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Items: 36

1.

Cocrystal structure of meningococcal factor H binding protein variant 3 reveals a new crossprotective epitope recognized by human mAb 1E6.

Bianchi F, Veggi D, Santini L, Buricchi F, Bartolini E, Lo Surdo P, Martinelli M, Finco O, Masignani V, Bottomley MJ, Maione D, Cozzi R.

FASEB J. 2019 Oct 5:fj201900374R. doi: 10.1096/fj.201900374R. [Epub ahead of print]

2.

Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody.

Maritan M, Veggi D, Cozzi R, Dello Iacono L, Bartolini E, Lo Surdo P, Maruggi G, Spraggon G, Bottomley MJ, Malito E.

PLoS One. 2018 Aug 22;13(8):e0201922. doi: 10.1371/journal.pone.0201922. eCollection 2018.

3.

Native State Organization of Outer Membrane Porins Unraveled by HDx-MS.

Donnarumma D, Maestri C, Giammarinaro PI, Capriotti L, Bartolini E, Veggi D, Petracca R, Scarselli M, Norais N.

J Proteome Res. 2018 May 4;17(5):1794-1800. doi: 10.1021/acs.jproteome.7b00830. Epub 2018 Apr 17.

4.

Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA.

Maritan M, Cozzi R, Lo Surdo P, Veggi D, Bottomley MJ, Malito E.

Acta Crystallogr F Struct Biol Commun. 2017 Jun 1;73(Pt 6):305-314. doi: 10.1107/S2053230X17006021. Epub 2017 May 11.

5.

Structure of a protective epitope of group B Streptococcus type III capsular polysaccharide.

Carboni F, Adamo R, Fabbrini M, De Ricco R, Cattaneo V, Brogioni B, Veggi D, Pinto V, Passalacqua I, Oldrini D, Rappuoli R, Malito E, Margarit IYR, Berti F.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):5017-5022. doi: 10.1073/pnas.1701885114. Epub 2017 Apr 24.

6.

Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy.

Malito E, Lo Surdo P, Veggi D, Santini L, Stefek H, Brunelli B, Luzzi E, Bottomley MJ, Beernink PT, Scarselli M.

Biochem J. 2016 Dec 15;473(24):4699-4713. Epub 2016 Oct 26.

7.

Molecular Engineering of Ghfp, the Gonococcal Orthologue of Neisseria meningitidis Factor H Binding Protein.

Rippa V, Santini L, Lo Surdo P, Cantini F, Veggi D, Gentile MA, Grassi E, Iannello G, Brunelli B, Ferlicca F, Palmieri E, Pallaoro M, Aricò B, Banci L, Pizza M, Scarselli M.

Clin Vaccine Immunol. 2015 Jul;22(7):769-77. doi: 10.1128/CVI.00794-14. Epub 2015 May 6.

8.

Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein.

Donnarumma D, Golfieri G, Brier S, Castagnini M, Veggi D, Bottomley MJ, Delany I, Norais N.

FASEB J. 2015 Jun;29(6):2260-7. doi: 10.1096/fj.14-263954. Epub 2015 Feb 20.

PMID:
25713028
9.

Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody.

Malito E, Biancucci M, Faleri A, Ferlenghi I, Scarselli M, Maruggi G, Lo Surdo P, Veggi D, Liguori A, Santini L, Bertoldi I, Petracca R, Marchi S, Romagnoli G, Cartocci E, Vercellino I, Savino S, Spraggon G, Norais N, Pizza M, Rappuoli R, Masignani V, Bottomley MJ.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17128-33. doi: 10.1073/pnas.1419686111. Epub 2014 Nov 17.

10.

Auto ADP-ribosylation of NarE, a Neisseria meningitidis ADP-ribosyltransferase, regulates its catalytic activities.

Picchianti M, Del Vecchio M, Di Marcello F, Biagini M, Veggi D, Norais N, Rappuoli R, Pizza M, Balducci E.

FASEB J. 2013 Dec;27(12):4723-30. doi: 10.1096/fj.13-229955. Epub 2013 Aug 20.

PMID:
23964075
11.

Protective efficacy induced by recombinant Clostridium difficile toxin fragments.

Leuzzi R, Spencer J, Buckley A, Brettoni C, Martinelli M, Tulli L, Marchi S, Luzzi E, Irvine J, Candlish D, Veggi D, Pansegrau W, Fiaschi L, Savino S, Swennen E, Cakici O, Oviedo-Orta E, Giraldi M, Baudner B, D'Urzo N, Maione D, Soriani M, Rappuoli R, Pizza M, Douce GR, Scarselli M.

Infect Immun. 2013 Aug;81(8):2851-60. doi: 10.1128/IAI.01341-12. Epub 2013 May 28.

12.

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen.

Malito E, Faleri A, Lo Surdo P, Veggi D, Maruggi G, Grassi E, Cartocci E, Bertoldi I, Genovese A, Santini L, Romagnoli G, Borgogni E, Brier S, Lo Passo C, Domina M, Castellino F, Felici F, van der Veen S, Johnson S, Lea SM, Tang CM, Pizza M, Savino S, Norais N, Rappuoli R, Bottomley MJ, Masignani V.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3304-9. doi: 10.1073/pnas.1222845110. Epub 2013 Feb 8.

13.

Targeted amino acid substitutions impair streptolysin O toxicity and group A Streptococcus virulence.

Chiarot E, Faralla C, Chiappini N, Tuscano G, Falugi F, Gambellini G, Taddei A, Capo S, Cartocci E, Veggi D, Corrado A, Mangiavacchi S, Tavarini S, Scarselli M, Janulczyk R, Grandi G, Margarit I, Bensi G.

MBio. 2013 Jan 8;4(1):e00387-12. doi: 10.1128/mBio.00387-12.

14.

The factor H binding protein of Neisseria meningitidis interacts with xenosiderophores in vitro.

Veggi D, Gentile MA, Cantini F, Lo Surdo P, Nardi-Dei V, Seib KL, Pizza M, Rappuoli R, Banci L, Savino S, Scarselli M.

Biochemistry. 2012 Nov 20;51(46):9384-93. doi: 10.1021/bi301161w. Epub 2012 Nov 12.

PMID:
23121397
15.

FdeC, a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections.

Nesta B, Spraggon G, Alteri C, Moriel DG, Rosini R, Veggi D, Smith S, Bertoldi I, Pastorello I, Ferlenghi I, Fontana MR, Frankel G, Mobley HL, Rappuoli R, Pizza M, Serino L, Soriani M.

MBio. 2012 Apr 10;3(2). pii: e00010-12. doi: 10.1128/mBio.00010-12. Print 2012.

16.

Structure of the C-terminal domain of Neisseria heparin binding antigen (NHBA), one of the main antigens of a novel vaccine against Neisseria meningitidis.

Esposito V, Musi V, de Chiara C, Veggi D, Serruto D, Scarselli M, Kelly G, Pizza M, Pastore A.

J Biol Chem. 2011 Dec 2;286(48):41767-75. doi: 10.1074/jbc.M111.289314. Epub 2011 Sep 29.

17.

Rational design of a meningococcal antigen inducing broad protective immunity.

Scarselli M, Aricò B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley MJ, Malito E, Lo Surdo P, Comanducci M, Giuliani MM, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogioni B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M, Rappuoli R.

Sci Transl Med. 2011 Jul 13;3(91):91ra62. doi: 10.1126/scitranslmed.3002234.

18.

Structure of the uncomplexed Neisseria meningitidis factor H-binding protein fHbp (rLP2086).

Cendron L, Veggi D, Girardi E, Zanotti G.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 May 1;67(Pt 5):531-5. doi: 10.1107/S1744309111006154. Epub 2011 Apr 20.

19.

Structural and functional characterization of the Streptococcus pneumoniae RrgB pilus backbone D1 domain.

Gentile MA, Melchiorre S, Emolo C, Moschioni M, Gianfaldoni C, Pancotto L, Ferlenghi I, Scarselli M, Pansegrau W, Veggi D, Merola M, Cantini F, Ruggiero P, Banci L, Masignani V.

J Biol Chem. 2011 Apr 22;286(16):14588-97. doi: 10.1074/jbc.M110.202739. Epub 2011 Mar 2.

20.

Structural and biochemical characterization of NarE, an iron-containing ADP-ribosyltransferase from Neisseria meningitidis.

Koehler C, Carlier L, Veggi D, Balducci E, Di Marcello F, Ferrer-Navarro M, Pizza M, Daura X, Soriani M, Boelens R, Bonvin AM.

J Biol Chem. 2011 Apr 29;286(17):14842-51. doi: 10.1074/jbc.M110.193623. Epub 2011 Mar 2.

21.

NMR resonance assignments of NarE, a putative ADP-ribosylating toxin from Neisseria meningitidis.

Carlier L, Koehler C, Veggi D, Pizza M, Soriani M, Boelens R, Bonvin AM.

Biomol NMR Assign. 2011 Apr;5(1):35-8. doi: 10.1007/s12104-010-9261-6. Epub 2010 Aug 25.

22.

1H, 13C and 15N assignment of the C-terminal domain of GNA2132 from Neisseria meningitidis.

Esposito V, Musi V, Veggi D, Pastore A, Pizza M.

Biomol NMR Assign. 2010 Apr;4(1):107-9. doi: 10.1007/s12104-010-9220-2. Epub 2010 Mar 20.

23.

Solution structure of the factor H-binding protein, a survival factor and protective antigen of Neisseria meningitidis.

Cantini F, Veggi D, Dragonetti S, Savino S, Scarselli M, Romagnoli G, Pizza M, Banci L, Rappuoli R.

J Biol Chem. 2009 Apr 3;284(14):9022-6. doi: 10.1074/jbc.C800214200. Epub 2009 Feb 4.

24.

Epitope mapping of a bactericidal monoclonal antibody against the factor H binding protein of Neisseria meningitidis.

Scarselli M, Cantini F, Santini L, Veggi D, Dragonetti S, Donati C, Savino S, Giuliani MM, Comanducci M, Di Marcello F, Romagnoli G, Pizza M, Banci L, Rappuoli R.

J Mol Biol. 2009 Feb 13;386(1):97-108. doi: 10.1016/j.jmb.2008.12.005. Epub 2008 Dec 11.

PMID:
19100746
25.

Factor H-binding protein is important for meningococcal survival in human whole blood and serum and in the presence of the antimicrobial peptide LL-37.

Seib KL, Serruto D, Oriente F, Delany I, Adu-Bobie J, Veggi D, Aricò B, Rappuoli R, Pizza M.

Infect Immun. 2009 Jan;77(1):292-9. doi: 10.1128/IAI.01071-08. Epub 2008 Oct 13.

26.

A universal vaccine for serogroup B meningococcus.

Giuliani MM, Adu-Bobie J, Comanducci M, Aricò B, Savino S, Santini L, Brunelli B, Bambini S, Biolchi A, Capecchi B, Cartocci E, Ciucchi L, Di Marcello F, Ferlicca F, Galli B, Luzzi E, Masignani V, Serruto D, Veggi D, Contorni M, Morandi M, Bartalesi A, Cinotti V, Mannucci D, Titta F, Ovidi E, Welsch JA, Granoff D, Rappuoli R, Pizza M.

Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10834-9. Epub 2006 Jul 6.

27.

Neisseria meningitidis NhhA is a multifunctional trimeric autotransporter adhesin.

Scarselli M, Serruto D, Montanari P, Capecchi B, Adu-Bobie J, Veggi D, Rappuoli R, Pizza M, Aricò B.

Mol Microbiol. 2006 Aug;61(3):631-44. Epub 2006 Jun 27.

28.

Solution structure of the immunodominant domain of protective antigen GNA1870 of Neisseria meningitidis.

Cantini F, Savino S, Scarselli M, Masignani V, Pizza M, Romagnoli G, Swennen E, Veggi D, Banci L, Rappuoli R.

J Biol Chem. 2006 Mar 17;281(11):7220-7. Epub 2005 Dec 31.

29.

In silico identification of novel bacterial ADP-ribosyltransferases.

Masignani V, Balducci E, Serruto D, Veggi D, Aricò B, Comanducci M, Pizza M, Rappuoli R.

Int J Med Microbiol. 2004 Apr;293(7-8):471-8. Review.

PMID:
15149020
30.

NarE: a novel ADP-ribosyltransferase from Neisseria meningitidis.

Masignani V, Balducci E, Di Marcello F, Savino S, Serruto D, Veggi D, Bambini S, Scarselli M, Aricò B, Comanducci M, Adu-Bobie J, Giuliani MM, Rappuoli R, Pizza M.

Mol Microbiol. 2003 Nov;50(3):1055-67.

31.

Reverse vaccinology.

Mora M, Veggi D, Santini L, Pizza M, Rappuoli R.

Drug Discov Today. 2003 May 15;8(10):459-64. Review.

PMID:
12801798
32.

Neisseria meningitidis App, a new adhesin with autocatalytic serine protease activity.

Serruto D, Adu-Bobie J, Scarselli M, Veggi D, Pizza M, Rappuoli R, Aricò B.

Mol Microbiol. 2003 Apr;48(2):323-34.

33.
34.

The contribution of acidic residues to the conformational stability of common-type acylphosphatase.

Paoli P, Taddei N, Fiaschi T, Veggi D, Camici G, Manao G, Raugei G, Chiti F, Ramponi G.

Arch Biochem Biophys. 1999 Mar 15;363(2):349-55.

PMID:
10068458
35.

Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3.

Fiaschi T, Marzella R, Veggi D, Marzocchini R, Raugei G, Rocchi M, Ramponi G.

Cytogenet Cell Genet. 1998;81(3-4):235-6. No abstract available.

PMID:
9730610
36.

The 5'-untranslated region of the human muscle acylphosphatase mRNA has an inhibitory effect on protein expression.

Fiaschi T, Marzocchini R, Raugei G, Veggi D, Chiarugi P, Ramponi G.

FEBS Lett. 1997 Nov 3;417(1):130-4.

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