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Items: 1 to 50 of 59

1.

Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults.

Heikkinen N, Kärkkäinen O, Laukkanen E, Kekkonen V, Kaarre O, Kivimäki P, Könönen M, Velagapudi V, Nandania J, Lehto SM, Niskanen E, Vanninen R, Tolmunen T.

Alcohol. 2018 May 31;75:89-97. doi: 10.1016/j.alcohol.2018.05.010. [Epub ahead of print]

PMID:
30513444
2.

Metabolomes of mitochondrial diseases and inclusion body myositis patients: treatment targets and biomarkers.

Buzkova J, Nikkanen J, Ahola S, Hakonen AH, Sevastianova K, Hovinen T, Yki-Järvinen H, Pietiläinen KH, Lönnqvist T, Velagapudi V, Carroll CJ, Suomalainen A.

EMBO Mol Med. 2018 Dec;10(12). pii: e9091. doi: 10.15252/emmm.201809091.

3.

Data Abstraction Error in Systematic Review of Global Longitudinal Strain Using Speckle-Tracking Echocardiography as a Mortality Predictor in Sepsis.

Velagapudi VM, Tighe D.

J Intensive Care Med. 2018 Sep 11:885066618799638. doi: 10.1177/0885066618799638. [Epub ahead of print] No abstract available.

PMID:
30205731
4.

A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents.

Zusinaite E, Ianevski A, Niukkanen D, Poranen MM, Bjørås M, Afset JE, Tenson T, Velagapudi V, Merits A, Kainov DE.

Viruses. 2018 Aug 12;10(8). pii: E423. doi: 10.3390/v10080423. Review.

5.
6.

Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative).

Kirwan JA, Brennan L, Broadhurst D, Fiehn O, Cascante M, Dunn WB, Schmidt MA, Velagapudi V.

Clin Chem. 2018 Aug;64(8):1158-1182. doi: 10.1373/clinchem.2018.287045. Epub 2018 Jun 19. Review.

PMID:
29921725
7.

Plasma metabolites reveal distinct profiles associating with different metabolic risk factors in monozygotic twin pairs.

Muniandy M, Velagapudi V, Hakkarainen A, Lundbom J, Lundbom N, Rissanen A, Kaprio J, Pietiläinen KH, Ollikainen M.

Int J Obes (Lond). 2018 Jun 15. doi: 10.1038/s41366-018-0132-z. [Epub ahead of print]

PMID:
29907843
8.

Simultaneous measurement of folate cycle intermediates in different biological matrices using liquid chromatography-tandem mass spectrometry.

Nandania J, Kokkonen M, Euro L, Velagapudi V.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:168-178. doi: 10.1016/j.jchromb.2018.06.008. Epub 2018 Jun 5.

PMID:
29906678
9.

Global arginine bioavailability ratio is decreased in patients with major depressive disorder.

Ali-Sisto T, Tolmunen T, Viinamäki H, Mäntyselkä P, Valkonen-Korhonen M, Koivumaa-Honkanen H, Honkalampi K, Ruusunen A, Nandania J, Velagapudi V, Lehto SM.

J Affect Disord. 2018 Mar 15;229:145-151. doi: 10.1016/j.jad.2017.12.030. Epub 2017 Dec 27.

PMID:
29310063
10.

Adipose tissue mitochondrial capacity associates with long-term weight loss success.

Jokinen R, Rinnankoski-Tuikka R, Kaye S, Saarinen L, Heinonen S, Myöhänen M, Rappou E, Jukarainen S, Rissanen A, Pessia A, Velagapudi V, Virtanen KA, Pirinen E, Pietiläinen KH.

Int J Obes (Lond). 2018 Apr;42(4):817-825. doi: 10.1038/ijo.2017.299. Epub 2017 Dec 5.

PMID:
29203860
11.

Understanding the metabolic burden of recombinant antibody production in Saccharomyces cerevisiae using a quantitative metabolomics approach.

de Ruijter JC, Koskela EV, Nandania J, Frey AD, Velagapudi V.

Yeast. 2018 Apr;35(4):331-341. doi: 10.1002/yea.3298. Epub 2018 Jan 29.

PMID:
29159981
12.

Metabolomic Profiling of Extracellular Vesicles and Alternative Normalization Methods Reveal Enriched Metabolites and Strategies to Study Prostate Cancer-Related Changes.

Puhka M, Takatalo M, Nordberg ME, Valkonen S, Nandania J, Aatonen M, Yliperttula M, Laitinen S, Velagapudi V, Mirtti T, Kallioniemi O, Rannikko A, Siljander PR, Af Hällström TM.

Theranostics. 2017 Aug 23;7(16):3824-3841. doi: 10.7150/thno.19890. eCollection 2017.

13.

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.

Bulanova D, Ianevski A, Bugai A, Akimov Y, Kuivanen S, Paavilainen H, Kakkola L, Nandania J, Turunen L, Ohman T, Ala-Hongisto H, Pesonen HM, Kuisma MS, Honkimaa A, Walton EL, Oksenych V, Lorey MB, Guschin D, Shim J, Kim J, Than TT, Chang SY, Hukkanen V, Kulesskiy E, Marjomaki VS, Julkunen I, Nyman TA, Matikainen S, Saarela JS, Sane F, Hober D, Gabriel G, De Brabander JK, Martikainen M, Windisch MP, Min JY, Bruzzone R, Aittokallio T, Vähä-Koskela M, Vapalahti O, Pulk A, Velagapudi V, Kainov DE.

Viruses. 2017 Sep 25;9(10). pii: E271. doi: 10.3390/v9100271.

14.

mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression.

Khan NA, Nikkanen J, Yatsuga S, Jackson C, Wang L, Pradhan S, Kivelä R, Pessia A, Velagapudi V, Suomalainen A.

Cell Metab. 2017 Aug 1;26(2):419-428.e5. doi: 10.1016/j.cmet.2017.07.007.

15.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

16.

Host-Microbe Co-metabolism Dictates Cancer Drug Efficacy in C. elegans.

Scott TA, Quintaneiro LM, Norvaisas P, Lui PP, Wilson MP, Leung KY, Herrera-Dominguez L, Sudiwala S, Pessia A, Clayton PT, Bryson K, Velagapudi V, Mills PB, Typas A, Greene NDE, Cabreiro F.

Cell. 2017 Apr 20;169(3):442-456.e18. doi: 10.1016/j.cell.2017.03.040.

17.

Ketogenic diet attenuates hepatopathy in mouse model of respiratory chain complex III deficiency caused by a Bcs1l mutation.

Purhonen J, Rajendran J, Mörgelin M, Uusi-Rauva K, Katayama S, Krjutskov K, Einarsdottir E, Velagapudi V, Kere J, Jauhiainen M, Fellman V, Kallijärvi J.

Sci Rep. 2017 Apr 19;7(1):957. doi: 10.1038/s41598-017-01109-4.

18.

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics.

Vorrink SU, Ullah S, Schmidt S, Nandania J, Velagapudi V, Beck O, Ingelman-Sundberg M, Lauschke VM.

FASEB J. 2017 Jun;31(6):2696-2708. doi: 10.1096/fj.201601375R. Epub 2017 Mar 6.

19.

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.

Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI.

J Cell Biol. 2017 Mar 6;216(3):675-693. doi: 10.1083/jcb.201607019. Epub 2017 Feb 10.

20.

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.

Szibor M, Dhandapani PK, Dufour E, Holmström KM, Zhuang Y, Salwig I, Wittig I, Heidler J, Gizatullina Z, Gainutdinov T; German Mouse Clinic Consortium, Fuchs H, Gailus-Durner V, de Angelis MH, Nandania J, Velagapudi V, Wietelmann A, Rustin P, Gellerich FN, Jacobs HT, Braun T.

Dis Model Mech. 2017 Feb 1;10(2):163-171. doi: 10.1242/dmm.027839. Epub 2016 Dec 14.

21.

Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism.

Kuivanen S, Bespalov MM, Nandania J, Ianevski A, Velagapudi V, De Brabander JK, Kainov DE, Vapalahti O.

Antiviral Res. 2017 Mar;139:117-128. doi: 10.1016/j.antiviral.2016.12.022. Epub 2016 Dec 31.

PMID:
28049006
22.

The Association Between Musculoskeletal Pain and Circulating Ornithine: A Population-Based Study.

Mäntyselkä P, Ali-Sisto T, Kautiainen H, Niskanen L, Viinamäki H, Velagapudi V, Lehto SM.

Pain Med. 2017 Jun 1;18(6):1145-1151. doi: 10.1093/pm/pnw285.

PMID:
28034972
23.

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

Haapaniemi EM, Fogarty CL, Keskitalo S, Katayama S, Vihinen H, Ilander M, Mustjoki S, Krjutškov K, Lehto M, Hautala T, Eriksson O, Jokitalo E, Velagapudi V, Varjosalo M, Seppänen M, Kere J.

J Allergy Clin Immunol. 2017 Apr;139(4):1391-1393.e11. doi: 10.1016/j.jaci.2016.09.050. Epub 2016 Nov 29. No abstract available.

24.

Regulation of kynurenine biosynthesis during influenza virus infection.

Gaelings L, Söderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomäki V, De Brabander J, Matikainen S, Nyman TA, Bamford DH, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, Kainov DE.

FEBS J. 2017 Jan;284(2):222-236. doi: 10.1111/febs.13966. Epub 2016 Dec 14.

25.

Effect of High-Carbohydrate Diet on Plasma Metabolome in Mice with Mitochondrial Respiratory Chain Complex III Deficiency.

Rajendran J, Tomašić N, Kotarsky H, Hansson E, Velagapudi V, Kallijärvi J, Fellman V.

Int J Mol Sci. 2016 Nov 1;17(11). pii: E1824.

26.

Modified Atkins diet induces subacute selective ragged-red-fiber lysis in mitochondrial myopathy patients.

Ahola S, Auranen M, Isohanni P, Niemisalo S, Urho N, Buzkova J, Velagapudi V, Lundbom N, Hakkarainen A, Muurinen T, Piirilä P, Pietiläinen KH, Suomalainen A.

EMBO Mol Med. 2016 Nov 2;8(11):1234-1247. doi: 10.15252/emmm.201606592. Print 2016 Nov.

27.

Activation of Tryptophan and Phenylalanine Catabolism in the Remission Phase of Allergic Contact Dermatitis: A Pilot Study.

Zinkevičienė A, Kainov D, Girkontaitė I, Lastauskienė E, Kvedarienė V, Fu Y, Anders S, Velagapudi V.

Int Arch Allergy Immunol. 2016;170(4):262-268. Epub 2016 Oct 22.

28.

Computer-assisted image processing 12 lead ECG model to diagnose hyperkalemia.

Velagapudi V, O'Horo JC, Vellanki A, Baker SP, Pidikiti R, Stoff JS, Tighe DA.

J Electrocardiol. 2017 Jan - Feb;50(1):131-138. doi: 10.1016/j.jelectrocard.2016.09.001. Epub 2016 Sep 9.

PMID:
27662777
29.

Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease.

Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V.

J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158.

PMID:
27609529
30.

The Pentose Phosphate Pathway Regulates the Circadian Clock.

Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O'Neill JS, Reddy AB.

Cell Metab. 2016 Sep 13;24(3):462-473. doi: 10.1016/j.cmet.2016.07.024. Epub 2016 Aug 18.

31.

JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses.

Fu Y, Gaelings L, Söderholm S, Belanov S, Nandania J, Nyman TA, Matikainen S, Anders S, Velagapudi V, Kainov DE.

Antiviral Res. 2016 Sep;133:23-31. doi: 10.1016/j.antiviral.2016.07.008. Epub 2016 Jul 20.

PMID:
27451344
32.

Purine metabolism is dysregulated in patients with major depressive disorder.

Ali-Sisto T, Tolmunen T, Toffol E, Viinamäki H, Mäntyselkä P, Valkonen-Korhonen M, Honkalampi K, Ruusunen A, Velagapudi V, Lehto SM.

Psychoneuroendocrinology. 2016 Aug;70:25-32. doi: 10.1016/j.psyneuen.2016.04.017. Epub 2016 Apr 30.

PMID:
27153521
33.

GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells.

Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez VM, Otte K, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M.

Endocrinology. 2016 Jun;157(6):2416-31. doi: 10.1210/en.2015-1927. Epub 2016 Mar 14.

34.

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism.

Nikkanen J, Forsström S, Euro L, Paetau I, Kohnz RA, Wang L, Chilov D, Viinamäki J, Roivainen A, Marjamäki P, Liljenbäck H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lönnqvist T, Sajantila A, Isohanni P, Tyynismaa H, Nomura DK, Battersby BJ, Velagapudi V, Carroll CJ, Suomalainen A.

Cell Metab. 2016 Apr 12;23(4):635-48. doi: 10.1016/j.cmet.2016.01.019. Epub 2016 Feb 25.

35.

Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission.

Arora T, Velagapudi V, Pournaras DJ, Welbourn R, le Roux CW, Orešič M, Bäckhed F.

PLoS One. 2015 May 6;10(5):e0126401. doi: 10.1371/journal.pone.0126401. eCollection 2015.

36.

GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells.

Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Häkkinen M, Fischer S, Alastalo TP, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M.

Endocrinology. 2015 May;156(5):1860-72. doi: 10.1210/en.2014-1931. Epub 2015 Feb 10.

37.

The role of the primary care team in the rapid response system.

O'Horo JC, Sevilla Berrios RA, Elmer JL, Velagapudi V, Caples SM, Kashyap R, Jensen JB.

J Crit Care. 2015 Apr;30(2):353-7. doi: 10.1016/j.jcrc.2014.10.022. Epub 2014 Oct 30.

38.

Derivation and validation of a search algorithm to retrospectively identify mechanical ventilation initiation in the intensive care unit.

Smischney NJ, Velagapudi VM, Onigkeit JA, Pickering BW, Herasevich V, Kashyap R.

BMC Med Inform Decis Mak. 2014 Jun 25;14:55. doi: 10.1186/1472-6947-14-55.

39.

Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass.

Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Wilkinson D, Santhanam B, Sarper N, Clare S, Vassiliou GS, Velagapudi VR, Dougan G, Yadav VK.

J Clin Invest. 2014 Jul;124(7):2988-3002. doi: 10.1172/JCI72606. Epub 2014 Jun 9.

40.

Correlation of left ventricular systolic dysfunction determined by low ejection fraction and 30-day mortality in patients with severe sepsis and septic shock: a systematic review and meta-analysis.

Sevilla Berrios RA, O'Horo JC, Velagapudi V, Pulido JN.

J Crit Care. 2014 Aug;29(4):495-9. doi: 10.1016/j.jcrc.2014.03.007. Epub 2014 Mar 21. Review.

PMID:
24746109
41.

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3.

Khan NA, Auranen M, Paetau I, Pirinen E, Euro L, Forsström S, Pasila L, Velagapudi V, Carroll CJ, Auwerx J, Suomalainen A.

EMBO Mol Med. 2014 Jun;6(6):721-31. doi: 10.1002/emmm.201403943.

42.

Retrospective derivation and validation of a search algorithm to identify emergent endotracheal intubations in the intensive care unit.

Smischney NJ, Velagapudi VM, Onigkeit JA, Pickering BW, Herasevich V, Kashyap R.

Appl Clin Inform. 2013 Sep 4;4(3):419-27. doi: 10.4338/ACI-2013-05-RA-0033. eCollection 2013.

43.

Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo.

Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešič M, Urade Y, Griffin JL, Vidal-Puig A.

PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5.

44.

Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model.

Martínez-García C, Izquierdo A, Velagapudi V, Vivas Y, Velasco I, Campbell M, Burling K, Cava F, Ros M, Oresic M, Vidal-Puig A, Medina-Gomez G.

Dis Model Mech. 2012 Sep;5(5):636-48. doi: 10.1242/dmm.009266. Epub 2012 Jul 5.

45.

Peroxisome proliferator-activated receptor γ-dependent regulation of lipolytic nodes and metabolic flexibility.

Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Orešic M, Vidal-Puig A.

Mol Cell Biol. 2012 Apr;32(8):1555-65. doi: 10.1128/MCB.06154-11. Epub 2012 Feb 6.

46.

Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans.

Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešič M.

PLoS Biol. 2011 Jun;9(6):e1000623. doi: 10.1371/journal.pbio.1000623. Epub 2011 Jun 7.

47.

Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia.

Gurung IS, Medina-Gomez G, Kis A, Baker M, Velagapudi V, Neogi SG, Campbell M, Rodriguez-Cuenca S, Lelliott C, McFarlane I, Oresic M, Grace AA, Vidal-Puig A, Huang CL.

Cardiovasc Res. 2011 Oct 1;92(1):29-38. doi: 10.1093/cvr/cvr155. Epub 2011 Jun 1.

48.

Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity.

Prawitt J, Abdelkarim M, Stroeve JH, Popescu I, Duez H, Velagapudi VR, Dumont J, Bouchaert E, van Dijk TH, Lucas A, Dorchies E, Daoudi M, Lestavel S, Gonzalez FJ, Oresic M, Cariou B, Kuipers F, Caron S, Staels B.

Diabetes. 2011 Jul;60(7):1861-71. doi: 10.2337/db11-0030. Epub 2011 May 18.

49.

Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice.

Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi JK, Dopazo J, Orešič M, Ricote M, Vidal-Puig A.

Diabetes. 2011 Mar;60(3):797-809. doi: 10.2337/db10-0705. Epub 2011 Jan 24.

50.

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.

López M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González CR, Velagapudi VR, Morgan DA, Schoenmakers E, Agassandian K, Lage R, Martínez de Morentin PB, Tovar S, Nogueiras R, Carling D, Lelliott C, Gallego R, Oresic M, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A.

Nat Med. 2010 Sep;16(9):1001-8. doi: 10.1038/nm.2207. Epub 2010 Aug 29.

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