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Items: 43

1.

Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy.

Trevino MB, Zhang X, Standley RA, Wang M, Han X, Reis FCG, Periasamy M, Yu G, Kelly DP, Goodpaster BH, Vega RB, Coen PM.

Am J Physiol Endocrinol Metab. 2019 Sep 3. doi: 10.1152/ajpendo.00161.2019. [Epub ahead of print]

PMID:
31479303
2.

MondoA drives muscle lipid accumulation and insulin resistance.

Ahn B, Wan S, Jaiswal N, Vega RB, Ayer DE, Titchenell PM, Han X, Won KJ, Kelly DP.

JCI Insight. 2019 Jul 9;5. pii: 129119. doi: 10.1172/jci.insight.129119.

3.

The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.

Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP.

JCI Insight. 2019 Feb 21;4(4). pii: 124079. doi: 10.1172/jci.insight.124079. eCollection 2019 Feb 21.

4.

Furthering Precision Medicine Genomics With Healthy Living Medicine.

Standley RA, Vega RB.

Prog Cardiovasc Dis. 2019 Jan - Feb;62(1):60-67. doi: 10.1016/j.pcad.2018.12.009. Epub 2019 Jan 2. Review.

PMID:
30610883
5.

Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis.

Tamura N, Maejima Y, Matsumura T, Vega RB, Amiya E, Ito Y, Shiheido-Watanabe Y, Ashikaga T, Komuro I, Kelly DP, Hirao K, Isobe M.

Circ Genom Precis Med. 2018 Oct;11(10):e002296. doi: 10.1161/CIRCGEN.118.002296.

6.

Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle.

Maurya SK, Herrera JL, Sahoo SK, Reis FCG, Vega RB, Kelly DP, Periasamy M.

Cell Rep. 2018 Sep 11;24(11):2919-2931. doi: 10.1016/j.celrep.2018.08.036.

7.

Skeletal muscle mitochondrial remodeling in exercise and diseases.

Gan Z, Fu T, Kelly DP, Vega RB.

Cell Res. 2018 Oct;28(10):969-980. doi: 10.1038/s41422-018-0078-7. Epub 2018 Aug 14. Review.

PMID:
30108290
8.

Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice.

Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM.

J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1313-1322. doi: 10.1093/gerona/gly051.

9.

CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice.

Zimmer M, Bista P, Benson EL, Lee DY, Liu F, Picarella D, Vega RB, Vu CB, Yeager M, Ding M, Liang G, Horton JD, Kleemann R, Kooistra T, Morrison MC, Wielinga PY, Milne JC, Jirousek MR, Nichols AJ.

Hepatol Commun. 2017 May 12;1(4):311-325. doi: 10.1002/hep4.1042. eCollection 2017 Jun.

10.

Molecular Mechanisms Underlying Cardiac Adaptation to Exercise.

Vega RB, Konhilas JP, Kelly DP, Leinwand LA.

Cell Metab. 2017 May 2;25(5):1012-1026. doi: 10.1016/j.cmet.2017.04.025. Review.

11.

Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice.

Lee S, Leone TC, Rogosa L, Rumsey J, Ayala J, Coen PM, Fitts RH, Vega RB, Kelly DP.

Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E394-E406. doi: 10.1152/ajpendo.00380.2016. Epub 2017 Mar 7.

12.

Cardiac nuclear receptors: architects of mitochondrial structure and function.

Vega RB, Kelly DP.

J Clin Invest. 2017 Apr 3;127(4):1155-1164. doi: 10.1172/JCI88888. Epub 2017 Feb 13. Review.

13.

Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle.

Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Kong Y, Xie H, Yi F, Lai L, Vega RB, Kelly DP, Smith SR, Gan Z.

J Biol Chem. 2016 Dec 2;291(49):25306-25318. Epub 2016 Oct 13.

14.

Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit.

Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega RB, Zhu MS, Kelly DP, Gao X, Gan Z.

EMBO Mol Med. 2016 Oct 4;8(10):1212-1228. doi: 10.15252/emmm.201606372. Print 2016 Oct.

15.

MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.

Ahn B, Soundarapandian MM, Sessions H, Peddibhotla S, Roth GP, Li JL, Sugarman E, Koo A, Malany S, Wang M, Yea K, Brooks J, Leone TC, Han X, Vega RB, Kelly DP.

J Clin Invest. 2016 Sep 1;126(9):3567-79. doi: 10.1172/JCI87382. Epub 2016 Aug 8.

16.

Mitochondrial protein hyperacetylation in the failing heart.

Horton JL, Martin OJ, Lai L, Riley NM, Richards AL, Vega RB, Leone TC, Pagliarini DJ, Muoio DM, Bedi KC Jr, Margulies KB, Coon JJ, Kelly DP.

JCI Insight. 2016 Feb;2(1). pii: e84897. Epub 2016 Feb 25.

17.

The Failing Heart Relies on Ketone Bodies as a Fuel.

Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Krüger M, Hoppel CL, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP.

Circulation. 2016 Feb 23;133(8):698-705. doi: 10.1161/CIRCULATIONAHA.115.017355. Epub 2016 Jan 27. Erratum in: Circulation. 2018 Oct 9;138(15):e422.

18.

Mitochondrial biogenesis and dynamics in the developing and diseased heart.

Dorn GW 2nd, Vega RB, Kelly DP.

Genes Dev. 2015 Oct 1;29(19):1981-91. doi: 10.1101/gad.269894.115. Review.

19.

Maintaining ancient organelles: mitochondrial biogenesis and maturation.

Vega RB, Horton JL, Kelly DP.

Circ Res. 2015 May 22;116(11):1820-34. doi: 10.1161/CIRCRESAHA.116.305420. Review.

20.

Inhibitors of Myocyte Triacylglyceride Accumulation.

Hershberger PM, Sugarman E, Maloney P, Peddibhotla S, Koo A, Suyama E, Ruidiaz ME, Heynen-Genel S, Nguyen KH, Vasile S, Mangravita-Novo A, Smith LH, Soundarapandian MM, Salaniwal S, Kung P, Vega RB, Chung TDY, Pinkerton AB, Malany S, Kelly DP.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Dec 15 [updated 2015 Feb 11].

21.

Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.

Lai L, Leone TC, Keller MP, Martin OJ, Broman AT, Nigro J, Kapoor K, Koves TR, Stevens R, Ilkayeva OR, Vega RB, Attie AD, Muoio DM, Kelly DP.

Circ Heart Fail. 2014 Nov;7(6):1022-31. doi: 10.1161/CIRCHEARTFAILURE.114.001469. Epub 2014 Sep 18.

22.

A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis.

Lai L, Wang M, Martin OJ, Leone TC, Vega RB, Han X, Kelly DP.

J Biol Chem. 2014 Jan 24;289(4):2250-9. doi: 10.1074/jbc.M113.523654. Epub 2013 Dec 11.

23.

Identification of Inhibitors of triacylglyceride accumulation in muscle cells: comparing HTS results from 1536-well plate-based and high-content platforms.

Sugarman E, Koo A, Suyama E, Ruidiaz ME, Heynen-Genel S, Nguyen KH, Vasile S, Soundarapandian MM, Vega RB, Kelly DP, Smith LH, Malany S.

J Biomol Screen. 2014 Jan;19(1):77-87. doi: 10.1177/1087057113501198. Epub 2013 Aug 29.

24.

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.

Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP.

J Clin Invest. 2013 Jun;123(6):2564-75. doi: 10.1172/JCI67652. Epub 2013 May 8.

25.

Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart.

Aubert G, Vega RB, Kelly DP.

Biochim Biophys Acta. 2013 Apr;1833(4):840-7. doi: 10.1016/j.bbamcr.2012.08.015. Epub 2012 Aug 31. Review.

26.

Transcriptional integration of mitochondrial biogenesis.

Scarpulla RC, Vega RB, Kelly DP.

Trends Endocrinol Metab. 2012 Sep;23(9):459-66. doi: 10.1016/j.tem.2012.06.006. Epub 2012 Jul 18. Review.

27.

3,5-diarylazoles as novel and selective inhibitors of protein kinase D.

Gamber GG, Meredith E, Zhu Q, Yan W, Rao C, Capparelli M, Burgis R, Enyedy I, Zhang JH, Soldermann N, Beattie K, Rozhitskaya O, Koch KA, Pagratis N, Hosagrahara V, Vega RB, McKinsey TA, Monovich L.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1447-51. doi: 10.1016/j.bmcl.2011.01.014. Epub 2011 Jan 11.

PMID:
21300545
28.

Identification of potent and selective amidobipyridyl inhibitors of protein kinase D.

Meredith EL, Beattie K, Burgis R, Capparelli M, Chapo J, Dipietro L, Gamber G, Enyedy I, Hood DB, Hosagrahara V, Jewell C, Koch KA, Lee W, Lemon DD, McKinsey TA, Miranda K, Pagratis N, Phan D, Plato C, Rao C, Rozhitskaya O, Soldermann N, Springer C, van Eis M, Vega RB, Yan W, Zhu Q, Monovich LG.

J Med Chem. 2010 Aug 12;53(15):5422-38. doi: 10.1021/jm100076w.

PMID:
20684592
29.

Identification of orally available naphthyridine protein kinase D inhibitors.

Meredith EL, Ardayfio O, Beattie K, Dobler MR, Enyedy I, Gaul C, Hosagrahara V, Jewell C, Koch K, Lee W, Lehmann H, McKinsey TA, Miranda K, Pagratis N, Pancost M, Patnaik A, Phan D, Plato C, Qian M, Rajaraman V, Rao C, Rozhitskaya O, Ruppen T, Shi J, Siska SJ, Springer C, van Eis M, Vega RB, von Matt A, Yang L, Yoon T, Zhang JH, Zhu N, Monovich LG.

J Med Chem. 2010 Aug 12;53(15):5400-21. doi: 10.1021/jm100075z.

PMID:
20684591
30.

A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase.

Monovich L, Vega RB, Meredith E, Miranda K, Rao C, Capparelli M, Lemon DD, Phan D, Koch KA, Chapo JA, Hood DB, McKinsey TA.

FEBS Lett. 2010 Feb 5;584(3):631-7. doi: 10.1016/j.febslet.2009.12.014. Epub 2009 Dec 14.

31.

Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1.

Monovich L, Koch KA, Burgis R, Osimboni E, Mann T, Wall D, Gao J, Feng Y, Vega RB, Turner BA, Hood DB, Law A, Papst PJ, Koditek D, Chapo JA, Reid BG, Melvin LS, Pagratis NC, McKinsey TA.

Biochim Biophys Acta. 2009 May;1789(5):422-31. doi: 10.1016/j.bbagrm.2009.04.001. Epub 2009 May 3.

PMID:
19414071
32.

Regulation of cardiac stress signaling by protein kinase d1.

Harrison BC, Kim MS, van Rooij E, Plato CF, Papst PJ, Vega RB, McAnally JA, Richardson JA, Bassel-Duby R, Olson EN, McKinsey TA.

Mol Cell Biol. 2006 May;26(10):3875-88.

33.

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.

Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, McAnally J, Pomajzl C, Shelton JM, Richardson JA, Karsenty G, Olson EN.

Cell. 2004 Nov 12;119(4):555-66.

34.

Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5.

Vega RB, Harrison BC, Meadows E, Roberts CR, Papst PJ, Olson EN, McKinsey TA.

Mol Cell Biol. 2004 Oct;24(19):8374-85.

35.

Control of cardiac growth and function by calcineurin signaling.

Vega RB, Bassel-Duby R, Olson EN.

J Biol Chem. 2003 Sep 26;278(39):36981-4. Epub 2003 Jul 24. Review. No abstract available.

36.

The role of modulatory calcineurin-interacting proteins in calcineurin signaling.

Rothermel BA, Vega RB, Williams RS.

Trends Cardiovasc Med. 2003 Jan;13(1):15-21. Review.

PMID:
12554096
37.

Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.

Vega RB, Rothermel BA, Weinheimer CJ, Kovacs A, Naseem RH, Bassel-Duby R, Williams RS, Olson EN.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):669-74. Epub 2003 Jan 6.

38.

Multiple domains of MCIP1 contribute to inhibition of calcineurin activity.

Vega RB, Yang J, Rothermel BA, Bassel-Duby R, Williams RS.

J Biol Chem. 2002 Aug 16;277(33):30401-7. Epub 2002 Jun 12.

39.

Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo.

Rothermel BA, McKinsey TA, Vega RB, Nicol RL, Mammen P, Yang J, Antos CL, Shelton JM, Bassel-Duby R, Olson EN, Williams RS.

Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3328-33.

40.

A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling.

Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, Williams RS.

J Biol Chem. 2000 Mar 24;275(12):8719-25.

42.

Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles.

Yang J, Rothermel B, Vega RB, Frey N, McKinsey TA, Olson EN, Bassel-Duby R, Williams RS.

Circ Res. 2000 Dec 8;87(12):E61-8.

PMID:
11110780

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