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Items: 1 to 50 of 60

1.

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.

Garg G, Muschaweckh A, Moreno H, Vasanthakumar A, Floess S, Lepennetier G, Oellinger R, Zhan Y, Regen T, Hiltensperger M, Peter C, Aly L, Knier B, Palam LR, Kapur R, Kaplan MH, Waisman A, Rad R, Schotta G, Huehn J, Kallies A, Korn T.

Cell Rep. 2019 Feb 12;26(7):1854-1868.e5. doi: 10.1016/j.celrep.2019.01.070.

PMID:
30759395
2.

CCR2 enhances CD25 expression by FoxP3+ regulatory T cells and regulates their abundance independently of chemotaxis and CCR2+ myeloid cells.

Zhan Y, Wang N, Vasanthakumar A, Zhang Y, Chopin M, Nutt SL, Kallies A, Lew AM.

Cell Mol Immunol. 2018 Dec 11. doi: 10.1038/s41423-018-0187-8. [Epub ahead of print]

PMID:
30538272
3.

Reduced ITPase activity and favorable IL28B genetic variant protect against ribavirin-induced anemia in interferon-free regimens.

Vasanthakumar A, Davis JW, Abunimeh M, Söderholm J, Zha J, Dumas EO, Cohen DE, Waring JF, Lagging M.

PLoS One. 2018 May 31;13(5):e0198296. doi: 10.1371/journal.pone.0198296. eCollection 2018.

4.

Regulatory T-cell heterogeneity.

Ward-Hartstonge KA, Vasanthakumar A.

Clin Transl Immunology. 2018 Mar 29;7(3):e01012. doi: 10.1002/cti2.1012. eCollection 2018. No abstract available.

5.

Interleukin (IL)-33 and the IL-1 Family of Cytokines-Regulators of Inflammation and Tissue Homeostasis.

Vasanthakumar A, Kallies A.

Cold Spring Harb Perspect Biol. 2017 Nov 3. pii: a028506. doi: 10.1101/cshperspect.a028506. [Epub ahead of print]

PMID:
29101106
6.

The TNF Receptor Superfamily-NF-κB Axis Is Critical to Maintain Effector Regulatory T Cells in Lymphoid and Non-lymphoid Tissues.

Vasanthakumar A, Liao Y, Teh P, Pascutti MF, Oja AE, Garnham AL, Gloury R, Tempany JC, Sidwell T, Cuadrado E, Tuijnenburg P, Kuijpers TW, Lalaoui N, Mielke LA, Bryant VL, Hodgkin PD, Silke J, Smyth GK, Nolte MA, Shi W, Kallies A.

Cell Rep. 2017 Sep 19;20(12):2906-2920. doi: 10.1016/j.celrep.2017.08.068. Epub 2017 Sep 7.

7.

A non-canonical function of Ezh2 preserves immune homeostasis.

Vasanthakumar A, Xu D, Lun AT, Kueh AJ, van Gisbergen KP, Iannarella N, Li X, Yu L, Wang D, Williams BR, Lee SC, Majewski IJ, Godfrey DI, Smyth GK, Alexander WS, Herold MJ, Kallies A, Nutt SL, Allan RS.

EMBO Rep. 2017 Apr;18(4):619-631. doi: 10.15252/embr.201643237. Epub 2017 Feb 21.

8.

The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

Tuzlak S, Schenk RL, Vasanthakumar A, Preston SP, Haschka MD, Zotos D, Kallies A, Strasser A, Villunger A, Herold MJ.

Cell Death Differ. 2017 Mar;24(3):523-533. doi: 10.1038/cdd.2016.155. Epub 2017 Jan 13.

9.

Melding the Old with the New: Trends in Methods Used to Identify, Monitor, and Control Microorganisms on Cultural Heritage Materials.

Sanmartín P, DeAraujo A, Vasanthakumar A.

Microb Ecol. 2018 Jul;76(1):64-80. doi: 10.1007/s00248-016-0770-4. Epub 2016 Apr 27. Review.

PMID:
27117796
10.

Erratum to "5-hydroxymethylcytosine in cancer: Significance in diagnosis and therapy" [Cancer Genet 208 (2015):167-177].

Vasanthakumar A, Godley LA.

Cancer Genet. 2016 Apr;209(4):177. doi: 10.1016/j.cancergen.2016.02.001. Epub 2016 Feb 12. No abstract available.

PMID:
27085961
11.

NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.

de Valle E, Grigoriadis G, O'Reilly LA, Willis SN, Maxwell MJ, Corcoran LM, Tsantikos E, Cornish JK, Fairfax KA, Vasanthakumar A, Febbraio MA, Hibbs ML, Pellegrini M, Banerjee A, Hodgkin PD, Kallies A, Mackay F, Strasser A, Gerondakis S, Gugasyan R.

J Exp Med. 2016 Apr 4;213(4):621-41. doi: 10.1084/jem.20151182. Epub 2016 Mar 28.

12.

Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice.

Vasanthakumar A, Arnovitz S, Marquez R, Lepore J, Rafidi G, Asom A, Weatherly M, Davis EM, Neistadt B, Duszynski R, Vardiman JW, Le Beau MM, Godley LA, Churpek JE.

Blood. 2016 Jan 21;127(3):310-3. doi: 10.1182/blood-2015-03-635599. Epub 2015 Dec 7.

13.

Development and Function of Effector Regulatory T Cells.

Teh PP, Vasanthakumar A, Kallies A.

Prog Mol Biol Transl Sci. 2015;136:155-74. doi: 10.1016/bs.pmbts.2015.08.005. Epub 2015 Sep 26. Review.

PMID:
26615096
14.

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Murphy AJ, Kraakman MJ, Kammoun HL, Dragoljevic D, Lee MK, Lawlor KE, Wentworth JM, Vasanthakumar A, Gerlic M, Whitehead LW, DiRago L, Cengia L, Lane RM, Metcalf D, Vince JE, Harrison LC, Kallies A, Kile BT, Croker BA, Febbraio MA, Masters SL.

Cell Metab. 2016 Jan 12;23(1):155-64. doi: 10.1016/j.cmet.2015.09.024. Epub 2015 Oct 22.

15.

The Regulatory T Cell: Jack-Of-All-Trades.

Vasanthakumar A, Kallies A.

Trends Immunol. 2015 Dec;36(12):756-758. doi: 10.1016/j.it.2015.10.002. Epub 2015 Oct 25.

PMID:
26511762
16.

Epigenetic Control of Apolipoprotein E Expression Mediates Gender-Specific Hematopoietic Regulation.

Vasanthakumar A, Zullow H, Lepore JB, Thomas K, Young N, Anastasi J, Reardon CA, Godley LA.

Stem Cells. 2015 Dec;33(12):3643-54. doi: 10.1002/stem.2214. Epub 2015 Oct 10.

17.

DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.

Dominguez PM, Teater M, Chambwe N, Kormaksson M, Redmond D, Ishii J, Vuong B, Chaudhuri J, Melnick A, Vasanthakumar A, Godley LA, Papavasiliou FN, Elemento O, Shaknovich R.

Cell Rep. 2015 Sep 29;12(12):2086-98. doi: 10.1016/j.celrep.2015.08.036. Epub 2015 Sep 10.

18.

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.

Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estecio MR, Godley LA, Issa JP.

Cancer Res. 2015 Jul 15;75(14):2833-43. doi: 10.1158/0008-5472.CAN-14-0739. Epub 2015 May 13.

19.

Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.

Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A.

Nat Immunol. 2015 May;16(5):544. doi: 10.1038/ni0515-544d. No abstract available.

PMID:
25898200
20.

5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy.

Vasanthakumar A, Godley LA.

Cancer Genet. 2015 May;208(5):167-77. doi: 10.1016/j.cancergen.2015.02.009. Epub 2015 Mar 3. Review. Erratum in: Cancer Genet. 2016 Apr;209(4):177.

PMID:
25892122
21.

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance.

Kraakman MJ, Kammoun HL, Allen TL, Deswaerte V, Henstridge DC, Estevez E, Matthews VB, Neill B, White DA, Murphy AJ, Peijs L, Yang C, Risis S, Bruce CR, Du XJ, Bobik A, Lee-Young RS, Kingwell BA, Vasanthakumar A, Shi W, Kallies A, Lancaster GI, Rose-John S, Febbraio MA.

Cell Metab. 2015 Mar 3;21(3):403-16. doi: 10.1016/j.cmet.2015.02.006. Erratum in: Cell Metab. 2016 Mar 8;23(3):563.

22.

Inactivation of foodborne microorganisms using engineered water nanostructures (EWNS).

Pyrgiotakis G, Vasanthakumar A, Gao Y, Eleftheriadou M, Toledo E, DeAraujo A, McDevitt J, Han T, Mainelis G, Mitchell R, Demokritou P.

Environ Sci Technol. 2015 Mar 17;49(6):3737-45. doi: 10.1021/es505868a. Epub 2015 Mar 3.

PMID:
25695127
23.

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.

Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A.

Nat Immunol. 2015 Mar;16(3):276-85. doi: 10.1038/ni.3085. Epub 2015 Jan 19. Erratum in: Nat Immunol. 2015 May;16(5):544.

PMID:
25599561
24.

Pyomelanin production in Penicillium chrysogenum is stimulated by L-tyrosine.

Vasanthakumar A, DeAraujo A, Mazurek J, Schilling M, Mitchell R.

Microbiology. 2015 Jun;161(6):1211-8. doi: 10.1099/mic.0.000030. Epub 2015 Jan 7.

PMID:
25568259
25.

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.

Rampal R, Alkalin A, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, Tallman JE, Zhao X, Daniels D, Dai Q, Ciminio L, Aifantis I, He C, Fuks F, Tallman MS, Ferrando A, Nimer S, Paietta E, Thompson CB, Licht JD, Mason CE, Godley LA, Melnick A, Figueroa ME, Levine RL.

Cell Rep. 2014 Dec 11;9(5):1841-1855. doi: 10.1016/j.celrep.2014.11.004. Epub 2014 Dec 4.

26.

RNA-based molecular survey of biodiversity of limestone tombstone microbiota in response to atmospheric sulphur pollution.

Villa F, Vasanthakumar A, Mitchell R, Cappitelli F.

Lett Appl Microbiol. 2015 Jan;60(1):92-102. doi: 10.1111/lam.12345. Epub 2014 Nov 21.

27.

Variations in erythrocyte antioxidant levels and lipid peroxidation status and in serum lipid profile parameters in relation to blood haemoglobin A1c values in individuals with type 2 diabetes mellitus.

Annadurai T, Vasanthakumar A, Geraldine P, Thomas PA.

Diabetes Res Clin Pract. 2014 Jul;105(1):58-69. doi: 10.1016/j.diabres.2014.04.018. Epub 2014 Apr 28.

PMID:
24842247
28.

TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.

Mariani CJ, Vasanthakumar A, Madzo J, Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL, Nanduri J, Verma A, Prabhakar NR, Godley LA.

Cell Rep. 2014 Jun 12;7(5):1343-1352. doi: 10.1016/j.celrep.2014.04.040. Epub 2014 May 15.

29.

IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1.

Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, Mitsdoerffer M, Sie C, Prazeres da Costa O, Buch T, Hemmer B, Oukka M, Kallies A, Korn T.

Nat Commun. 2014 May 6;5:3770. doi: 10.1038/ncomms4770.

PMID:
24796719
30.

On the origin of leukemic species.

Vasanthakumar A, Godley LA.

Cell Stem Cell. 2014 Apr 3;14(4):421-2. doi: 10.1016/j.stem.2014.03.008.

31.

Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.

Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces DBD, Looney TJ, Zhang L, Lepore JB, Macrae T, Duszynski R, Shih AH, Song CX, Yu M, Yu Y, Grossman R, Raumann B, Verma A, He C, Levine RL, Lavelle D, Lahn BT, Wickrema A, Godley LA.

Cell Rep. 2014 Jan 16;6(1):231-244. doi: 10.1016/j.celrep.2013.11.044. Epub 2013 Dec 27.

32.

Thymic regulatory T cell development: role of signalling pathways and transcription factors.

Engel M, Sidwell T, Vasanthakumar A, Grigoriadis G, Banerjee A.

Clin Dev Immunol. 2013;2013:617595. doi: 10.1155/2013/617595. Epub 2013 Sep 26. Review.

33.

Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma.

Clozel T, Yang S, Elstrom RL, Tam W, Martin P, Kormaksson M, Banerjee S, Vasanthakumar A, Culjkovic B, Scott DW, Wyman S, Leser M, Shaknovich R, Chadburn A, Tabbo F, Godley LA, Gascoyne RD, Borden KL, Inghirami G, Leonard JP, Melnick A, Cerchietti L.

Cancer Discov. 2013 Sep;3(9):1002-19. doi: 10.1158/2159-8290.CD-13-0117. Epub 2013 Aug 16.

34.

Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.

Bhattacharyya S, Yu Y, Suzuki M, Campbell N, Mazdo J, Vasanthakumar A, Bhagat TD, Nischal S, Christopeit M, Parekh S, Steidl U, Godley L, Maitra A, Greally JM, Verma A.

Nucleic Acids Res. 2013 Sep;41(16):e157. doi: 10.1093/nar/gkt601. Epub 2013 Jul 16.

35.

Transcription factor Bach2 balances tolerance and immunity.

Kallies A, Vasanthakumar A.

Immunol Cell Biol. 2013 Sep;91(8):491-2. doi: 10.1038/icb.2013.32. Epub 2013 Jul 2. No abstract available.

PMID:
23817578
36.

Modulating T regulatory cells in cancer: how close are we?

Banerjee A, Vasanthakumar A, Grigoriadis G.

Immunol Cell Biol. 2013 May;91(5):340-9. doi: 10.1038/icb.2013.12. Epub 2013 Apr 9. Review.

PMID:
23567897
37.

Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.

Madzo J, Vasanthakumar A, Godley LA.

Semin Hematol. 2013 Jan;50(1):61-9. doi: 10.1053/j.seminhematol.2013.01.004. Review.

PMID:
23507484
38.

IL-27 paves different roads to Tr1.

Vasanthakumar A, Kallies A.

Eur J Immunol. 2013 Apr;43(4):882-5. doi: 10.1002/eji.201343479.

39.

Abnormal body iron distribution and erythropoiesis in a novel mouse model with inducible gain of iron regulatory protein (IRP)-1 function.

Casarrubea D, Viatte L, Hallas T, Vasanthakumar A, Eisenstein RS, Schümann K, Hentze MW, Galy B.

J Mol Med (Berl). 2013 Jul;91(7):871-81. doi: 10.1007/s00109-013-1008-2. Epub 2013 Mar 1.

40.

Regulation of daunorubicin biosynthesis in Streptomyces peucetius - feed forward and feedback transcriptional control.

Vasanthakumar A, Kattusamy K, Prasad R.

J Basic Microbiol. 2013 Aug;53(8):636-44. doi: 10.1002/jobm.201200302. Epub 2013 Feb 18. Review.

PMID:
23417448
41.

Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.

Vasanthakumar A, Lepore JB, Zegarek MH, Kocherginsky M, Singh M, Davis EM, Link PA, Anastasi J, Le Beau MM, Karpf AR, Godley LA.

Blood. 2013 Mar 14;121(11):2059-63. doi: 10.1182/blood-2012-04-421065. Epub 2013 Jan 11.

42.

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.

Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, Mollica L, Li J, Viale A, Heguy A, Hassimi M, Socci N, Bhatt PK, Gonen M, Mason CE, Melnick A, Godley LA, Brennan CW, Abdel-Wahab O, Levine RL.

Nat Genet. 2012 Nov;44(11):1179-81. doi: 10.1038/ng.2413. Epub 2012 Sep 23.

43.

Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma.

Ostler KR, Yang Q, Looney TJ, Zhang L, Vasanthakumar A, Tian Y, Kocherginsky M, Raimondi SL, DeMaio JG, Salwen HR, Gu S, Chlenski A, Naranjo A, Gill A, Peddinti R, Lahn BT, Cohn SL, Godley LA.

Cancer Res. 2012 Sep 15;72(18):4714-23. doi: 10.1158/0008-5472.CAN-12-0886. Epub 2012 Jul 18.

44.

2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels.

Pollyea DA, Kohrt HE, Zhang B, Zehnder J, Schenkein D, Fantin V, Straley K, Vasanthakumar A, Abdel-Wahab O, Levine R, Godley LA, Medeiros BC.

Leuk Lymphoma. 2013 Feb;54(2):408-10. doi: 10.3109/10428194.2012.701009. Epub 2012 Jul 9. No abstract available.

45.

NF-κB subunit specificity in hemopoiesis.

Gerondakis S, Banerjee A, Grigoriadis G, Vasanthakumar A, Gugasyan R, Sidwell T, Grumont RJ.

Immunol Rev. 2012 Mar;246(1):272-85. doi: 10.1111/j.1600-065X.2011.01090.x. Review.

PMID:
22435561
46.

Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.

Yamazaki J, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Shen L, Kantarjian HM, Estecio MR, Jelinek J, Godley LA, Issa JP.

Epigenetics. 2012 Feb;7(2):201-7. doi: 10.4161/epi.7.2.19015.

47.

Dnmt3a is essential for hematopoietic stem cell differentiation.

Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA.

Nat Genet. 2011 Dec 4;44(1):23-31. doi: 10.1038/ng.1009.

48.

c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.

Grigoriadis G, Vasanthakumar A, Banerjee A, Grumont R, Overall S, Gleeson P, Shannon F, Gerondakis S.

PLoS One. 2011;6(10):e26851. doi: 10.1371/journal.pone.0026851. Epub 2011 Oct 31.

49.

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.

Szulwach KE, Li X, Li Y, Song CX, Wu H, Dai Q, Irier H, Upadhyay AK, Gearing M, Levey AI, Vasanthakumar A, Godley LA, Chang Q, Cheng X, He C, Jin P.

Nat Neurosci. 2011 Oct 30;14(12):1607-16. doi: 10.1038/nn.2959.

50.

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.

Shaknovich R, Cerchietti L, Tsikitas L, Kormaksson M, De S, Figueroa ME, Ballon G, Yang SN, Weinhold N, Reimers M, Clozel T, Luttrop K, Ekstrom TJ, Frank J, Vasanthakumar A, Godley LA, Michor F, Elemento O, Melnick A.

Blood. 2011 Sep 29;118(13):3559-69. doi: 10.1182/blood-2011-06-357996. Epub 2011 Aug 9.

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