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In vivo localization of human acetylcholinesterase-derived species in a β-sheet conformation at the core of senile plaques in Alzheimer's disease.

Jean L, Brimijoin S, Vaux DJ.

J Biol Chem. 2019 Apr 19;294(16):6253-6272. doi: 10.1074/jbc.RA118.006230. Epub 2019 Feb 20.


In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose.

Dong L, Reljic B, Cheung JG, Ng ES, Lindqvist LM, Elefanty AG, Vaux DL, Tran H.

Cell Death Differ. 2019 Feb 15. doi: 10.1038/s41418-019-0275-z. [Epub ahead of print]


Activated MLKL attenuates autophagy following its translocation to intracellular membranes.

Frank D, Vaux DL, Murphy JM, Vince JE, Lindqvist LM.

J Cell Sci. 2019 Feb 28;132(5). pii: jcs220996. doi: 10.1242/jcs.220996.


Recent advances in understanding inhibitor of apoptosis proteins.

Lalaoui N, Vaux DL.

F1000Res. 2018 Dec 3;7. pii: F1000 Faculty Rev-1889. doi: 10.12688/f1000research.16439.1. eCollection 2018. Review.


Multiphasic effect of vinyl pyrrolidone polymers on amyloidogenesis, from macromolecular crowding to inhibition.

Berwick R, Vaux DJ, Jean L.

Biochem J. 2018 Nov 9;475(21):3417-3436. doi: 10.1042/BCJ20180715.


Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion.

Lindqvist LM, Frank D, McArthur K, Dite TA, Lazarou M, Oakhill JS, Kile BT, Vaux DL.

Cell Death Differ. 2018 Mar;25(4):784-796. doi: 10.1038/s41418-017-0017-z. Epub 2017 Dec 11.


Viewing BCL2 and cell death control from an evolutionary perspective.

Strasser A, Vaux DL.

Cell Death Differ. 2018 Jan;25(1):13-20. doi: 10.1038/cdd.2017.145. Epub 2017 Nov 3. Review.


The Physiological and Pathological Implications of the Formation of Hydrogels, with a Specific Focus on Amyloid Polypeptides.

Jean L, Foley AC, Vaux DJT.

Biomolecules. 2017 Sep 22;7(4). pii: E70. doi: 10.3390/biom7040070. Review.


Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham RL, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J.

J Biol Chem. 2017 Aug 25;292(34):14310. doi: 10.1074/jbc.A109.087635. No abstract available.


Formation of a nucleoplasmic reticulum requires de novo assembly of nascent phospholipids and shows preferential incorporation of nascent lamins.

Drozdz MM, Jiang H, Pytowski L, Grovenor C, Vaux DJ.

Sci Rep. 2017 Aug 7;7(1):7454. doi: 10.1038/s41598-017-07614-w.


XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation.

Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE.

Cell Rep. 2017 Jul 18;20(3):668-682. doi: 10.1016/j.celrep.2017.06.073.


Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J.

Elife. 2017 Jun 27;6. pii: e29849. doi: 10.7554/eLife.29849. No abstract available.


Stress-induced release of Oct-1 from the nuclear envelope is mediated by JNK phosphorylation of lamin B1.

Boubriak II, Malhas AN, Drozdz MM, Pytowski L, Vaux DJ.

PLoS One. 2017 May 24;12(5):e0177990. doi: 10.1371/journal.pone.0177990. eCollection 2017.


Foxp3 drives oxidative phosphorylation and protection from lipotoxicity.

Howie D, Cobbold SP, Adams E, Ten Bokum A, Necula AS, Zhang W, Huang H, Roberts DJ, Thomas B, Hester SS, Vaux DJ, Betz AG, Waldmann H.

JCI Insight. 2017 Feb 9;2(3):e89160. doi: 10.1172/jci.insight.89160.


Nanoscale mapping of newly-synthesised phospholipid molecules in a biological cell using tip-enhanced Raman spectroscopy.

Kumar N, Drozdz MM, Jiang H, Santos DM, Vaux DJ.

Chem Commun (Camb). 2017 Feb 21;53(16):2451-2454. doi: 10.1039/c6cc10226c.


Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner.

Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):E961-E969. doi: 10.1073/pnas.1613305114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5762-E5763.


Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins.

Goodall KJ, Finch-Edmondson ML, van Vuuren J, Yeoh GC, Gentle IE, Vince JE, Ekert PG, Vaux DL, Callus BA.

PLoS One. 2016 Nov 2;11(11):e0164003. doi: 10.1371/journal.pone.0164003. eCollection 2016.


Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation.

Drozdz MM, Vaux DJ.

Nucleus. 2017 Jan 2;8(1):34-45. doi: 10.1080/19491034.2016.1252893. Epub 2016 Oct 31. Review.


Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion.

Conos SA, Lawlor KE, Vaux DL, Vince JE, Lindqvist LM.

Cell Death Differ. 2016 Nov 1;23(11):1827-1838. doi: 10.1038/cdd.2016.69. Epub 2016 Jul 15.


Australia needs an Ombudsman or Office for Research Integrity.

Brooks PM, Vaux DL, Williamson R.

Intern Med J. 2016 Oct;46(10):1233-1235. doi: 10.1111/imj.13211. No abstract available.


Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NN, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J.

Cancer Cell. 2016 Sep 12;30(3):499-500. doi: 10.1016/j.ccell.2016.08.009. Epub 2016 Sep 12. No abstract available.


Dynamics of the formation of a hydrogel by a pathogenic amyloid peptide: islet amyloid polypeptide.

Jean L, Lee CF, Hodder P, Hawkins N, Vaux DJ.

Sci Rep. 2016 Aug 18;6:32124. doi: 10.1038/srep32124.


The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia.

Brumatti G, Ma C, Lalaoui N, Nguyen NY, Navarro M, Tanzer MC, Richmond J, Ghisi M, Salmon JM, Silke N, Pomilio G, Glaser SP, de Valle E, Gugasyan R, Gurthridge MA, Condon SM, Johnstone RW, Lock R, Salvesen G, Wei A, Vaux DL, Ekert PG, Silke J.

Sci Transl Med. 2016 May 18;8(339):339ra69. doi: 10.1126/scitranslmed.aad3099. Erratum in: Sci Transl Med. 2017 May 31;9(392):.


BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux.

Reljic B, Conos S, Lee EF, Garnier JM, Dong L, Lessene G, Fairlie WD, Vaux DL, Lindqvist LM.

Autophagy. 2016 Jul 2;12(7):1083-93. doi: 10.1080/15548627.2016.1179406. Epub 2016 May 12.


Methods for Single-Cell Pulse-Chase Analysis of Nuclear Components.

Drozdz M, Vaux DJ.

Methods Mol Biol. 2016;1411:159-76. doi: 10.1007/978-1-4939-3530-7_10.


Evolutionary divergence of the necroptosis effector MLKL.

Tanzer MC, Matti I, Hildebrand JM, Young SN, Wardak A, Tripaydonis A, Petrie EJ, Mildenhall AL, Vaux DL, Vince JE, Czabotar PE, Silke J, Murphy JM.

Cell Death Differ. 2016 Jul;23(7):1185-97. doi: 10.1038/cdd.2015.169. Epub 2016 Feb 12.


Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics.

Lalaoui N, Hänggi K, Brumatti G, Chau D, Nguyen NY, Vasilikos L, Spilgies LM, Heckmann DA, Ma C, Ghisi M, Salmon JM, Matthews GM, de Valle E, Moujalled DM, Menon MB, Spall SK, Glaser SP, Richmond J, Lock RB, Condon SM, Gugasyan R, Gaestel M, Guthridge M, Johnstone RW, Munoz L, Wei A, Ekert PG, Vaux DL, Wong WW, Silke J.

Cancer Cell. 2016 Feb 8;29(2):145-58. doi: 10.1016/j.ccell.2016.01.006. Erratum in: Cancer Cell. 2016 Sep 12;30(3):499-500.


In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-κB and activation of caspase-8.

Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR, Nachbur U, Rickard J, Anderton H, Moulin M, Lluis JM, Moujalled DM, Silke J, Vaux DL.

J Biol Chem. 2016 Jan 29;291(5):2547. doi: 10.1074/jbc.A110.216226. No abstract available.


Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies.

Delbridge AR, Grabow S, Strasser A, Vaux DL.

Nat Rev Cancer. 2016 Feb;16(2):99-109. doi: 10.1038/nrc.2015.17. Review.


TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.

Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J.

Elife. 2015 Dec 23;4. pii: e10592. doi: 10.7554/eLife.10592. Erratum in: Elife. 2017 Jun 27;6:.


Response to Heard et al.

Moulin M, Voss AK, Thomas T, Wong WW, Cook WD, Koentgen F, Vince J, Silke J, Vaux DL.

EMBO J. 2015 Oct 1;34(19):2396-7. doi: 10.15252/embj.201592761. No abstract available.


RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.

Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE.

Nat Commun. 2015 Feb 18;6:6282. doi: 10.1038/ncomms7282.


IAP gene deletion and conditional knockout models.

Silke J, Vaux DL.

Semin Cell Dev Biol. 2015 Mar;39:97-105. doi: 10.1016/j.semcdb.2014.12.004. Epub 2014 Dec 26. Review.


TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

Rickard JA, Anderton H, Etemadi N, Nachbur U, Darding M, Peltzer N, Lalaoui N, Lawlor KE, Vanyai H, Hall C, Bankovacki A, Gangoda L, Wong WW, Corbin J, Huang C, Mocarski ES, Murphy JM, Alexander WS, Voss AK, Vaux DL, Kaiser WJ, Walczak H, Silke J.

Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03464.


Biosensor architectures for high-fidelity reporting of cellular signaling.

Dushek O, Lellouch AC, Vaux DJ, Shahrezaei V.

Biophys J. 2014 Aug 5;107(3):773-782. doi: 10.1016/j.bpj.2014.06.021.


Basic statistics in cell biology.

Vaux DL.

Annu Rev Cell Dev Biol. 2014;30:23-37. doi: 10.1146/annurev-cellbio-100913-013303. Epub 2014 Jul 2. Review.


BCL2 and related prosurvival proteins require BAK1 and BAX to affect autophagy.

Lindqvist LM, Vaux DL.

Autophagy. 2014 Aug;10(8):1474-5. doi: 10.4161/auto.29639. Epub 2014 Jun 27.


Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming.

Allam R, Lawlor KE, Yu EC, Mildenhall AL, Moujalled DM, Lewis RS, Ke F, Mason KD, White MJ, Stacey KJ, Strasser A, O'Reilly LA, Alexander W, Kile BT, Vaux DL, Vince JE.

EMBO Rep. 2014 Sep;15(9):982-90. doi: 10.15252/embr.201438463. Epub 2014 Jul 2.


Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.

Lindqvist LM, Heinlein M, Huang DC, Vaux DL.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8512-7. doi: 10.1073/pnas.1406425111. Epub 2014 May 27.


RIPK1- and RIPK3-induced cell death mode is determined by target availability.

Cook WD, Moujalled DM, Ralph TJ, Lock P, Young SN, Murphy JM, Vaux DL.

Cell Death Differ. 2014 Oct;21(10):1600-12. doi: 10.1038/cdd.2014.70. Epub 2014 Jun 6.


RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H, Hall C, Spall SK, Phesse TJ, Abud HE, Cengia LH, Corbin J, Mifsud S, Di Rago L, Metcalf D, Ernst M, Dewson G, Roberts AW, Alexander WS, Murphy JM, Ekert PG, Masters SL, Vaux DL, Croker BA, Gerlic M, Silke J.

Cell. 2014 May 22;157(5):1175-88. doi: 10.1016/j.cell.2014.04.019. Epub 2014 May 8.


Necroptosis induced by RIPK3 requires MLKL but not Drp1.

Moujalled DM, Cook WD, Murphy JM, Vaux DL.

Cell Death Dis. 2014 Feb 27;5:e1086. doi: 10.1038/cddis.2014.18.


Nuclear envelope invaginations and cancer.

Malhas AN, Vaux DJ.

Adv Exp Med Biol. 2014;773:523-35. doi: 10.1007/978-1-4899-8032-8_24. Review.


cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

Wong WW, Vince JE, Lalaoui N, Lawlor KE, Chau D, Bankovacki A, Anderton H, Metcalf D, O'Reilly L, Jost PJ, Murphy JM, Alexander WS, Strasser A, Vaux DL, Silke J.

Blood. 2014 Apr 17;123(16):2562-72. doi: 10.1182/blood-2013-06-510743. Epub 2014 Feb 4.


The air-water interface determines the outcome of seeding during amyloidogenesis.

Trigg BJ, Lee CF, Vaux DJ, Jean L.

Biochem J. 2013 Nov 15;456(1):67-80. doi: 10.1042/BJ20130605.


Another twist in the on and off affair between cell suicide and inflammation.

Vaux DL.

Cell Death Differ. 2013 Aug;20(8):974-5. doi: 10.1038/cdd.2013.57. No abstract available.


Combined biochemical and cytological analysis of membrane trafficking using lectins.

Morgan GW, Kail M, Hollinshead M, Vaux DJ.

Anal Biochem. 2013 Oct 1;441(1):21-31. doi: 10.1016/j.ab.2013.05.034. Epub 2013 Jun 10.


Is LMNB1 a susceptibility gene for neural tube defects in humans?

Robinson A, Partridge D, Malhas A, De Castro SC, Gustavsson P, Thompson DN, Vaux DJ, Copp AJ, Stanier P, Bassuk AG, Greene ND.

Birth Defects Res A Clin Mol Teratol. 2013 Jun;97(6):398-402. doi: 10.1002/bdra.23141. Epub 2013 Jun 3.


Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity.

Raghunathan VK, Devey M, Hawkins S, Hails L, Davis SA, Mann S, Chang IT, Ingham E, Malhas A, Vaux DJ, Lane JD, Case CP.

Biomaterials. 2013 May;34(14):3559-70. doi: 10.1016/j.biomaterials.2013.01.085. Epub 2013 Feb 20.


TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

Moujalled DM, Cook WD, Okamoto T, Murphy J, Lawlor KE, Vince JE, Vaux DL.

Cell Death Dis. 2013 Jan 17;4:e465. doi: 10.1038/cddis.2012.201.

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