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Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes.

Sghaier R, Zarrouk A, Nury T, Badreddine I, O'Brien N, Mackrill JJ, Vejux A, Samadi M, Nasser B, Caccia C, Leoni V, Moreau T, Cherkaoui-Malki M, Salhedine Masmoudi A, Lizard G.

Free Radic Res. 2019 May;53(5):535-561. doi: 10.1080/10715762.2019.1612891.


Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells.

Sassi K, Nury T, Zarrouk A, Sghaier R, Khalafi-Nezhad A, Vejux A, Samadi M, Aissa-Fennira FB, Lizard G.

J Steroid Biochem Mol Biol. 2019 Jul;191:105371. doi: 10.1016/j.jsbmb.2019.04.020. Epub 2019 Apr 26.


Protective function of autophagy during VLCFA-induced cytotoxicity in a neurodegenerative cell model.

Doria M, Nury T, Delmas D, Moreau T, Lizard G, Vejux A.

Free Radic Biol Med. 2019 Jun;137:46-58. doi: 10.1016/j.freeradbiomed.2019.04.016. Epub 2019 Apr 17.


Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin.

Namsi A, Nury T, Hamdouni H, Yammine A, Vejux A, Vervandier-Fasseur D, Latruffe N, Masmoudi-Kouki O, Lizard G.

Diseases. 2018 Jul 22;6(3). pii: E67. doi: 10.3390/diseases6030067.


Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol.

Nury T, Sghaier R, Zarrouk A, Ménétrier F, Uzun T, Leoni V, Caccia C, Meddeb W, Namsi A, Sassi K, Mihoubi W, Riedinger JM, Cherkaoui-Malki M, Moreau T, Vejux A, Lizard G.

Biochimie. 2018 Oct;153:181-202. doi: 10.1016/j.biochi.2018.07.009. Epub 2018 Jul 19.


Cytoprotective Activities of Milk Thistle Seed Oil Used in Traditional Tunisian Medicine on 7-Ketocholesterol and 24S-Hydroxycholesterol-Induced Toxicity on 158N Murine Oligodendrocytes.

Meddeb W, Rezig L, Zarrouk A, Nury T, Vejux A, Prost M, Bretillon L, Mejri M, Lizard G.

Antioxidants (Basel). 2018 Jul 19;7(7). pii: E95. doi: 10.3390/antiox7070095.


Prevention of 7-ketocholesterol-induced side effects by natural compounds.

Brahmi F, Vejux A, Sghaier R, Zarrouk A, Nury T, Meddeb W, Rezig L, Namsi A, Sassi K, Yammine A, Badreddine I, Vervandier-Fasseur D, Madani K, Boulekbache-Makhlouf L, Nasser B, Lizard G.

Crit Rev Food Sci Nutr. 2018 Oct 16:1-20. doi: 10.1080/10408398.2018.1491828. [Epub ahead of print]


The effect of oxysterols on nerve impulses.

Bezine M, Namsi A, Sghaier R, Ben Khalifa R, Hamdouni H, Brahmi F, Badreddine I, Mihoubi W, Nury T, Vejux A, Zarrouk A, de Sèze J, Moreau T, Nasser B, Lizard G.

Biochimie. 2018 Oct;153:46-51. doi: 10.1016/j.biochi.2018.04.013. Epub 2018 Apr 21. Review.


Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0).

Bezine M, Maatoug S, Ben Khalifa R, Debbabi M, Zarrouk A, Wang Y, Griffiths WJ, Nury T, Samadi M, Vejux A, de Sèze J, Moreau T, Kharrat R, El Ayeb M, Lizard G.

Biochimie. 2018 Oct;153:56-69. doi: 10.1016/j.biochi.2018.02.008. Epub 2018 Feb 17.


Biomarkers of Amyotrophic Lateral Sclerosis: Current Status and Interest of Oxysterols and Phytosterols.

Vejux A, Namsi A, Nury T, Moreau T, Lizard G.

Front Mol Neurosci. 2018 Jan 31;11:12. doi: 10.3389/fnmol.2018.00012. eCollection 2018. Review.


Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N.

Badreddine A, Zarrouk A, Karym EM, Debbabi M, Nury T, Meddeb W, Sghaier R, Bezine M, Vejux A, Martine L, Grégoire S, Bretillon L, Prost-Camus E, Durand P, Prost M, Moreau T, Cherkaoui-Malki M, Nasser B, Lizard G.

Int J Mol Sci. 2017 Oct 23;18(10). pii: E2220. doi: 10.3390/ijms18102220.


Flow Cytometric Analysis of the Expression Pattern of Peroxisomal Proteins, Abcd1, Abcd2, and Abcd3 in BV-2 Murine Microglial Cells.

Debbabi M, Nury T, Helali I, Karym EM, Geillon F, Gondcaille C, Trompier D, Najid A, Terreau S, Bezine M, Zarrouk A, Vejux A, Andreoletti P, Cherkaoui-Malki M, Savary S, Lizard G.

Methods Mol Biol. 2017;1595:257-265. doi: 10.1007/978-1-4939-6937-1_25.


Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes.

Bezine M, Debbabi M, Nury T, Ben-Khalifa R, Samadi M, Cherkaoui-Malki M, Vejux A, Raas Q, de Sèze J, Moreau T, El-Ayeb M, Lizard G.

Chem Phys Lipids. 2017 Oct;207(Pt B):135-150. doi: 10.1016/j.chemphyslip.2017.03.006. Epub 2017 Mar 18.


Evidence of biological activity of Mentha species extracts on apoptotic and autophagic targets on murine RAW264.7 and human U937 monocytic cells.

Brahmi F, Hadj-Ahmed S, Zarrouk A, Bezine M, Nury T, Madani K, Chibane M, Vejux A, Andreoletti P, Boulekbache-Makhlouf L, Lizard G.

Pharm Biol. 2017 Dec;55(1):286-293.


Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells.

Debbabi M, Nury T, Zarrouk A, Mekahli N, Bezine M, Sghaier R, Grégoire S, Martine L, Durand P, Camus E, Vejux A, Jabrane A, Bretillon L, Prost M, Moreau T, Ammou SB, Hammami M, Lizard G.

Int J Mol Sci. 2016 Nov 25;17(12). pii: E1973.


Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease.

Doria M, Maugest L, Moreau T, Lizard G, Vejux A.

Free Radic Biol Med. 2016 Dec;101:393-400. doi: 10.1016/j.freeradbiomed.2016.10.008. Epub 2016 Nov 9. Review.


7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD.

Nury T, Zarrouk A, Ragot K, Debbabi M, Riedinger JM, Vejux A, Aubourg P, Lizard G.

J Steroid Biochem Mol Biol. 2017 May;169:123-136. doi: 10.1016/j.jsbmb.2016.03.037. Epub 2016 Apr 1.


Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors.

Leoni V, Nury T, Vejux A, Zarrouk A, Caccia C, Debbabi M, Fromont A, Sghaier R, Moreau T, Lizard G.

J Steroid Biochem Mol Biol. 2017 May;169:96-110. doi: 10.1016/j.jsbmb.2016.03.029. Epub 2016 Mar 25.


Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.

Zarrouk A, Nury T, Karym EM, Vejux A, Sghaier R, Gondcaille C, Andreoletti P, Trompier D, Savary S, Cherkaoui-Malki M, Debbabi M, Fromont A, Riedinger JM, Moreau T, Lizard G.

J Steroid Biochem Mol Biol. 2017 May;169:29-38. doi: 10.1016/j.jsbmb.2016.02.024. Epub 2016 Feb 24.


Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3).

Nury T, Zarrouk A, Mackrill JJ, Samadi M, Durand P, Riedinger JM, Doria M, Vejux A, Limagne E, Delmas D, Prost M, Moreau T, Hammami M, Delage-Mourroux R, O'Brien NM, Lizard G.

Steroids. 2015 Jul;99(Pt B):194-203. doi: 10.1016/j.steroids.2015.02.003. Epub 2015 Feb 12.


Involvement of oxysterols in age-related diseases and ageing processes.

Zarrouk A, Vejux A, Mackrill J, O'Callaghan Y, Hammami M, O'Brien N, Lizard G.

Ageing Res Rev. 2014 Nov;18:148-62. doi: 10.1016/j.arr.2014.09.006. Epub 2014 Oct 14. Review.


Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: impairment by α-tocopherol.

Nury T, Zarrouk A, Vejux A, Doria M, Riedinger JM, Delage-Mourroux R, Lizard G.

Biochem Biophys Res Commun. 2014 Apr 11;446(3):714-9. doi: 10.1016/j.bbrc.2013.11.081. Epub 2013 Dec 2.


Brain peroxisomes.

Trompier D, Vejux A, Zarrouk A, Gondcaille C, Geillon F, Nury T, Savary S, Lizard G.

Biochimie. 2014 Mar;98:102-10. doi: 10.1016/j.biochi.2013.09.009. Epub 2013 Sep 21. Review.


Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes.

Ragot K, Mackrill JJ, Zarrouk A, Nury T, Aires V, Jacquin A, Athias A, Pais de Barros JP, Véjux A, Riedinger JM, Delmas D, Lizard G.

Biochem Pharmacol. 2013 Jul 1;86(1):67-79. doi: 10.1016/j.bcp.2013.02.028. Epub 2013 Mar 5.


Biological activities of the LXRα and β agonist, 4β-hydroxycholesterol, and of its isomer, 4α-hydroxycholesterol, on oligodendrocytes: effects on cell growth and viability, oxidative and inflammatory status.

Nury T, Samadi M, Varin A, Lopez T, Zarrouk A, Boumhras M, Riedinger JM, Masson D, Vejux A, Lizard G.

Biochimie. 2013 Mar;95(3):518-30. doi: 10.1016/j.biochi.2012.11.013. Epub 2012 Dec 7.


High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients.

Pernodet N, Hermetet F, Adami P, Vejux A, Descotes F, Borg C, Adams M, Pallandre JR, Viennet G, Esnard F, Jouvenot M, Despouy G.

Breast Cancer Res. 2012 Oct 25;14(5):R136. doi: 10.1186/bcr3341.


Induction of mitochondrial changes associated with oxidative stress on very long chain fatty acids (C22:0, C24:0, or C26:0)-treated human neuronal cells (SK-NB-E).

Zarrouk A, Vejux A, Nury T, El Hajj HI, Haddad M, Cherkaoui-Malki M, Riedinger JM, Hammami M, Lizard G.

Oxid Med Cell Longev. 2012;2012:623257. doi: 10.1155/2012/623257. Epub 2012 Aug 5.


Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins.

Baarine M, Andréoletti P, Athias A, Nury T, Zarrouk A, Ragot K, Vejux A, Riedinger JM, Kattan Z, Bessede G, Trompier D, Savary S, Cherkaoui-Malki M, Lizard G.

Neuroscience. 2012 Jun 28;213:1-18. doi: 10.1016/j.neuroscience.2012.03.058. Epub 2012 Apr 19.


Absence of oxysterol-like side effects in human monocytic cells treated with phytosterols and oxyphytosterols.

Vejux A, Montange T, Martine L, Zarrouk A, Riedinger JM, Lizard G.

J Agric Food Chem. 2012 Apr 25;60(16):4060-6. doi: 10.1021/jf300487r. Epub 2012 Apr 16.


Contribution of cholesterol and oxysterols in the physiopathology of cataract: implication for the development of pharmacological treatments.

Vejux A, Samadi M, Lizard G.

J Ophthalmol. 2011;2011:471947. doi: 10.1155/2011/471947. Epub 2011 Apr 4.


Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis.

Vejux A, Lizard G.

Mol Aspects Med. 2009 Jun;30(3):153-70. doi: 10.1016/j.mam.2009.02.006. Epub 2009 Feb 25. Review.


Activation of a caspase-3-independent mode of cell death associated with lysosomal destabilization in cultured human retinal pigment epithelial cells (ARPE-19) exposed to 7beta-hydroxycholesterol.

Malvitte L, Montange T, Vejux A, Joffre C, Bron A, Creuzot-Garcher C, Lizard G.

Curr Eye Res. 2008 Sep;33(9):769-81. doi: 10.1080/02713680802337397.


Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis.

Vejux A, Malvitte L, Lizard G.

Braz J Med Biol Res. 2008 Jul;41(7):545-56. Review.


Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.

Vejux A, Guyot S, Montange T, Riedinger JM, Kahn E, Lizard G.

J Nutr Biochem. 2009 Jan;20(1):45-61. doi: 10.1016/j.jnutbio.2007.12.001. Epub 2008 May 20.


Cytotoxic oxysterols induce caspase-independent myelin figure formation and caspase-dependent polar lipid accumulation.

Vejux A, Kahn E, Ménétrier F, Montange T, Lherminier J, Riedinger JM, Lizard G.

Histochem Cell Biol. 2007 Jun;127(6):609-24. Epub 2007 Jan 17.


Flow cytometry and spectral imaging multiphoton microscopy analysis of CD36 expression with quantum dots 605 of untreated and 7-ketocholesterol-treated human monocytic cells.

Kahn E, Ménétrier F, Vejux A, Montange T, Dumas D, Riedinger JM, Frouin F, Tourneur Y, Brau F, Stoltz JF, Lizard G.

Anal Quant Cytol Histol. 2006 Dec;28(6):316-30.


Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs.

Malvitte L, Montange T, Vejux A, Baudouin C, Bron AM, Creuzot-Garcher C, Lizard G.

Br J Ophthalmol. 2007 Jan;91(1):29-32. Epub 2006 Aug 30.


[Analogies between atherosclerosis and age-related maculopathy: expected roles of oxysterols].

Malvitte L, Montange T, Joffre C, Vejux A, Maïza C, Bron A, Creuzot-Garcher C, Lizard G.

J Fr Ophtalmol. 2006 May;29(5):570-8. Review. French.


Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients.

Prunet C, Montange T, Véjux A, Laubriet A, Rohmer JF, Riedinger JM, Athias A, Lemaire-Ewing S, Néel D, Petit JM, Steinmetz E, Brenot R, Gambert P, Lizard G.

Cytometry A. 2006 May;69(5):359-73.


Analysis of CD36 expression on human monocytic cells and atherosclerotic tissue sections with quantum dots: investigation by flow cytometry and spectral imaging microscopy.

Kahn E, Vejux A, Ménétrier F, Maiza C, Hammann A, Sequeira-Le Grand A, Frouin F, Tourneur Y, Brau F, Riedinger JM, Steinmetz E, Todd-Pokropek A, Lizard G.

Anal Quant Cytol Histol. 2006 Feb;28(1):14-26.


Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols.

Lemaire-Ewing S, Prunet C, Montange T, Vejux A, Berthier A, Bessède G, Corcos L, Gambert P, Néel D, Lizard G.

Cell Biol Toxicol. 2005 Mar;21(2):97-114.


7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways.

Berthier A, Lemaire-Ewing S, Prunet C, Montange T, Vejux A, Pais de Barros JP, Monier S, Gambert P, Lizard G, Néel D.

FEBS J. 2005 Jun;272(12):3093-104.


FRET multiphoton spectral imaging microscopy of 7-ketocholesterol and Nile Red in U937 monocytic cells loaded with 7-ketocholesterol.

Kahn E, Vejux A, Dumas D, Montange T, Frouin F, Robert V, Riedinger JM, Stoltz JF, Gambert P, Todd-Pokropek A, Lizard G.

Anal Quant Cytol Histol. 2004 Dec;26(6):304-13.


Analysis of the fluorescence of monodansylcadaverine-positive cytoplasmic structures during 7-ketocholesterol-induced cell death.

Kahn E, Vejux A, Lizard G, Bessède G, Frouin F, Prunet C, Bernengo JC, Brau F, Todd-Pokropek A, Gambert P.

Anal Quant Cytol Histol. 2004 Feb;26(1):47-56.


MexXY-OprM efflux pump is necessary for a adaptive resistance of Pseudomonas aeruginosa to aminoglycosides.

Hocquet D, Vogne C, El Garch F, Vejux A, Gotoh N, Lee A, Lomovskaya O, Plésiat P.

Antimicrob Agents Chemother. 2003 Apr;47(4):1371-5.


Fluorescence and photoacoustic spectroscopy of immobilized thylakoids.

Thomasset B, Barbotin JN, Thomas D, Thomasset T, Vejux A, Jeanfils J.

Biotechnol Bioeng. 1983 Oct;25(10):2453-68.


Photoacoustic spectroscopy of active immobilized chloroplast membranes.

Thomasset B, Thomasset T, Barbotin JN, Vejux A.

Appl Opt. 1982 Jan 1;21(1):124-6. doi: 10.1364/AO.21.000124.


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