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Inhibition of Endocytosis of Clathrin-Mediated Angiotensin II Receptor Type 1 in Podocytes Augments Glomerular Injury.

Inoue K, Tian X, Velazquez H, Soda K, Wang Z, Pedigo CE, Wang Y, Cross E, Groener M, Shin JW, Li W, Hassan H, Yamamoto K, Mundel P, Ishibe S.

J Am Soc Nephrol. 2019 Sep 11. pii: ASN.2019010053. doi: 10.1681/ASN.2019010053. [Epub ahead of print]


Early B Cell Factor 1 (EBF1) Regulates Glomerular Development by Controlling Mesangial Maturation and Consequently COX-2 Expression.

Nelson T, Velazquez H, Troiano N, Fretz JA.

J Am Soc Nephrol. 2019 Sep;30(9):1559-1572. doi: 10.1681/ASN.2018070699. Epub 2019 Aug 12.


Diffuse Hepatic Infiltration by Metastatic Melanoma.

Velázquez HE, Castro-Alonso FJ, Bourlon C, Gabutti A, Gallegos C, Bourlon MT.

Oncology (Williston Park). 2019 Jul 16;33(7). pii: 629386. No abstract available.


Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium.

Ricard N, Scott RP, Booth CJ, Velazquez H, Cilfone NA, Baylon JL, Gulcher JR, Quaggin SE, Chittenden TW, Simons M.

J Exp Med. 2019 Aug 5;216(8):1874-1890. doi: 10.1084/jem.20182151. Epub 2019 Jun 13.


Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation.

Ramírez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C.

Circulation. 2019 Jul 16;140(3):225-239. doi: 10.1161/CIRCULATIONAHA.118.038571. Epub 2019 Jun 3.


Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease.

Landau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R.

Kidney Int. 2019 Apr;95(4):797-814. doi: 10.1016/j.kint.2018.11.042.


Characterization of renal NaCl and oxalate transport in Slc26a6-/- mice.

Knauf F, Velazquez H, Pfann V, Jiang Z, Aronson PS.

Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F128-F133. doi: 10.1152/ajprenal.00309.2018. Epub 2018 Nov 14.


CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues.

Luciano AK, Zhou W, Santana JM, Kyriakides C, Velazquez H, Sessa WC.

J Biol Chem. 2018 Jun 8;293(23):9126-9136. doi: 10.1074/jbc.RA117.000773. Epub 2018 Mar 27.


Is This Patient With Metastatic Bladder Cancer a Candidate for Second-Line Immunotherapy Treatment?

Bourlon MT, Velázquez HE, Luna-Santiago R, Vázquez-Manjarrez S, Bourlon C.

Oncology (Williston Park). 2018 Feb 15;32(2):64-8. No abstract available.


Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis.

Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC.

Arterioscler Thromb Vasc Biol. 2018 Apr;38(4):870-879. doi: 10.1161/ATVBAHA.118.310748. Epub 2018 Feb 15.


"To Be or Not to Be" Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation.

Kovalevsky A, Aggarwal M, Velazquez H, Cuneo MJ, Blakeley MP, Weiss KL, Smith JC, Fisher SZ, McKenna R.

Structure. 2018 Mar 6;26(3):383-390.e3. doi: 10.1016/j.str.2018.01.006. Epub 2018 Feb 8.


Ensemble docking to difficult targets in early-stage drug discovery: Methodology and application to fibroblast growth factor 23.

Velazquez HA, Riccardi D, Xiao Z, Quarles LD, Yates CR, Baudry J, Smith JC.

Chem Biol Drug Des. 2018 Feb;91(2):491-504. doi: 10.1111/cbdd.13110. Epub 2017 Nov 3.


Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug.

Aggarwal M, Kovalevsky AY, Velazquez H, Fisher SZ, Smith JC, McKenna R.

IUCrJ. 2016 Jul 22;3(Pt 5):319-325. doi: 10.1107/S2052252516010514. eCollection 2016 Sep 1.


Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression.

Luciano AK, Santana JM, Velazquez H, Sessa WC.

J Biol Rhythms. 2017 Jun;32(3):212-221. doi: 10.1177/0748730417704534. Epub 2017 Apr 28.


Extracellular renalase protects cells and organs by outside-in signalling.

Wang Y, Safirstein R, Velazquez H, Guo XJ, Hollander L, Chang J, Chen TM, Mu JJ, Desir GV.

J Cell Mol Med. 2017 Jul;21(7):1260-1265. doi: 10.1111/jcmm.13062. Epub 2017 Feb 26. Review.


A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia.

Xiao Z, Riccardi D, Velazquez HA, Chin AL, Yates CR, Carrick JD, Smith JC, Baudry J, Quarles LD.

Sci Signal. 2016 Nov 22;9(455):ra113. Erratum in: Sci Signal. 2016 Dec 06;9(457):er3.


Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism.

Hollander L, Guo X, Velazquez H, Chang J, Safirstein R, Kluger H, Cha C, Desir GV.

Cancer Res. 2016 Jul 1;76(13):3884-94. doi: 10.1158/0008-5472.CAN-15-1524. Epub 2016 May 9.


Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer.

Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, Safirstein R, Cha C, Gorelick F, Desir GV.

Sci Rep. 2016 Mar 14;6:22996. doi: 10.1038/srep22996.


The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics.

Marin EP, Jozsef L, Di Lorenzo A, Held KF, Luciano AK, Melendez J, Milstone LM, Velazquez H, Sessa WC.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):370-9. doi: 10.1161/ATVBAHA.115.306942. Epub 2015 Dec 29.


Uncoupling Caveolae From Intracellular Signaling In Vivo.

Kraehling JR, Hao Z, Lee MY, Vinyard DJ, Velazquez H, Liu X, Stan RV, Brudvig GW, Sessa WC.

Circ Res. 2016 Jan 8;118(1):48-55. doi: 10.1161/CIRCRESAHA.115.307767. Epub 2015 Nov 24.


Three-Dimensional Morphology by Multiphoton Microscopy with Clearing in a Model of Cisplatin-Induced CKD.

Torres R, Velazquez H, Chang JJ, Levene MJ, Moeckel G, Desir GV, Safirstein R.

J Am Soc Nephrol. 2016 Apr;27(4):1102-12. doi: 10.1681/ASN.2015010079. Epub 2015 Aug 24.


Identification of a receptor for extracellular renalase.

Wang L, Velazquez H, Chang J, Safirstein R, Desir GV.

PLoS One. 2015 Apr 23;10(4):e0122932. doi: 10.1371/journal.pone.0122932. eCollection 2015.


Dynamical role of phosphorylation on serine/threonine-proline Pin1 substrates from constant force molecular dynamics simulations.

Velazquez HA, Hamelberg D.

J Chem Phys. 2015 Feb 21;142(7):075102. doi: 10.1063/1.4907884.


Loss of the endothelial glucocorticoid receptor prevents the therapeutic protection afforded by dexamethasone after LPS.

Goodwin JE, Feng Y, Velazquez H, Zhou H, Sessa WC.

PLoS One. 2014 Oct 9;9(10):e108126. doi: 10.1371/journal.pone.0108126. eCollection 2014.


Renalase: its role as a cytokine, and an update on its association with type 1 diabetes and ischemic stroke.

Guo X, Wang L, Velazquez H, Safirstein R, Desir GV.

Curr Opin Nephrol Hypertens. 2014 Sep;23(5):513-8. doi: 10.1097/MNH.0000000000000044. Review.


Reducing exposure to long days from 75 to 30 days of extra-light treatment does not decrease the capacity of male goats to stimulate ovulatory activity in seasonally anovulatory females.

Ponce JL, Velázquez H, Duarte G, Bedos M, Hernández H, Keller M, Chemineau P, Delgadillo JA.

Domest Anim Endocrinol. 2014 Jul;48:119-25. doi: 10.1016/j.domaniend.2014.03.002. Epub 2014 Mar 20.


Podocyte-specific VEGF-a gain of function induces nodular glomerulosclerosis in eNOS null mice.

Veron D, Aggarwal PK, Velazquez H, Kashgarian M, Moeckel G, Tufro A.

J Am Soc Nephrol. 2014 Aug;25(8):1814-24. doi: 10.1681/ASN.2013070752. Epub 2014 Feb 27.


Renalase prevents AKI independent of amine oxidase activity.

Wang L, Velazquez H, Moeckel G, Chang J, Ham A, Lee HT, Safirstein R, Desir GV.

J Am Soc Nephrol. 2014 Jun;25(6):1226-35. doi: 10.1681/ASN.2013060665. Epub 2014 Feb 7.


Early B-cell factor 1 is an essential transcription factor for postnatal glomerular maturation.

Fretz JA, Nelson T, Velazquez H, Xi Y, Moeckel GW, Horowitz MC.

Kidney Int. 2014 May;85(5):1091-102. doi: 10.1038/ki.2013.433. Epub 2013 Oct 30.


Conformation-directed catalysis and coupled enzyme-substrate dynamics in Pin1 phosphorylation-dependent cis-trans isomerase.

Velazquez HA, Hamelberg D.

J Phys Chem B. 2013 Oct 3;117(39):11509-17. doi: 10.1021/jp405271s. Epub 2013 Sep 17.


Renalase regulates renal dopamine and phosphate metabolism.

Sizova D, Velazquez H, Sampaio-Maia B, Quelhas-Santos J, Pestana M, Desir GV.

Am J Physiol Renal Physiol. 2013 Sep 15;305(6):F839-44. doi: 10.1152/ajprenal.00616.2012. Epub 2013 Jul 17.


Endothelial glucocorticoid receptor is required for protection against sepsis.

Goodwin JE, Feng Y, Velazquez H, Sessa WC.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):306-11. doi: 10.1073/pnas.1210200110. Epub 2012 Dec 17.


Renalase lowers ambulatory blood pressure by metabolizing circulating adrenaline.

Desir GV, Tang L, Wang P, Li G, Sampaio-Maia B, Quelhas-Santos J, Pestana M, Velazquez H.

J Am Heart Assoc. 2012 Aug;1(4):e002634. doi: 10.1161/JAHA.112.002634. Epub 2012 Aug 24.


N-Heterocyclic carbene transition metal complexes for catalysis in aqueous media.

Velazquez HD, Verpoort F.

Chem Soc Rev. 2012 Nov 7;41(21):7032-60. doi: 10.1039/c2cs35102a. Epub 2012 Jul 30.


Acute podocyte vascular endothelial growth factor (VEGF-A) knockdown disrupts alphaVbeta3 integrin signaling in the glomerulus.

Veron D, Villegas G, Aggarwal PK, Bertuccio C, Jimenez J, Velazquez H, Reidy K, Abrahamson DR, Moeckel G, Kashgarian M, Tufro A.

PLoS One. 2012;7(7):e40589. doi: 10.1371/journal.pone.0040589. Epub 2012 Jul 13.


Sexually active bucks are able to stimulate three successive groups of females per day with a 4-hour period of contact.

Bedos M, Velázquez H, Fitz-Rodríguez G, Flores JA, Hernández H, Duarte G, Vielma J, Fernández IG, Retana-Márquez MS, Muñoz-Gutiérrez M, Keller M, Delgadillo JA.

Physiol Behav. 2012 May 15;106(2):259-63. doi: 10.1016/j.physbeh.2012.02.015. Epub 2012 Feb 18.


Conformational selection in the recognition of phosphorylated substrates by the catalytic domain of human Pin1.

Velazquez HA, Hamelberg D.

Biochemistry. 2011 Nov 8;50(44):9605-15. doi: 10.1021/bi2009954. Epub 2011 Oct 11.


Ostα depletion protects liver from oral bile acid load.

Soroka CJ, Velazquez H, Mennone A, Ballatori N, Boyer JL.

Am J Physiol Gastrointest Liver Physiol. 2011 Sep;301(3):G574-9. doi: 10.1152/ajpgi.00141.2011. Epub 2011 Jun 30.


Podocyte vascular endothelial growth factor (Vegf₁₆₄) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes.

Veron D, Bertuccio CA, Marlier A, Reidy K, Garcia AM, Jimenez J, Velazquez H, Kashgarian M, Moeckel GW, Tufro A.

Diabetologia. 2011 May;54(5):1227-41. doi: 10.1007/s00125-010-2034-z. Epub 2011 Feb 12.


Renalase deficiency aggravates ischemic myocardial damage.

Wu Y, Xu J, Velazquez H, Wang P, Li G, Liu D, Sampaio-Maia B, Quelhas-Santos J, Russell K, Russell R, Flavell RA, Pestana M, Giordano F, Desir GV.

Kidney Int. 2011 Apr;79(8):853-60. doi: 10.1038/ki.2010.488. Epub 2010 Dec 22.


The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension.

Goodwin JE, Zhang J, Velazquez H, Geller DS.

Biochem Biophys Res Commun. 2010 Apr 2;394(2):266-71. doi: 10.1016/j.bbrc.2010.02.123. Epub 2010 Feb 24.


Torasemide significantly reduces thiazide-induced potassium and magnesium loss despite supra-additive natriuresis.

Knauf H, Mutschler E, Velazquez H, Giebisch G.

Eur J Clin Pharmacol. 2009 May;65(5):465-72. doi: 10.1007/s00228-009-0626-7. Epub 2009 Feb 20.


Catecholamines regulate the activity, secretion, and synthesis of renalase.

Li G, Xu J, Wang P, Velazquez H, Li Y, Wu Y, Desir GV.

Circulation. 2008 Mar 11;117(10):1277-82. doi: 10.1161/CIRCULATIONAHA.107.732032. Epub 2008 Feb 25.


Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

Shibazaki S, Yu Z, Nishio S, Tian X, Thomson RB, Mitobe M, Louvi A, Velazquez H, Ishibe S, Cantley LG, Igarashi P, Somlo S.

Hum Mol Genet. 2008 Jun 1;17(11):1505-16. doi: 10.1093/hmg/ddn039. Epub 2008 Feb 7.


Instrument development of the Confidence in Home Care Services Questionnaire for use with elders and caregivers of Mexican descent.

Crist JD, Velazquez H, Durnan I, Figueroa DR.

Public Health Nurs. 2006 May-Jun;23(3):284-91.


Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6.

Jiang Z, Asplin JR, Evan AP, Rajendran VM, Velazquez H, Nottoli TP, Binder HJ, Aronson PS.

Nat Genet. 2006 Apr;38(4):474-8. Epub 2006 Mar 12.


[Nasal budesonide plus zafirlukast vs nasal budesonide plus loratadine-pseudoephedrine for controlling the symptoms of rhinitis and asthma].

Benitez HH, Arvizu VM, Gutiérrez DJ, Fogelbach GA, Castellanos Olivares A, Vázquez Nava F, Velázquez HC, González Pérez Mdel C, Mora Nieto A, Rodríguez EC.

Rev Alerg Mex. 2005 Mar-Apr;52(2):90-5. Spanish.


Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.

Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV.

J Clin Invest. 2005 May;115(5):1275-80. Epub 2005 Apr 7.


Segment-specific expression of 2P domain potassium channel genes in human nephron.

Levy DI, Velazquez H, Goldstein SA, Bockenhauer D.

Kidney Int. 2004 Mar;65(3):918-26.

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