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Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization.

Parks KR, MacCamy AJ, Trichka J, Gray M, Weidle C, Borst AJ, Khechaduri A, Takushi B, Agrawal P, Guenaga J, Wyatt RT, Coler R, Seaman M, LaBranche C, Montefiori DC, Veesler D, Pancera M, McGuire A, Stamatatos L.

Cell Rep. 2019 Dec 3;29(10):3060-3072.e7. doi: 10.1016/j.celrep.2019.10.071.


Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors.

Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, Bosch BJ, DiMaio F, Veesler D.

Nat Struct Mol Biol. 2019 Dec;26(12):1151-1157. doi: 10.1038/s41594-019-0334-7. Epub 2019 Dec 2.


A Cross-Reactive Humanized Monoclonal Antibody Targeting Fusion Glycoprotein Function Protects Ferrets Against Lethal Nipah Virus and Hendra Virus Infection.

Mire CE, Chan YP, Borisevich V, Cross RW, Yan L, Agans KN, Dang HV, Veesler D, Fenton KA, Geisbert TW, Broder CC.

J Infect Dis. 2019 Nov 4. pii: jiz515. doi: 10.1093/infdis/jiz515. [Epub ahead of print]


An antibody against the F glycoprotein inhibits Nipah and Hendra virus infections.

Dang HV, Chan YP, Park YJ, Snijder J, Da Silva SC, Vu B, Yan L, Feng YR, Rockx B, Geisbert TW, Mire CE, Broder CC, Veesler D.

Nat Struct Mol Biol. 2019 Oct;26(10):980-987. doi: 10.1038/s41594-019-0308-9. Epub 2019 Sep 30.


Structural insights into coronavirus entry.

Tortorici MA, Veesler D.

Adv Virus Res. 2019;105:93-116. doi: 10.1016/bs.aivir.2019.08.002. Epub 2019 Aug 22.


Structural basis for human coronavirus attachment to sialic acid receptors.

Tortorici MA, Walls AC, Lang Y, Wang C, Li Z, Koerhuis D, Boons GJ, Bosch BJ, Rey FA, de Groot RJ, Veesler D.

Nat Struct Mol Biol. 2019 Jun;26(6):481-489. doi: 10.1038/s41594-019-0233-y. Epub 2019 Jun 3.


Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus.

Marcandalli J, Fiala B, Ols S, Perotti M, de van der Schueren W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, Sallusto F, Lee KK, Veesler D, Correnti CE, Stewart LJ, Baker D, Loré K, Perez L, King NP.

Cell. 2019 Mar 7;176(6):1420-1431.e17. doi: 10.1016/j.cell.2019.01.046.


Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion.

Walls AC, Xiong X, Park YJ, Tortorici MA, Snijder J, Quispe J, Cameroni E, Gopal R, Dai M, Lanzavecchia A, Zambon M, Rey FA, Corti D, Veesler D.

Cell. 2019 Feb 21;176(5):1026-1039.e15. doi: 10.1016/j.cell.2018.12.028. Epub 2019 Jan 31.


Structure of the type VI secretion system TssK-TssF-TssG baseplate subcomplex revealed by cryo-electron microscopy.

Park YJ, Lacourse KD, Cambillau C, DiMaio F, Mougous JD, Veesler D.

Nat Commun. 2018 Dec 19;9(1):5385. doi: 10.1038/s41467-018-07796-5.


Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core.

Borst AJ, Weidle CE, Gray MD, Frenz B, Snijder J, Joyce MG, Georgiev IS, Stewart-Jones GB, Kwong PD, McGuire AT, DiMaio F, Stamatatos L, Pancera M, Veesler D.

Elife. 2018 Nov 7;7. pii: e37688. doi: 10.7554/eLife.37688.


Automatically Fixing Errors in Glycoprotein Structures with Rosetta.

Frenz B, Rämisch S, Borst AJ, Walls AC, Adolf-Bryfogle J, Schief WR, Veesler D, DiMaio F.

Structure. 2019 Jan 2;27(1):134-139.e3. doi: 10.1016/j.str.2018.09.006. Epub 2018 Oct 18.


Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins.

Ting SY, Bosch DE, Mangiameli SM, Radey MC, Huang S, Park YJ, Kelly KA, Filip SK, Goo YA, Eng JK, Allaire M, Veesler D, Wiggins PA, Peterson SB, Mougous JD.

Cell. 2018 Nov 15;175(5):1380-1392.e14. doi: 10.1016/j.cell.2018.09.037. Epub 2018 Oct 18.


An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus.

Snijder J, Ortego MS, Weidle C, Stuart AB, Gray MD, McElrath MJ, Pancera M, Veesler D, McGuire AT.

Immunity. 2018 Apr 17;48(4):799-811.e9. doi: 10.1016/j.immuni.2018.03.026.


Allosteric effects in bacteriophage HK97 procapsids revealed directly from covariance analysis of cryo EM data.

Xu N, Veesler D, Doerschuk PC, Johnson JE.

J Struct Biol. 2018 May;202(2):129-141. doi: 10.1016/j.jsb.2017.12.013. Epub 2018 Jan 10.


Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections.

Xiong X, Tortorici MA, Snijder J, Yoshioka C, Walls AC, Li W, McGuire AT, Rey FA, Bosch BJ, Veesler D.

J Virol. 2018 Jan 30;92(4). pii: e01628-17. doi: 10.1128/JVI.01628-17. Print 2018 Feb 15.


Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion.

Walls AC, Tortorici MA, Snijder J, Xiong X, Bosch BJ, Rey FA, Veesler D.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11157-11162. doi: 10.1073/pnas.1708727114. Epub 2017 Oct 3.


The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human αVβ3 Integrin via Steric Hindrance.

Borst AJ, James ZM, Zagotta WN, Ginsberg M, Rey FA, DiMaio F, Backovic M, Veesler D.

Structure. 2017 Nov 7;25(11):1732-1739.e5. doi: 10.1016/j.str.2017.09.007. Epub 2017 Oct 12.


Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity.

Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD.

Elife. 2017 Oct 2;6. pii: e30872. doi: 10.7554/eLife.30872.


Local protein kinase A action proceeds through intact holoenzymes.

Smith FD, Esseltine JL, Nygren PJ, Veesler D, Byrne DP, Vonderach M, Strashnov I, Eyers CE, Eyers PA, Langeberg LK, Scott JD.

Science. 2017 Jun 23;356(6344):1288-1293. doi: 10.1126/science.aaj1669.


RosettaES: a sampling strategy enabling automated interpretation of difficult cryo-EM maps.

Frenz B, Walls AC, Egelman EH, Veesler D, DiMaio F.

Nat Methods. 2017 Aug;14(8):797-800. doi: 10.1038/nmeth.4340. Epub 2017 Jun 19.


Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses.

Yu X, Veesler D, Campbell MG, Barry ME, Asturias FJ, Barry MA, Reddy VS.

Sci Adv. 2017 May 10;3(5):e1602670. doi: 10.1126/sciadv.1602670. eCollection 2017 May.


CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel.

James ZM, Borst AJ, Haitin Y, Frenz B, DiMaio F, Zagotta WN, Veesler D.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4430-4435. doi: 10.1073/pnas.1700248114. Epub 2017 Apr 10.


Vitrification after multiple rounds of sample application and blotting improves particle density on cryo-electron microscopy grids.

Snijder J, Borst AJ, Dosey A, Walls AC, Burrell A, Reddy VS, Kollman JM, Veesler D.

J Struct Biol. 2017 Apr;198(1):38-42. doi: 10.1016/j.jsb.2017.02.008. Epub 2017 Feb 22.


Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth.

Eshraghi A, Kim J, Walls AC, Ledvina HE, Miller CN, Ramsey KM, Whitney JC, Radey MC, Peterson SB, Ruhland BR, Tran BQ, Goo YA, Goodlett DR, Dove SL, Celli J, Veesler D, Mougous JD.

Cell Host Microbe. 2016 Nov 9;20(5):573-583. doi: 10.1016/j.chom.2016.10.008.


Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo-electron microscopy.

Walls A, Tortorici MA, Bosch BJ, Frenz B, Rottier PJ, DiMaio F, Rey FA, Veesler D.

Protein Sci. 2017 Jan;26(1):113-121. doi: 10.1002/pro.3048. Epub 2016 Oct 18.


Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy.

Walls AC, Tortorici MA, Frenz B, Snijder J, Li W, Rey FA, DiMaio F, Bosch BJ, Veesler D.

Nat Struct Mol Biol. 2016 Oct;23(10):899-905. doi: 10.1038/nsmb.3293. Epub 2016 Sep 12.


Role of bacteriophage T4 baseplate in regulating assembly and infection.

Yap ML, Klose T, Arisaka F, Speir JA, Veesler D, Fokine A, Rossmann MG.

Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2654-9. doi: 10.1073/pnas.1601654113. Epub 2016 Feb 29.


Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer.

Walls AC, Tortorici MA, Bosch BJ, Frenz B, Rottier PJM, DiMaio F, Rey FA, Veesler D.

Nature. 2016 Mar 3;531(7592):114-117. doi: 10.1038/nature16988. Epub 2016 Feb 8.


Effect of the viral protease on the dynamics of bacteriophage HK97 maturation intermediates characterized by variance analysis of cryo EM particle ensembles.

Gong Y, Veesler D, Doerschuk PC, Johnson JE.

J Struct Biol. 2016 Mar;193(3):188-195. doi: 10.1016/j.jsb.2015.12.012. Epub 2015 Dec 24.


2.8 Å resolution reconstruction of the Thermoplasma acidophilum 20S proteasome using cryo-electron microscopy.

Campbell MG, Veesler D, Cheng A, Potter CS, Carragher B.

Elife. 2015 Mar 11;4. doi: 10.7554/eLife.06380.


Near-atomic resolution reconstructions using a mid-range electron microscope operated at 200 kV.

Campbell MG, Kearney BM, Cheng A, Potter CS, Johnson JE, Carragher B, Veesler D.

J Struct Biol. 2014 Nov;188(2):183-7. Epub 2014 Sep 30.


Single-particle EM reveals plasticity of interactions between the adenovirus penton base and integrin αVβ3.

Veesler D, Cupelli K, Burger M, Gräber P, Stehle T, Johnson JE.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8815-9. doi: 10.1073/pnas.1404575111. Epub 2014 Jun 2.


Structures and host-adhesion mechanisms of lactococcal siphophages.

Spinelli S, Veesler D, Bebeacua C, Cambillau C.

Front Microbiol. 2014 Jan 16;5:3. doi: 10.3389/fmicb.2014.00003. eCollection 2014. Review.


Distinguishing direct binding interactions from allosteric effects in the protease-HK97 prohead I δ domain complex by amide H/D exchange mass spectrometry.

Krishnamurthy S, Veesler D, Khayat R, Snijder J, Huang R, Heck A, Johnson J, Anand GS.

Bacteriophage. 2014 Dec 16;4(4):e959816. eCollection 2014.


Architecture of a dsDNA viral capsid in complex with its maturation protease.

Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE.

Structure. 2014 Feb 4;22(2):230-7. doi: 10.1016/j.str.2013.11.007. Epub 2013 Dec 19.


Maximizing the potential of electron cryomicroscopy data collected using direct detectors.

Veesler D, Campbell MG, Cheng A, Fu CY, Murez Z, Johnson JE, Potter CS, Carragher B.

J Struct Biol. 2013 Nov;184(2):193-202. doi: 10.1016/j.jsb.2013.09.003. Epub 2013 Sep 12.


Structure, adsorption to host, and infection mechanism of virulent lactococcal phage p2.

Bebeacua C, Tremblay D, Farenc C, Chapot-Chartier MP, Sadovskaya I, van Heel M, Veesler D, Moineau S, Cambillau C.

J Virol. 2013 Nov;87(22):12302-12. doi: 10.1128/JVI.02033-13. Epub 2013 Sep 11.


Cystovirus maturation at atomic resolution.

Veesler D, Johnson JE.

Structure. 2013 Aug 6;21(8):1266-8. doi: 10.1016/j.str.2013.07.009.


Structure and functional analysis of the host recognition device of lactococcal phage tuc2009.

Collins B, Bebeacua C, Mahony J, Blangy S, Douillard FP, Veesler D, Cambillau C, van Sinderen D.

J Virol. 2013 Aug;87(15):8429-40. doi: 10.1128/JVI.00907-13. Epub 2013 May 22.


Viral infection modulation and neutralization by camelid nanobodies.

Desmyter A, Farenc C, Mahony J, Spinelli S, Bebeacua C, Blangy S, Veesler D, van Sinderen D, Cambillau C.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1371-9. doi: 10.1073/pnas.1301336110. Epub 2013 Mar 25.


Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography.

Veesler D, Ng TS, Sendamarai AK, Eilers BJ, Lawrence CM, Lok SM, Young MJ, Johnson JE, Fu CY.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5504-9. doi: 10.1073/pnas.1300601110. Epub 2013 Mar 21.


Studying 18 MDa virus assemblies with native mass spectrometry.

Snijder J, Rose RJ, Veesler D, Johnson JE, Heck AJ.

Angew Chem Int Ed Engl. 2013 Apr 2;52(14):4020-3. doi: 10.1002/anie.201210197. Epub 2013 Feb 28. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2014 Mar 17;53(12):3051.


Visualizing a complete Siphoviridae member by single-particle electron microscopy: the structure of lactococcal phage TP901-1.

Bebeacua C, Lai L, Vegge CS, Brøndsted L, van Heel M, Veesler D, Cambillau C.

J Virol. 2013 Jan;87(2):1061-8. doi: 10.1128/JVI.02836-12. Epub 2012 Nov 7.


Movies of ice-embedded particles enhance resolution in electron cryo-microscopy.

Campbell MG, Cheng A, Brilot AF, Moeller A, Lyumkis D, Veesler D, Pan J, Harrison SC, Potter CS, Carragher B, Grigorieff N.

Structure. 2012 Nov 7;20(11):1823-8. doi: 10.1016/j.str.2012.08.026. Epub 2012 Sep 27.


Maturation in action: CryoEM study of a viral capsid caught during expansion.

Veesler D, Quispe J, Grigorieff N, Potter CS, Carragher B, Johnson JE.

Structure. 2012 Aug 8;20(8):1384-90. doi: 10.1016/j.str.2012.05.011. Epub 2012 Jun 28.


Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism.

Veesler D, Spinelli S, Mahony J, Lichière J, Blangy S, Bricogne G, Legrand P, Ortiz-Lombardia M, Campanacci V, van Sinderen D, Cambillau C.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8954-8. doi: 10.1073/pnas.1200966109. Epub 2012 May 18.


Virus maturation.

Veesler D, Johnson JE.

Annu Rev Biophys. 2012;41:473-96. doi: 10.1146/annurev-biophys-042910-155407. Epub 2012 Feb 23. Review.


A common evolutionary origin for tailed-bacteriophage functional modules and bacterial machineries.

Veesler D, Cambillau C.

Microbiol Mol Biol Rev. 2011 Sep;75(3):423-33, first page of table of contents. doi: 10.1128/MMBR.00014-11. Review.


Unraveling lactococcal phage baseplate assembly by mass spectrometry.

Shepherd DA, Veesler D, Lichière J, Ashcroft AE, Cambillau C.

Mol Cell Proteomics. 2011 Sep;10(9):M111.009787. doi: 10.1074/mcp.M111.009787. Epub 2011 Jun 6.


The opening of the SPP1 bacteriophage tail, a prevalent mechanism in Gram-positive-infecting siphophages.

Goulet A, Lai-Kee-Him J, Veesler D, Auzat I, Robin G, Shepherd DA, Ashcroft AE, Richard E, Lichière J, Tavares P, Cambillau C, Bron P.

J Biol Chem. 2011 Jul 15;286(28):25397-405. doi: 10.1074/jbc.M111.243360. Epub 2011 May 26.

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