Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 152

1.

Spatial arrangement of LD motif-interacting residues on focal adhesion targeting domain of Focal Adhesion Kinase determine domain-motif interaction affinity and specificity.

Gupta AB, Mukherjee S, Pan CQ, Velazquez-Campoy A, Sivaraman J, Low BC.

Biochim Biophys Acta Gen Subj. 2019 Oct 30;1864(1):129450. doi: 10.1016/j.bbagen.2019.129450. [Epub ahead of print]

2.

Targeting intrinsically disordered proteins involved in cancer.

Santofimia-Castaño P, Rizzuti B, Xia Y, Abian O, Peng L, Velázquez-Campoy A, Neira JL, Iovanna J.

Cell Mol Life Sci. 2019 Oct 30. doi: 10.1007/s00018-019-03347-3. [Epub ahead of print] Review.

PMID:
31667555
3.

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2.

Martínez de Paz A, Khajavi L, Martin H, Claveria-Gimeno R, Tom Dieck S, Cheema MS, Sanchez-Mut JV, Moksa MM, Carles A, Brodie NI, Sheikh TI, Freeman ME, Petrotchenko EV, Borchers CH, Schuman EM, Zytnicki M, Velazquez-Campoy A, Abian O, Hirst M, Esteller M, Vincent JB, Malnou CE, Ausió J.

Epigenetics Chromatin. 2019 Oct 10;12(1):63. doi: 10.1186/s13072-019-0298-1.

4.

2-oxoglutarate modulates the affinity of FurA for the ntcA promoter in Anabaena sp. PCC 7120.

Guío J, Sarasa-Buisan C, Velázquez-Campoy A, Bes MT, Fillat MF, Peleato ML, Sevilla E.

FEBS Lett. 2019 Sep 20. doi: 10.1002/1873-3468.13610. [Epub ahead of print]

PMID:
31538336
5.

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm.

Santofimia-Castaño P, Rizzuti B, Xia Y, Abian O, Peng L, Velázquez-Campoy A, Iovanna JL, Neira JL.

Mol Cell Oncol. 2019 May 16;6(5):e1612678. doi: 10.1080/23723556.2019.1612678. eCollection 2019.

PMID:
31528692
6.

Mechanism of the allosteric activation of the ClpP protease machinery by substrates and active-site inhibitors.

Felix J, Weinhäupl K, Chipot C, Dehez F, Hessel A, Gauto DF, Morlot C, Abian O, Gutsche I, Velazquez-Campoy A, Schanda P, Fraga H.

Sci Adv. 2019 Sep 4;5(9):eaaw3818. doi: 10.1126/sciadv.aaw3818. eCollection 2019 Sep.

7.

Towards the competent conformation for catalysis in the ferredoxin-NADP+ reductase from the Brucella ovis pathogen.

Pérez-Amigot D, Taleb V, Boneta S, Anoz-Carbonell E, Sebastián M, Velázquez-Campoy A, Polo V, Martínez-Júlvez M, Medina M.

Biochim Biophys Acta Bioenerg. 2019 Oct 1;1860(10):148058. doi: 10.1016/j.bbabio.2019.148058. Epub 2019 Aug 5.

PMID:
31394095
8.

Identifying potential novel drugs against Helicobacter pylori by targeting the essential response regulator HsrA.

González A, Salillas S, Velázquez-Campoy A, Espinosa Angarica V, Fillat MF, Sancho J, Lanas Á.

Sci Rep. 2019 Aug 5;9(1):11294. doi: 10.1038/s41598-019-47746-9.

9.

Thermal Liquid Biopsy (TLB): A Predictive Score Derived from Serum Thermograms as a Clinical Tool for Screening Lung Cancer Patients.

Rodrigo A, Ojeda JL, Vega S, Sanchez-Gracia O, Lanas A, Isla D, Velazquez-Campoy A, Abian O.

Cancers (Basel). 2019 Jul 19;11(7). pii: E1012. doi: 10.3390/cancers11071012.

10.

Emissive Enhancement of the Singlet Oxygen Chemiluminescence Probe after Binding to Bovine Serum Albumin.

Miranda-Apodaca J, Hananya N, Velázquez-Campoy A, Shabat D, Arellano JB.

Molecules. 2019 Jul 1;24(13). pii: E2422. doi: 10.3390/molecules24132422.

11.

Structural insights into the ability of nucleoplasmin to assemble and chaperone histone octamers for DNA deposition.

Franco A, Arranz R, Fernández-Rivero N, Velázquez-Campoy A, Martín-Benito J, Segura J, Prado A, Valpuesta JM, Muga A.

Sci Rep. 2019 Jul 1;9(1):9487. doi: 10.1038/s41598-019-45726-7.

12.

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice.

Salillas S, Alías M, Michel V, Mahía A, Lucía A, Rodrigues L, Bueno J, Galano-Frutos JJ, De Reuse H, Velázquez-Campoy A, Carrodeguas JA, Sostres C, Castillo J, Aínsa JA, Díaz-de-Villegas MD, Lanas Á, Touati E, Sancho J.

J Med Chem. 2019 Jul 11;62(13):6102-6115. doi: 10.1021/acs.jmedchem.9b00355. Epub 2019 Jun 21.

PMID:
31244111
13.

Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1.

Neira JL, Correa J, Rizzuti B, Santofimia-Castaño P, Abian O, Velázquez-Campoy A, Fernandez-Megia E, Iovanna JL.

Biomacromolecules. 2019 Jul 8;20(7):2567-2576. doi: 10.1021/acs.biomac.9b00378. Epub 2019 Jun 24.

PMID:
31181156
14.

Molecular crowding effects on the distribution of amphiphiles in biological media.

Martins PAT, Domingues N, Pires C, Alves AM, Palmeira T, Samelo J, Cardoso R, Velazquez-Campoy A, Moreno MJ.

Colloids Surf B Biointerfaces. 2019 Aug 1;180:319-325. doi: 10.1016/j.colsurfb.2019.04.065. Epub 2019 Apr 30.

PMID:
31071572
15.

Tinkering with Binding Polynomials in Isothermal Titration Calorimetry.

Claveria-Gimeno R, Vega S, Abian O, Velazquez-Campoy A.

Methods Mol Biol. 2019;1964:185-213. doi: 10.1007/978-1-4939-9179-2_14.

PMID:
30929244
16.

Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position.

Gálvez JA, Clavería-Gimeno R, Galano-Frutos JJ, Sancho J, Velázquez-Campoy A, Abian O, Díaz-de-Villegas MD.

Eur J Med Chem. 2019 Jun 1;171:401-419. doi: 10.1016/j.ejmech.2019.03.019. Epub 2019 Mar 12.

PMID:
30928711
17.

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.

Santofimia-Castaño P, Xia Y, Lan W, Zhou Z, Huang C, Peng L, Soubeyran P, Velázquez-Campoy A, Abián O, Rizzuti B, Neira JL, Iovanna J.

J Clin Invest. 2019 Mar 28;129(6):2500-2513. doi: 10.1172/JCI127223.

18.

AFFINImeter: A software to analyze molecular recognition processes from experimental data.

Piñeiro Á, Muñoz E, Sabín J, Costas M, Bastos M, Velázquez-Campoy A, Garrido PF, Dumas P, Ennifar E, García-Río L, Rial J, Pérez D, Fraga P, Rodríguez A, Cotelo C.

Anal Biochem. 2019 Jul 15;577:117-134. doi: 10.1016/j.ab.2019.02.031. Epub 2019 Mar 5.

PMID:
30849378
19.

Redox- and Ligand Binding-Dependent Conformational Ensembles in the Human Apoptosis-Inducing Factor Regulate Its Pro-Life and Cell Death Functions.

Villanueva R, Romero-Tamayo S, Laplaza R, Martínez-Olivan J, Velázquez-Campoy A, Sancho J, Ferreira P, Medina M.

Antioxid Redox Signal. 2019 Jun 20;30(18):2013-2029. doi: 10.1089/ars.2018.7658. Epub 2019 Jan 11.

PMID:
30450916
20.

An Alternative Homodimerization Interface of MnmG Reveals a Conformational Dynamics that Is Essential for Its tRNA Modification Function.

Ruiz-Partida R, Prado S, Villarroya M, Velázquez-Campoy A, Bravo J, Armengod ME.

J Mol Biol. 2018 Aug 17;430(17):2822-2842. doi: 10.1016/j.jmb.2018.05.035. Epub 2018 Jun 2.

21.

Thermal liquid biopsy for monitoring melanoma patients under surveillance during treatment: A pilot study.

Velazquez-Campoy A, Vega S, Sanchez-Gracia O, Lanas A, Rodrigo A, Kaliappan A, Hall MB, Nguyen TQ, Brock GN, Chesney JA, Garbett NC, Abian O.

Biochim Biophys Acta Gen Subj. 2018 Aug;1862(8):1701-1710. doi: 10.1016/j.bbagen.2018.04.020. Epub 2018 Apr 26.

22.

The RFK catalytic cycle of the pathogen Streptococcus pneumoniae shows species-specific features in prokaryotic FMN synthesis.

Sebastián M, Velázquez-Campoy A, Medina M.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):842-849. doi: 10.1080/14756366.2018.1461857.

23.

Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog.

Spigolon D, Gallagher DT, Velazquez-Campoy A, Bulone D, Narang J, San Biagio PL, Cappello F, Macario AJL, Conway de Macario E, Robb FT.

Biochem Biophys Rep. 2017 Sep 1;12:66-71. doi: 10.1016/j.bbrep.2017.07.011. eCollection 2017 Dec.

24.

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

Santofimia-Castaño P, Rizzuti B, Abián O, Velázquez-Campoy A, Iovanna JL, Neira JL.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1283-1295. doi: 10.1016/j.bbagen.2018.03.009. Epub 2018 Mar 10.

PMID:
29530795
25.

Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition.

Elena-Real CA, Díaz-Quintana A, González-Arzola K, Velázquez-Campoy A, Orzáez M, López-Rivas A, Gil-Caballero S, De la Rosa MÁ, Díaz-Moreno I.

Cell Death Dis. 2018 Mar 6;9(3):365. doi: 10.1038/s41419-018-0408-1.

26.

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction.

Verma A, Jing-Song F, Finch-Edmondson ML, Velazquez-Campoy A, Balasegaran S, Sudol M, Sivaraman J.

Oncotarget. 2018 Jan 3;9(8):8068-8080. doi: 10.18632/oncotarget.23909. eCollection 2018 Jan 30.

27.

Differential NtcA Responsiveness to 2-Oxoglutarate Underlies the Diversity of C/N Balance Regulation in Prochlorococcus.

Domínguez-Martín MA, López-Lozano A, Clavería-Gimeno R, Velázquez-Campoy A, Seidel G, Burkovski A, Díez J, García-Fernández JM.

Front Microbiol. 2018 Jan 9;8:2641. doi: 10.3389/fmicb.2017.02641. eCollection 2017.

28.

A Functional Analysis on the Interspecies Interaction between Mouse LFA-1 and Human Intercellular Adhesion Molecule-1 at the Cell Level.

Núñez D, Comas L, Lanuza PM, Sánchez-Martinez D, Pérez-Hernández M, Catalán E, Domingo MP, Velázquez-Campoy A, Pardo J, Gálvez EM.

Front Immunol. 2017 Dec 21;8:1817. doi: 10.3389/fimmu.2017.01817. eCollection 2017.

29.

The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments.

Neira JL, Hornos F, Cozza C, Cámara-Artigas A, Abián O, Velázquez-Campoy A.

Arch Biochem Biophys. 2018 Feb 1;639:26-37. doi: 10.1016/j.abb.2017.12.017. Epub 2017 Dec 27.

PMID:
29288053
30.

Molecular basis for the integration of environmental signals by FurB from Anabaena sp. PCC 7120.

Sein-Echaluce VC, Pallarés MC, Lostao A, Yruela I, Velázquez-Campoy A, Luisa Peleato M, Fillat MF.

Biochem J. 2018 Jan 5;475(1):151-168. doi: 10.1042/BCJ20170692.

PMID:
29203647
31.

DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway.

de Barros AC, Takeda AAS, Dreyer TR, Velazquez-Campoy A, Kobe B, Fontes MRM.

Biochimie. 2018 Mar;146:87-96. doi: 10.1016/j.biochi.2017.11.013. Epub 2017 Nov 24.

32.

Unprecedented pathway of reducing equivalents in a diflavin-linked disulfide oxidoreductase.

Buey RM, Arellano JB, López-Maury L, Galindo-Trigo S, Velázquez-Campoy A, Revuelta JL, de Pereda JM, Florencio FJ, Schürmann P, Buchanan BB, Balsera M.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12725-12730. doi: 10.1073/pnas.1713698114. Epub 2017 Nov 13.

33.

Thermodynamics of cooperative binding of FAD to human NQO1: Implications to understanding cofactor-dependent function and stability of the flavoproteome.

Clavería-Gimeno R, Velazquez-Campoy A, Pey AL.

Arch Biochem Biophys. 2017 Dec 15;636:17-27. doi: 10.1016/j.abb.2017.10.020. Epub 2017 Oct 31.

PMID:
29100982
34.

Arabidopsis FNRL protein is an NADPH-dependent chloroplast oxidoreductase resembling bacterial ferredoxin-NADP+ reductases.

Koskela MM, Dahlström KM, Goñi G, Lehtimäki N, Nurmi M, Velazquez-Campoy A, Hanke G, Bölter B, Salminen TA, Medina M, Mulo P.

Physiol Plant. 2018 Feb;162(2):177-190. doi: 10.1111/ppl.12621. Epub 2017 Nov 12.

PMID:
28833218
35.

The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements.

Sebastián M, Lira-Navarrete E, Serrano A, Marcuello C, Velázquez-Campoy A, Lostao A, Hurtado-Guerrero R, Medina M, Martínez-Júlvez M.

Sci Rep. 2017 Aug 8;7(1):7609. doi: 10.1038/s41598-017-07716-5.

36.

Kinetics and thermodynamics of the protein-ligand interactions in the riboflavin kinase activity of the FAD synthetase from Corynebacterium ammoniagenes.

Sebastián M, Serrano A, Velázquez-Campoy A, Medina M.

Sci Rep. 2017 Aug 4;7(1):7281. doi: 10.1038/s41598-017-07875-5.

37.

Direct examination of the relevance for folding, binding and electron transfer of a conserved protein folding intermediate.

Lamazares E, Vega S, Ferreira P, Medina M, Galano-Frutos JJ, Martínez-Júlvez M, Velázquez-Campoy A, Sancho J.

Phys Chem Chem Phys. 2017 Jul 26;19(29):19021-19031. doi: 10.1039/c7cp02606d.

PMID:
28702545
38.

Microcystin-LR Binds Iron, and Iron Promotes Self-Assembly.

Ceballos-Laita L, Marcuello C, Lostao A, Calvo-Begueria L, Velazquez-Campoy A, Bes MT, Fillat MF, Peleato ML.

Environ Sci Technol. 2017 May 2;51(9):4841-4850. doi: 10.1021/acs.est.6b05939. Epub 2017 Apr 17.

PMID:
28368104
39.

Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48.

Moreno-Beltrán B, Guerra-Castellano A, Díaz-Quintana A, Del Conte R, García-Mauriño SM, Díaz-Moreno S, González-Arzola K, Santos-Ocaña C, Velázquez-Campoy A, De la Rosa MA, Turano P, Díaz-Moreno I.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3041-E3050. doi: 10.1073/pnas.1618008114. Epub 2017 Mar 27.

40.

The trimer interface in the quaternary structure of the bifunctional prokaryotic FAD synthetase from Corynebacterium ammoniagenes.

Serrano A, Sebastián M, Arilla-Luna S, Baquedano S, Herguedas B, Velázquez-Campoy A, Martínez-Júlvez M, Medina M.

Sci Rep. 2017 Mar 24;7(1):404. doi: 10.1038/s41598-017-00402-6.

41.

A look at ligand binding thermodynamics in drug discovery.

Claveria-Gimeno R, Vega S, Abian O, Velazquez-Campoy A.

Expert Opin Drug Discov. 2017 Apr;12(4):363-377. doi: 10.1080/17460441.2017.1297418. Epub 2017 Mar 1. Review.

PMID:
28276703
42.

The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site.

Claveria-Gimeno R, Lanuza PM, Morales-Chueca I, Jorge-Torres OC, Vega S, Abian O, Esteller M, Velazquez-Campoy A.

Sci Rep. 2017 Jan 31;7:41635. doi: 10.1038/srep41635.

43.

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.

Neira JL, Bintz J, Arruebo M, Rizzuti B, Bonacci T, Vega S, Lanas A, Velázquez-Campoy A, Iovanna JL, Abián O.

Sci Rep. 2017 Jan 5;7:39732. doi: 10.1038/srep39732.

44.

Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c.

González-Arzola K, Díaz-Quintana A, Rivero-Rodríguez F, Velázquez-Campoy A, De la Rosa MA, Díaz-Moreno I.

Nucleic Acids Res. 2017 Feb 28;45(4):2150-2165. doi: 10.1093/nar/gkw1215.

45.

Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target.

Rodríguez-Cárdenas Á, Rojas AL, Conde-Giménez M, Velázquez-Campoy A, Hurtado-Guerrero R, Sancho J.

PLoS One. 2016 Sep 20;11(9):e0161020. doi: 10.1371/journal.pone.0161020. eCollection 2016.

46.

A Quantitative Characterization of Nucleoplasmin/Histone Complexes Reveals Chaperone Versatility.

Fernández-Rivero N, Franco A, Velázquez-Campoy A, Alonso E, Muga A, Prado A.

Sci Rep. 2016 Aug 25;6:32114. doi: 10.1038/srep32114.

47.

A New Member of the Thioredoxin Reductase Family from Early Oxygenic Photosynthetic Organisms.

Buey RM, Galindo-Trigo S, López-Maury L, Velázquez-Campoy A, Revuelta JL, Florencio FJ, de Pereda JM, Schürmann P, Buchanan BB, Balsera M.

Mol Plant. 2017 Jan 9;10(1):212-215. doi: 10.1016/j.molp.2016.06.019. Epub 2016 Jul 12. No abstract available.

48.

Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors.

Hidalgo J, Latorre P, Carrodeguas JA, Velázquez-Campoy A, Sancho J, López-Buesa P.

PLoS One. 2016 Jul 8;11(7):e0159002. doi: 10.1371/journal.pone.0159002. eCollection 2016.

49.

Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALA.

Ruiz-Ramos A, Velázquez-Campoy A, Grande-García A, Moreno-Morcillo M, Ramón-Maiques S.

Structure. 2016 Jul 6;24(7):1081-94. doi: 10.1016/j.str.2016.05.001. Epub 2016 Jun 2.

50.

Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.

Sant'Anna R, Gallego P, Robinson LZ, Pereira-Henriques A, Ferreira N, Pinheiro F, Esperante S, Pallares I, Huertas O, Almeida MR, Reixach N, Insa R, Velazquez-Campoy A, Reverter D, Reig N, Ventura S.

Nat Commun. 2016 Feb 23;7:10787. doi: 10.1038/ncomms10787.

Supplemental Content

Loading ...
Support Center