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Items: 23

1.

FDA Approval Summary: Pembrolizumab for Recurrent Locally Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing PD-L1.

Fashoyin-Aje L, Donoghue M, Chen H, He K, Veeraraghavan J, Goldberg KB, Keegan P, McKee AE, Pazdur R.

Oncologist. 2018 Aug 17. pii: theoncologist.2018-0221. doi: 10.1634/theoncologist.2018-0221. [Epub ahead of print]

PMID:
30120163
2.

De-escalation of treatment in HER2-positive breast cancer: Determinants of response and mechanisms of resistance.

Veeraraghavan J, De Angelis C, Reis-Filho JS, Pascual T, Prat A, Rimawi MF, Osborne CK, Schiff R.

Breast. 2017 Aug;34 Suppl 1:S19-S26. doi: 10.1016/j.breast.2017.06.022. Epub 2017 Jul 4. Review.

3.

HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer.

Xu X, De Angelis C, Burke KA, Nardone A, Hu H, Qin L, Veeraraghavan J, Sethunath V, Heiser LM, Wang N, Ng CKY, Chen ES, Renwick A, Wang T, Nanda S, Shea M, Mitchell T, Rajendran M, Waters I, Zabransky DJ, Scott KL, Gutierrez C, Nagi C, Geyer FC, Chamness GC, Park BH, Shaw CA, Hilsenbeck SG, Rimawi MF, Gray JW, Weigelt B, Reis-Filho JS, Osborne CK, Schiff R.

Clin Cancer Res. 2017 Sep 1;23(17):5123-5134. doi: 10.1158/1078-0432.CCR-16-2191. Epub 2017 May 9.

PMID:
28487443
4.

Comprehensive functional analysis of the tousled-like kinase 2 frequently amplified in aggressive luminal breast cancers.

Kim JA, Tan Y, Wang X, Cao X, Veeraraghavan J, Liang Y, Edwards DP, Huang S, Pan X, Li K, Schiff R, Wang XS.

Nat Commun. 2016 Oct 3;7:12991. doi: 10.1038/ncomms12991.

5.

Amplification of TLK2 Induces Genomic Instability via Impairing the G2-M Checkpoint.

Kim JA, Anurag M, Veeraraghavan J, Schiff R, Li K, Wang XS.

Mol Cancer Res. 2016 Oct;14(10):920-927. Epub 2016 Aug 3.

6.

Recurrent and pathological gene fusions in breast cancer: current advances in genomic discovery and clinical implications.

Veeraraghavan J, Ma J, Hu Y, Wang XS.

Breast Cancer Res Treat. 2016 Jul;158(2):219-32. doi: 10.1007/s10549-016-3876-y. Epub 2016 Jul 2. Review.

7.

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease.

Southwell AL, Franciosi S, Villanueva EB, Xie Y, Winter LA, Veeraraghavan J, Jonason A, Felczak B, Zhang W, Kovalik V, Waltl S, Hall G, Pouladi MA, Smith ES, Bowers WJ, Zauderer M, Hayden MR.

Neurobiol Dis. 2015 Apr;76:46-56. doi: 10.1016/j.nbd.2015.01.002. Epub 2015 Feb 3.

8.

Antibody Blockade of Semaphorin 4D Promotes Immune Infiltration into Tumor and Enhances Response to Other Immunomodulatory Therapies.

Evans EE, Jonason AS Jr, Bussler H, Torno S, Veeraraghavan J, Reilly C, Doherty MA, Seils J, Winter LA, Mallow C, Kirk R, Howell A, Giralico S, Scrivens M, Klimatcheva K, Fisher TL, Bowers WJ, Paris M, Smith ES, Zauderer M.

Cancer Immunol Res. 2015 Jun;3(6):689-701. doi: 10.1158/2326-6066.CIR-14-0171. Epub 2015 Jan 22.

9.

SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease.

Smith ES, Jonason A, Reilly C, Veeraraghavan J, Fisher T, Doherty M, Klimatcheva E, Mallow C, Cornelius C, Leonard JE, Marchi N, Janigro D, Argaw AT, Pham T, Seils J, Bussler H, Torno S, Kirk R, Howell A, Evans EE, Paris M, Bowers WJ, John G, Zauderer M.

Neurobiol Dis. 2015 Jan;73:254-68. doi: 10.1016/j.nbd.2014.10.008. Epub 2014 Oct 18.

10.

Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers.

Veeraraghavan J, Tan Y, Cao XX, Kim JA, Wang X, Chamness GC, Maiti SN, Cooper LJ, Edwards DP, Contreras A, Hilsenbeck SG, Chang EC, Schiff R, Wang XS.

Nat Commun. 2014 Aug 7;5:4577. doi: 10.1038/ncomms5577.

11.

Irreversible EGFR inhibitor EKB-569 targets low-LET γ-radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma.

Aravindan N, Thomas CR Jr, Aravindan S, Mohan AS, Veeraraghavan J, Natarajan M.

PLoS One. 2011;6(12):e29705. doi: 10.1371/journal.pone.0029705. Epub 2011 Dec 29.

12.

Impact of curcumin, raspberry extract, and neem leaf extract on rel protein-regulated cell death/radiosensitization in pancreatic cancer cells.

Veeraraghavan J, Natarajan M, Lagisetty P, Awasthi V, Herman TS, Aravindan N.

Pancreas. 2011 Oct;40(7):1107-19. doi: 10.1097/MPA.0b013e31821f677d.

PMID:
21697760
13.

Radiation-triggered tumor necrosis factor (TNF) alpha-NFkappaB cross-signaling favors survival advantage in human neuroblastoma cells.

Veeraraghavan J, Natarajan M, Aravindan S, Herman TS, Aravindan N.

J Biol Chem. 2011 Jun 17;286(24):21588-600. doi: 10.1074/jbc.M110.193755. Epub 2011 Apr 28.

14.

Neem leaf extract induces radiosensitization in human neuroblastoma xenograft through modulation of apoptotic pathway.

Veeraraghavan J, Aravindan S, Natarajan M, Awasthi V, Herman TS, Aravindan N.

Anticancer Res. 2011 Jan;31(1):161-70.

PMID:
21273594
15.

Curcumin regulates low-linear energy transfer γ-radiation-induced NFκB-dependent telomerase activity in human neuroblastoma cells.

Aravindan N, Veeraraghavan J, Madhusoodhanan R, Herman TS, Natarajan M.

Int J Radiat Oncol Biol Phys. 2011 Mar 15;79(4):1206-15. doi: 10.1016/j.ijrobp.2010.10.058. Epub 2011 Jan 13.

16.

Low-dose γ-radiation-induced oxidative stress response in mouse brain and gut: regulation by NFκB-MnSOD cross-signaling.

Veeraraghavan J, Natarajan M, Herman TS, Aravindan N.

Mutat Res. 2011 Jan 10;718(1-2):44-55. doi: 10.1016/j.mrgentox.2010.10.006. Epub 2010 Nov 4.

PMID:
21056117
17.

Curcumin-altered p53-response genes regulate radiosensitivity in p53-mutant Ewing's sarcoma cells.

Veeraraghavan J, Natarajan M, Herman TS, Aravindan N.

Anticancer Res. 2010 Oct;30(10):4007-15.

PMID:
21036715
18.

NFkappaB signaling related molecular alterations in human neuroblastoma cells after fractionated irradiation.

Madhusoodhanan R, Natarajan M, Veeraraghavan J, Herman TS, Jamgade A, Singh N, Aravindan N.

J Radiat Res. 2009 Jul;50(4):311-24. Epub 2009 May 12.

19.

NFkappaB activity and transcriptional responses in human breast adenocarcinoma cells after single and fractionated irradiation.

Madhusoodhanan R, Natarajan M, Veeraraghavan J, Herman TS, Aravindan N.

Cancer Biol Ther. 2009 May;8(9):765-73. Epub 2009 May 9.

PMID:
19276662
20.

Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability.

Liu Y, Zhang H, Veeraraghavan J, Bambara RA, Freudenreich CH.

Mol Cell Biol. 2004 May;24(9):4049-64.

21.

On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing.

Kao HI, Veeraraghavan J, Polaczek P, Campbell JL, Bambara RA.

J Biol Chem. 2004 Apr 9;279(15):15014-24. Epub 2004 Jan 26.

22.

Analysis of DNA replication intermediates suggests mechanisms of repeat sequence expansion.

Veeraraghavan J, Rossi ML, Bambara RA.

J Biol Chem. 2003 Oct 31;278(44):42854-66. Epub 2003 Aug 5.

23.

DNA ligase I competes with FEN1 to expand repetitive DNA sequences in vitro.

Henricksen LA, Veeraraghavan J, Chafin DR, Bambara RA.

J Biol Chem. 2002 Jun 21;277(25):22361-9. Epub 2002 Apr 10.

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