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Items: 48

1.

Cellular models of alpha-synuclein toxicity and aggregation.

Delenclos M, Burgess JD, Lamprokostopoulou A, Outeiro TF, Vekrellis K, McLean PJ.

J Neurochem. 2019 Jul 2. doi: 10.1111/jnc.14806. [Epub ahead of print] Review.

PMID:
31265132
2.

How is alpha-synuclein cleared from the cell?

Stefanis L, Emmanouilidou E, Pantazopoulou M, Kirik D, Vekrellis K, Tofaris GK.

J Neurochem. 2019 May 8. doi: 10.1111/jnc.14704. [Epub ahead of print] Review.

PMID:
31069800
3.

Heterogeneity in α-synuclein subtypes and their expression in cortical brain tissue lysates from Lewy body diseases and Alzheimer's disease.

Vaikath NN, Erskine D, Morris CM, Majbour NK, Vekrellis K, Li JY, El-Agnaf OMA.

Neuropathol Appl Neurobiol. 2018 Nov 13. doi: 10.1111/nan.12531. [Epub ahead of print]

PMID:
30422353
4.

Modulation of β-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson's disease.

Papadopoulos VE, Nikolopoulou G, Antoniadou I, Karachaliou A, Arianoglou G, Emmanouilidou E, Sardi SP, Stefanis L, Vekrellis K.

Hum Mol Genet. 2018 May 15;27(10):1696-1710. doi: 10.1093/hmg/ddy075.

PMID:
29547959
5.

Publisher Correction: An integrated bacterial system for the discovery of chemical rescuers of disease-associated protein misfolding.

Matis I, Delivoria DC, Mavroidi B, Papaevgeniou N, Panoutsou S, Bellou S, Papavasileiou KD, Linardaki ZI, Stavropoulou AV, Vekrellis K, Boukos N, Kolisis FN, Gonos ES, Margarity M, Papadopoulos MG, Efthimiopoulos S, Pelecanou M, Chondrogianni N, Skretas G.

Nat Biomed Eng. 2018 Jan;2(1):49. doi: 10.1038/s41551-017-0164-z.

PMID:
31015658
6.

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.

Minakaki G, Menges S, Kittel A, Emmanouilidou E, Schaeffner I, Barkovits K, Bergmann A, Rockenstein E, Adame A, Marxreiter F, Mollenhauer B, Galasko D, Buzás EI, Schlötzer-Schrehardt U, Marcus K, Xiang W, Lie DC, Vekrellis K, Masliah E, Winkler J, Klucken J.

Autophagy. 2018;14(1):98-119. doi: 10.1080/15548627.2017.1395992. Epub 2018 Jan 15.

7.

Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice.

Karampetsou M, Ardah MT, Semitekolou M, Polissidis A, Samiotaki M, Kalomoiri M, Majbour N, Xanthou G, El-Agnaf OMA, Vekrellis K.

Sci Rep. 2017 Nov 28;7(1):16533. doi: 10.1038/s41598-017-15813-8.

8.

CSF biomarkers β-amyloid, tau proteins and a-synuclein in the differential diagnosis of Parkinson-plus syndromes.

Constantinides VC, Paraskevas GP, Emmanouilidou E, Petropoulou O, Bougea A, Vekrellis K, Evdokimidis I, Stamboulis E, Kapaki E.

J Neurol Sci. 2017 Nov 15;382:91-95. doi: 10.1016/j.jns.2017.09.039. Epub 2017 Sep 28.

PMID:
29111028
9.

An integrated bacterial system for the discovery of chemical rescuers of disease-associated protein misfolding.

Matis I, Delivoria DC, Mavroidi B, Papaevgeniou N, Panoutsou S, Bellou S, Papavasileiou KD, Linardaki ZI, Stavropoulou AV, Vekrellis K, Boukos N, Kolisis FN, Gonos ES, Margarity M, Papadopoulos MG, Efthimiopoulos S, Pelecanou M, Chondrogianni N, Skretas G.

Nat Biomed Eng. 2017 Oct;1(10):838-852. doi: 10.1038/s41551-017-0144-3. Epub 2017 Oct 10. Erratum in: Nat Biomed Eng. 2018 Jan;2(1):49.

PMID:
31015593
10.

The role of the endoplasmic reticulum stress response following cerebral ischemia.

Hadley G, Neuhaus AA, Couch Y, Beard DJ, Adriaanse BA, Vekrellis K, DeLuca GC, Papadakis M, Sutherland BA, Buchan AM.

Int J Stroke. 2018 Jun;13(4):379-390. doi: 10.1177/1747493017724584. Epub 2017 Aug 4.

PMID:
28776456
11.

Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease.

Kouroupi G, Taoufik E, Vlachos IS, Tsioras K, Antoniou N, Papastefanaki F, Chroni-Tzartou D, Wrasidlo W, Bohl D, Stellas D, Politis PK, Vekrellis K, Papadimitriou D, Stefanis L, Bregestovski P, Hatzigeorgiou AG, Masliah E, Matsas R.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3679-E3688. doi: 10.1073/pnas.1617259114. Epub 2017 Apr 17.

12.

"Activography": a novel, versatile and easily adaptable method for monitoring enzymatic activities in situ.

Pampalakis G, Zingkou E, Vekrellis K, Sotiropoulou G.

Chem Commun (Camb). 2017 Mar 18;53(22):3246-3248. doi: 10.1039/c7cc01081h. Epub 2017 Mar 3.

PMID:
28256664
13.

Lee Rubin: Our mentor and role model.

Bazenet C, Desmond H, Frank E, Doherty P, Eilers A, Gatchalian C, Glicksman M, Graczyk P, Gusovsky F, Ham J, Kaplan D, Klymkoswsky M, Kotkow K, Krolewski R, Lang P, O'Neil AL, McCarthy MJ, Meiri K, Miller F, Neumage MM, Ozek C, Philpott K, Piccinotti S, Price F, Raff M, Ratcliffe M, Relton J, Rhodes K, Schwob J, Smales C, Smith T, Spadoni C, Taylor J, Vekrellis K, Whitfield J.

Science. 2017 Feb 24;355(6327):806. doi: 10.1126/science.aam8703. No abstract available.

PMID:
28232547
14.

KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species.

Pampalakis G, Sykioti VS, Ximerakis M, Stefanakou-Kalakou I, Melki R, Vekrellis K, Sotiropoulou G.

Oncotarget. 2017 Feb 28;8(9):14502-14515. doi: 10.18632/oncotarget.13264.

15.

Exocytosis and Spreading of Normal and Aberrant α-Synuclein.

Emmanouilidou E, Vekrellis K.

Brain Pathol. 2016 May;26(3):398-403. doi: 10.1111/bpa.12373. Review.

PMID:
26940375
16.

GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum.

Emmanouilidou E, Minakaki G, Keramioti MV, Xylaki M, Balafas E, Chrysanthou-Piterou M, Kloukina I, Vekrellis K.

Brain. 2016 Mar;139(Pt 3):871-90. doi: 10.1093/brain/awv403. Epub 2016 Feb 8.

PMID:
26912647
17.

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

Fernandes HJ, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R.

Stem Cell Reports. 2016 Mar 8;6(3):342-56. doi: 10.1016/j.stemcr.2016.01.013. Epub 2016 Feb 18.

18.

Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation.

Oueslati A, Ximerakis M, Vekrellis K.

Exp Neurobiol. 2014 Dec;23(4):324-36. doi: 10.5607/en.2014.23.4.324. Epub 2014 Dec 12. Review.

19.

Response of Caenorhabditis elegans to wireless devices radiation exposure.

Fasseas MK, Fragopoulou AF, Manta AK, Skouroliakou A, Vekrellis K, Margaritis LH, Syntichaki P.

Int J Radiat Biol. 2015 Mar;91(3):286-93. doi: 10.3109/09553002.2014.995384. Epub 2015 Jan 29.

PMID:
25488006
20.

The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.

Chutna O, Gonçalves S, Villar-Piqué A, Guerreiro P, Marijanovic Z, Mendes T, Ramalho J, Emmanouilidou E, Ventura S, Klucken J, Barral DC, Giorgini F, Vekrellis K, Outeiro TF.

Hum Mol Genet. 2014 Dec 20;23(25):6732-45. doi: 10.1093/hmg/ddu391. Epub 2014 Aug 4.

PMID:
25092884
21.

In silico modeling of the effects of alpha-synuclein oligomerization on dopaminergic neuronal homeostasis.

Ouzounoglou E, Kalamatianos D, Emmanouilidou E, Xilouri M, Stefanis L, Vekrellis K, Manolakos ES.

BMC Syst Biol. 2014 May 13;8:54. doi: 10.1186/1752-0509-8-54.

22.

Resistance of naturally secreted α-synuclein to proteolysis.

Ximerakis M, Pampalakis G, Roumeliotis TI, Sykioti VS, Garbis SD, Stefanis L, Sotiropoulou G, Vekrellis K.

FASEB J. 2014 Jul;28(7):3146-58. doi: 10.1096/fj.13-245852. Epub 2014 Apr 10.

PMID:
24723692
23.

The diagnostic value of CSF α-synuclein in the differential diagnosis of dementia with Lewy bodies vs. normal subjects and patients with Alzheimer's disease.

Kapaki E, Paraskevas GP, Emmanouilidou E, Vekrellis K.

PLoS One. 2013 Nov 25;8(11):e81654. doi: 10.1371/journal.pone.0081654. eCollection 2013.

24.

Deregulation of calcium homeostasis mediates secreted α-synuclein-induced neurotoxicity.

Melachroinou K, Xilouri M, Emmanouilidou E, Masgrau R, Papazafiri P, Stefanis L, Vekrellis K.

Neurobiol Aging. 2013 Dec;34(12):2853-65. doi: 10.1016/j.neurobiolaging.2013.06.006. Epub 2013 Jul 25.

PMID:
23891486
25.

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.

Papadakis M, Hadley G, Xilouri M, Hoyte LC, Nagel S, McMenamin MM, Tsaknakis G, Watt SM, Drakesmith CW, Chen R, Wood MJ, Zhao Z, Kessler B, Vekrellis K, Buchan AM.

Nat Med. 2013 Mar;19(3):351-7. doi: 10.1038/nm.3097. Epub 2013 Feb 24.

26.

Increased dimerization of alpha-synuclein in erythrocytes in Gaucher disease and aging.

Argyriou A, Dermentzaki G, Papasilekas T, Moraitou M, Stamboulis E, Vekrellis K, Michelakakis H, Stefanis L.

Neurosci Lett. 2012 Oct 24;528(2):205-9. doi: 10.1016/j.neulet.2012.08.069. Epub 2012 Sep 7.

PMID:
22981881
27.

Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies.

Vekrellis K, Stefanis L.

Expert Opin Ther Targets. 2012 Apr;16(4):421-32. doi: 10.1517/14728222.2012.674111. Review.

PMID:
22480256
28.

Pathological roles of α-synuclein in neurological disorders.

Vekrellis K, Xilouri M, Emmanouilidou E, Rideout HJ, Stefanis L.

Lancet Neurol. 2011 Nov;10(11):1015-25. doi: 10.1016/S1474-4422(11)70213-7. Review. Erratum in: Lancet Neurol. 2011 Dec;10(12):1041.

PMID:
22014436
29.

Extracellular progranulin protects cortical neurons from toxic insults by activating survival signaling.

Xu J, Xilouri M, Bruban J, Shioi J, Shao Z, Papazoglou I, Vekrellis K, Robakis NK.

Neurobiol Aging. 2011 Dec;32(12):2326.e5-16. doi: 10.1016/j.neurobiolaging.2011.06.017. Epub 2011 Aug 4.

30.

Assessment of α-synuclein secretion in mouse and human brain parenchyma.

Emmanouilidou E, Elenis D, Papasilekas T, Stranjalis G, Gerozissis K, Ioannou PC, Vekrellis K.

PLoS One. 2011;6(7):e22225. doi: 10.1371/journal.pone.0022225. Epub 2011 Jul 14.

31.

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival.

Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M, Margaritis LH, Stefanis L, Vekrellis K.

J Neurosci. 2010 May 19;30(20):6838-51. doi: 10.1523/JNEUROSCI.5699-09.2010.

32.

Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death.

Vekrellis K, Xilouri M, Emmanouilidou E, Stefanis L.

J Neurochem. 2009 Jun;109(5):1348-62. doi: 10.1111/j.1471-4159.2009.06054.x. Epub 2009 Mar 23.

33.

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.

Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L.

PLoS One. 2009;4(5):e5515. doi: 10.1371/journal.pone.0005515. Epub 2009 May 13.

34.

Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome.

Emmanouilidou E, Stefanis L, Vekrellis K.

Neurobiol Aging. 2010 Jun;31(6):953-68. doi: 10.1016/j.neurobiolaging.2008.07.008. Epub 2008 Aug 20.

PMID:
18715677
35.

alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis.

Xilouri M, Vogiatzi T, Vekrellis K, Stefanis L.

Autophagy. 2008 Oct;4(7):917-9. Epub 2008 Oct 26.

PMID:
18708765
36.

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells.

Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L.

J Biol Chem. 2008 Aug 29;283(35):23542-56. doi: 10.1074/jbc.M801992200. Epub 2008 Jun 19.

37.

A novel cell death pathway that is partially caspase dependent, but morphologically non-apoptotic, elicited by proteasomal inhibition of rat sympathetic neurons.

Lang-Rollin I, Dermentzaki G, Vekrellis K, Xilouri M, Rideout HJ, Stefanis L.

J Neurochem. 2008 May;105(3):653-65. doi: 10.1111/j.1471-4159.2007.05165.x. Epub 2008 Jan 8.

38.

Apoptosis and the conformational change of Bax induced by proteasomal inhibition of PC12 cells are inhibited by bcl-xL and bcl-2.

Lang-Rollin I, Maniati M, Jabado O, Vekrellis K, Papantonis S, Rideout HJ, Stefanis L.

Apoptosis. 2005 Aug;10(4):809-20.

PMID:
16133871
39.

Application of proteasomal inhibitors to mouse sympathetic neurons activates the intrinsic apoptotic pathway.

Lang-Rollin I, Vekrellis K, Wang Q, Rideout HJ, Stefanis L.

J Neurochem. 2004 Sep;90(6):1511-20.

40.

Neurobiology of alpha-synuclein.

Vekrellis K, Rideout HJ, Stefanis L.

Mol Neurobiol. 2004 Aug;30(1):1-21. Review.

PMID:
15247485
41.

RAIDD aggregation facilitates apoptotic death of PC12 cells and sympathetic neurons.

Jabado O, Wang Q, Rideout HJ, Yeasmin M, Guo KX, Vekrellis K, Papantonis S, Angelastro JM, Troy CM, Stefanis L.

Cell Death Differ. 2004 Jun;11(6):618-30.

42.

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE.

Science. 2000 Dec 22;290(5500):2302-3.

43.

Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.

Chesneau V, Vekrellis K, Rosner MR, Selkoe DJ.

Biochem J. 2000 Oct 15;351 Pt 2:509-16.

44.

c-Jun and Bax: regulators of programmed cell death in developing neurons.

Eilers A, Whitfield J, Vekrellis K, Neame SJ, Shah B, Ham J.

Biochem Soc Trans. 1999 Dec;27(6):790-7. Review. No abstract available.

PMID:
10830103
45.

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.

Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ.

J Neurosci. 2000 Mar 1;20(5):1657-65.

46.

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ.

J Biol Chem. 1998 Dec 4;273(49):32730-8.

47.

Bax promotes neuronal cell death and is downregulated during the development of the nervous system.

Vekrellis K, McCarthy MJ, Watson A, Whitfield J, Rubin LL, Ham J.

Development. 1997 Mar;124(6):1239-49.

48.

Factors affecting the beta-amyloid precursor in PC12 cells.

Webster MT, Vekrellis K, Francis PT, Pearce BR, Bowen DM.

Biochem Soc Trans. 1993 Aug;21 ( Pt 3)(3):239S. No abstract available.

PMID:
8224395

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