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Items: 50

1.

Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma.

Melo AM, O'Brien AM, Phelan JJ, Kennedy SA, Wood NAW, Veerapen N, Besra GS, Clarke NE, Foley EK, Ravi A, MacCarthy F, O'Toole D, Ravi N, Reynolds JV, Conroy MJ, Hogan AE, O'Sullivan J, Dunne MR.

Front Immunol. 2019 Jul 10;10:1580. doi: 10.3389/fimmu.2019.01580. eCollection 2019.

2.

The hydrolase LpqI primes mycobacterial peptidoglycan recycling.

Moynihan PJ, Cadby IT, Veerapen N, Jankute M, Crosatti M, Mukamolova GV, Lovering AL, Besra GS.

Nat Commun. 2019 Jun 14;10(1):2647. doi: 10.1038/s41467-019-10586-2.

3.

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses.

O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D, Hogan AE.

J Immunol. 2019 Jun 15;202(12):3404-3411. doi: 10.4049/jimmunol.1801600. Epub 2019 May 10.

PMID:
31076528
4.

Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.

Chandra S, Gray J, Kiosses WB, Khurana A, Hitomi K, Crosby CM, Chawla A, Fu Z, Zhao M, Veerapen N, Richardson SK, Porcelli SA, Besra G, Howell AR, Sharma S, Peters B, Kronenberg M.

Nat Commun. 2018 Oct 15;9(1):4279. doi: 10.1038/s41467-018-06646-8.

5.

Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1.

Richter A, Rudolph I, Möllmann U, Voigt K, Chung CW, Singh OMP, Rees M, Mendoza-Losana A, Bates R, Ballell L, Batt S, Veerapen N, Fütterer K, Besra G, Imming P, Argyrou A.

Sci Rep. 2018 Sep 7;8(1):13473. doi: 10.1038/s41598-018-31316-6.

6.

Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation.

Veerapen N, Kharkwal SS, Jervis P, Bhowruth V, Besra AK, North SJ, Haslam SM, Dell A, Hobrath J, Quaid PJ, Moynihan PJ, Cox LR, Kharkwal H, Zauderer M, Besra GS, Porcelli SA.

Bioconjug Chem. 2018 Sep 19;29(9):3161-3173. doi: 10.1021/acs.bioconjchem.8b00484. Epub 2018 Aug 23.

PMID:
30085659
7.

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function.

Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1204-E1213. doi: 10.1073/pnas.1716669115. Epub 2018 Jan 19.

8.

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A.

Howson LJ, Napolitani G, Shepherd D, Ghadbane H, Kurupati P, Preciado-Llanes L, Rei M, Dobinson HC, Gibani MM, Teng KWW, Newell EW, Veerapen N, Besra GS, Pollard AJ, Cerundolo V.

Nat Commun. 2018 Jan 17;9(1):253. doi: 10.1038/s41467-017-02540-x.

9.

Visualising the global structure of search landscapes: genetic improvement as a case study.

Veerapen N, Ochoa G.

Genet Program Evolvable Mach. 2018;19(3):317-349. doi: 10.1007/s10710-018-9328-1. Epub 2018 Aug 6.

10.

Activation of Human Mucosal-Associated Invariant T Cells Induces CD40L-Dependent Maturation of Monocyte-Derived and Primary Dendritic Cells.

Salio M, Gasser O, Gonzalez-Lopez C, Martens A, Veerapen N, Gileadi U, Verter JG, Napolitani G, Anderson R, Painter G, Besra GS, Hermans IF, Cerundolo V.

J Immunol. 2017 Oct 15;199(8):2631-2638. doi: 10.4049/jimmunol.1700615. Epub 2017 Sep 6.

11.

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface.

Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8348-8353. doi: 10.1073/pnas.1705882114. Epub 2017 Jul 17.

12.

Disruption of Mycobacterial AftB Results in Complete Loss of Terminal β(1 → 2) Arabinofuranose Residues of Lipoarabinomannan.

Jankute M, Alderwick LJ, Noack S, Veerapen N, Nigou J, Besra GS.

ACS Chem Biol. 2017 Jan 20;12(1):183-190. doi: 10.1021/acschembio.6b00898. Epub 2016 Dec 5.

13.

Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis.

Singh A, Varela C, Bhatt K, Veerapen N, Lee OY, Wu HH, Besra GS, Minnikin DE, Fujiwara N, Teramoto K, Bhatt A.

PLoS One. 2016 Oct 14;11(10):e0164253. doi: 10.1371/journal.pone.0164253. eCollection 2016.

14.

Cognate interaction with iNKT cells expands IL-10-producing B regulatory cells.

Vomhof-DeKrey EE, Yates J, Hägglöf T, Lanthier P, Amiel E, Veerapen N, Besra GS, Karlsson MC, Leadbetter EA.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12474-9. doi: 10.1073/pnas.1504790112. Epub 2015 Sep 21.

15.

MKAN27435 is required for the biosynthesis of higher subclasses of lipooligosaccharides in Mycobacterium kansasii.

Nataraj V, Pang PC, Haslam SM, Veerapen N, Minnikin DE, Dell A, Besra GS, Bhatt A.

PLoS One. 2015 Apr 20;10(3):e0122804. doi: 10.1371/journal.pone.0122804. eCollection 2015.

16.

Essential role for autophagy during invariant NKT cell development.

Salio M, Puleston DJ, Mathan TS, Shepherd D, Stranks AJ, Adamopoulou E, Veerapen N, Besra GS, Hollander GA, Simon AK, Cerundolo V.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5678-87. doi: 10.1073/pnas.1413935112. Epub 2014 Dec 15.

17.

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction.

Brennan PJ, Tatituri RV, Heiss C, Watts GF, Hsu FF, Veerapen N, Cox LR, Azadi P, Besra GS, Brenner MB.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13433-8. doi: 10.1073/pnas.1415357111. Epub 2014 Sep 2.

18.

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate.

Khanim F, Davies N, Veliça P, Hayden R, Ride J, Pararasa C, Chong MG, Gunther U, Veerapen N, Winn P, Farmer R, Trivier E, Rigoreau L, Drayson M, Bunce C.

Br J Cancer. 2014 Mar 18;110(6):1506-16. doi: 10.1038/bjc.2014.83. Epub 2014 Feb 25.

19.

A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens.

Arora P, Baena A, Yu KO, Saini NK, Kharkwal SS, Goldberg MF, Kunnath-Velayudhan S, Carreño LJ, Venkataswamy MM, Kim J, Lazar-Molnar E, Lauvau G, Chang YT, Liu Z, Bittman R, Al-Shamkhani A, Cox LR, Jervis PJ, Veerapen N, Besra GS, Porcelli SA.

Immunity. 2014 Jan 16;40(1):105-16. doi: 10.1016/j.immuni.2013.12.004. Epub 2014 Jan 9.

20.

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.

Salio M, Ghadbane H, Dushek O, Shepherd D, Cypen J, Gileadi U, Aichinger MC, Napolitani G, Qi X, van der Merwe PA, Wojno J, Veerapen N, Cox LR, Besra GS, Yuan W, Cresswell P, Cerundolo V.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4753-61. doi: 10.1073/pnas.1310050110. Epub 2013 Nov 18.

21.

Expression of CD1c enhances human invariant NKT cell activation by α-GalCer.

Fox LM, Miksanek J, May NA, Scharf L, Lockridge JL, Veerapen N, Besra GS, Adams EJ, Hudson AW, Gumperz JE.

Cancer Immun. 2013 May 10;13:9. Print 2013.

22.

The mechanism of splenic invariant NKT cell activation dictates localization in vivo.

King IL, Amiel E, Tighe M, Mohrs K, Veerapen N, Besra G, Mohrs M, Leadbetter EA.

J Immunol. 2013 Jul 15;191(2):572-82. doi: 10.4049/jimmunol.1300299. Epub 2013 Jun 19.

23.

Endoplasmic reticulum glycoprotein quality control regulates CD1d assembly and CD1d-mediated antigen presentation.

Kunte A, Zhang W, Paduraru C, Veerapen N, Cox LR, Besra GS, Cresswell P.

J Biol Chem. 2013 Jun 7;288(23):16391-402. doi: 10.1074/jbc.M113.474221. Epub 2013 Apr 24.

24.

Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.

Paduraru C, Bezbradica JS, Kunte A, Kelly R, Shayman JA, Veerapen N, Cox LR, Besra GS, Cresswell P.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5097-102. doi: 10.1073/pnas.1302923110. Epub 2013 Mar 14.

25.

SAP expression in invariant NKT cells is required for cognate help to support B-cell responses.

Detre C, Keszei M, Garrido-Mesa N, Kis-Toth K, Castro W, Agyemang AF, Veerapen N, Besra GS, Carroll MC, Tsokos GC, Wang N, Leadbetter EA, Terhorst C.

Blood. 2012 Jul 5;120(1):122-9. doi: 10.1182/blood-2011-11-395913. Epub 2012 May 21.

26.

Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.

Speak AO, Platt N, Salio M, te Vruchte D, Smith DA, Shepherd D, Veerapen N, Besra GS, Yanjanin NM, Simmons L, Imrie J, Wraith JE, Lachmann RH, Hartung R, Runz H, Mengel E, Beck M, Hendriksz CJ, Porter FD, Cerundolo V, Platt FM.

Eur J Immunol. 2012 Jul;42(7):1886-92. doi: 10.1002/eji.201141821. Epub 2012 Jun 14.

27.

Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.

León L, Tatituri RV, Grenha R, Sun Y, Barral DC, Minnaard AJ, Bhowruth V, Veerapen N, Besra GS, Kasmar A, Peng W, Moody DB, Grabowski GA, Brenner MB.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4357-64. doi: 10.1073/pnas.1200764109. Epub 2012 Feb 13.

28.

Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner.

King IL, Fortier A, Tighe M, Dibble J, Watts GF, Veerapen N, Haberman AM, Besra GS, Mohrs M, Brenner MB, Leadbetter EA.

Nat Immunol. 2011 Nov 27;13(1):44-50. doi: 10.1038/ni.2172.

29.

Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.

Muppidi JR, Arnon TI, Bronevetsky Y, Veerapen N, Tanaka M, Besra GS, Cyster JG.

J Exp Med. 2011 Sep 26;208(10):1941-8. doi: 10.1084/jem.20111083. Epub 2011 Aug 29.

30.

Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.

Garg S, Sharma M, Ung C, Tuli A, Barral DC, Hava DL, Veerapen N, Besra GS, Hacohen N, Brenner MB.

Immunity. 2011 Aug 26;35(2):182-93. doi: 10.1016/j.immuni.2011.06.009. Epub 2011 Jul 28.

31.

A rapid fluorescence-based assay for classification of iNKT cell activating glycolipids.

Arora P, Venkataswamy MM, Baena A, Bricard G, Li Q, Veerapen N, Ndonye R, Park JJ, Lee JH, Seo KC, Howell AR, Chang YT, Illarionov PA, Besra GS, Chung SK, Porcelli SA.

J Am Chem Soc. 2011 Apr 13;133(14):5198-201. doi: 10.1021/ja200070u. Epub 2011 Mar 22.

32.

Stimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes.

Tohn R, Blumenfeld H, Haeryfar SM, Veerapen N, Besra GS, Porcelli SA, Delovitch TL.

Clin Exp Immunol. 2011 Apr;164(1):26-41. doi: 10.1111/j.1365-2249.2011.04323.x. Epub 2011 Mar 1.

33.

Α-galactosylceramide analogs with weak agonist activity for human iNKT cells define new candidate anti-inflammatory agents.

Bricard G, Venkataswamy MM, Yu KO, Im JS, Ndonye RM, Howell AR, Veerapen N, Illarionov PA, Besra GS, Li Q, Chang YT, Porcelli SA.

PLoS One. 2010 Dec 17;5(12):e14374. doi: 10.1371/journal.pone.0014374.

34.

Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation.

Veerapen N, Reddington F, Salio M, Cerundolo V, Besra GS.

Bioorg Med Chem. 2011 Jan 1;19(1):221-8. doi: 10.1016/j.bmc.2010.11.032. Epub 2010 Nov 19.

35.

Calreticulin controls the rate of assembly of CD1d molecules in the endoplasmic reticulum.

Zhu Y, Zhang W, Veerapen N, Besra G, Cresswell P.

J Biol Chem. 2010 Dec 3;285(49):38283-92. doi: 10.1074/jbc.M110.170530. Epub 2010 Sep 22.

36.

Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB'.

Batt SM, Jabeen T, Mishra AK, Veerapen N, Krumbach K, Eggeling L, Besra GS, Fütterer K.

J Biol Chem. 2010 Nov 26;285(48):37741-52. doi: 10.1074/jbc.M110.165407. Epub 2010 Sep 15.

37.

Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.

Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS.

J Clin Invest. 2010 Aug;120(8):2889-99. doi: 10.1172/JCI42703. Epub 2010 Jul 1.

38.

Synthesis and biological activity of alpha-glucosyl C24:0 and C20:2 ceramides.

Jervis PJ, Veerapen N, Bricard G, Cox LR, Porcelli SA, Besra GS.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3475-8. doi: 10.1016/j.bmcl.2010.05.010.

39.

Synthesis and biological activity of alpha-L-fucosyl ceramides, analogues of the potent agonist, alpha-D-galactosyl ceramide KRN7000.

Veerapen N, Reddington F, Bricard G, Porcelli SA, Besra GS.

Bioorg Med Chem Lett. 2010 Jun 1;20(11):3223-6. doi: 10.1016/j.bmcl.2010.04.079. Epub 2010 Apr 22.

40.
41.

An alpha-galactosylceramide C20:2 N-acyl variant enhances anti-inflammatory and regulatory T cell-independent responses that prevent type 1 diabetes.

Ly D, Tohn R, Rubin B, Blumenfeld H, Besra GS, Veerapen N, Porcelli SA, Delovitch TL.

Clin Exp Immunol. 2010 May;160(2):185-98. doi: 10.1111/j.1365-2249.2009.04074.x. Epub 2009 Dec 15.

42.

Recognition of lyso-phospholipids by human natural killer T lymphocytes.

Fox LM, Cox DG, Lockridge JL, Wang X, Chen X, Scharf L, Trott DL, Ndonye RM, Veerapen N, Besra GS, Howell AR, Cook ME, Adams EJ, Hildebrand WH, Gumperz JE.

PLoS Biol. 2009 Oct;7(10):e1000228. doi: 10.1371/journal.pbio.1000228. Epub 2009 Oct 27.

43.

Distinct requirements for CD1d intracellular transport for development of V(alpha)14 iNKT cells.

Sillé FC, Boxem M, Sprengers D, Veerapen N, Besra G, Boes M.

J Immunol. 2009 Aug 1;183(3):1780-8. doi: 10.4049/jimmunol.0901354. Epub 2009 Jul 8.

44.

Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.

Veerapen N, Brigl M, Garg S, Cerundolo V, Cox LR, Brenner MB, Besra GS.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4288-91. doi: 10.1016/j.bmcl.2009.05.095. Epub 2009 May 27.

45.

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.

De Santo C, Salio M, Masri SH, Lee LY, Dong T, Speak AO, Porubsky S, Booth S, Veerapen N, Besra GS, Gröne HJ, Platt FM, Zambon M, Cerundolo V.

J Clin Invest. 2008 Dec;118(12):4036-48. doi: 10.1172/JCI36264. Epub 2008 Nov 13.

46.

Natural killer T-cell autoreactivity leads to a specialized activation state.

Wang X, Chen X, Rodenkirch L, Simonson W, Wernimont S, Ndonye RM, Veerapen N, Gibson D, Howell AR, Besra GS, Painter GF, Huttenlocher A, Gumperz JE.

Blood. 2008 Nov 15;112(10):4128-38. doi: 10.1182/blood-2008-05-157529. Epub 2008 Sep 8.

47.

Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.

Alderwick LJ, Dover LG, Veerapen N, Gurcha SS, Kremer L, Roper DL, Pathak AK, Reynolds RC, Besra GS.

Protein Expr Purif. 2008 Apr;58(2):332-41. doi: 10.1016/j.pep.2007.11.012. Epub 2007 Dec 8.

PMID:
18248822
48.

Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation.

Salio M, Speak AO, Shepherd D, Polzella P, Illarionov PA, Veerapen N, Besra GS, Platt FM, Cerundolo V.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20490-5. Epub 2007 Dec 11.

49.
50.

Synthesis of novel ammonium and selenonium ions and their evaluation as inhibitors of UDP-galactopyranose mutase.

Veerapen N, Yuan Y, Sanders DA, Pinto BM.

Carbohydr Res. 2004 Sep 13;339(13):2205-17.

PMID:
15337448

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