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Items: 1 to 50 of 133

1.

An Alternative Homodimerization Interface of MnmG Reveals a Conformational Dynamics that Is Essential for Its tRNA Modification Function.

Ruiz-Partida R, Prado S, Villarroya M, Velázquez-Campoy A, Bravo J, Armengod ME.

J Mol Biol. 2018 Jun 2. pii: S0022-2836(18)30304-8. doi: 10.1016/j.jmb.2018.05.035. [Epub ahead of print]

2.

Thermal liquid biopsy for monitoring melanoma patients under surveillance during treatment: A pilot study.

Velazquez-Campoy A, Vega S, Sanchez-Gracia O, Lanas A, Rodrigo A, Kaliappan A, Hall MB, Nguyen TQ, Brock GN, Chesney JA, Garbett NC, Abian O.

Biochim Biophys Acta. 2018 Aug;1862(8):1701-1710. doi: 10.1016/j.bbagen.2018.04.020. Epub 2018 Apr 26.

PMID:
29705200
3.

The RFK catalytic cycle of the pathogen Streptococcus pneumoniae shows species-specific features in prokaryotic FMN synthesis.

Sebastián M, Velázquez-Campoy A, Medina M.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):842-849. doi: 10.1080/14756366.2018.1461857.

4.

Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog.

Spigolon D, Gallagher DT, Velazquez-Campoy A, Bulone D, Narang J, San Biagio PL, Cappello F, Macario AJL, Conway de Macario E, Robb FT.

Biochem Biophys Rep. 2017 Sep 1;12:66-71. doi: 10.1016/j.bbrep.2017.07.011. eCollection 2017 Dec.

5.

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

Santofimia-Castaño P, Rizzuti B, Abián O, Velázquez-Campoy A, Iovanna JL, Neira JL.

Biochim Biophys Acta. 2018 Jun;1862(6):1283-1295. doi: 10.1016/j.bbagen.2018.03.009. Epub 2018 Mar 10.

PMID:
29530795
6.

Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition.

Elena-Real CA, Díaz-Quintana A, González-Arzola K, Velázquez-Campoy A, Orzáez M, López-Rivas A, Gil-Caballero S, De la Rosa MÁ, Díaz-Moreno I.

Cell Death Dis. 2018 Mar 6;9(3):365. doi: 10.1038/s41419-018-0408-1.

7.

Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction.

Verma A, Jing-Song F, Finch-Edmondson ML, Velazquez-Campoy A, Balasegaran S, Sudol M, Sivaraman J.

Oncotarget. 2018 Jan 3;9(8):8068-8080. doi: 10.18632/oncotarget.23909. eCollection 2018 Jan 30.

8.

Differential NtcA Responsiveness to 2-Oxoglutarate Underlies the Diversity of C/N Balance Regulation in Prochlorococcus.

Domínguez-Martín MA, López-Lozano A, Clavería-Gimeno R, Velázquez-Campoy A, Seidel G, Burkovski A, Díez J, García-Fernández JM.

Front Microbiol. 2018 Jan 9;8:2641. doi: 10.3389/fmicb.2017.02641. eCollection 2017.

9.

A Functional Analysis on the Interspecies Interaction between Mouse LFA-1 and Human Intercellular Adhesion Molecule-1 at the Cell Level.

Núñez D, Comas L, Lanuza PM, Sánchez-Martinez D, Pérez-Hernández M, Catalán E, Domingo MP, Velázquez-Campoy A, Pardo J, Gálvez EM.

Front Immunol. 2017 Dec 21;8:1817. doi: 10.3389/fimmu.2017.01817. eCollection 2017.

10.

The histidine phosphocarrier protein, HPr, binds to the highly thermostable regulator of sigma D protein, Rsd, and its isolated helical fragments.

Neira JL, Hornos F, Cozza C, Cámara-Artigas A, Abián O, Velázquez-Campoy A.

Arch Biochem Biophys. 2018 Feb 1;639:26-37. doi: 10.1016/j.abb.2017.12.017. Epub 2017 Dec 27.

PMID:
29288053
11.

Molecular basis for the integration of environmental signals by FurB from Anabaena sp. PCC 7120.

Sein-Echaluce VC, Pallarés MC, Lostao A, Yruela I, Velázquez-Campoy A, Luisa Peleato M, Fillat MF.

Biochem J. 2018 Jan 5;475(1):151-168. doi: 10.1042/BCJ20170692.

PMID:
29203647
12.

DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway.

de Barros AC, Takeda AAS, Dreyer TR, Velazquez-Campoy A, Kobe B, Fontes MRM.

Biochimie. 2018 Mar;146:87-96. doi: 10.1016/j.biochi.2017.11.013. Epub 2017 Nov 24.

PMID:
29175432
13.

Unprecedented pathway of reducing equivalents in a diflavin-linked disulfide oxidoreductase.

Buey RM, Arellano JB, López-Maury L, Galindo-Trigo S, Velázquez-Campoy A, Revuelta JL, de Pereda JM, Florencio FJ, Schürmann P, Buchanan BB, Balsera M.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12725-12730. doi: 10.1073/pnas.1713698114. Epub 2017 Nov 13.

14.

Thermodynamics of cooperative binding of FAD to human NQO1: Implications to understanding cofactor-dependent function and stability of the flavoproteome.

Clavería-Gimeno R, Velazquez-Campoy A, Pey AL.

Arch Biochem Biophys. 2017 Dec 15;636:17-27. doi: 10.1016/j.abb.2017.10.020. Epub 2017 Oct 31.

PMID:
29100982
15.

Arabidopsis FNRL protein is an NADPH-dependent chloroplast oxidoreductase resembling bacterial ferredoxin-NADP+ reductases.

Koskela MM, Dahlström KM, Goñi G, Lehtimäki N, Nurmi M, Velazquez-Campoy A, Hanke G, Bölter B, Salminen TA, Medina M, Mulo P.

Physiol Plant. 2018 Feb;162(2):177-190. doi: 10.1111/ppl.12621. Epub 2017 Nov 12.

PMID:
28833218
16.

The FAD synthetase from the human pathogen Streptococcus pneumoniae: a bifunctional enzyme exhibiting activity-dependent redox requirements.

Sebastián M, Lira-Navarrete E, Serrano A, Marcuello C, Velázquez-Campoy A, Lostao A, Hurtado-Guerrero R, Medina M, Martínez-Júlvez M.

Sci Rep. 2017 Aug 8;7(1):7609. doi: 10.1038/s41598-017-07716-5.

17.

Kinetics and thermodynamics of the protein-ligand interactions in the riboflavin kinase activity of the FAD synthetase from Corynebacterium ammoniagenes.

Sebastián M, Serrano A, Velázquez-Campoy A, Medina M.

Sci Rep. 2017 Aug 4;7(1):7281. doi: 10.1038/s41598-017-07875-5.

18.

Direct examination of the relevance for folding, binding and electron transfer of a conserved protein folding intermediate.

Lamazares E, Vega S, Ferreira P, Medina M, Galano-Frutos JJ, Martínez-Júlvez M, Velázquez-Campoy A, Sancho J.

Phys Chem Chem Phys. 2017 Jul 26;19(29):19021-19031. doi: 10.1039/c7cp02606d.

PMID:
28702545
19.

Microcystin-LR Binds Iron, and Iron Promotes Self-Assembly.

Ceballos-Laita L, Marcuello C, Lostao A, Calvo-Begueria L, Velazquez-Campoy A, Bes MT, Fillat MF, Peleato ML.

Environ Sci Technol. 2017 May 2;51(9):4841-4850. doi: 10.1021/acs.est.6b05939. Epub 2017 Apr 17.

PMID:
28368104
20.

Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48.

Moreno-Beltrán B, Guerra-Castellano A, Díaz-Quintana A, Del Conte R, García-Mauriño SM, Díaz-Moreno S, González-Arzola K, Santos-Ocaña C, Velázquez-Campoy A, De la Rosa MA, Turano P, Díaz-Moreno I.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3041-E3050. doi: 10.1073/pnas.1618008114. Epub 2017 Mar 27.

21.

The trimer interface in the quaternary structure of the bifunctional prokaryotic FAD synthetase from Corynebacterium ammoniagenes.

Serrano A, Sebastián M, Arilla-Luna S, Baquedano S, Herguedas B, Velázquez-Campoy A, Martínez-Júlvez M, Medina M.

Sci Rep. 2017 Mar 24;7(1):404. doi: 10.1038/s41598-017-00402-6.

22.

A look at ligand binding thermodynamics in drug discovery.

Claveria-Gimeno R, Vega S, Abian O, Velazquez-Campoy A.

Expert Opin Drug Discov. 2017 Apr;12(4):363-377. doi: 10.1080/17460441.2017.1297418. Epub 2017 Mar 1. Review.

PMID:
28276703
23.

The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site.

Claveria-Gimeno R, Lanuza PM, Morales-Chueca I, Jorge-Torres OC, Vega S, Abian O, Esteller M, Velazquez-Campoy A.

Sci Rep. 2017 Jan 31;7:41635. doi: 10.1038/srep41635.

24.

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.

Neira JL, Bintz J, Arruebo M, Rizzuti B, Bonacci T, Vega S, Lanas A, Velázquez-Campoy A, Iovanna JL, Abián O.

Sci Rep. 2017 Jan 5;7:39732. doi: 10.1038/srep39732.

25.

Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c.

González-Arzola K, Díaz-Quintana A, Rivero-Rodríguez F, Velázquez-Campoy A, De la Rosa MA, Díaz-Moreno I.

Nucleic Acids Res. 2017 Feb 28;45(4):2150-2165. doi: 10.1093/nar/gkw1215.

26.

Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target.

Rodríguez-Cárdenas Á, Rojas AL, Conde-Giménez M, Velázquez-Campoy A, Hurtado-Guerrero R, Sancho J.

PLoS One. 2016 Sep 20;11(9):e0161020. doi: 10.1371/journal.pone.0161020. eCollection 2016.

27.

A Quantitative Characterization of Nucleoplasmin/Histone Complexes Reveals Chaperone Versatility.

Fernández-Rivero N, Franco A, Velázquez-Campoy A, Alonso E, Muga A, Prado A.

Sci Rep. 2016 Aug 25;6:32114. doi: 10.1038/srep32114.

28.

A New Member of the Thioredoxin Reductase Family from Early Oxygenic Photosynthetic Organisms.

Buey RM, Galindo-Trigo S, López-Maury L, Velázquez-Campoy A, Revuelta JL, Florencio FJ, de Pereda JM, Schürmann P, Buchanan BB, Balsera M.

Mol Plant. 2017 Jan 9;10(1):212-215. doi: 10.1016/j.molp.2016.06.019. Epub 2016 Jul 12. No abstract available.

29.

Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors.

Hidalgo J, Latorre P, Carrodeguas JA, Velázquez-Campoy A, Sancho J, López-Buesa P.

PLoS One. 2016 Jul 8;11(7):e0159002. doi: 10.1371/journal.pone.0159002. eCollection 2016.

30.

Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALA.

Ruiz-Ramos A, Velázquez-Campoy A, Grande-García A, Moreno-Morcillo M, Ramón-Maiques S.

Structure. 2016 Jul 6;24(7):1081-94. doi: 10.1016/j.str.2016.05.001. Epub 2016 Jun 2.

31.

Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.

Sant'Anna R, Gallego P, Robinson LZ, Pereira-Henriques A, Ferreira N, Pinheiro F, Esperante S, Pallares I, Huertas O, Almeida MR, Reixach N, Insa R, Velazquez-Campoy A, Reverter D, Reig N, Ventura S.

Nat Commun. 2016 Feb 23;7:10787. doi: 10.1038/ncomms10787.

32.

Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases.

Velazquez-Campoy A, Sancho J, Abian O, Vega S.

Curr Drug Targets. 2016;17(13):1492-505. Review.

PMID:
26844568
33.

Structural and Calorimetric Studies Demonstrate that Xeroderma Pigmentosum Type G (XPG) Can Be Imported to the Nucleus by a Classical Nuclear Import Pathway via a Monopartite NLS Sequence.

Barros AC, Takeda AA, Dreyer TR, Velazquez-Campoy A, Kobe B, Fontes MR.

J Mol Biol. 2016 May 22;428(10 Pt A):2120-31. doi: 10.1016/j.jmb.2016.01.019. Epub 2016 Jan 23.

PMID:
26812207
34.

Structural and functional characterization of phosphomimetic mutants of cytochrome c at threonine 28 and serine 47.

Guerra-Castellano A, Díaz-Moreno I, Velázquez-Campoy A, De la Rosa MA, Díaz-Quintana A.

Biochim Biophys Acta. 2016 Apr;1857(4):387-95. doi: 10.1016/j.bbabio.2016.01.011. Epub 2016 Jan 22.

35.

Guanine nucleotide binding to the Bateman domain mediates the allosteric inhibition of eukaryotic IMP dehydrogenases.

Buey RM, Ledesma-Amaro R, Velázquez-Campoy A, Balsera M, Chagoyen M, de Pereda JM, Revuelta JL.

Nat Commun. 2015 Nov 12;6:8923. doi: 10.1038/ncomms9923.

36.

On the link between conformational changes, ligand binding and heat capacity.

Vega S, Abian O, Velazquez-Campoy A.

Biochim Biophys Acta. 2016 May;1860(5):868-878. doi: 10.1016/j.bbagen.2015.10.010. Epub 2015 Oct 22. Review.

PMID:
26476135
37.

Structural and functional evidence for membrane docking and disruption sites on phospholipase A2-like proteins revealed by complexation with the inhibitor suramin.

Salvador GH, Dreyer TR, Cavalcante WL, Matioli FF, Dos Santos JI, Velazquez-Campoy A, Gallacci M, Fontes MR.

Acta Crystallogr D Biol Crystallogr. 2015 Oct;71(Pt 10):2066-78. doi: 10.1107/S1399004715014443. Epub 2015 Sep 26.

PMID:
26457430
38.

Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120.

Botello-Morte L, Pellicer S, Sein-Echaluce VC, Contreras LM, Neira JL, Abián O, Velázquez-Campoy A, Peleato ML, Fillat MF, Bes MT.

Antioxid Redox Signal. 2015 Oct 9. [Epub ahead of print]

39.

Structural Basis for a Unique ATP Synthase Core Complex from Nanoarcheaum equitans.

Mohanty S, Jobichen C, Chichili VP, Velázquez-Campoy A, Low BC, Hogue CW, Sivaraman J.

J Biol Chem. 2015 Nov 6;290(45):27280-96. doi: 10.1074/jbc.M115.677492. Epub 2015 Sep 14.

40.

Interaction of Bile Salts with Model Membranes Mimicking the Gastrointestinal Epithelium: A Study by Isothermal Titration Calorimetry.

Coreta-Gomes FM, Martins PA, Velazquez-Campoy A, Vaz WL, Geraldes CF, Moreno MJ.

Langmuir. 2015 Aug 25;31(33):9097-104. doi: 10.1021/acs.langmuir.5b01810. Epub 2015 Aug 12.

PMID:
26241730
41.

Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochrome c.

González-Arzola K, Díaz-Moreno I, Cano-González A, Díaz-Quintana A, Velázquez-Campoy A, Moreno-Beltrán B, López-Rivas A, De la Rosa MA.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9908-13. doi: 10.1073/pnas.1508040112. Epub 2015 Jul 27.

42.

Shell Cross-Linked Polymeric Micelles as Camptothecin Nanocarriers for Anti-HCV Therapy.

Jiménez-Pardo I, González-Pastor R, Lancelot A, Claveria-Gimeno R, Velázquez-Campoy A, Abian O, Ros MB, Sierra T.

Macromol Biosci. 2015 Oct;15(10):1381-91. doi: 10.1002/mabi.201500094. Epub 2015 Jun 5.

PMID:
26045353
43.

Characterization of protein-protein interactions by isothermal titration calorimetry.

Velazquez-Campoy A, Leavitt SA, Freire E.

Methods Mol Biol. 2015;1278:183-204. doi: 10.1007/978-1-4939-2425-7_11.

PMID:
25859950
44.

A Non-Invasive NMR Method Based on Histidine Imidazoles to Analyze the pH-Modulation of Protein-Nucleic Acid Interfaces.

Cruz-Gallardo I, Del Conte R, Velázquez-Campoy A, García-Mauriño SM, Díaz-Moreno I.

Chemistry. 2015 May 11;21(20):7588-95. doi: 10.1002/chem.201405538. Epub 2015 Apr 1.

PMID:
25846236
45.

Rescuing compound bioactivity in a secondary cell-based screening by using γ-cyclodextrin as a molecular carrier.

Claveria-Gimeno R, Vega S, Grazu V, de la Fuente JM, Lanas A, Velazquez-Campoy A, Abian O.

Int J Nanomedicine. 2015 Mar 19;10:2249-59. doi: 10.2147/IJN.S79480. eCollection 2015.

46.

Quaternary organization in a bifunctional prokaryotic FAD synthetase: Involvement of an arginine at its adenylyltransferase module on the riboflavin kinase activity.

Serrano A, Sebastián M, Arilla-Luna S, Baquedano S, Pallarés MC, Lostao A, Herguedas B, Velázquez-Campoy A, Martínez-Júlvez M, Medina M.

Biochim Biophys Acta. 2015 Aug;1854(8):897-906. doi: 10.1016/j.bbapap.2015.03.005. Epub 2015 Mar 21.

PMID:
25801930
47.

Rational stabilization of complex proteins: a divide and combine approach.

Lamazares E, Clemente I, Bueno M, Velázquez-Campoy A, Sancho J.

Sci Rep. 2015 Mar 16;5:9129. doi: 10.1038/srep09129.

48.

Deconvolution analysis for classifying gastric adenocarcinoma patients based on differential scanning calorimetry serum thermograms.

Vega S, Garcia-Gonzalez MA, Lanas A, Velazquez-Campoy A, Abian O.

Sci Rep. 2015 Jan 23;5:7988. doi: 10.1038/srep07988.

49.

Respiratory complexes III and IV can each bind two molecules of cytochrome c at low ionic strength.

Moreno-Beltrán B, Díaz-Moreno I, González-Arzola K, Guerra-Castellano A, Velázquez-Campoy A, De la Rosa MA, Díaz-Quintana A.

FEBS Lett. 2015 Feb 13;589(4):476-83. doi: 10.1016/j.febslet.2015.01.004. Epub 2015 Jan 14.

50.

Extending in silico mechanism-of-action analysis by annotating targets with pathways: application to cellular cytotoxicity readouts.

Liggi S, Drakakis G, Koutsoukas A, Cortes-Ciriano I, Martínez-Alonso P, Malliavin TE, Velazquez-Campoy A, Brewerton SC, Bodkin MJ, Evans DA, Glen RC, Carrodeguas JA, Bender A.

Future Med Chem. 2014;6(18):2029-56. doi: 10.4155/fmc.14.137.

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