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Items: 1 to 50 of 160

1.

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion.

Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL.

Cell Death Differ. 2018 Mar;25(4):782-794. doi: 10.1038/s41418-017-0017-z. Epub 2017 Dec 11.

PMID:
29229994
2.

Viewing BCL2 and cell death control from an evolutionary perspective.

Strasser A, Vaux DL.

Cell Death Differ. 2018 Jan;25(1):13-20. doi: 10.1038/cdd.2017.145. Epub 2017 Nov 3. Review.

PMID:
29099481
3.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham RL, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J.

J Biol Chem. 2017 Aug 25;292(34):14310. doi: 10.1074/jbc.A109.087635. No abstract available.

4.

XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE.

Cell Rep. 2017 Jul 18;20(3):668-682. doi: 10.1016/j.celrep.2017.06.073.

5.

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J.

Elife. 2017 Jun 27;6. pii: e29849. doi: 10.7554/eLife.29849. No abstract available.

6.

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5762-E5763.

7.

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins.

Goodall KJ, Finch-Edmondson ML, van Vuuren J, Yeoh GC, Gentle IE, Vince JE, Ekert PG, Vaux DL, Callus BA.

PLoS One. 2016 Nov 2;11(11):e0164003. doi: 10.1371/journal.pone.0164003. eCollection 2016.

8.

Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion.

Conos SA, Lawlor KE, Vaux DL, Vince JE, Lindqvist LM.

Cell Death Differ. 2016 Nov 1;23(11):1827-1838. doi: 10.1038/cdd.2016.69. Epub 2016 Jul 15.

9.

Australia needs an Ombudsman or Office for Research Integrity.

Brooks PM, Vaux DL, Williamson R.

Intern Med J. 2016 Oct;46(10):1233-1235. doi: 10.1111/imj.13211. No abstract available.

PMID:
27734623
10.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NN, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J.

Cancer Cell. 2016 Sep 12;30(3):499-500. doi: 10.1016/j.ccell.2016.08.009. Epub 2016 Sep 12. No abstract available.

11.

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.

Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J.

Sci Transl Med. 2016 May 18;8(339):339ra69. doi: 10.1126/scitranslmed.aad3099. Erratum in: Sci Transl Med. 2017 May 31;9(392):.

PMID:
27194727
12.

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux.

Reljic B, Conos S, Lee EF, Garnier JM, Dong L, Lessene G, Fairlie WD, Vaux DL, Lindqvist LM.

Autophagy. 2016 Jul 2;12(7):1083-93. doi: 10.1080/15548627.2016.1179406. Epub 2016 May 12.

13.

Evolutionary divergence of the necroptosis effector MLKL.

Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM.

Cell Death Differ. 2016 Jul;23(7):1185-97. doi: 10.1038/cdd.2015.169. Epub 2016 Feb 12.

14.

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J.

Cancer Cell. 2016 Feb 8;29(2):145-58. doi: 10.1016/j.ccell.2016.01.006. Erratum in: Cancer Cell. 2016 Sep 12;30(3):499-500.

15.

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL.

J Biol Chem. 2016 Jan 29;291(5):2547. doi: 10.1074/jbc.A110.216226. No abstract available.

16.

Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies.

Delbridge AR, Grabow S, Strasser A, Vaux DL.

Nat Rev Cancer. 2016 Feb;16(2):99-109. doi: 10.1038/nrc.2015.17. Review.

PMID:
26822577
17.

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J.

Elife. 2015 Dec 23;4. pii: e10592. doi: 10.7554/eLife.10592. Erratum in: Elife. 2017 Jun 27;6:.

18.

Response to Heard et al.

Moulin M, Voss AK, Thomas T, Wong WW, Cook WD, Koentgen F, Vince J, Silke J, Vaux DL.

EMBO J. 2015 Oct 1;34(19):2396-7. doi: 10.15252/embj.201592761. No abstract available.

19.

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE.

Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282.

20.

IAP gene deletion and conditional knockout models.

Silke J, Vaux DL.

Semin Cell Dev Biol. 2015 Mar;39:97-105. doi: 10.1016/j.semcdb.2014.12.004. Epub 2014 Dec 26. Review.

PMID:
25545814
21.

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J.

Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03464.

22.

Basic statistics in cell biology.

Vaux DL.

Annu Rev Cell Dev Biol. 2014;30:23-37. doi: 10.1146/annurev-cellbio-100913-013303. Epub 2014 Jul 2. Review.

PMID:
25000992
23.

BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy.

Lindqvist LM, Vaux DL.

Autophagy. 2014 Aug;10(8):1474-5. doi: 10.4161/auto.29639. Epub 2014 Jun 27.

24.

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE.

EMBO Rep. 2014 Sep;15(9):982-90. doi: 10.15252/embr.201438463. Epub 2014 Jul 2.

25.

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.

Lindqvist LM, Heinlein M, Huang DC, Vaux DL.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8512-7. doi: 10.1073/pnas.1406425111. Epub 2014 May 27.

26.

RIPK1- and RIPK3-induced cell death mode is determined by target availability.

Cook WD, Moujalled DM, Ralph TJ, Lock P, Young SN, Murphy JM, Vaux DL.

Cell Death Differ. 2014 Oct;21(10):1600-12. doi: 10.1038/cdd.2014.70. Epub 2014 Jun 6.

27.

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J.

Cell. 2014 May 22;157(5):1175-88. doi: 10.1016/j.cell.2014.04.019. Epub 2014 May 8.

28.

Necroptosis induced by RIPK3 requires MLKL but not Drp1.

Moujalled DM, Cook WD, Murphy JM, Vaux DL.

Cell Death Dis. 2014 Feb 27;5:e1086. doi: 10.1038/cddis.2014.18.

29.

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

Wong WW, Vince JE, Lalaoui N, Lawlor KE, Chau D, Bankovacki A, Anderton H, Metcalf D, O'Reilly L, Jost PJ, Murphy JM, Alexander WS, Strasser A, Vaux DL, Silke J.

Blood. 2014 Apr 17;123(16):2562-72. doi: 10.1182/blood-2013-06-510743. Epub 2014 Feb 4.

30.

Another twist in the on and off affair between cell suicide and inflammation.

Vaux DL.

Cell Death Differ. 2013 Aug;20(8):974-5. doi: 10.1038/cdd.2013.57. No abstract available.

31.

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

Moujalled DM, Cook WD, Okamoto T, Murphy J, Lawlor KE, Vince JE, Vaux DL.

Cell Death Dis. 2013 Jan 17;4:e465. doi: 10.1038/cddis.2012.201.

32.

Research methods: Know when your numbers are significant.

Vaux DL.

Nature. 2012 Dec 13;492(7428):180-1. doi: 10.1038/492180a. No abstract available.

PMID:
23235861
33.

Replicates and repeats--what is the difference and is it significant? A brief discussion of statistics and experimental design.

Vaux DL, Fidler F, Cumming G.

EMBO Rep. 2012 Apr 2;13(4):291-6. doi: 10.1038/embor.2012.36. No abstract available.

34.

IAPs limit activation of RIP kinases by TNF receptor 1 during development.

Moulin M, Anderton H, Voss AK, Thomas T, Wong WW, Bankovacki A, Feltham R, Chau D, Cook WD, Silke J, Vaux DL.

EMBO J. 2012 Apr 4;31(7):1679-91. doi: 10.1038/emboj.2012.18. Epub 2012 Feb 10.

35.
36.

A biased comment on double-blind review.

Vaux DL.

Br J Dermatol. 2011 Sep;165(3):454. doi: 10.1111/j.1365-2133.2011.10546.x. No abstract available.

PMID:
21884038
37.

Response to "The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory". DOI: 10.1002/bies.201100025.

Vaux DL.

Bioessays. 2011 Sep;33(9):660-1. doi: 10.1002/bies.201100063. Epub 2011 Jul 7. No abstract available.

PMID:
21735460
38.

In defense of the somatic mutation theory of cancer.

Vaux DL.

Bioessays. 2011 May;33(5):341-3. doi: 10.1002/bies.201100022.

PMID:
21503936
39.

Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.

Feltham R, Bettjeman B, Budhidarmo R, Mace PD, Shirley S, Condon SM, Chunduru SK, McKinlay MA, Vaux DL, Silke J, Day CL.

J Biol Chem. 2011 May 13;286(19):17015-28. doi: 10.1074/jbc.M111.222919. Epub 2011 Mar 10.

40.

In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.

Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL.

J Biol Chem. 2011 Apr 15;286(15):13282-91. doi: 10.1074/jbc.M110.216226. Epub 2011 Feb 21. Erratum in: J Biol Chem. 2016 Jan 29;291(5):2547.

41.

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.

Gardam S, Turner VM, Anderton H, Limaye S, Basten A, Koentgen F, Vaux DL, Silke J, Brink R.

Blood. 2011 Apr 14;117(15):4041-51. doi: 10.1182/blood-2010-10-312793. Epub 2011 Feb 7.

42.

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor.

Lazarou M, Stojanovski D, Frazier AE, Kotevski A, Dewson G, Craigen WJ, Kluck RM, Vaux DL, Ryan MT.

J Biol Chem. 2010 Nov 19;285(47):36876-83. doi: 10.1074/jbc.M110.159301. Epub 2010 Sep 17.

43.

Apoptogenic factors released from mitochondria.

Vaux DL.

Biochim Biophys Acta. 2011 Apr;1813(4):546-50. doi: 10.1016/j.bbamcr.2010.08.002. Epub 2010 Aug 14. Review.

44.

Asymmetric recruitment of cIAPs by TRAF2.

Mace PD, Smits C, Vaux DL, Silke J, Day CL.

J Mol Biol. 2010 Jul 2;400(1):8-15. doi: 10.1016/j.jmb.2010.04.055. Epub 2010 May 4.

PMID:
20447407
45.

Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham R, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J.

J Biol Chem. 2010 Jun 4;285(23):17525-36. doi: 10.1074/jbc.M109.087635. Epub 2010 Mar 30. Erratum in: J Biol Chem. 2017 Aug 25;292(34):14310.

46.

TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL.

Lluis JM, Nachbur U, Cook WD, Gentle IE, Moujalled D, Moulin M, Wong WW, Khan N, Chau D, Callus BA, Vince JE, Silke J, Vaux DL.

PLoS One. 2010 Jan 8;5(1):e8620. doi: 10.1371/journal.pone.0008620. Erratum in: PLoS One. 2010;5(12) doi: 10.1371/annotation/4e35cd59-c68f-4020-addb-18eb896112c5.

47.

Identification of an Xiap-like pseudogene on mouse chromosome 7.

Kotevski A, Cook WD, Vaux DL, Callus BA.

PLoS One. 2009 Nov 30;4(11):e8078. doi: 10.1371/journal.pone.0008078.

48.

RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

Wong WW, Gentle IE, Nachbur U, Anderton H, Vaux DL, Silke J.

Cell Death Differ. 2010 Mar;17(3):482-7. doi: 10.1038/cdd.2009.178. Epub 2009 Nov 20.

49.

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

Vince JE, Pantaki D, Feltham R, Mace PD, Cordier SM, Schmukle AC, Davidson AJ, Callus BA, Wong WW, Gentle IE, Carter H, Lee EF, Walczak H, Day CL, Vaux DL, Silke J.

J Biol Chem. 2009 Dec 18;284(51):35906-15. doi: 10.1074/jbc.M109.072256.

50.

CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha.

Ahmed AU, Moulin M, Coumailleau F, Wong WW, Miasari M, Carter H, Silke J, Cohen-Tannoudji M, Vince JE, Vaux DL.

Curr Biol. 2009 Jan 13;19(1):R15-7; author reply R17-9. doi: 10.1016/j.cub.2008.11.040. No abstract available.

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