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Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells.

Uygur B, Leikina E, Melikov K, Villasmil R, Verma SK, Vary CPH, Chernomordik LV.

Mol Cancer Res. 2019 Mar;17(3):806-820. doi: 10.1158/1541-7786.MCR-18-0500. Epub 2018 Dec 26.


The HU177 Collagen Epitope Controls Melanoma Cell Migration and Experimental Metastasis by a CDK5/YAP-Dependent Mechanism.

Caron JM, Han X, Contois L, Vary CPH, Brooks PC.

Am J Pathol. 2018 Oct;188(10):2356-2368. doi: 10.1016/j.ajpath.2018.06.017. Epub 2018 Aug 14.


Notch2 and Proteomic Signatures in Mouse Neointimal Lesion Formation.

Peterson SM, Turner JE, Harrington A, Davis-Knowlton J, Lindner V, Gridley T, Vary CPH, Liaw L.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1576-1593. doi: 10.1161/ATVBAHA.118.311092. Epub 2018 May 31.


Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling.

Davis-Knowlton J, Turner JE, Turner A, Damian-Loring S, Hagler N, Henderson T, Emery IF, Bond K, Duarte CW, Vary CPH, Eldrup-Jorgensen J, Liaw L.

Lab Invest. 2019 Mar;99(3):290-304. doi: 10.1038/s41374-018-0072-1. Epub 2018 May 23.


ErbB2 promotes endothelial phenotype of human left ventricular epicardial highly proliferative cells (eHiPC).

Ryzhov S, Robich MP, Roberts DJ, Favreau-Lessard AJ, Peterson SM, Jachimowicz E, Rath R, Vary CPH, Quinn R, Kramer RS, Sawyer DB.

J Mol Cell Cardiol. 2018 Feb;115:39-50. doi: 10.1016/j.yjmcc.2017.12.013. Epub 2017 Dec 29.


Novel roles for podocalyxin in regulating stress myelopoiesis, Rap1a, and neutrophil migration.

Li P, Karaczyn AA, McGlauflin R, Favreau-Lessard AJ, Jachimowicz E, Vary CP, Xu K, Wojchowski DM, Sathyanarayana P.

Exp Hematol. 2017 Jun;50:77-83.e6. doi: 10.1016/j.exphem.2017.04.001. Epub 2017 Apr 10.


Cancer incidence in patients with hereditary hemorrhagic telangiectasia.

Duarte CW, Black AW, Lucas FL, Vary CP.

J Cancer Res Clin Oncol. 2017 Feb;143(2):209-214. doi: 10.1007/s00432-016-2272-7. Epub 2016 Sep 16.


Inhibition of Ovarian Tumor Growth by Targeting the HU177 Cryptic Collagen Epitope.

Caron JM, Ames JJ, Contois L, Liebes L, Friesel R, Muggia F, Vary CP, Oxburgh L, Brooks PC.

Am J Pathol. 2016 Jun;186(6):1649-61. doi: 10.1016/j.ajpath.2016.01.015.


Lipid Profiling of In Vitro Cell Models of Adipogenic Differentiation: Relationships With Mouse Adipose Tissues.

Liaw L, Prudovsky I, Koza RA, Anunciado-Koza RV, Siviski ME, Lindner V, Friesel RE, Rosen CJ, Baker PR, Simons B, Vary CP.

J Cell Biochem. 2016 Sep;117(9):2182-93. doi: 10.1002/jcb.25522. Epub 2016 Mar 16.


DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence via P27KIP1 and Thrombospondin-1.

Rostama B, Turner JE, Seavey GT, Norton CR, Gridley T, Vary CP, Liaw L.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2626-37. doi: 10.1161/ATVBAHA.115.306541. Epub 2015 Oct 15.


Cthrc1 controls adipose tissue formation, body composition, and physical activity.

Stohn JP, Wang Q, Siviski ME, Kennedy K, Jin YR, Kacer D, DeMambro V, Liaw L, Vary CP, Rosen CJ, Prudovsky I, Lindner V.

Obesity (Silver Spring). 2015 Aug;23(8):1633-42. doi: 10.1002/oby.21144. Epub 2015 Jul 7.


BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses.

Young K, Tweedie E, Conley B, Ames J, FitzSimons M, Brooks P, Liaw L, Vary CP.

PLoS One. 2015 Apr 24;10(4):e0122892. doi: 10.1371/journal.pone.0122892. eCollection 2015.


AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway.

Kirov A, Kacer D, Conley BA, Vary CP, Prudovsky I.

J Cell Biochem. 2015 Aug;116(8):1522-31. doi: 10.1002/jcb.25047.


Notch signal integration in the vasculature during remodeling.

Rostama B, Peterson SM, Vary CP, Liaw L.

Vascul Pharmacol. 2014 Nov;63(2):97-104. Review.


Cryptic collagen IV promotes cell migration and adhesion in myeloid leukemia.

Favreau AJ, Vary CP, Brooks PC, Sathyanarayana P.

Cancer Med. 2014 Apr;3(2):265-72. doi: 10.1002/cam4.203. Epub 2014 Feb 12.


Improved survival outcomes in cancer patients with hereditary hemorrhagic telangiectasia.

Duarte CW, Murray K, Lucas FL, Fairfield K, Miller H, Brooks P, Vary CPH.

Cancer Epidemiol Biomarkers Prev. 2014 Jan;23(1):117-125. doi: 10.1158/1055-9965.EPI-13-0665. Epub 2013 Nov 5. Erratum in: Cancer Epidemiol Biomarkers Prev. 2015 May;24(5):880.


Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors.

Breen MJ, Moran DM, Liu W, Huang X, Vary CP, Bergan RC.

PLoS One. 2013 Aug 13;8(8):e72407. doi: 10.1371/journal.pone.0072407. eCollection 2013.


Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src.

Gong Y, Yang X, He Q, Gower L, Prudovsky I, Vary CP, Brooks PC, Friesel RE.

Angiogenesis. 2013 Oct;16(4):861-75. doi: 10.1007/s10456-013-9361-x. Epub 2013 Aug 17.


BMP9 regulates endoglin-dependent chemokine responses in endothelial cells.

Young K, Conley B, Romero D, Tweedie E, O'Neill C, Pinz I, Brogan L, Lindner V, Liaw L, Vary CP.

Blood. 2012 Nov 15;120(20):4263-73. doi: 10.1182/blood-2012-07-440784. Epub 2012 Sep 26. Erratum in: Blood. 2018 Dec 6;132(23):2526.


Phosphatidylserine colocalizes with epichromatin in interphase nuclei and mitotic chromosomes.

Prudovsky I, Vary CP, Markaki Y, Olins AL, Olins DE.

Nucleus. 2012 Mar 1;3(2):200-10. doi: 10.4161/nucl.19662. Epub 2012 Mar 1.


Mechanisms of TGF-β-induced differentiation in human vascular smooth muscle cells.

Tang Y, Yang X, Friesel RE, Vary CP, Liaw L.

J Vasc Res. 2011;48(6):485-94. doi: 10.1159/000327776. Epub 2011 Aug 11.


Strain diversity of Borrelia burgdorferi in ticks dispersed in North America by migratory birds.

Mathers A, Smith RP, Cahill B, Lubelczyk C, Elias SP, Lacombe E, Morris SR, Vary CP, Parent CE, Rand PW.

J Vector Ecol. 2011 Jun;36(1):24-9. doi: 10.1111/j.1948-7134.2011.00137.x.


Endoglin regulates cancer-stromal cell interactions in prostate tumors.

Romero D, O'Neill C, Terzic A, Contois L, Young K, Conley BA, Bergan RC, Brooks PC, Vary CP.

Cancer Res. 2011 May 15;71(10):3482-93. doi: 10.1158/0008-5472.CAN-10-2665. Epub 2011 Mar 28. Erratum in: Cancer Res. 2012 Feb 15;72(4):1037.


RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction.

Venkatesh D, Fredette N, Rostama B, Tang Y, Vary CP, Liaw L, Urs S.

Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):876-82. doi: 10.1161/ATVBAHA.110.221945. Epub 2011 Jan 27.


Endoglin suppresses human prostate cancer metastasis.

Lakshman M, Huang X, Ananthanarayanan V, Jovanovic B, Liu Y, Craft CS, Romero D, Vary CP, Bergan RC.

Clin Exp Metastasis. 2011 Jan;28(1):39-53. doi: 10.1007/s10585-010-9356-6. Epub 2010 Oct 28.


The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras.

Santibanez JF, Pérez-Gómez E, Fernandez-L A, Garrido-Martin EM, Carnero A, Malumbres M, Vary CP, Quintanilla M, Bernabéu C.

Carcinogenesis. 2010 Dec;31(12):2145-54. doi: 10.1093/carcin/bgq199. Epub 2010 Sep 30.


Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1.

Garrido-Martin EM, Blanco FJ, Fernandez-L A, Langa C, Vary CP, Lee UE, Friedman SL, Botella LM, Bernabeu C.

BMC Mol Biol. 2010 Jun 29;11:51. doi: 10.1186/1471-2199-11-51.


Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation.

Tang Y, Urs S, Boucher J, Bernaiche T, Venkatesh D, Spicer DB, Vary CP, Liaw L.

J Biol Chem. 2010 Jun 4;285(23):17556-63. doi: 10.1074/jbc.M109.076414. Epub 2010 Apr 5. Erratum in: J Biol Chem. 2012 Jan 6;287(2):1609.


Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration.

Romero D, Terzic A, Conley BA, Craft CS, Jovanovic B, Bergan RC, Vary CP.

Carcinogenesis. 2010 Mar;31(3):359-66. doi: 10.1093/carcin/bgp217. Epub 2009 Sep 7.


Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.

Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP.

Dev Dyn. 2009 Oct;238(10):2670-9. doi: 10.1002/dvdy.22078.


Endoglin plays distinct roles in vascular smooth muscle cell recruitment and regulation of arteriovenous identity during angiogenesis.

Mancini ML, Terzic A, Conley BA, Oxburgh LH, Nicola T, Vary CP.

Dev Dyn. 2009 Oct;238(10):2479-93. doi: 10.1002/dvdy.22066.


Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells.

Romero D, Iglesias M, Vary CP, Quintanilla M.

Carcinogenesis. 2008 May;29(5):1070-6. doi: 10.1093/carcin/bgn054. Epub 2008 Feb 28.


Novel biochemical pathways of endoglin in vascular cell physiology.

Bernabeu C, Conley BA, Vary CP.

J Cell Biochem. 2007 Dec 15;102(6):1375-88. Review.


Genistein induces phenotypic reversion of endoglin deficiency in human prostate cancer cells.

Craft CS, Xu L, Romero D, Vary CP, Bergan RC.

Mol Pharmacol. 2008 Jan;73(1):235-42. Epub 2007 Oct 19.


Endoglin is required for myogenic differentiation potential of neural crest stem cells.

Mancini ML, Verdi JM, Conley BA, Nicola T, Spicer DB, Oxburgh LH, Vary CP.

Dev Biol. 2007 Aug 15;308(2):520-33. Epub 2007 Jun 16.


Endoglin inhibits prostate cancer motility via activation of the ALK2-Smad1 pathway.

Craft CS, Romero D, Vary CP, Bergan RC.

Oncogene. 2007 Nov 8;26(51):7240-50. Epub 2007 May 14.


Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling.

Santibanez JF, Letamendia A, Perez-Barriocanal F, Silvestri C, Saura M, Vary CP, Lopez-Novoa JM, Attisano L, Bernabeu C.

J Cell Physiol. 2007 Feb;210(2):456-68.


Interactions of ribosomal protein S1 with DsrA and rpoS mRNA.

Koleva RI, Austin CA, Kowaleski JM, Neems DS, Wang L, Vary CP, Schlax PJ.

Biochem Biophys Res Commun. 2006 Sep 22;348(2):662-8. Epub 2006 Jul 28.


Endoglin regulates cyclooxygenase-2 expression and activity.

Jerkic M, Rivas-Elena JV, Santibanez JF, Prieto M, Rodríguez-Barbero A, Perez-Barriocanal F, Pericacho M, Arévalo M, Vary CP, Letarte M, Bernabeu C, López-Novoa JM.

Circ Res. 2006 Aug 4;99(3):248-56. Epub 2006 Jul 13.


Endoglin structure and function: Determinants of endoglin phosphorylation by transforming growth factor-beta receptors.

Koleva RI, Conley BA, Romero D, Riley KS, Marto JA, Lux A, Vary CP.

J Biol Chem. 2006 Sep 1;281(35):25110-23. Epub 2006 Jun 19.


Increases in serum estrogen levels during major illness are caused by increased peripheral aromatization.

Spratt DI, Morton JR, Kramer RS, Mayo SW, Longcope C, Vary CP.

Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E631-8. Epub 2006 May 2.


Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats.

Prieto M, Rodríguez-Peña AB, Düwel A, Rivas JV, Docherty N, Pérez-Barriocanal F, Arévalo M, Vary CP, Bernabeu C, López-Novoa JM, Eleno N.

J Physiol Biochem. 2005 Sep;61(3):457-67.


Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex.

Blanco FJ, Santibanez JF, Guerrero-Esteo M, Langa C, Vary CP, Bernabeu C.

J Cell Physiol. 2005 Aug;204(2):574-84.


Collagen, type V, alpha1 (COL5A1) is regulated by TGF-beta in osteoblasts.

Kahai S, Vary CP, Gao Y, Seth A.

Matrix Biol. 2004 Nov;23(7):445-55.


Vascular injury induces expression of periostin: implications for vascular cell differentiation and migration.

Lindner V, Wang Q, Conley BA, Friesel RE, Vary CP.

Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):77-83. Epub 2004 Oct 28. Erratum in: Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):e49.


Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins.

Sanz-Rodriguez F, Guerrero-Esteo M, Botella LM, Banville D, Vary CP, Bernabéu C.

J Biol Chem. 2004 Jul 30;279(31):32858-68. Epub 2004 May 17.


Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain.

Conley BA, Koleva R, Smith JD, Kacer D, Zhang D, Bernabéu C, Vary CP.

J Biol Chem. 2004 Jun 25;279(26):27440-9. Epub 2004 Apr 14.


Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury.

Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Langa C, Vary CP, Ramirez JR, Friedman S, Bernabéu C.

Blood. 2002 Dec 1;100(12):4001-10.


Coordinate gene expression patterns during osteoblast maturation and retinoic acid treatment of MC3T3-E1 cells.

Kitching R, Qi S, Li V, Raouf A, Vary CP, Seth A.

J Bone Miner Metab. 2002;20(5):269-80.


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