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Items: 1 to 50 of 210

1.

Apelin directs endothelial cell differentiation and vascular repair following immune-mediated injury.

Masoud AG, Lin J, Azad AK, Farhan MA, Fischer C, Zhu LF, Zhang H, Sis B, Kassiri Z, Moore RB, Kim D, Anderson CC, Vederas JC, Adam BA, Oudit GY, Murray AG.

J Clin Invest. 2019 Nov 18. pii: 128469. doi: 10.1172/JCI128469. [Epub ahead of print]

2.

Dissecting the Binding Interactions of Teixobactin with the Bacterial Cell-Wall Precursor Lipid II.

Chiorean S, Antwi I, Carney DW, Kotsogianni I, Giltrap AM, Alexander FM, Cochrane SA, Payne RJ, Martin NI, Henninot A, Vederas JC.

Chembiochem. 2019 Sep 24. doi: 10.1002/cbic.201900504. [Epub ahead of print]

PMID:
31552694
3.

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.

Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, Kassiri Z, Oudit GY.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13006-13015. doi: 10.1073/pnas.1900152116. Epub 2019 Jun 12.

4.

Catalytic mechanism and properties of pyridoxal 5'-phosphate independent racemases: how enzymes alter mismatched acidity and basicity.

Fischer C, Ahn YC, Vederas JC.

Nat Prod Rep. 2019 Apr 17. doi: 10.1039/c9np00017h. [Epub ahead of print] Review.

PMID:
30994146
5.

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents.

Fischer C, Lamer T, Wang W, McKinnie SMK, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC.

Eur J Med Chem. 2019 Mar 15;166:119-124. doi: 10.1016/j.ejmech.2019.01.040. Epub 2019 Jan 18.

PMID:
30690406
6.

Insights into the draft genome sequence of bioactives-producing Bacillus thuringiensis DNG9 isolated from Algerian soil-oil slough.

Daas MS, Rosana ARR, Acedo JZ, Douzane M, Nateche F, Kebbouche-Gana S, Vederas JC.

Stand Genomic Sci. 2018 Oct 11;13:25. doi: 10.1186/s40793-018-0331-1. eCollection 2018.

7.

Isolation, expression and biochemical characterization of recombinant hyoscyamine-6β-hydroxylase from Brugmansia sanguinea - tuning the scopolamine production.

Fischer C, Kwon M, Ro DK, van Belkum MJ, Vederas JC.

Medchemcomm. 2018 May 2;9(5):888-892. doi: 10.1039/c8md00090e. eCollection 2018 May 1.

8.

The expanding structural variety among bacteriocins from Gram-positive bacteria.

Acedo JZ, Chiorean S, Vederas JC, van Belkum MJ.

FEMS Microbiol Rev. 2018 Nov 1;42(6):805-828. doi: 10.1093/femsre/fuy033. Review.

PMID:
30085042
9.

Draft Genome Sequence of Bacillus paralicheniformis F47, Isolated from an Algerian Salty Lake.

Daas MS, Rosana ARR, Acedo JZ, Douzane M, Nateche F, Kebbouche-Gana S, Vederas JC.

Genome Announc. 2018 Mar 29;6(13). pii: e00190-18. doi: 10.1128/genomeA.00190-18.

10.

PLP-independent racemization: mechanistic and mutational studies of O-ureidoserine racemase (DcsC).

Ahn YC, Fischer C, van Belkum MJ, Vederas JC.

Org Biomol Chem. 2018 Feb 14;16(7):1126-1133. doi: 10.1039/c7ob03013d.

PMID:
29362754
11.

Identification and Heterologous Expression of the sec-Dependent Bacteriocin Faerocin MK from Enterococcus faecium M3K31.

Chiorean S, Vederas JC, van Belkum MJ.

Probiotics Antimicrob Proteins. 2018 Jun;10(2):142-147. doi: 10.1007/s12602-017-9374-7.

PMID:
29306983
12.

Dess-Martin periodinane oxidative rearrangement for preparation of α-keto thioesters.

Sanichar R, Carroll C, Kimmis R, Reiz B, Vederas JC.

Org Biomol Chem. 2018 Jan 24;16(4):593-597. doi: 10.1039/c7ob02959d.

PMID:
29296982
13.

Bacillus amyloliquefaciens ssp. plantarum F11 isolated from Algerian salty lake as a source of biosurfactants and bioactive lipopeptides.

Daas MS, Acedo JZ, Rosana ARR, Orata FD, Reiz B, Zheng J, Nateche F, Case RJ, Kebbouche-Gana S, Vederas JC.

FEMS Microbiol Lett. 2018 Jan 1;365(1). doi: 10.1093/femsle/fnx248.

PMID:
29186395
14.

Insights into the Mechanism of Action of the Two-Peptide Lantibiotic Lacticin 3147.

Bakhtiary A, Cochrane SA, Mercier P, McKay RT, Miskolzie M, Sit CS, Vederas JC.

J Am Chem Soc. 2017 Dec 13;139(49):17803-17810. doi: 10.1021/jacs.7b04728. Epub 2017 Nov 22.

PMID:
29164875
15.

Draft Genome Sequence of Enterococcus canintestini 49, a Potential Probiotic That Produces Multiple Bacteriocins.

Acedo JZ, Ibarra Romero C, Miyata ST, Blaine AH, McMullen LM, Vederas JC, van Belkum MJ.

Genome Announc. 2017 Oct 5;5(40). pii: e01131-17. doi: 10.1128/genomeA.01131-17.

16.

Diacylglycerol Acyltransferase 1 Is Regulated by Its N-Terminal Domain in Response to Allosteric Effectors.

Caldo KMP, Acedo JZ, Panigrahi R, Vederas JC, Weselake RJ, Lemieux MJ.

Plant Physiol. 2017 Oct;175(2):667-680. doi: 10.1104/pp.17.00934. Epub 2017 Aug 21.

17.

Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

McKinnie SMK, Wang W, Fischer C, McDonald T, Kalin KR, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC.

J Med Chem. 2017 Jul 27;60(14):6408-6427. doi: 10.1021/acs.jmedchem.7b00723. Epub 2017 Jul 7.

PMID:
28685579
18.

Draft Genome Sequences of Bacillus cereus E41 and Bacillus anthracis F34 Isolated from Algerian Salt Lakes.

Daas MS, Rosana ARR, Acedo JZ, Nateche F, Kebbouche-Gana S, Vederas JC, Case RJ.

Genome Announc. 2017 May 18;5(20). pii: e00383-17. doi: 10.1128/genomeA.00383-17.

19.

One-Step Transformation of Coenzyme A into Analogues by Transamidation.

Sanichar R, Vederas JC.

Org Lett. 2017 Apr 21;19(8):1950-1953. doi: 10.1021/acs.orglett.7b00291. Epub 2017 Apr 10.

20.

Identification and three-dimensional structure of carnobacteriocin XY, a class IIb bacteriocin produced by Carnobacteria.

Acedo JZ, Towle KM, Lohans CT, Miskolzie M, McKay RT, Doerksen TA, Vederas JC, Martin-Visscher LA.

FEBS Lett. 2017 May;591(10):1349-1359. doi: 10.1002/1873-3468.12648. Epub 2017 Apr 27.

21.

Structural features of many circular and leaderless bacteriocins are similar to those in saposins and saposin-like peptides.

Towle KM, Vederas JC.

Medchemcomm. 2017 Jan 11;8(2):276-285. doi: 10.1039/c6md00607h. eCollection 2017 Feb 1. Review.

22.

Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.

Zhong JC, Zhang ZZ, Wang W, McKinnie SMK, Vederas JC, Oudit GY.

Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):1942-1950. doi: 10.1016/j.bbadis.2016.11.007. Epub 2016 Nov 4. Review.

23.

Antimicrobial lipopeptide tridecaptin A1 selectively binds to Gram-negative lipid II.

Cochrane SA, Findlay B, Bakhtiary A, Acedo JZ, Rodriguez-Lopez EM, Mercier P, Vederas JC.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11561-11566. Epub 2016 Sep 29.

24.

Solution Structures of Phenol-Soluble Modulins α1, α3, and β2, Virulence Factors from Staphylococcus aureus.

Towle KM, Lohans CT, Miskolzie M, Acedo JZ, van Belkum MJ, Vederas JC.

Biochemistry. 2016 Aug 30;55(34):4798-806. doi: 10.1021/acs.biochem.6b00615. Epub 2016 Aug 15.

25.

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides.

McKinnie SM, Fischer C, Tran KM, Wang W, Mosquera F, Oudit GY, Vederas JC.

Chembiochem. 2016 Aug 17;17(16):1495-8. doi: 10.1002/cbic.201600244. Epub 2016 Jul 5.

PMID:
27377680
26.

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.

Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, Oudit GY.

Hypertension. 2016 Aug;68(2):365-77. doi: 10.1161/HYPERTENSIONAHA.115.06892. Epub 2016 May 23.

PMID:
27217402
27.

Draft Genome Sequence of the Bacteriocin-Producing Strain Enterococcus faecium M3K31, Isolated from Griffon Vultures (Gyps fulvus subsp. fulvus).

Arbulu S, Frantzen C, Lohans CT, Cintas LM, Herranz C, Holo H, Diep DB, Vederas JC, Hernández PE.

Genome Announc. 2016 Mar 24;4(2). pii: e00055-16. doi: 10.1128/genomeA.00055-16.

28.

Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent.

Cochrane RV, Sanichar R, Lambkin GR, Reiz B, Xu W, Tang Y, Vederas JC.

Angew Chem Int Ed Engl. 2016 Jan 11;55(2):664-8. doi: 10.1002/anie.201509345. Epub 2015 Nov 24.

29.

Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity.

Acedo JZ, van Belkum MJ, Lohans CT, Towle KM, Miskolzie M, Vederas JC.

Biochemistry. 2016 Feb 2;55(4):733-42. doi: 10.1021/acs.biochem.5b01306. Epub 2016 Jan 15.

PMID:
26771761
30.

Synthesis of Tridecaptin-Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria.

Cochrane SA, Li X, He S, Yu M, Wu M, Vederas JC.

J Med Chem. 2015 Dec 24;58(24):9779-85. doi: 10.1021/acs.jmedchem.5b01578. Epub 2015 Dec 4.

PMID:
26636619
31.

Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase.

Cacho RA, Thuss J, Xu W, Sanichar R, Gao Z, Nguyen A, Vederas JC, Tang Y.

J Am Chem Soc. 2015 Dec 23;137(50):15688-91. doi: 10.1021/jacs.5b11814. Epub 2015 Dec 10.

32.

Solution Structure of Enterocin HF, an Antilisterial Bacteriocin Produced by Enterococcus faecium M3K31.

Arbulu S, Lohans CT, van Belkum MJ, Cintas LM, Herranz C, Vederas JC, Hernández PE.

J Agric Food Chem. 2015 Dec 16;63(49):10689-95. doi: 10.1021/acs.jafc.5b03882. Epub 2015 Dec 1.

PMID:
26585399
33.

Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs.

Cochrane RV, Gao Z, Lambkin GR, Xu W, Winter JM, Marcus SL, Tang Y, Vederas JC.

Chembiochem. 2015 Nov;16(17):2479-83. doi: 10.1002/cbic.201500428. Epub 2015 Oct 23.

34.

Total Synthesis and Stereochemical Assignment of the Antimicrobial Lipopeptide Cerexin A1.

Cochrane SA, Surgenor RR, Khey KM, Vederas JC.

Org Lett. 2015 Nov 6;17(21):5428-31. doi: 10.1021/acs.orglett.5b02779. Epub 2015 Oct 14.

PMID:
26465807
35.

Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis.

Winter JM, Cascio D, Dietrich D, Sato M, Watanabe K, Sawaya MR, Vederas JC, Tang Y.

J Am Chem Soc. 2015 Aug 12;137(31):9885-93. doi: 10.1021/jacs.5b04520. Epub 2015 Jul 30.

36.

Studies on tridecaptin B(1), a lipopeptide with activity against multidrug resistant Gram-negative bacteria.

Cochrane SA, Lohans CT, van Belkum MJ, Bels MA, Vederas JC.

Org Biomol Chem. 2015 Jun 7;13(21):6073-81. doi: 10.1039/c5ob00780a.

PMID:
25959079
37.
38.

Identification of didecyldimethylammonium salts and salicylic acid as antimicrobial compounds in commercial fermented radish kimchi.

Li J, Chaytor JL, Findlay B, McMullen LM, Smith DC, Vederas JC.

J Agric Food Chem. 2015 Mar 25;63(11):3053-8. doi: 10.1021/jf5063588. Epub 2015 Mar 17.

39.

Solution structure of acidocin B, a circular bacteriocin produced by Lactobacillus acidophilus M46.

Acedo JZ, van Belkum MJ, Lohans CT, McKay RT, Miskolzie M, Vederas JC.

Appl Environ Microbiol. 2015 Apr;81(8):2910-8. doi: 10.1128/AEM.04265-14. Epub 2015 Feb 13.

40.

Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri.

Lin XB, Lohans CT, Duar R, Zheng J, Vederas JC, Walter J, Gänzle M.

Appl Environ Microbiol. 2015 Mar;81(6):2032-41. doi: 10.1128/AEM.03691-14. Epub 2015 Jan 9.

41.

Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis).

Kwon M, Cochrane SA, Vederas JC, Ro DK.

FEBS Lett. 2014 Dec 20;588(24):4597-603. doi: 10.1016/j.febslet.2014.10.031. Epub 2014 Nov 4.

42.

Novel pyrano and vinylphenol adducts of deoxyanthocyanidins in sorghum sourdough.

Bai Y, Findlay B, Maldonado AF, Schieber A, Vederas JC, Gänzle MG.

J Agric Food Chem. 2014 Nov 26;62(47):11536-46. doi: 10.1021/jf503330b. Epub 2014 Nov 13.

PMID:
25370078
43.

Unacylated tridecaptin A₁ acts as an effective sensitiser of Gram-negative bacteria to other antibiotics.

Cochrane SA, Vederas JC.

Int J Antimicrob Agents. 2014 Dec;44(6):493-9. doi: 10.1016/j.ijantimicag.2014.08.008. Epub 2014 Sep 27.

PMID:
25315408
44.

Highly selective but multifunctional oxygenases in secondary metabolism.

Cochrane RV, Vederas JC.

Acc Chem Res. 2014 Oct 21;47(10):3148-61. doi: 10.1021/ar500242c. Epub 2014 Sep 24. Review.

PMID:
25250512
45.

Structure and biosynthesis of carnolysin, a homologue of enterococcal cytolysin with D-amino acids.

Lohans CT, Li JL, Vederas JC.

J Am Chem Soc. 2014 Sep 24;136(38):13150-3. doi: 10.1021/ja5070813. Epub 2014 Sep 10.

PMID:
25207953
46.

Explorations of fungal biosynthesis of reduced polyketides - a personal viewpoint.

Vederas JC.

Nat Prod Rep. 2014 Oct;31(10):1253-9. doi: 10.1039/c4np00091a. Review.

PMID:
25058153
47.

Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates.

Cochrane SA, Vederas JC.

Med Res Rev. 2016 Jan;36(1):4-31. doi: 10.1002/med.21321. Epub 2014 May 28. Review.

PMID:
24866700
48.

A carbonate-forming Baeyer-Villiger monooxygenase.

Hu Y, Dietrich D, Xu W, Patel A, Thuss JA, Wang J, Yin WB, Qiao K, Houk KN, Vederas JC, Tang Y.

Nat Chem Biol. 2014 Jul;10(7):552-4. doi: 10.1038/nchembio.1527. Epub 2014 May 18.

49.

Key residues in octyl-tridecaptin A1 analogues linked to stable secondary structures in the membrane.

Cochrane SA, Findlay B, Vederas JC, Ratemi ES.

Chembiochem. 2014 Jun 16;15(9):1295-9. doi: 10.1002/cbic.201402024. Epub 2014 May 9.

PMID:
24816483
50.

Synthesis and structure-activity relationship studies of N-terminal analogues of the antimicrobial peptide tridecaptin A(1).

Cochrane SA, Lohans CT, Brandelli JR, Mulvey G, Armstrong GD, Vederas JC.

J Med Chem. 2014 Feb 13;57(3):1127-31. doi: 10.1021/jm401779d. Epub 2014 Jan 30.

PMID:
24479847

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