Small Animal Irradiation Systems.

Brodin NP, Velcich A, Guha C, Tomé WA.

Dose Response. 2017 Jan 4;15(1):1559325816685798. doi: 10.1177/1559325816685798. eCollection 2017 Jan-Mar.


Natural anti-intestinal goblet cell autoantibody production from marginal zone B cells.

Ichikawa D, Asano M, Shinton SA, Brill-Dashoff J, Formica AM, Velcich A, Hardy RR, Hayakawa K.

J Immunol. 2015 Jan 15;194(2):606-14. doi: 10.4049/jimmunol.1402383. Epub 2014 Dec 5.


Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis.

Wenzel UA, Magnusson MK, Rydström A, Jonstrand C, Hengst J, Johansson ME, Velcich A, Öhman L, Strid H, Sjövall H, Hansson GC, Wick MJ.

PLoS One. 2014 Jun 19;9(6):e100217. doi: 10.1371/journal.pone.0100217. eCollection 2014.


Radiation-induced modulation of costimulatory and coinhibitory T-cell signaling molecules on human prostate carcinoma cells promotes productive antitumor immune interactions.

Bernstein MB, Garnett CT, Zhang H, Velcich A, Wattenberg MM, Gameiro SR, Kalnicki S, Hodge JW, Guha C.

Cancer Biother Radiopharm. 2014 May;29(4):153-61. doi: 10.1089/cbr.2013.1578. Epub 2014 Apr 2.


Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.

Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A.

Science. 2013 Oct 25;342(6157):447-53. doi: 10.1126/science.1237910. Epub 2013 Sep 26.


The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis.

Zarepour M, Bhullar K, Montero M, Ma C, Huang T, Velcich A, Xia L, Vallance BA.

Infect Immun. 2013 Oct;81(10):3672-83. doi: 10.1128/IAI.00854-13. Epub 2013 Jul 22.


Importance and regulation of the colonic mucus barrier in a mouse model of colitis.

Petersson J, Schreiber O, Hansson GC, Gendler SJ, Velcich A, Lundberg JO, Roos S, Holm L, Phillipson M.

Am J Physiol Gastrointest Liver Physiol. 2011 Feb;300(2):G327-33. doi: 10.1152/ajpgi.00422.2010. Epub 2010 Nov 25.


Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa.

Bergstrom KS, Kissoon-Singh V, Gibson DL, Ma C, Montero M, Sham HP, Ryz N, Huang T, Velcich A, Finlay BB, Chadee K, Vallance BA.

PLoS Pathog. 2010 May 13;6(5):e1000902. doi: 10.1371/journal.ppat.1000902.


Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.

Hasnain SZ, Wang H, Ghia JE, Haq N, Deng Y, Velcich A, Grencis RK, Thornton DJ, Khan WI.

Gastroenterology. 2010 May;138(5):1763-71. doi: 10.1053/j.gastro.2010.01.045. Epub 2010 Feb 4.


Threonine metabolism in the intestine of mice: loss of mucin 2 induces the threonine catabolic pathway.

van der Sluis M, Schaart MW, de Koning BA, Schierbeek H, Velcich A, Renes IB, van Goudoever JB.

J Pediatr Gastroenterol Nutr. 2009 Jul;49(1):99-107. doi: 10.1097/MPG.0b013e3181a23dbe.


PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.

Pysz MA, Leontieva OV, Bateman NW, Uronis JM, Curry KJ, Threadgill DW, Janssen KP, Robine S, Velcich A, Augenlicht LH, Black AR, Black JD.

Exp Cell Res. 2009 May 1;315(8):1415-28. doi: 10.1016/j.yexcr.2009.02.002. Epub 2009 Feb 14.


Expression of Pla2g2a prevents carcinogenesis in Muc2-deficient mice.

Fijneman RJ, Peham JR, van de Wiel MA, Meijer GA, Matise I, Velcich A, Cormier RT.

Cancer Sci. 2008 Nov;99(11):2113-9. doi: 10.1111/j.1349-7006.2008.00924.x.


Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells.

Maier S, Daroqui MC, Scherer S, Roepcke S, Velcich A, Shenoy SM, Singer RH, Augenlicht LH.

J Cell Physiol. 2009 Mar;218(3):638-42. doi: 10.1002/jcp.21642.


Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.

Yang K, Kurihara N, Fan K, Newmark H, Rigas B, Bancroft L, Corner G, Livote E, Lesser M, Edelmann W, Velcich A, Lipkin M, Augenlicht L.

Cancer Res. 2008 Oct 1;68(19):7803-10. doi: 10.1158/0008-5472.CAN-08-1209.


The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.

Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC.

Proc Natl Acad Sci U S A. 2008 Sep 30;105(39):15064-9. doi: 10.1073/pnas.0803124105. Epub 2008 Sep 19.


Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation.

Yang K, Popova NV, Yang WC, Lozonschi I, Tadesse S, Kent S, Bancroft L, Matise I, Cormier RT, Scherer SJ, Edelmann W, Lipkin M, Augenlicht L, Velcich A.

Cancer Res. 2008 Sep 15;68(18):7313-22. doi: 10.1158/0008-5472.CAN-08-0598.


Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice.

van der Sluis M, Bouma J, Vincent A, Velcich A, Carraway KL, Büller HA, Einerhand AW, van Goudoever JB, Van Seuningen I, Renes IB.

Lab Invest. 2008 Jun;88(6):634-42. doi: 10.1038/labinvest.2008.28. Epub 2008 Apr 21.


Methotrexate-induced mucositis in mucin 2-deficient mice.

de Koning BA, Sluis Mv, Lindenbergh-Kortleve DJ, Velcich A, Pieters R, Büller HA, Einerhand AW, Renes IB.

J Cell Physiol. 2007 Jan;210(1):144-52.


Interaction of genetic and dietary factors in mouse intestinal tumorigenesis.

Augenlicht LH, Yang W, Mariadason J, Velcich A, Klampfer L, Lipkin M, Yang K.

J Nutr. 2006 Oct;136(10):2695S-6S. No abstract available.


Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.

Van der Sluis M, De Koning BA, De Bruijn AC, Velcich A, Meijerink JP, Van Goudoever JB, Büller HA, Dekker J, Van Seuningen I, Renes IB, Einerhand AW.

Gastroenterology. 2006 Jul;131(1):117-29.


Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer.

Wilson AJ, Byun DS, Popova N, Murray LB, L'Italien K, Sowa Y, Arango D, Velcich A, Augenlicht LH, Mariadason JM.

J Biol Chem. 2006 May 12;281(19):13548-58. Epub 2006 Mar 13.


Dietary components modify gene expression: implications for carcinogenesis.

Yang K, Yang W, Mariadason J, Velcich A, Lipkin M, Augenlicht L.

J Nutr. 2005 Nov;135(11):2710-4.


Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice.

Yang W, Velcich A, Lozonschi I, Liang J, Nicholas C, Zhuang M, Bancroft L, Augenlicht LH.

Am J Pathol. 2005 Apr;166(4):1239-46.


Quantitative rather than qualitative differences in gene expression predominate in intestinal cell maturation along distinct cell lineages.

Velcich A, Corner G, Paul D, Zhuang M, Mariadason JM, Laboisse C, Augenlicht L.

Exp Cell Res. 2005 Mar 10;304(1):28-39. Epub 2004 Nov 19.


Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation.

Augenlicht L, Shi L, Mariadason J, Laboisse C, Velcich A.

Oncogene. 2003 Aug 7;22(32):4983-92.


Application of gene expression profiling to colon cell maturation, transformation and chemoprevention.

Augenlicht LH, Velcich A, Klampfer L, Huang J, Corner G, Aranes M, Laboisse C, Rigas B, Lipkin M, Yang K, Shi Q, Lesser M, Heerdt B, Arango D, Yang W, Wilson A, Mariadason JM.

J Nutr. 2003 Jul;133(7 Suppl):2410S-2416S. doi: 10.1093/jn/133.7.2410S. Review.


Environment-gene interactions in intestinal cancer.

Augenlicht LH, Heerdt BG, Mariadason JM, Yang W, Wilson AJ, Fragale A, Velcich A.

Eur J Cancer Prev. 2002 Aug;11 Suppl 2:S12-7. Review.


Short chain fatty acids and colon cancer.

Augenlicht LH, Mariadason JM, Wilson A, Arango D, Yang W, Heerdt BG, Velcich A.

J Nutr. 2002 Dec;132(12):3804S-3808S.


Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention.

Wilson AJ, Velcich A, Arango D, Kurland AR, Shenoy SM, Pezo RC, Levsky JM, Singer RH, Augenlicht LH.

Cancer Res. 2002 Nov 1;62(21):6006-10.


Colorectal cancer in mice genetically deficient in the mucin Muc2.

Velcich A, Yang W, Heyer J, Fragale A, Nicholas C, Viani S, Kucherlapati R, Lipkin M, Yang K, Augenlicht L.

Science. 2002 Mar 1;295(5560):1726-9.


p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo.

Yang W, Velcich A, Mariadason J, Nicholas C, Corner G, Houston M, Edelmann W, Kucherlapati R, Holt PR, Augenlicht LH.

Cancer Res. 2001 Aug 15;61(16):6297-302.


Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation.

Mariadason JM, Bordonaro M, Aslam F, Shi L, Kuraguchi M, Velcich A, Augenlicht LH.

Cancer Res. 2001 Apr 15;61(8):3465-71.


Resistance to butyrate-induced cell differentiation and apoptosis during spontaneous Caco-2 cell differentiation.

Mariadason JM, Velcich A, Wilson AJ, Augenlicht LH, Gibson PR.

Gastroenterology. 2001 Mar;120(4):889-99.


The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters.

Aslam F, Palumbo L, Augenlicht LH, Velcich A.

Cancer Res. 2001 Jan 15;61(2):570-6.


Colonic cell proliferation, differentiation, and apoptosis.

Augenlicht L, Velcich A, Mariadason J, Bordonaro M, Heerdt B.

Adv Exp Med Biol. 1999;470:15-22. Review. No abstract available.


Cellular mechanisms of risk and transformation.

Augenlicht LH, Bordonaro M, Heerdt BG, Mariadason J, Velcich A.

Ann N Y Acad Sci. 1999;889:20-31. Review.


Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene.

Velcich A, Corner G, Palumbo L, Augenlicht L.

Oncogene. 1999 Apr 22;18(16):2599-606.


Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus.

Velcich A, Palumbo L, Selleri L, Evans G, Augenlicht L.

J Biol Chem. 1997 Mar 21;272(12):7968-76.


Patterns of expression of lineage-specific markers during the in vitro-induced differentiation of HT29 colon carcinoma cells.

Velcich A, Palumbo L, Jarry A, Laboisse C, Racevskis J, Augenlicht L.

Cell Growth Differ. 1995 Jun;6(6):749-57.


Short-chain fatty acids and molecular and cellular mechanisms of colonic cell differentiation and transformation.

Augenlicht L, Velcich A, Heerdt BG.

Adv Exp Med Biol. 1995;375:137-48. Review. No abstract available.


Interferon-gamma modulates cAMP-induced mucin exocytosis without affecting mucin gene expression in a human colonic goblet cell line.

Jarry A, Merlin D, Velcich A, Hopfer U, Augenlicht LH, Laboisse CL.

Eur J Pharmacol. 1994 Mar 15;267(1):95-103.


Regulated expression of an intestinal mucin gene in HT29 colonic carcinoma cells.

Velcich A, Augenlicht LH.

J Biol Chem. 1993 Jul 5;268(19):13956-61.


Expression of the K-fgf protooncogene is repressed during differentiation of F9 cells.

Velcich A, Delli-Bovi P, Mansukhani A, Ziff EB, Basilico C.

Oncogene Res. 1989;5(1):31-7.


Expression and activation of the K-fgf oncogene.

Basilico C, Newman KM, Curatola AM, Talarico D, Mansukhani A, Velcich A, Delli-Bovi P.

Ann N Y Acad Sci. 1989;567:95-103. Review. No abstract available.


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