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Items: 1 to 50 of 168


Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.

Walker C, Wang Y, Olivieri C, Karamafrooz A, Casby J, Bathon K, Calebiro D, Gao J, Bernlohr DA, Taylor SS, Veglia G.

Sci Adv. 2019 Aug 28;5(8):eaaw9298. doi: 10.1126/sciadv.aaw9298. eCollection 2019 Aug.


Improving the quality of oriented membrane protein spectra using heat-compensated separated local field experiments.

Wang S, Gopinath T, Veglia G.

J Biomol NMR. 2019 Aug 28. doi: 10.1007/s10858-019-00273-1. [Epub ahead of print]


Intrinsically disordered HAX-1 regulates Ca2+ cycling by interacting with lipid membranes and the phospholamban cytoplasmic region.

Larsen EK, Weber DK, Wang S, Gopinath T, Blackwell DJ, Dalton MP, Robia SL, Gao J, Veglia G.

Biochim Biophys Acta Biomembr. 2019 Aug 7:183034. doi: 10.1016/j.bbamem.2019.183034. [Epub ahead of print]


Use of paramagnetic systems to speed-up NMR data acquisition and for structural and dynamic studies.

Kocman V, Di Mauro GM, Veglia G, Ramamoorthy A.

Solid State Nucl Magn Reson. 2019 Oct;102:36-46. doi: 10.1016/j.ssnmr.2019.07.002. Epub 2019 Jul 12. Review.


Dynamic allostery-based molecular workings of kinase:peptide complexes.

Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15052-15061. doi: 10.1073/pnas.1900163116. Epub 2019 Jul 8.


T2* weighted Deconvolution of NMR Spectra: Application to 2D Homonuclear MAS Solid-State NMR of Membrane Proteins.

V S M, Gopinath T, Wang S, Veglia G.

Sci Rep. 2019 Jun 3;9(1):8225. doi: 10.1038/s41598-019-44461-3.


Cysteine-ethylation of tissue-extracted membrane proteins as a tool to detect conformational states by solid-state NMR spectroscopy.

Weber DK, Bader T, Larsen EK, Wang S, Gopinath T, Distefano M, Veglia G.

Methods Enzymol. 2019;621:281-304. doi: 10.1016/bs.mie.2019.02.001. Epub 2019 Mar 8.


More than a Liquid Junction: Effect of Stirring, Flow Rate, and Inward and Outward Electrolyte Diffusion on Reference Electrodes with Salt Bridges Contained in Nanoporous Glass.

Anderson EL, Lodge TP, Gopinath T, Veglia G, Bühlmann P.

Anal Chem. 2019 Jun 18;91(12):7698-7704. doi: 10.1021/acs.analchem.9b00876. Epub 2019 Jun 7.


An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins.

Hall JW, Lima BP, Herbomel GG, Gopinath T, McDonald L, Shyne MT, Lee JK, Kreth J, Ross KF, Veglia G, Herzberg MC.

Sci Signal. 2019 May 7;12(580). pii: eaas9941. doi: 10.1126/scisignal.aas9941.


Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex.

Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A.

Sci Adv. 2019 Mar 20;5(3):eaav0482. doi: 10.1126/sciadv.aav0482. eCollection 2019 Mar.


Structure and Function of Tryptophan-Tyrosine Dyads in Biomimetic β Hairpins.

McCaslin TG, Pagba CV, Chi SH, Hwang HJ, Gumbart JC, Perry JW, Olivieri C, Porcelli F, Veglia G, Guo Z, McDaniel M, Barry BA.

J Phys Chem B. 2019 Apr 4;123(13):2780-2791. doi: 10.1021/acs.jpcb.8b12452. Epub 2019 Mar 19.


Cytoplasmic nucleic acid-based XNAs directly enhance live cardiac cell function by a Ca2+ cycling-independent mechanism via the sarcomere.

Thompson BR, Soller KJ, Vetter A, Yang J, Veglia G, Bowser MT, Metzger JM.

J Mol Cell Cardiol. 2019 May;130:1-9. doi: 10.1016/j.yjmcc.2019.02.016. Epub 2019 Mar 5.


Hybridization of TEDOR and NCX MAS solid-state NMR experiments for simultaneous acquisition of heteronuclear correlation spectra and distance measurements.

Gopinath T, Wang S, Lee J, Aihara H, Veglia G.

J Biomol NMR. 2019 Apr;73(3-4):141-153. doi: 10.1007/s10858-019-00237-5. Epub 2019 Feb 25.


Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle.

Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G.

Nat Commun. 2019 Feb 18;10(1):799. doi: 10.1038/s41467-019-08655-7.


Synthesis and NMR Characterization of the Prenylated Peptide, a-Factor.

Bader TK, Rappe TM, Veglia G, Distefano MD.

Methods Enzymol. 2019;614:207-238. doi: 10.1016/bs.mie.2018.09.025. Epub 2018 Dec 22.


Probing Protein-Protein Interactions Using Asymmetric Labeling and Carbonyl-Carbon Selective Heteronuclear NMR Spectroscopy.

Larsen EK, Olivieri C, Walker C, V S M, Gao J, Bernlohr DA, Tonelli M, Markley JL, Veglia G.

Molecules. 2018 Aug 3;23(8). pii: E1937. doi: 10.3390/molecules23081937. Review.


ALARM NMR for HTS triage and chemical probe validation.

Dahlin JL, Cuellar M, Singh G, Nelson KM, Strasser J, Rappe T, Xia Y, Veglia G, Walters MA.

Curr Protoc Chem Biol. 2018 Mar;10(1):91-117. doi: 10.1002/cpch.35. Epub 2018 Apr 9.


Probing membrane protein ground and conformationally excited states using dipolar- and J-coupling mediated MAS solid state NMR experiments.

Gopinath T, Veglia G.

Methods. 2018 Sep 15;148:115-122. doi: 10.1016/j.ymeth.2018.07.003. Epub 2018 Jul 23. Review.


Clearance kinetics of the VGF-derived neuropeptide TLQP-21.

Guo Z, Sahu BS, He R, Finan B, Cero C, Verardi R, Razzoli M, Veglia G, Di Marchi RD, Miles JM, Bartolomucci A.

Neuropeptides. 2018 Oct;71:97-103. doi: 10.1016/j.npep.2018.06.003. Epub 2018 Jun 19.


Effects of the Arg9Cys and Arg25Cys mutations on phospholamban's conformational equilibrium in membrane bilayers.

Nelson SED, Ha KN, Gopinath T, Exline MH, Mascioni A, Thomas DD, Veglia G.

Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1335-1341. doi: 10.1016/j.bbamem.2018.02.030. Epub 2018 Mar 2.


Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies.

Chipot C, Dehez F, Schnell JR, Zitzmann N, Pebay-Peyroula E, Catoire LJ, Miroux B, Kunji ERS, Veglia G, Cross TA, Schanda P.

Chem Rev. 2018 Apr 11;118(7):3559-3607. doi: 10.1021/acs.chemrev.7b00570. Epub 2018 Feb 28. Review.


Simultaneous detection of intra- and inter-molecular paramagnetic relaxation enhancements in protein complexes.

Olivieri C, Subrahmanian MV, Xia Y, Kim J, Porcelli F, Veglia G.

J Biomol NMR. 2018 Mar;70(3):133-140. doi: 10.1007/s10858-018-0165-6. Epub 2018 Feb 2.


Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.

Tomasini MD, Wang Y, Karamafrooz A, Li G, Beuming T, Gao J, Taylor SS, Veglia G, Simon SM.

Sci Rep. 2018 Jan 15;8(1):720. doi: 10.1038/s41598-017-18956-w.


Application of paramagnetic relaxation enhancements to accelerate the acquisition of 2D and 3D solid-state NMR spectra of oriented membrane proteins.

Wang S, Gopinath T, Veglia G.

Methods. 2018 Apr 1;138-139:54-61. doi: 10.1016/j.ymeth.2017.12.017. Epub 2017 Dec 22.


1H-detected MAS solid-state NMR experiments enable the simultaneous mapping of rigid and dynamic domains of membrane proteins.

Gopinath T, Nelson SED, Veglia G.

J Magn Reson. 2017 Dec;285:101-107. doi: 10.1016/j.jmr.2017.09.003.


Enhancing the sensitivity of multidimensional NMR experiments by using triply-compensated π pulses.

Xia Y, Rossi P, Subrahmanian MV, Huang C, Saleh T, Olivieri C, Kalodimos CG, Veglia G.

J Biomol NMR. 2017 Dec;69(4):237-243. doi: 10.1007/s10858-017-0153-2. Epub 2017 Nov 21.


Optimization of 1H decoupling eliminates sideband artifacts in 3D TROSY-based triple resonance experiments.

Xia Y, Rossi P, Tonelli M, Huang C, Kalodimos CG, Veglia G.

J Biomol NMR. 2017 Sep;69(1):45-52. doi: 10.1007/s10858-017-0133-6. Epub 2017 Sep 8.


Solution and Solid-State Nuclear Magnetic Resonance Structural Investigations of the Antimicrobial Designer Peptide GL13K in Membranes.

Harmouche N, Aisenbrey C, Porcelli F, Xia Y, Nelson SED, Chen X, Raya J, Vermeer L, Aparicio C, Veglia G, Gorr SU, Bechinger B.

Biochemistry. 2017 Aug 15;56(32):4269-4278. doi: 10.1021/acs.biochem.7b00526. Epub 2017 Aug 1.


Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein.

Fusco G, Pape T, Stephens AD, Mahou P, Costa AR, Kaminski CF, Schierle GSK, Vendruscolo M, Veglia G, Dobson CM, De Simone A.

Nat Commun. 2017 May 11;8:15667. doi: 10.1038/ncomms15667. No abstract available.


A dynamic hydrophobic core orchestrates allostery in protein kinases.

Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor SS, Veglia G.

Sci Adv. 2017 Apr 7;3(4):e1600663. doi: 10.1126/sciadv.1600663. eCollection 2017 Apr.


Probing the Conformationally Excited States of Membrane Proteins via 1H-Detected MAS Solid-State NMR Spectroscopy.

Gopinath T, Nelson SED, Soller KJ, Veglia G.

J Phys Chem B. 2017 May 4;121(17):4456-4465. doi: 10.1021/acs.jpcb.7b03268. Epub 2017 Apr 20.


Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer.

Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E931-E940. doi: 10.1073/pnas.1620667114. Epub 2017 Jan 23.


15N and 13C- SOFAST-HMQC editing enhances 3D-NOESY sensitivity in highly deuterated, selectively [1H,13C]-labeled proteins.

Rossi P, Xia Y, Khanra N, Veglia G, Kalodimos CG.

J Biomol NMR. 2016 Dec;66(4):259-271. doi: 10.1007/s10858-016-0074-5. Epub 2016 Nov 23.


NMR structure and conformational dynamics of AtPDFL2.1, a defensin-like peptide from Arabidopsis thaliana.

Omidvar R, Xia Y, Porcelli F, Bohlmann H, Veglia G.

Biochim Biophys Acta. 2016 Dec;1864(12):1739-1747. doi: 10.1016/j.bbapap.2016.08.017. Epub 2016 Aug 31.


Optimization of identity operation in NMR spectroscopy via genetic algorithm: Application to the TEDOR experiment.

Manu VS, Veglia G.

J Magn Reson. 2016 Dec;273:40-46. doi: 10.1016/j.jmr.2016.09.021. Epub 2016 Sep 27.


Probing Residue-Specific Water-Protein Interactions in Oriented Lipid Membranes via Solid-State NMR Spectroscopy.

Dicke A, Gopinath T, Wang Y, Veglia G.

J Phys Chem B. 2016 Oct 27;120(42):10959-10968. doi: 10.1021/acs.jpcb.6b08282. Epub 2016 Oct 18.


Structural basis of synaptic vesicle assembly promoted by α-synuclein.

Fusco G, Pape T, Stephens AD, Mahou P, Costa AR, Kaminski CF, Kaminski Schierle GS, Vendruscolo M, Veglia G, Dobson CM, De Simone A.

Nat Commun. 2016 Sep 19;7:12563. doi: 10.1038/ncomms12563.


Tunable Liaisons: eEF-2K, CaM, and Calcium.

Veglia G, Li G.

Structure. 2016 Sep 6;24(9):1438-9. doi: 10.1016/j.str.2016.08.005.


Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity.

Fusco G, De Simone A, Arosio P, Vendruscolo M, Veglia G, Dobson CM.

Sci Rep. 2016 Jun 8;6:27125. doi: 10.1038/srep27125.


Allosteric Regulation of the M2 Protein from Influenza A by Cholesterol.

Veglia G, Nelson SE, Gopinath T.

Biophys J. 2016 Mar 29;110(6):1207-8. doi: 10.1016/j.bpj.2016.01.034. No abstract available.


Accurate Determination of Conformational Transitions in Oligomeric Membrane Proteins.

Sanz-Hernández M, Vostrikov VV, Veglia G, De Simone A.

Sci Rep. 2016 Mar 15;6:23063. doi: 10.1038/srep23063.


Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A.

Kim J, Li G, Walters MA, Taylor SS, Veglia G.

Structure. 2016 Mar 1;24(3):353-63. doi: 10.1016/j.str.2015.11.016. Epub 2016 Jan 28.


A Semiautomated Assignment Protocol for Methyl Group Side Chains in Large Proteins.

Kim J, Wang Y, Li G, Veglia G.

Methods Enzymol. 2016;566:35-57. doi: 10.1016/bs.mie.2015.08.033. Epub 2015 Sep 26.


Ca(2+) ATPase Conformational Transitions in Lipid Bilayers Mapped by Site-directed Ethylation and Solid-State NMR.

Vostrikov VV, Gustavsson M, Gopinath T, Mullen D, Dicke AA, Truong V, Veglia G.

ACS Chem Biol. 2016 Feb 19;11(2):329-34. doi: 10.1021/acschembio.5b00953. Epub 2015 Dec 18.


A tyrosine-tryptophan dyad and radical-based charge transfer in a ribonucleotide reductase-inspired maquette.

Pagba CV, McCaslin TG, Veglia G, Porcelli F, Yohannan J, Guo Z, McDaniel M, Barry BA.

Nat Commun. 2015 Dec 2;6:10010. doi: 10.1038/ncomms10010.


Genetic algorithm optimized triply compensated pulses in NMR spectroscopy.

Manu VS, Veglia G.

J Magn Reson. 2015 Nov;260:136-43. doi: 10.1016/j.jmr.2015.09.010. Epub 2015 Sep 28.


Rheostatic Regulation of the SERCA/Phospholamban Membrane Protein Complex Using Non-Coding RNA and Single-Stranded DNA oligonucleotides.

Soller KJ, Verardi R, Jing M, Abrol N, Yang J, Walsh N, Vostrikov VV, Robia SL, Bowser MT, Veglia G.

Sci Rep. 2015 Aug 21;5:13000. doi: 10.1038/srep13000.

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