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Items: 1 to 50 of 60

1.

In vivo localization of human acetylcholinesterase-derived species in a β-sheet conformation at the core of senile plaques in Alzheimer's disease.

Jean L, Brimijoin S, Vaux DJ.

J Biol Chem. 2019 Feb 20. pii: jbc.RA118.006230. doi: 10.1074/jbc.RA118.006230. [Epub ahead of print]

2.

Multiphasic effect of vinyl pyrrolidone polymers on amyloidogenesis, from macromolecular crowding to inhibition.

Berwick R, Vaux DJ, Jean L.

Biochem J. 2018 Nov 9;475(21):3417-3436. doi: 10.1042/BCJ20180715.

PMID:
30287490
3.

The Physiological and Pathological Implications of the Formation of Hydrogels, with a Specific Focus on Amyloid Polypeptides.

Jean L, Foley AC, Vaux DJT.

Biomolecules. 2017 Sep 22;7(4). pii: E70. doi: 10.3390/biom7040070. Review.

4.

Formation of a nucleoplasmic reticulum requires de novo assembly of nascent phospholipids and shows preferential incorporation of nascent lamins.

Drozdz MM, Jiang H, Pytowski L, Grovenor C, Vaux DJ.

Sci Rep. 2017 Aug 7;7(1):7454. doi: 10.1038/s41598-017-07614-w.

5.

Stress-induced release of Oct-1 from the nuclear envelope is mediated by JNK phosphorylation of lamin B1.

Boubriak II, Malhas AN, Drozdz MM, Pytowski L, Vaux DJ.

PLoS One. 2017 May 24;12(5):e0177990. doi: 10.1371/journal.pone.0177990. eCollection 2017.

6.

Foxp3 drives oxidative phosphorylation and protection from lipotoxicity.

Howie D, Cobbold SP, Adams E, Ten Bokum A, Necula AS, Zhang W, Huang H, Roberts DJ, Thomas B, Hester SS, Vaux DJ, Betz AG, Waldmann H.

JCI Insight. 2017 Feb 9;2(3):e89160. doi: 10.1172/jci.insight.89160.

7.

Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy.

Kumar N, Drozdz MM, Jiang H, Santos DM, Vaux DJ.

Chem Commun (Camb). 2017 Feb 21;53(16):2451-2454. doi: 10.1039/c6cc10226c.

PMID:
28177338
8.

Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation.

Drozdz MM, Vaux DJ.

Nucleus. 2017 Jan 2;8(1):34-45. doi: 10.1080/19491034.2016.1252893. Epub 2016 Oct 31. Review.

9.

Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide.

Jean L, Lee CF, Hodder P, Hawkins N, Vaux DJ.

Sci Rep. 2016 Aug 18;6:32124. doi: 10.1038/srep32124.

10.

Methods for Single-Cell Pulse-Chase Analysis of Nuclear Components.

Drozdz M, Vaux DJ.

Methods Mol Biol. 2016;1411:159-76. doi: 10.1007/978-1-4939-3530-7_10.

PMID:
27147041
11.

Biosensor architectures for high-fidelity reporting of cellular signaling.

Dushek O, Lellouch AC, Vaux DJ, Shahrezaei V.

Biophys J. 2014 Aug 5;107(3):773-782. doi: 10.1016/j.bpj.2014.06.021.

12.

Nuclear envelope invaginations and cancer.

Malhas AN, Vaux DJ.

Adv Exp Med Biol. 2014;773:523-35. doi: 10.1007/978-1-4899-8032-8_24. Review.

PMID:
24563364
13.

The air-water interface determines the outcome of seeding during amyloidogenesis.

Trigg BJ, Lee CF, Vaux DJ, Jean L.

Biochem J. 2013 Nov 15;456(1):67-80. doi: 10.1042/BJ20130605.

PMID:
24015785
14.

Combined biochemical and cytological analysis of membrane trafficking using lectins.

Morgan GW, Kail M, Hollinshead M, Vaux DJ.

Anal Biochem. 2013 Oct 1;441(1):21-31. doi: 10.1016/j.ab.2013.05.034. Epub 2013 Jun 10.

PMID:
23756734
15.

Is LMNB1 a susceptibility gene for neural tube defects in humans?

Robinson A, Partridge D, Malhas A, De Castro SC, Gustavsson P, Thompson DN, Vaux DJ, Copp AJ, Stanier P, Bassuk AG, Greene ND.

Birth Defects Res A Clin Mol Teratol. 2013 Jun;97(6):398-402. doi: 10.1002/bdra.23141. Epub 2013 Jun 3.

16.

Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity.

Raghunathan VK, Devey M, Hawkins S, Hails L, Davis SA, Mann S, Chang IT, Ingham E, Malhas A, Vaux DJ, Lane JD, Case CP.

Biomaterials. 2013 May;34(14):3559-70. doi: 10.1016/j.biomaterials.2013.01.085. Epub 2013 Feb 20.

PMID:
23433773
17.

Lamin b1 polymorphism influences morphology of the nuclear envelope, cell cycle progression, and risk of neural tube defects in mice.

De Castro SC, Malhas A, Leung KY, Gustavsson P, Vaux DJ, Copp AJ, Greene ND.

PLoS Genet. 2012;8(11):e1003059. doi: 10.1371/journal.pgen.1003059. Epub 2012 Nov 15.

18.

Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells.

Davies BS, Goulbourne CN, Barnes RH 2nd, Turlo KA, Gin P, Vaughan S, Vaux DJ, Bensadoun A, Beigneux AP, Fong LG, Young SG.

J Lipid Res. 2012 Dec;53(12):2690-7. doi: 10.1194/jlr.M031559. Epub 2012 Sep 24.

19.

Combined effects of agitation, macromolecular crowding, and interfaces on amyloidogenesis.

Lee CF, Bird S, Shaw M, Jean L, Vaux DJ.

J Biol Chem. 2012 Nov 2;287(45):38006-19. doi: 10.1074/jbc.M112.400580. Epub 2012 Sep 17.

20.

Activation rather than Foxp3 expression determines that TGF-β-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering.

Chen Y, Adams E, Regateiro FS, Vaux DJ, Betz AG, Andersen KG, Waldmann H, Howie D.

Eur J Immunol. 2012 Jun;42(6):1436-48. doi: 10.1002/eji.201142207.

21.

Enrichment of amyloidogenesis at an air-water interface.

Jean L, Lee CF, Vaux DJ.

Biophys J. 2012 Mar 7;102(5):1154-62. doi: 10.1016/j.bpj.2012.01.041. Epub 2012 Mar 6.

22.

The induction of a nucleoplasmic reticulum by prelamin A accumulation requires CTP:phosphocholine cytidylyltransferase-α.

Goulbourne CN, Malhas AN, Vaux DJ.

J Cell Sci. 2011 Dec 15;124(Pt 24):4253-66. doi: 10.1242/jcs.091009. Epub 2012 Jan 5.

23.

The nuclear envelope and its involvement in cellular stress responses.

Malhas AN, Vaux DJ.

Biochem Soc Trans. 2011 Dec;39(6):1795-8. doi: 10.1042/BST20110719. Review.

PMID:
22103528
24.

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies.

De Vos WH, Houben F, Kamps M, Malhas A, Verheyen F, Cox J, Manders EM, Verstraeten VL, van Steensel MA, Marcelis CL, van den Wijngaard A, Vaux DJ, Ramaekers FC, Broers JL.

Hum Mol Genet. 2011 Nov 1;20(21):4175-86. doi: 10.1093/hmg/ddr344. Epub 2011 Aug 10.

PMID:
21831885
25.

The nucleoplasmic reticulum: form and function.

Malhas A, Goulbourne C, Vaux DJ.

Trends Cell Biol. 2011 Jun;21(6):362-73. doi: 10.1016/j.tcb.2011.03.008. Epub 2011 Apr 21. Review.

PMID:
21514163
26.

A novel role for BRCA1 in regulating breast cancer cell spreading and motility.

Coene ED, Gadelha C, White N, Malhas A, Thomas B, Shaw M, Vaux DJ.

J Cell Biol. 2011 Feb 7;192(3):497-512. doi: 10.1083/jcb.201004136. Epub 2011 Jan 31.

27.

The nuclear envelope can control gene expression and cell cycle progression via miRNA regulation.

Malhas A, Saunders NJ, Vaux DJ.

Cell Cycle. 2010 Feb 1;9(3):531-9.

PMID:
20081371
28.

HIV protease inhibitors inhibit FACE1/ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy?

Goulbourne CN, Vaux DJ.

Biochem Soc Trans. 2010 Feb;38(Pt 1):292-6. doi: 10.1042/BST0380292.

PMID:
20074077
29.

Elongation dynamics of amyloid fibrils: a rugged energy landscape picture.

Lee CF, Loken J, Jean L, Vaux DJ.

Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Oct;80(4 Pt 1):041906. Epub 2009 Oct 6.

PMID:
19905341
30.

Competing discrete interfacial effects are critical for amyloidogenesis.

Jean L, Lee CF, Lee C, Shaw M, Vaux DJ.

FASEB J. 2010 Jan;24(1):309-17. doi: 10.1096/fj.09-137653. Epub 2009 Sep 9.

PMID:
19741169
31.

Transcription factor sequestration by nuclear envelope components.

Malhas AN, Vaux DJ.

Cell Cycle. 2009 Apr 1;8(7):959-60. Epub 2009 Apr 9. No abstract available.

PMID:
19287201
32.

Lamin B1 controls oxidative stress responses via Oct-1.

Malhas AN, Lee CF, Vaux DJ.

J Cell Biol. 2009 Jan 12;184(1):45-55. doi: 10.1083/jcb.200804155.

33.

Structural elements regulating amyloidogenesis: a cholinesterase model system.

Jean L, Lee CF, Shaw M, Vaux DJ.

PLoS One. 2008 Mar 19;3(3):e1834. doi: 10.1371/journal.pone.0001834.

34.
35.

Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease.

Jean L, Thomas B, Tahiri-Alaoui A, Shaw M, Vaux DJ.

PLoS One. 2007 Jul 25;2(7):e652.

36.

Defects in lamin B1 expression or processing affect interphase chromosome position and gene expression.

Malhas A, Lee CF, Sanders R, Saunders NJ, Vaux DJ.

J Cell Biol. 2007 Feb 26;176(5):593-603. Epub 2007 Feb 20.

37.

Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria.

Coene ED, Hollinshead MS, Waeytens AA, Schelfhout VR, Eechaute WP, Shaw MK, Van Oostveldt PM, Vaux DJ.

Mol Biol Cell. 2005 Feb;16(2):997-1010. Epub 2004 Dec 9.

38.

CAAX-dependent modifications of the lamin proteins in the organization of the nuclear periphery.

Maske CP, Vaux DJ.

Symp Soc Exp Biol. 2004;(56):317-28. Review. No abstract available.

PMID:
15565890
39.

Rapid method for measurement of surface tension in multiwell plates.

Cottingham MG, Bain CD, Vaux DJ.

Lab Invest. 2004 Apr;84(4):523-9.

40.

The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells.

Ferry H, Jones M, Vaux DJ, Roberts IS, Cornall RJ.

J Exp Med. 2003 Nov 3;198(9):1415-25.

41.

A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation.

Maske CP, Hollinshead MS, Higbee NC, Bergo MO, Young SG, Vaux DJ.

J Cell Biol. 2003 Sep 29;162(7):1223-32. Epub 2003 Sep 22.

43.

A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading.

Wonerow P, Pearce AC, Vaux DJ, Watson SP.

J Biol Chem. 2003 Sep 26;278(39):37520-9. Epub 2003 Jun 27.

44.
45.

Mutations in congenital myasthenic syndromes reveal an epsilon subunit C-terminal cysteine, C470, crucial for maturation and surface expression of adult AChR.

Ealing J, Webster R, Brownlow S, Abdelgany A, Oosterhuis H, Muntoni F, Vaux DJ, Vincent A, Beeson D.

Hum Mol Genet. 2002 Nov 15;11(24):3087-96.

PMID:
12417530
46.
47.

Vaccinia virus utilizes microtubules for movement to the cell surface.

Hollinshead M, Rodger G, Van Eijl H, Law M, Hollinshead R, Vaux DJ, Smith GL.

J Cell Biol. 2001 Jul 23;154(2):389-402.

48.

Polycystin-1 expression in PKD1, early-onset PKD1, and TSC2/PKD1 cystic tissue.

Ong AC, Harris PC, Davies DR, Pritchard L, Rossetti S, Biddolph S, Vaux DJ, Migone N, Ward CJ.

Kidney Int. 1999 Oct;56(4):1324-33.

49.

Vaccinia virus intracellular mature virions contain only one lipid membrane.

Hollinshead M, Vanderplasschen A, Smith GL, Vaux DJ.

J Virol. 1999 Feb;73(2):1503-17.

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