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Items: 1 to 50 of 98

1.

DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.

Fehrenbacher JC, Guo C, Kelley MR, Vasko MR.

Neuroscience. 2017 Dec 16;366:23-35. doi: 10.1016/j.neuroscience.2017.09.039. Epub 2017 Sep 28.

PMID:
28965839
2.

A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch.

Ramsden CE, Domenichiello AF, Yuan ZX, Sapio MR, Keyes GS, Mishra SK, Gross JR, Majchrzak-Hong S, Zamora D, Horowitz MS, Davis JM, Sorokin AV, Dey A, LaPaglia DM, Wheeler JJ, Vasko MR, Mehta NN, Mannes AJ, Iadarola MJ.

Sci Signal. 2017 Aug 22;10(493). pii: eaal5241. doi: 10.1126/scisignal.aal5241.

3.

Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy.

Kelley MR, Wikel JH, Guo C, Pollok KE, Bailey BJ, Wireman R, Fishel ML, Vasko MR.

J Pharmacol Exp Ther. 2016 Nov;359(2):300-309. Epub 2016 Sep 8.

4.

Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A.

Malty RH, Hudmon A, Fehrenbacher JC, Vasko MR.

J Neuroinflammation. 2016 Jul 11;13(1):181. doi: 10.1186/s12974-016-0645-0.

5.

Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons.

Georgiadis MM, Chen Q, Meng J, Guo C, Wireman R, Reed A, Vasko MR, Kelley MR.

DNA Repair (Amst). 2016 May;41:32-41. doi: 10.1016/j.dnarep.2016.03.009. Epub 2016 Mar 29.

6.

Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons.

Robarge JD, Duarte DB, Shariati B, Wang R, Flockhart DA, Vasko MR.

Exp Neurol. 2016 Jul;281:53-65. doi: 10.1016/j.expneurol.2016.04.006. Epub 2016 Apr 9.

7.

Models of Inflammation: Carrageenan Air Pouch.

Duarte DB, Vasko MR, Fehrenbacher JC.

Curr Protoc Pharmacol. 2016 Mar 18;72:5.6.1-9. doi: 10.1002/0471141755.ph0506s72.

8.

Epac activation sensitizes rat sensory neurons through activation of Ras.

Shariati B, Thompson EL, Nicol GD, Vasko MR.

Mol Cell Neurosci. 2016 Jan;70:54-67. doi: 10.1016/j.mcn.2015.11.005. Epub 2015 Nov 18.

9.

Navβ4 regulates fast resurgent sodium currents and excitability in sensory neurons.

Barbosa C, Tan ZY, Wang R, Xie W, Strong JA, Patel RR, Vasko MR, Zhang JM, Cummins TR.

Mol Pain. 2015 Sep 25;11:60. doi: 10.1186/s12990-015-0063-9.

10.

APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER.

Kim HS, Guo C, Thompson EL, Jiang Y, Kelley MR, Vasko MR, Lee SH.

Mutat Res. 2015 Sep;779:96-104. doi: 10.1016/j.mrfmmm.2015.06.010. Epub 2015 Jun 26.

11.

Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy.

Kelley MR, Jiang Y, Guo C, Reed A, Meng H, Vasko MR.

PLoS One. 2014 Sep 4;9(9):e106485. doi: 10.1371/journal.pone.0106485. eCollection 2014.

12.

Nerve growth factor mediates a switch in intracellular signaling for PGE2-induced sensitization of sensory neurons from protein kinase A to Epac.

Vasko MR, Habashy Malty R, Guo C, Duarte DB, Zhang Y, Nicol GD.

PLoS One. 2014 Aug 15;9(8):e104529. doi: 10.1371/journal.pone.0104529. eCollection 2014.

13.

Paclitaxel alters the evoked release of calcitonin gene-related peptide from rat sensory neurons in culture.

Pittman SK, Gracias NG, Vasko MR, Fehrenbacher JC.

Exp Neurol. 2014 Mar;253:146-53. doi: 10.1016/j.expneurol.2013.12.011. Epub 2013 Dec 26.

14.

CRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy.

Piekarz AD, Due MR, Khanna M, Wang B, Ripsch MS, Wang R, Meroueh SO, Vasko MR, White FA, Khanna R.

Mol Pain. 2012 Jul 24;8:54. doi: 10.1186/1744-8069-8-54.

15.

Models of inflammation: carrageenan air pouch.

Duarte DB, Vasko MR, Fehrenbacher JC.

Curr Protoc Pharmacol. 2012 Mar;Chapter 5:Unit5.6. doi: 10.1002/0471141755.ph0506s56.

16.

Models of inflammation: Carrageenan- or complete Freund's Adjuvant (CFA)-induced edema and hypersensitivity in the rat.

Fehrenbacher JC, Vasko MR, Duarte DB.

Curr Protoc Pharmacol. 2012 Mar;Chapter 5:Unit5.4. doi: 10.1002/0471141755.ph0504s56.

17.

The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation.

Vasko MR, Guo C, Thompson EL, Kelley MR.

DNA Repair (Amst). 2011 Sep 5;10(9):942-52. doi: 10.1016/j.dnarep.2011.06.004. Epub 2011 Jul 8.

18.

Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex.

Brittain JM, Duarte DB, Wilson SM, Zhu W, Ballard C, Johnson PL, Liu N, Xiong W, Ripsch MS, Wang Y, Fehrenbacher JC, Fitz SD, Khanna M, Park CK, Schmutzler BS, Cheon BM, Due MR, Brustovetsky T, Ashpole NM, Hudmon A, Meroueh SO, Hingtgen CM, Brustovetsky N, Ji RR, Hurley JH, Jin X, Shekhar A, Xu XM, Oxford GS, Vasko MR, White FA, Khanna R.

Nat Med. 2011 Jun 5;17(7):822-9. doi: 10.1038/nm.2345.

19.

Reduced expression of SynGAP, a neuronal GTPase-activating protein, enhances capsaicin-induced peripheral sensitization.

Duarte DB, Duan JH, Nicol GD, Vasko MR, Hingtgen CM.

J Neurophysiol. 2011 Jul;106(1):309-18. doi: 10.1152/jn.00963.2010. Epub 2011 Apr 27.

20.

Ras signaling pathways mediate NGF-induced enhancement of excitability of small-diameter capsaicin-sensitive sensory neurons from wildtype but not Nf1+/- mice.

Duan JH, Wang Y, Duarte D, Vasko MR, Nicol GD, Hingtgen CM.

Neurosci Lett. 2011 Jun 1;496(2):70-4. doi: 10.1016/j.neulet.2011.03.083. Epub 2011 Apr 8.

21.

Vasodilatation in the rat dorsal hindpaw induced by activation of sensory neurons is reduced by paclitaxel.

Gracias NG, Cummins TR, Kelley MR, Basile DP, Iqbal T, Vasko MR.

Neurotoxicology. 2011 Jan;32(1):140-9. doi: 10.1016/j.neuro.2010.09.006. Epub 2010 Oct 7.

22.

Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons.

Park KA, Fehrenbacher JC, Thompson EL, Duarte DB, Hingtgen CM, Vasko MR.

Neuroscience. 2010 Dec 15;171(3):910-23. doi: 10.1016/j.neuroscience.2010.09.027. Epub 2010 Sep 24.

23.

The deorphanization of TRPV1 and the emergence of octadecadienoids as a new class of lipid transmitters.

Flores CM, Vasko MR.

Mol Interv. 2010 Jun;10(3):137-40. doi: 10.1124/mi.10.3.4. Review. No abstract available.

PMID:
20539032
24.

Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions.

Jiang Y, Guo C, Fishel ML, Wang ZY, Vasko MR, Kelley MR.

DNA Repair (Amst). 2009 Nov 2;8(11):1273-82. doi: 10.1016/j.dnarep.2009.08.003. Epub 2009 Sep 1.

25.

Early and late contributions of glutamate and CGRP to mechanical sensitization by endothelin-1.

Khodorova A, Richter J, Vasko MR, Strichartz G.

J Pain. 2009 Jul;10(7):740-9. doi: 10.1016/j.jpain.2009.01.265.

26.

Local antinociception induced by endothelin-1 in the hairy skin of the rat's back.

Shrestha S, Gracias NG, Mujenda F, Khodorova A, Vasko MR, Strichartz GR.

J Pain. 2009 Jul;10(7):702-14. doi: 10.1016/j.jpain.2008.12.005.

27.

The c-kit signaling pathway is involved in the development of persistent pain.

Sun YG, Gracias NG, Drobish JK, Vasko MR, Gereau RW, Chen ZF.

Pain. 2009 Jul;144(1-2):178-86. doi: 10.1016/j.pain.2009.04.011. Epub 2009 May 13.

28.

Peripheral mechanisms of pain and analgesia.

Stein C, Clark JD, Oh U, Vasko MR, Wilcox GL, Overland AC, Vanderah TW, Spencer RH.

Brain Res Rev. 2009 Apr;60(1):90-113. doi: 10.1016/j.brainresrev.2008.12.017. Epub 2008 Dec 31. Review.

29.

Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons.

Jiang Y, Guo C, Vasko MR, Kelley MR.

Cancer Res. 2008 Aug 1;68(15):6425-34. doi: 10.1158/0008-5472.CAN-08-1173.

30.

N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons.

Rimmerman N, Bradshaw HB, Hughes HV, Chen JS, Hu SS, McHugh D, Vefring E, Jahnsen JA, Thompson EL, Masuda K, Cravatt BF, Burstein S, Vasko MR, Prieto AL, O'Dell DK, Walker JM.

Mol Pharmacol. 2008 Jul;74(1):213-24. doi: 10.1124/mol.108.045997. Epub 2008 Apr 18.

31.

Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung.

Chiyo M, Iwata T, Webb TJ, Vasko MR, Thompson EL, Heidler KM, Cummings OW, Yoshida S, Fujisawa T, Brand DD, Wilkes DS.

Am J Transplant. 2008 Mar;8(3):537-46. doi: 10.1111/j.1600-6143.2007.02116.x.

32.

Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P.

Nazarian A, Gu G, Gracias NG, Wilkinson K, Hua XY, Vasko MR, Yaksh TL.

Neuroscience. 2008 Mar 3;152(1):119-27. doi: 10.1016/j.neuroscience.2007.11.037.

33.
34.

DNA repair in neurons: so if they don't divide what's to repair?

Fishel ML, Vasko MR, Kelley MR.

Mutat Res. 2007 Jan 3;614(1-2):24-36. Epub 2006 Aug 1. Review.

PMID:
16879837
35.
36.

Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons.

Zhang YH, Fehrenbacher JC, Vasko MR, Nicol GD.

J Neurophysiol. 2006 Sep;96(3):1042-52. Epub 2006 May 24.

37.

Lipid mediators of sensitivity in sensory neurons.

Park KA, Vasko MR.

Trends Pharmacol Sci. 2005 Nov;26(11):571-7. Epub 2005 Sep 26. Review.

PMID:
16185776
38.

The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress.

Vasko MR, Guo C, Kelley MR.

DNA Repair (Amst). 2005 Mar 2;4(3):367-79.

PMID:
15661660
40.

Isolation and culture of sensory neurons from the dorsal-root ganglia of embryonic or adult rats.

Burkey TH, Hingtgen CM, Vasko MR.

Methods Mol Med. 2004;99:189-202.

PMID:
15131338
42.

ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors.

Huang H, Wu X, Nicol GD, Meller S, Vasko MR.

J Pharmacol Exp Ther. 2003 Sep;306(3):1137-44. Epub 2003 Jun 26.

44.

Cellular mechanisms of neurogenic inflammation.

Richardson JD, Vasko MR.

J Pharmacol Exp Ther. 2002 Sep;302(3):839-45. Review.

46.

Mechanisms of the release of anterogradely transported neurotrophin-3 from axon terminals.

Wang X, Butowt R, Vasko MR, von Bartheld CS.

J Neurosci. 2002 Feb 1;22(3):931-45.

47.
49.

Isoprostanes, novel eicosanoids that produce nociception and sensitize rat sensory neurons.

Evans AR, Junger H, Southall MD, Nicol GD, Sorkin LS, Broome JT, Bailey TW, Vasko MR.

J Pharmacol Exp Ther. 2000 Jun;293(3):912-20.

50.

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