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Items: 1 to 50 of 217

1.

Longitudinal Pattern of First-Phase Insulin Response Is Associated with Genetic Variants Outside the Class II HLA Region in Children with Multiple Autoantibodies.

Koskinen MK, Mikk ML, Laine AP, Lempainen J, Löyttyniemi E, Vähäsalo P, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Veijola R, Ilonen J, Toppari J.

Diabetes. 2019 Oct 7. pii: db190329. doi: 10.2337/db19-0329. [Epub ahead of print]

PMID:
31591105
2.

The heterogeneous pathogenesis of type 1 diabetes mellitus.

Ilonen J, Lempainen J, Veijola R.

Nat Rev Endocrinol. 2019 Nov;15(11):635-650. doi: 10.1038/s41574-019-0254-y. Epub 2019 Sep 18. Review.

PMID:
31534209
3.

Circulating metabolites in progression to islet autoimmunity and type 1 diabetes.

Lamichhane S, Kemppainen E, Trošt K, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Diabetologia. 2019 Aug 23. doi: 10.1007/s00125-019-04980-0. [Epub ahead of print]

PMID:
31444528
4.

Association of Cereal, Gluten, and Dietary Fiber Intake With Islet Autoimmunity and Type 1 Diabetes.

Hakola L, Miettinen ME, Syrjälä E, Åkerlund M, Takkinen HM, Korhonen TE, Ahonen S, Ilonen J, Toppari J, Veijola R, Nevalainen J, Knip M, Virtanen SM.

JAMA Pediatr. 2019 Aug 12. doi: 10.1001/jamapediatrics.2019.2564. [Epub ahead of print]

PMID:
31403683
5.

Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk.

Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Ilonen J, Siljander H, Knip M.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5585-5594. doi: 10.1210/jc.2019-01069.

PMID:
31314077
6.

Circulating CXCR5-PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes.

Ekman I, Ihantola EL, Viisanen T, Rao DA, Näntö-Salonen K, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T.

Diabetologia. 2019 Sep;62(9):1681-1688. doi: 10.1007/s00125-019-4936-8. Epub 2019 Jul 3.

7.

A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity.

Syrjälä E, Nevalainen J, Peltonen J, Takkinen HM, Hakola L, Åkerlund M, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM.

Sci Rep. 2019 May 23;9(1):7760. doi: 10.1038/s41598-019-44196-1.

8.

Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood.

Bauer W, Veijola R, Lempainen J, Kiviniemi M, Härkönen T, Toppari J, Knip M, Gyenesei A, Ilonen J.

J Clin Endocrinol Metab. 2019 Oct 1;104(10):4521-4530. doi: 10.1210/jc.2019-00421.

PMID:
31120497
9.

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease.

Sen P, Carlsson C, Virtanen SM, Simell S, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Clin Transl Gastroenterol. 2019 May 22;10(5):1-10. doi: 10.14309/ctg.0000000000000044.

10.

FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children.

Viisanen T, Gazali AM, Ihantola EL, Ekman I, Näntö-Salonen K, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

Front Immunol. 2019 Jan 22;10:19. doi: 10.3389/fimmu.2019.00019. eCollection 2019.

11.

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Dickens AM, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Biomolecules. 2019 Jan 21;9(1). pii: E33. doi: 10.3390/biom9010033.

12.

Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes.

Mäkinen M, Löyttyniemi E, Koskinen M, Vähä-Mäkilä M, Siljander H, Nurmio M, Mykkänen J, Virtanen SM, Simell O, Hyöty H, Ilonen J, Knip M, Veijola R, Toppari J.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2277-2285. doi: 10.1210/jc.2018-02094.

13.

Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children.

Jacobsen LM, Larsson HE, Tamura RN, Vehik K, Clasen J, Sosenko J, Hagopian WA, She JX, Steck AK, Rewers M, Simell O, Toppari J, Veijola R, Ziegler AG, Krischer JP, Akolkar B, Haller MJ; TEDDY Study Group.

Pediatr Diabetes. 2019 May;20(3):263-270. doi: 10.1111/pedi.12812. Epub 2019 Jan 29.

PMID:
30628751
14.

A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Sci Data. 2018 Nov 13;5:180250. doi: 10.1038/sdata.2018.250.

15.

No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort.

Jääskeläinen AJ, Nurminen N, Kolehmainen P, Smura T, Tauriainen S, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H, Vapalahti O, Kallio-Kokko H.

Pediatr Infect Dis J. 2019 Mar;38(3):314-316. doi: 10.1097/INF.0000000000002201.

PMID:
30346370
16.

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.

Ekman I, Vuorinen T, Knip M, Veijola R, Toppari J, Hyöty H, Kinnunen T, Ilonen J, Lempainen J.

Pediatr Diabetes. 2019 Feb;20(1):73-77. doi: 10.1111/pedi.12788. Epub 2018 Nov 19.

PMID:
30338642
17.

Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption.

Prasad M, Takkinen HM, Uusitalo L, Tapanainen H, Ovaskainen ML, Alfthan G, Erlund I, Ahonen S, Åkerlund M, Toppari J, Ilonen J, Knip M, Veijola R, Virtanen SM.

Nutrients. 2018 Oct 17;10(10). pii: E1533. doi: 10.3390/nu10101533.

18.

Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring.

Korhonen L, Seiskari T, Lehtonen J, Puustinen L, Surcel HM, Haapala AM, Niemelä O, Virtanen SM, Honkanen H, Karjalainen M, Ilonen J, Veijola R, Knip M, Lönnrot M, Hyöty H.

Clin Exp Allergy. 2018 Dec;48(12):1698-1704. doi: 10.1111/cea.13280. Epub 2018 Oct 16.

PMID:
30230072
19.

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP).

Lamichhane S, Ahonen L, Dyrlund TS, Kemppainen E, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Sci Rep. 2018 Jul 13;8(1):10635. doi: 10.1038/s41598-018-28907-8.

20.

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes.

Ihantola EL, Viisanen T, Gazali AM, Näntö-Salonen K, Juutilainen A, Moilanen L, Rintamäki R, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

J Immunol. 2018 Aug 15;201(4):1144-1153. doi: 10.4049/jimmunol.1701199. Epub 2018 Jul 13.

21.

Family adjustment to diabetes diagnosis in children: Can participation in a study on type 1 diabetes genetic risk be helpful?

Smith LB, Liu X, Johnson SB, Tamura R, Elding Larsson H, Ahmed S, Veijola R, Haller MJ, Akolkar B, Hagopian WA, Rewers MJ, Krischer J, Steck AK; TEDDY study group.

Pediatr Diabetes. 2018 Aug;19(5):1025-1033. doi: 10.1111/pedi.12674. Epub 2018 May 2.

22.

Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.

Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vähä-Mäkilä M, Ilonen J, Veijola R, Knip M, Hyöty H.

Diabetologia. 2018 May;61(5):1193-1202. doi: 10.1007/s00125-018-4561-y. Epub 2018 Feb 5.

PMID:
29404673
23.

Infant Feeding in Relation to the Risk of Advanced Islet Autoimmunity and Type 1 Diabetes in Children With Increased Genetic Susceptibility: A Cohort Study.

Hakola L, Takkinen HM, Niinistö S, Ahonen S, Nevalainen J, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM.

Am J Epidemiol. 2018 Jan 1;187(1):34-44. doi: 10.1093/aje/kwx191.

PMID:
29309515
24.

Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.

Koskinen MK, Lempainen J, Löyttyniemi E, Helminen O, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Ilonen J, Toppari J, Veijola R.

J Clin Endocrinol Metab. 2018 Aug 1;103(8):2870-2878. doi: 10.1210/jc.2017-02040.

25.

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes.

Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL.

Diabetologia. 2018 Feb;61(2):381-388. doi: 10.1007/s00125-017-4460-7. Epub 2017 Nov 8.

26.

Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis.

Tommiska J, Känsäkoski J, Skibsbye L, Vaaralahti K, Liu X, Lodge EJ, Tang C, Yuan L, Fagerholm R, Kanters JK, Lahermo P, Kaunisto M, Keski-Filppula R, Vuoristo S, Pulli K, Ebeling T, Valanne L, Sankila EM, Kivirikko S, Lääperi M, Casoni F, Giacobini P, Phan-Hug F, Buki T, Tena-Sempere M, Pitteloud N, Veijola R, Lipsanen-Nyman M, Kaunisto K, Mollard P, Andoniadou CL, Hirsch JA, Varjosalo M, Jespersen T, Raivio T.

Nat Commun. 2017 Nov 3;8(1):1289. doi: 10.1038/s41467-017-01429-z.

27.

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.

Kondrashova A, Nurminen N, Lehtonen J, Hyöty M, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H.

Pediatr Diabetes. 2018 May;19(3):398-402. doi: 10.1111/pedi.12592. Epub 2017 Oct 17.

PMID:
29044779
28.

Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study.

Viskari H, Oikarinen S, Hoppu S, Vuorinen T, Huhtala H, Toppari J, Veijola R, Ilonen J, Knip M, Hyöty H.

Diabetologia. 2018 Jan;61(1):203-209. doi: 10.1007/s00125-017-4410-4. Epub 2017 Sep 2.

PMID:
28866779
29.

Vitamin D intake during the first 4 years and onset of asthma by age 5: A nested case-control study.

Nwaru BI, Hadkhale K, Hämäläinen N, Takkinen HM, Ahonen S, Ilonen J, Toppari J, Niemelä O, Haapala AM, Veijola R, Knip M, Virtanen SM.

Pediatr Allergy Immunol. 2017 Nov;28(7):641-648. doi: 10.1111/pai.12773. Epub 2017 Sep 8.

PMID:
28815786
30.

Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.

Ilonen J, Lempainen J, Hammais A, Laine AP, Härkönen T, Toppari J, Veijola R, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Mar;19(2):284-292. doi: 10.1111/pedi.12545. Epub 2017 Jun 9.

PMID:
28597949
31.

Ketoacidosis at diagnosis of type 1 diabetes: Effect of prospective studies with newborn genetic screening and follow up of risk children.

Hekkala AM, Ilonen J, Toppari J, Knip M, Veijola R.

Pediatr Diabetes. 2018 Mar;19(2):314-319. doi: 10.1111/pedi.12541. Epub 2017 May 23.

PMID:
28544185
32.

Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity.

Niinistö S, Takkinen HM, Erlund I, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Vaarala O, Virtanen SM.

Diabetologia. 2017 Jul;60(7):1223-1233. doi: 10.1007/s00125-017-4280-9. Epub 2017 May 4.

PMID:
28474159
33.

Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility.

Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Vähäsalo P, Ilonen J, Siljander H, Knip M.

Diabetologia. 2017 Jul;60(7):1284-1293. doi: 10.1007/s00125-017-4258-7. Epub 2017 Mar 31.

PMID:
28364254
34.

Eliminating cows' milk, but not wheat, barley or rye, increases the risk of growth deceleration and nutritional inadequacies.

Tuokkola J, Luukkainen P, Nevalainen J, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Virtanen SM, Kaila M.

Acta Paediatr. 2017 Jul;106(7):1142-1149. doi: 10.1111/apa.13846. Epub 2017 Apr 25.

PMID:
28345135
35.

Serum carotenoid and tocopherol concentrations and risk of asthma in childhood: a nested case-control study.

Hämäläinen N, Nwaru BI, Erlund I, Takkinen HM, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Kaila M, Virtanen SM.

Clin Exp Allergy. 2017 Mar;47(3):401-409. doi: 10.1111/cea.12904.

PMID:
28198577
36.

The association of the HLA-A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in Finns.

Mikk ML, Heikkinen T, El-Amir MI, Kiviniemi M, Laine AP, Härkönen T, Veijola R, Toppari J, Knip M, Ilonen J; Finnish Paediatric Diabetes Register.

HLA. 2017 Apr;89(4):215-224. doi: 10.1111/tan.12967. Epub 2017 Feb 10.

PMID:
28185422
37.

Correction: B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.

Kantola K, Hedman L, Tanner L, Simell V, Mäkinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyöty H, Toppari J, Simell O, Hedman K, Söderlund-Venermo M.

PLoS One. 2017 Feb 8;12(2):e0172078. doi: 10.1371/journal.pone.0172078. eCollection 2017.

38.

Residual beta-cell function in diabetes children followed and diagnosed in the TEDDY study compared to community controls.

Steck AK, Larsson HE, Liu X, Veijola R, Toppari J, Hagopian WA, Haller MJ, Ahmed S, Akolkar B, Lernmark Å, Rewers MJ, Krischer JP; and the TEDDY Study Group.

Pediatr Diabetes. 2017 Dec;18(8):794-802. doi: 10.1111/pedi.12485. Epub 2017 Jan 27.

39.

Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies.

Viisanen T, Ihantola EL, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

Diabetes. 2017 Feb;66(2):437-447. doi: 10.2337/db16-0714. Epub 2016 Oct 10.

40.

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.

Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Lecouturier V, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H, Knip M, Hyöty H.

Diabetologia. 2017 Mar;60(3):424-431. doi: 10.1007/s00125-016-4177-z. Epub 2017 Jan 9.

PMID:
28070615
41.

A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diabetes.

Salonen KM, Ryhänen SJ, Forbes JM, Härkönen T, Ilonen J, Simell O, Veijola R, Groop PH, Knip M.

Diabetes Metab Res Rev. 2017 May;33(4). doi: 10.1002/dmrr.2872. Epub 2017 Jan 23.

PMID:
27883367
42.

Imbalance of bacteriome profiles within the Finnish Diabetes Prediction and Prevention study: Parallel use of 16S profiling and virome sequencing in stool samples from children with islet autoimmunity and matched controls.

Cinek O, Kramna L, Lin J, Oikarinen S, Kolarova K, Ilonen J, Simell O, Veijola R, Autio R, Hyöty H.

Pediatr Diabetes. 2017 Nov;18(7):588-598. doi: 10.1111/pedi.12468. Epub 2016 Nov 17.

PMID:
27860030
43.

Reclassification of asymptomatic beta cell autoimmunity: a critical perspective.

Knip M, Selvenius J, Siljander H, Veijola R.

Diabetologia. 2017 Jan;60(1):39-42. Epub 2016 Oct 27.

PMID:
27787620
44.

Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study.

Seppälä E, Sillanpää S, Nurminen N, Huhtala H, Toppari J, Ilonen J, Veijola R, Knip M, Sipilä M, Laranne J, Oikarinen S, Hyöty H.

J Clin Virol. 2016 Dec;85:1-6. doi: 10.1016/j.jcv.2016.10.010. Epub 2016 Oct 20.

PMID:
27780081
45.

Natural Development of Antibodies against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis Protein Antigens during the First 13 Years of Life.

Borges IC, Andrade DC, Cardoso MR, Toppari J, Vähä-Mäkilä M, Ilonen J, Knip M, Hyöty H, Veijola R, Simell O, Jartti T, Käyhty H, Ruuskanen O, Nascimento-Carvalho CM.

Clin Vaccine Immunol. 2016 Nov 4;23(11):878-883. Print 2016 Nov.

46.

Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus.

Helminen O, Pokka T, Tossavainen P, Ilonen J, Knip M, Veijola R.

Diabetes Res Clin Pract. 2016 Oct;120:89-96. doi: 10.1016/j.diabres.2016.07.027. Epub 2016 Aug 6.

PMID:
27525364
47.

Dysregulation of glucose metabolism in preclinical type 1 diabetes.

Veijola R, Koskinen M, Helminen O, Hekkala A.

Pediatr Diabetes. 2016 Jul;17 Suppl 22:25-30. doi: 10.1111/pedi.12392. Review.

PMID:
27411433
48.

Role of humoral beta-cell autoimmunity in type 1 diabetes.

Knip M, Siljander H, Ilonen J, Simell O, Veijola R.

Pediatr Diabetes. 2016 Jul;17 Suppl 22:17-24. doi: 10.1111/pedi.12386. Review.

PMID:
27411432
49.

Genetic susceptibility to type 1 diabetes in childhood - estimation of HLA class II associated disease risk and class II effect in various phases of islet autoimmunity.

Ilonen J, Kiviniemi M, Lempainen J, Simell O, Toppari J, Veijola R, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2016 Jul;17 Suppl 22:8-16. doi: 10.1111/pedi.12327.

PMID:
27411431
50.

Maternal fatty acid intake during pregnancy and the development of childhood overweight: a birth cohort study.

Hakola L, Takkinen HM, Niinistö S, Ahonen S, Erlund I, Rautanen J, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM, Lehtinen-Jacks S.

Pediatr Obes. 2017 Aug;12 Suppl 1:26-37. doi: 10.1111/ijpo.12170. Epub 2016 Jul 5.

PMID:
27378525

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