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Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle.

Li X, Kumar S, McDew-White M, Haile M, Cheeseman IH, Emrich S, Button-Simons K, Nosten F, Kappe SHI, Ferdig MT, Anderson TJC, Vaughan AM.

PLoS Genet. 2019 Oct 14;15(10):e1008453. doi: 10.1371/journal.pgen.1008453. eCollection 2019 Oct.


Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites.

Minkah NK, Wilder BK, Sheikh AA, Martinson T, Wegmair L, Vaughan AM, Kappe SHI.

Nat Commun. 2019 Sep 2;10(1):3950. doi: 10.1038/s41467-019-11819-0.


Pairwise growth competitions identify relative fitness relationships among artemisinin resistant Plasmodium falciparum field isolates.

Tirrell AR, Vendrely KM, Checkley LA, Davis SZ, McDew-White M, Cheeseman IH, Vaughan AM, Nosten FH, Anderson TJC, Ferdig MT.

Malar J. 2019 Aug 28;18(1):295. doi: 10.1186/s12936-019-2934-4.


Non-Fatal Injuries and Injury Treatment in the West Coast Dungeness Crab Fishery.

Bovbjerg VE, Vaughan AM, Syron LN, Jacobson KR, Pillai S, Kincl LD.

J Agromedicine. 2019 Oct;24(4):316-323. doi: 10.1080/1059924X.2019.1638860. Epub 2019 Jul 23.


Plasmodium vivax.

Flannery EL, Markus MB, Vaughan AM.

Trends Parasitol. 2019 Jul;35(7):583-584. doi: 10.1016/ Epub 2019 Jun 5. No abstract available.


The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development.

Gupta DK, Dembele L, Voorberg-van der Wel A, Roma G, Yip A, Chuenchob V, Kangwanrangsan N, Ishino T, Vaughan AM, Kappe SH, Flannery EL, Sattabongkot J, Mikolajczak S, Bifani P, Kocken CH, Diagana TT.

Elife. 2019 May 16;8. pii: e43362. doi: 10.7554/eLife.43362.


Beyond Blood Smears: Qualification of Plasmodium 18S rRNA as a Biomarker for Controlled Human Malaria Infections.

Seilie AM, Chang M, Hanron AE, Billman ZP, Stone BC, Zhou K, Olsen TM, Daza G, Ortega J, Cruz KR, Smith N, Healy SA, Neal J, Wallis CK, Shelton L, Mankowski TV, Wong-Madden S, Mikolajczak SA, Vaughan AM, Kappe SHI, Fishbaugher M, Betz W, Kennedy M, Hume JCC, Talley AK, Hoffman SL, Chakravarty S, Sim BKL, Richie TL, Wald A, Plowe CV, Lyke KE, Adams M, Fahle GA, Cowan EP, Duffy PE, Kublin JG, Murphy SC.

Am J Trop Med Hyg. 2019 Jun;100(6):1466-1476. doi: 10.4269/ajtmh.19-0094.


The Development of Whole Sporozoite Vaccines for Plasmodium falciparum Malaria.

Itsara LS, Zhou Y, Do J, Grieser AM, Vaughan AM, Ghosh AK.

Front Immunol. 2018 Dec 11;9:2748. doi: 10.3389/fimmu.2018.02748. eCollection 2018. Review.


The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes.

Arredondo SA, Swearingen KE, Martinson T, Steel R, Dankwa DA, Harupa A, Camargo N, Betz W, Vigdorovich V, Oliver BG, Kangwanrangsan N, Ishino T, Sather N, Mikolajczak S, Vaughan AM, Torii M, Moritz RL, Kappe SHI.

Front Cell Infect Microbiol. 2018 Nov 27;8:413. doi: 10.3389/fcimb.2018.00413. eCollection 2018.


DDX17 Specifically, and Independently of DDX5, Controls Use of the HIV A4/5 Splice Acceptor Cluster and Is Essential for Efficient Replication of HIV.

Sithole N, Williams CA, Vaughan AM, Kenyon JC, Lever AML.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3111-3128. doi: 10.1016/j.jmb.2018.06.052. Epub 2018 Jul 2.


Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.

Zander RA, Vijay R, Pack AD, Guthmiller JJ, Graham AC, Lindner SE, Vaughan AM, Kappe SHI, Butler NS.

Cell Rep. 2018 Apr 24;23(4):1230-1237. doi: 10.1016/j.celrep.2018.04.048. No abstract available.


PfCap380 as a marker for Plasmodium falciparum oocyst development in vivo and in vitro.

Itsara LS, Zhou Y, Do J, Dungel S, Fishbaugher ME, Betz WW, Nguyen T, Navarro MJ, Flannery EL, Vaughan AM, Kappe SHI, Ghosh AK.

Malar J. 2018 Apr 2;17(1):135. doi: 10.1186/s12936-018-2277-6.


A Plasmodium Parasite with Complete Late Liver Stage Arrest Protects against Preerythrocytic and Erythrocytic Stage Infection in Mice.

Vaughan AM, Sack BK, Dankwa D, Minkah N, Nguyen T, Cardamone H, Kappe SHI.

Infect Immun. 2018 Apr 23;86(5). pii: e00088-18. doi: 10.1128/IAI.00088-18. Print 2018 May.


Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice.

Sack BK, Mikolajczak SA, Fishbaugher M, Vaughan AM, Flannery EL, Nguyen T, Betz W, Jane Navarro M, Foquet L, Steel RWJ, Billman ZP, Murphy SC, Hoffman SL, Chakravarty S, Sim BKL, Behet M, Reuling IJ, Walk J, Scholzen A, Sauerwein RW, Ishizuka AS, Flynn B, Seder RA, Kappe SHI.

NPJ Vaccines. 2017 Oct 9;2:27. doi: 10.1038/s41541-017-0028-2. eCollection 2017.


Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal.

Steel RWJ, Pei Y, Camargo N, Kaushansky A, Dankwa DA, Martinson T, Nguyen T, Betz W, Cardamone H, Vigdorovich V, Dambrauskas N, Carbonetti S, Vaughan AM, Sather DN, Kappe SHI.

Cell Microbiol. 2018 Apr;20(4). doi: 10.1111/cmi.12817. Epub 2018 Jan 12.


Th1-like Plasmodium-Specific Memory CD4+ T Cells Support Humoral Immunity.

Zander RA, Vijay R, Pack AD, Guthmiller JJ, Graham AC, Lindner SE, Vaughan AM, Kappe SHI, Butler NS.

Cell Rep. 2017 Nov 14;21(7):1839-1852. doi: 10.1016/j.celrep.2017.10.077. Erratum in: Cell Rep. 2018 Apr 24;23 (4):1230-1237.


Mucosal Barrier Injury Central-Line-Associated Bloodstream Infections: What is the Impact of Standard Prevention Bundles?

Vaughan AM, Ross R, Gilman MM, Satchell L, Ditaranto S, Reilly AF, Kersun LS, Shanahan A, Coffin SE, Sammons JS.

Infect Control Hosp Epidemiol. 2017 Nov;38(11):1385-1387. doi: 10.1017/ice.2017.188. Epub 2017 Sep 6. No abstract available.


Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites.

Swearingen KE, Lindner SE, Flannery EL, Vaughan AM, Morrison RD, Patrapuvich R, Koepfli C, Muller I, Jex A, Moritz RL, Kappe SHI, Sattabongkot J, Mikolajczak SA.

PLoS Negl Trop Dis. 2017 Jul 31;11(7):e0005791. doi: 10.1371/journal.pntd.0005791. eCollection 2017 Jul.


Genetically attenuated malaria parasites as vaccines.

Vaughan AM, Kappe SHI.

Expert Rev Vaccines. 2017 Aug;16(8):765-767. doi: 10.1080/14760584.2017.1341835. Epub 2017 Jun 16. No abstract available.


Malaria Parasite Liver Infection and Exoerythrocytic Biology.

Vaughan AM, Kappe SHI.

Cold Spring Harb Perspect Med. 2017 Jun 1;7(6). pii: a025486. doi: 10.1101/cshperspect.a025486. Review.


Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects.

Kublin JG, Mikolajczak SA, Sack BK, Fishbaugher ME, Seilie A, Shelton L, VonGoedert T, Firat M, Magee S, Fritzen E, Betz W, Kain HS, Dankwa DA, Steel RW, Vaughan AM, Noah Sather D, Murphy SC, Kappe SH.

Sci Transl Med. 2017 Jan 4;9(371). pii: eaad9099. doi: 10.1126/scitranslmed.aad9099.


Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein.

Keitany GJ, Kim KS, Krishnamurty AT, Hondowicz BD, Hahn WO, Dambrauskas N, Sather DN, Vaughan AM, Kappe SHI, Pepper M.

Cell Rep. 2016 Dec 20;17(12):3193-3205. doi: 10.1016/j.celrep.2016.11.060.


Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics.

Swearingen KE, Lindner SE, Shi L, Shears MJ, Harupa A, Hopp CS, Vaughan AM, Springer TA, Moritz RL, Kappe SH, Sinnis P.

PLoS Pathog. 2016 Apr 29;12(4):e1005606. doi: 10.1371/journal.ppat.1005606. eCollection 2016 Apr.


A Plasmodium yoelii Mei2-Like RNA Binding Protein Is Essential for Completion of Liver Stage Schizogony.

Dankwa DA, Davis MJ, Kappe SHI, Vaughan AM.

Infect Immun. 2016 Apr 22;84(5):1336-1345. doi: 10.1128/IAI.01417-15. Print 2016 May.



Vaughan AM.

Methods Mol Biol. 2015;1325:v-vi. No abstract available.


Measurement of Antibody-Mediated Reduction of Plasmodium yoelii Liver Burden by Bioluminescent Imaging.

Sack BK, Miller JL, Vaughan AM, Kappe SH.

Methods Mol Biol. 2015;1325:69-80. doi: 10.1007/978-1-4939-2815-6_6.


Plasmodium falciparum genetic crosses in a humanized mouse model.

Vaughan AM, Pinapati RS, Cheeseman IH, Camargo N, Fishbaugher M, Checkley LA, Nair S, Hutyra CA, Nosten FH, Anderson TJ, Ferdig MT, Kappe SH.

Nat Methods. 2015 Jul;12(7):631-3. doi: 10.1038/nmeth.3432. Epub 2015 Jun 1.


Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites.

Sack BK, Keitany GJ, Vaughan AM, Miller JL, Wang R, Kappe SH.

PLoS Pathog. 2015 May 14;11(5):e1004855. doi: 10.1371/journal.ppat.1004855. eCollection 2015 May.


Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice.

Mikolajczak SA, Vaughan AM, Kangwanrangsan N, Roobsoong W, Fishbaugher M, Yimamnuaychok N, Rezakhani N, Lakshmanan V, Singh N, Kaushansky A, Camargo N, Baldwin M, Lindner SE, Adams JH, Sattabongkot J, Kappe SH.

Cell Host Microbe. 2015 Apr 8;17(4):526-35. doi: 10.1016/j.chom.2015.02.011. Epub 2015 Mar 19.


Cyclic GMP balance is critical for malaria parasite transmission from the mosquito to the mammalian host.

Lakshmanan V, Fishbaugher ME, Morrison B, Baldwin M, Macarulay M, Vaughan AM, Mikolajczak SA, Kappe SH.

mBio. 2015 Mar 17;6(2):e02330. doi: 10.1128/mBio.02330-14.


CD40 is required for protective immunity against liver stage Plasmodium infection.

Murray SA, Mohar I, Miller JL, Brempelis KJ, Vaughan AM, Kappe SH, Crispe IN.

J Immunol. 2015 Mar 1;194(5):2268-79. doi: 10.4049/jimmunol.1401724. Epub 2015 Feb 2.


Susceptibility to Plasmodium yoelii preerythrocytic infection in BALB/c substrains is determined at the point of hepatocyte invasion.

Kaushansky A, Austin LS, Mikolajczak SA, Lo FY, Miller JL, Douglass AN, Arang N, Vaughan AM, Gardner MJ, Kappe SH.

Infect Immun. 2015 Jan;83(1):39-47. doi: 10.1128/IAI.02230-14. Epub 2014 Oct 13.


Immunization of mice with live-attenuated late liver stage-arresting Plasmodium yoelii parasites generates protective antibody responses to preerythrocytic stages of malaria.

Keitany GJ, Sack B, Smithers H, Chen L, Jang IK, Sebastian L, Gupta M, Sather DN, Vignali M, Vaughan AM, Kappe SH, Wang R.

Infect Immun. 2014 Dec;82(12):5143-53. doi: 10.1128/IAI.02320-14. Epub 2014 Sep 29.


A scalable assessment of Plasmodium falciparum transmission in the standard membrane-feeding assay, using transgenic parasites expressing green fluorescent protein-luciferase.

Stone WJ, Churcher TS, Graumans W, van Gemert GJ, Vos MW, Lanke KH, van de Vegte-Bolmer MG, Siebelink-Stoter R, Dechering KJ, Vaughan AM, Camargo N, Kappe SH, Sauerwein RW, Bousema T.

J Infect Dis. 2014 Nov 1;210(9):1456-63. doi: 10.1093/infdis/jiu271. Epub 2014 May 14.


Interferon-mediated innate immune responses against malaria parasite liver stages.

Miller JL, Sack BK, Baldwin M, Vaughan AM, Kappe SHI.

Cell Rep. 2014 Apr 24;7(2):436-447. doi: 10.1016/j.celrep.2014.03.018. Epub 2014 Apr 3.


Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum.

Sack BK, Miller JL, Vaughan AM, Douglass A, Kaushansky A, Mikolajczak S, Coppi A, Gonzalez-Aseguinolaza G, Tsuji M, Zavala F, Sinnis P, Kappe SH.

Infect Immun. 2014 Feb;82(2):808-17. doi: 10.1128/IAI.01249-13. Epub 2013 Dec 9.


Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver-stage development.

Lindner SE, Sartain MJ, Hayes K, Harupa A, Moritz RL, Kappe SH, Vaughan AM.

Mol Microbiol. 2014 Feb;91(4):679-93. doi: 10.1111/mmi.12485. Epub 2014 Jan 7.


Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes.

van Schaijk BC, Kumar TR, Vos MW, Richman A, van Gemert GJ, Li T, Eappen AG, Williamson KC, Morahan BJ, Fishbaugher M, Kennedy M, Camargo N, Khan SM, Janse CJ, Sim KL, Hoffman SL, Kappe SH, Sauerwein RW, Fidock DA, Vaughan AM.

Eukaryot Cell. 2014 May;13(5):550-9. doi: 10.1128/EC.00264-13. Epub 2013 Dec 2.


Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum.

Cobbold SA, Vaughan AM, Lewis IA, Painter HJ, Camargo N, Perlman DH, Fishbaugher M, Healer J, Cowman AF, Kappe SH, Llinás M.

J Biol Chem. 2013 Dec 20;288(51):36338-50. doi: 10.1074/jbc.M113.503557. Epub 2013 Oct 25.


Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes.

Williams AR, Zakutansky SE, Miura K, Dicks MD, Churcher TS, Jewell KE, Vaughan AM, Turner AV, Kapulu MC, Michel K, Long CA, Sinden RE, Hill AV, Draper SJ, Biswas S.

Int J Parasitol. 2013 Oct;43(11):869-74. doi: 10.1016/j.ijpara.2013.06.004. Epub 2013 Jul 18.


Quantitative bioluminescent imaging of pre-erythrocytic malaria parasite infection using luciferase-expressing Plasmodium yoelii.

Miller JL, Murray S, Vaughan AM, Harupa A, Sack B, Baldwin M, Crispe IN, Kappe SH.

PLoS One. 2013 Apr 11;8(4):e60820. doi: 10.1371/journal.pone.0060820. Print 2013.


Suppression of host p53 is critical for Plasmodium liver-stage infection.

Kaushansky A, Ye AS, Austin LS, Mikolajczak SA, Vaughan AM, Camargo N, Metzger PG, Douglass AN, MacBeath G, Kappe SH.

Cell Rep. 2013 Mar 28;3(3):630-7. doi: 10.1016/j.celrep.2013.02.010. Epub 2013 Mar 7.


Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage development.

Pei Y, Miller JL, Lindner SE, Vaughan AM, Torii M, Kappe SHI.

Cell Microbiol. 2013 Sep;15(9):1508-1526. doi: 10.1111/cmi.12124. Epub 2013 Mar 14.


Perturbations of Plasmodium Puf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility.

Lindner SE, Mikolajczak SA, Vaughan AM, Moon W, Joyce BR, Sullivan WJ Jr, Kappe SH.

Cell Microbiol. 2013 Jul;15(7):1266-83. doi: 10.1111/cmi.12116. Epub 2013 Feb 27.


Total and putative surface proteomics of malaria parasite salivary gland sporozoites.

Lindner SE, Swearingen KE, Harupa A, Vaughan AM, Sinnis P, Moritz RL, Kappe SH.

Mol Cell Proteomics. 2013 May;12(5):1127-43. doi: 10.1074/mcp.M112.024505. Epub 2013 Jan 16.


A rapid and scalable density gradient purification method for Plasmodium sporozoites.

Kennedy M, Fishbaugher ME, Vaughan AM, Patrapuvich R, Boonhok R, Yimamnuaychok N, Rezakhani N, Metzger P, Ponpuak M, Sattabongkot J, Kappe SH, Hume JC, Lindner SE.

Malar J. 2012 Dec 17;11:421. doi: 10.1186/1475-2875-11-421.


A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle.

Vaughan AM, Mikolajczak SA, Camargo N, Lakshmanan V, Kennedy M, Lindner SE, Miller JL, Hume JC, Kappe SH.

Mol Biochem Parasitol. 2012 Dec;186(2):143-7. doi: 10.1016/j.molbiopara.2012.10.004. Epub 2012 Oct 27.


Complete Plasmodium falciparum liver-stage development in liver-chimeric mice.

Vaughan AM, Mikolajczak SA, Wilson EM, Grompe M, Kaushansky A, Camargo N, Bial J, Ploss A, Kappe SH.

J Clin Invest. 2012 Oct;122(10):3618-28. doi: 10.1172/JCI62684. Epub 2012 Sep 10.


Vaccination using radiation- or genetically attenuated live sporozoites.

Vaughan AM, Kappe SH.

Methods Mol Biol. 2013;923:549-66.


Development of humanized mouse models to study human malaria parasite infection.

Vaughan AM, Kappe SH, Ploss A, Mikolajczak SA.

Future Microbiol. 2012 May;7(5):657-65. doi: 10.2217/fmb.12.27. Review.

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