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Items: 37

1.

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin.

Piper SJ, Brillault L, Rothnagel R, Croll TI, Box JK, Chassagnon I, Scherer S, Goldie KN, Jones SA, Schepers F, Hartley-Tassell L, Ve T, Busby JN, Dalziel JE, Lott JS, Hankamer B, Stahlberg H, Hurst MRH, Landsberg MJ.

Nat Commun. 2019 Apr 26;10(1):1952. doi: 10.1038/s41467-019-09890-8.

2.

The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses.

Dowling JK, Tate MD, Rosli S, Bourke NM, Bitto N, Lauterbach MA, Cheung S, Ve T, Kobe B, Golenbock D, Mansell A.

J Immunol. 2019 Apr 15;202(8):2384-2396. doi: 10.4049/jimmunol.1800501. Epub 2019 Feb 20.

PMID:
30787108
3.

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88.

O'Carroll A, Chauvin B, Brown JWP, Meagher A, Coyle J, Schill J, Bhumkhar A, Hunter DJB, Ve T, Kobe B, Sierecki E, Gambin Y.

BMC Biol. 2018 Dec 24;16(1):149. doi: 10.1186/s12915-018-0611-7.

4.

Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling.

Nanson JD, Kobe B, Ve T.

J Leukoc Biol. 2019 Feb;105(2):363-375. doi: 10.1002/JLB.MR0318-123R. Epub 2018 Dec 5. Review.

PMID:
30517972
5.

Megahertz serial crystallography.

Wiedorn MO, Oberthür D, Bean R, Schubert R, Werner N, Abbey B, Aepfelbacher M, Adriano L, Allahgholi A, Al-Qudami N, Andreasson J, Aplin S, Awel S, Ayyer K, Bajt S, Barák I, Bari S, Bielecki J, Botha S, Boukhelef D, Brehm W, Brockhauser S, Cheviakov I, Coleman MA, Cruz-Mazo F, Danilevski C, Darmanin C, Doak RB, Domaracky M, Dörner K, Du Y, Fangohr H, Fleckenstein H, Frank M, Fromme P, Gañán-Calvo AM, Gevorkov Y, Giewekemeyer K, Ginn HM, Graafsma H, Graceffa R, Greiffenberg D, Gumprecht L, Göttlicher P, Hajdu J, Hauf S, Heymann M, Holmes S, Horke DA, Hunter MS, Imlau S, Kaukher A, Kim Y, Klyuev A, Knoška J, Kobe B, Kuhn M, Kupitz C, Küpper J, Lahey-Rudolph JM, Laurus T, Le Cong K, Letrun R, Xavier PL, Maia L, Maia FRNC, Mariani V, Messerschmidt M, Metz M, Mezza D, Michelat T, Mills G, Monteiro DCF, Morgan A, Mühlig K, Munke A, Münnich A, Nette J, Nugent KA, Nuguid T, Orville AM, Pandey S, Pena G, Villanueva-Perez P, Poehlsen J, Previtali G, Redecke L, Riekehr WM, Rohde H, Round A, Safenreiter T, Sarrou I, Sato T, Schmidt M, Schmitt B, Schönherr R, Schulz J, Sellberg JA, Seibert MM, Seuring C, Shelby ML, Shoeman RL, Sikorski M, Silenzi A, Stan CA, Shi X, Stern S, Sztuk-Dambietz J, Szuba J, Tolstikova A, Trebbin M, Trunk U, Vagovic P, Ve T, Weinhausen B, White TA, Wrona K, Xu C, Yefanov O, Zatsepin N, Zhang J, Perbandt M, Mancuso AP, Betzel C, Chapman H, Barty A.

Nat Commun. 2018 Oct 2;9(1):4025. doi: 10.1038/s41467-018-06156-7.

6.

Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics.

Nanson JD, Rahaman MH, Ve T, Kobe B.

Semin Cell Dev Biol. 2018 May 23. pii: S1084-9521(17)30423-8. doi: 10.1016/j.semcdb.2018.05.002. [Epub ahead of print] Review.

PMID:
29738879
7.

Structural Insights into Human Parainfluenza Virus 3 Hemagglutinin-Neuraminidase Using Unsaturated 3- N-Substituted Sialic Acids as Probes.

Pascolutti M, Dirr L, Guillon P, Van Den Bergh A, Ve T, Thomson RJ, von Itzstein M.

ACS Chem Biol. 2018 Jun 15;13(6):1544-1550. doi: 10.1021/acschembio.8b00150. Epub 2018 May 21.

PMID:
29693380
8.

A Sulfonozanamivir Analogue Has Potent Anti-influenza Virus Activity.

Hadházi Á, Li L, Bailly B, Maggioni A, Martin G, Dirr L, Dyason JC, Thomson RJ, Gao GF, Borbás A, Ve T, Pascolutti M, von Itzstein M.

ChemMedChem. 2018 Apr 23;13(8):785-789. doi: 10.1002/cmdc.201800092. Epub 2018 Mar 15.

PMID:
29453852
9.

Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P.

Zhang X, Farah N, Rolston L, Ericsson DJ, Catanzariti AM, Bernoux M, Ve T, Bendak K, Chen C, Mackay JP, Lawrence GJ, Hardham A, Ellis JG, Williams SJ, Dodds PN, Jones DA, Kobe B.

Mol Plant Pathol. 2018 May;19(5):1196-1209. doi: 10.1111/mpp.12597. Epub 2017 Nov 16.

PMID:
28817232
10.

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.

Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carroll A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B.

Nat Struct Mol Biol. 2017 Sep;24(9):743-751. doi: 10.1038/nsmb.3444. Epub 2017 Jul 31.

PMID:
28759049
11.

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

Hughes MM, Lavrencic P, Coll RC, Ve T, Ryan DG, Williams NC, Menon D, Mansell A, Board PG, Mobli M, Kobe B, O'Neill LAJ.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6480-E6489. doi: 10.1073/pnas.1701868114. Epub 2017 Jul 24.

12.

The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways.

Vajjhala PR, Ve T, Bentham A, Stacey KJ, Kobe B.

Mol Immunol. 2017 Jun;86:23-37. doi: 10.1016/j.molimm.2017.02.012. Epub 2017 Feb 27. Review.

PMID:
28249680
13.

Multiple functional self-association interfaces in plant TIR domains.

Zhang X, Bernoux M, Bentham AR, Newman TE, Ve T, Casey LW, Raaymakers TM, Hu J, Croll TI, Schreiber KJ, Staskawicz BJ, Anderson PA, Sohn KH, Williams SJ, Dodds PN, Kobe B.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E2046-E2052. doi: 10.1073/pnas.1621248114. Epub 2017 Feb 3.

14.

Blood Group Antigen Recognition via the Group A Streptococcal M Protein Mediates Host Colonization.

De Oliveira DM, Hartley-Tassell L, Everest-Dass A, Day CJ, Dabbs RA, Ve T, Kobe B, Nizet V, Packer NH, Walker MJ, Jennings MP, Sanderson-Smith ML.

MBio. 2017 Jan 24;8(1). pii: e02237-16. doi: 10.1128/mBio.02237-16.

15.

Towards the structure of the TIR-domain signalosome.

Nimma S, Ve T, Williams SJ, Kobe B.

Curr Opin Struct Biol. 2017 Apr;43:122-130. doi: 10.1016/j.sbi.2016.12.014. Epub 2017 Jan 13. Review.

PMID:
28092811
16.

Protein crystal screening and characterization for serial femtosecond nanocrystallography.

Darmanin C, Strachan J, Adda CG, Ve T, Kobe B, Abbey B.

Sci Rep. 2016 May 3;6:25345. doi: 10.1038/srep25345.

17.

Fusion-protein-assisted protein crystallization.

Kobe B, Ve T, Williams SJ.

Acta Crystallogr F Struct Biol Commun. 2015 Jul;71(Pt 7):861-9. doi: 10.1107/S2053230X15011061. Epub 2015 Jun 27.

18.

A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexes.

Williams SJ, Ve T, Kobe B.

Protein Eng Des Sel. 2015 May;28(5):137-45. doi: 10.1093/protein/gzv013. Epub 2015 Mar 15.

PMID:
25777769
19.

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains.

Ve T, Williams SJ, Kobe B.

Apoptosis. 2015 Feb;20(2):250-61. doi: 10.1007/s10495-014-1064-2. Review.

PMID:
25451009
20.

Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in Toll-like receptor and interferon signaling.

Ullah MO, Valkov E, Ve T, Williams S, Mas C, Mansell A, Kobe B.

Protein Expr Purif. 2015 Feb;106:31-40. doi: 10.1016/j.pep.2014.09.019. Epub 2014 Oct 13.

PMID:
25306876
21.

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.

Verstak B, Stack J, Ve T, Mangan M, Hjerrild K, Jeon J, Stahl R, Latz E, Gay N, Kobe B, Bowie AG, Mansell A.

J Leukoc Biol. 2014 Sep;96(3):427-36. doi: 10.1189/jlb.2A0913-487R. Epub 2014 May 8.

22.

Structural basis for assembly and function of a heterodimeric plant immune receptor.

Williams SJ, Sohn KH, Wan L, Bernoux M, Sarris PF, Segonzac C, Ve T, Ma Y, Saucet SB, Ericsson DJ, Casey LW, Lonhienne T, Winzor DJ, Zhang X, Coerdt A, Parker JE, Dodds PN, Kobe B, Jones JD.

Science. 2014 Apr 18;344(6181):299-303. doi: 10.1126/science.1247357.

23.

CorA is a copper repressible surface-associated copper(I)-binding protein produced in Methylomicrobium album BG8.

Johnson KA, Ve T, Larsen O, Pedersen RB, Lillehaug JR, Jensen HB, Helland R, Karlsen OA.

PLoS One. 2014 Feb 3;9(2):e87750. doi: 10.1371/journal.pone.0087750. eCollection 2014.

24.

The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins.

Ullah MO, Ve T, Mangan M, Alaidarous M, Sweet MJ, Mansell A, Kobe B.

Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2420-30. doi: 10.1107/S0907444913022385. Epub 2013 Nov 19.

PMID:
24311583
25.

Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB.

Alaidarous M, Ve T, Casey LW, Valkov E, Ericsson DJ, Ullah MO, Schembri MA, Mansell A, Sweet MJ, Kobe B.

J Biol Chem. 2014 Jan 10;289(2):654-68. doi: 10.1074/jbc.M113.523274. Epub 2013 Nov 21.

26.

Crystallization and preliminary X-ray diffraction analyses of the TIR domains of three TIR-NB-LRR proteins that are involved in disease resistance in Arabidopsis thaliana.

Wan L, Zhang X, Williams SJ, Ve T, Bernoux M, Sohn KH, Jones JD, Dodds PN, Kobe B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1275-80. doi: 10.1107/S1744309113026614. Epub 2013 Oct 30.

27.

Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity.

Ve T, Williams SJ, Catanzariti AM, Rafiqi M, Rahman M, Ellis JG, Hardham AR, Jones DA, Anderson PA, Dodds PN, Kobe B.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17594-9. doi: 10.1073/pnas.1307614110. Epub 2013 Oct 7.

28.

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB.

Alaidarous M, Ve T, Ullah MO, Valkov E, Mansell A, Schembri MA, Sweet MJ, Kobe B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct;69(Pt 10):1167-70. doi: 10.1107/S1744309113024408. Epub 2013 Sep 28.

29.

Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1.

Ullah MO, Ve T, Dkhar J, Alaidarous M, Ericsson DJ, Sweet MJ, Mansell A, Kobe B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul;69(Pt 7):766-70. doi: 10.1107/S174430911301419X. Epub 2013 Jun 28.

30.

Intramolecular interaction influences binding of the Flax L5 and L6 resistance proteins to their AvrL567 ligands.

Ravensdale M, Bernoux M, Ve T, Kobe B, Thrall PH, Ellis JG, Dodds PN.

PLoS Pathog. 2012;8(11):e1003004. doi: 10.1371/journal.ppat.1003004. Epub 2012 Nov 29.

31.

The Methylococcus capsulatus (Bath) secreted protein, MopE*, binds both reduced and oxidized copper.

Ve T, Mathisen K, Helland R, Karlsen OA, Fjellbirkeland A, Røhr ÅK, Andersson KK, Pedersen RB, Lillehaug JR, Jensen HB.

PLoS One. 2012;7(8):e43146. doi: 10.1371/journal.pone.0043146. Epub 2012 Aug 20.

32.

Adaptors in toll-like receptor signaling and their potential as therapeutic targets.

Ve T, Gay NJ, Mansell A, Kobe B, Kellie S.

Curr Drug Targets. 2012 Oct;13(11):1360-74. Review.

PMID:
22664090
33.

Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM.

Ve T, Williams SJ, Stamp A, Valkov E, Dodds PN, Anderson PA, Kobe B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1603-7. doi: 10.1107/S1744309111037675. Epub 2011 Nov 26.

34.

Structural and functional analysis of a plant resistance protein TIR domain reveals interfaces for self-association, signaling, and autoregulation.

Bernoux M, Ve T, Williams S, Warren C, Hatters D, Valkov E, Zhang X, Ellis JG, Kobe B, Dodds PN.

Cell Host Microbe. 2011 Mar 17;9(3):200-211. doi: 10.1016/j.chom.2011.02.009.

35.

Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6.

Ve T, Williams S, Valkov E, Ellis JG, Dodds PN, Kobe B.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):237-40. doi: 10.1107/S1744309110051006. Epub 2011 Jan 22.

36.

The AvrM effector from flax rust has a structured C-terminal domain and interacts directly with the M resistance protein.

Catanzariti AM, Dodds PN, Ve T, Kobe B, Ellis JG, Staskawicz BJ.

Mol Plant Microbe Interact. 2010 Jan;23(1):49-57. doi: 10.1094/MPMI-23-1-0049.

37.

An oxidized tryptophan facilitates copper binding in Methylococcus capsulatus-secreted protein MopE.

Helland R, Fjellbirkeland A, Karlsen OA, Ve T, Lillehaug JR, Jensen HB.

J Biol Chem. 2008 May 16;283(20):13897-904. doi: 10.1074/jbc.M800340200. Epub 2008 Mar 18.

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