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Items: 40


Regulation of nuclear actin dynamics in development and disease.

Hyrskyluoto A, Vartiainen MK.

Curr Opin Cell Biol. 2020 Feb 20;64:18-24. doi: 10.1016/ [Epub ahead of print] Review.


Optogenetic regulation of endogenous proteins.

Redchuk TA, Karasev MM, Verkhusha PV, Donnelly SK, Hülsemann M, Virtanen J, Moore HM, Vartiainen MK, Hodgson L, Verkhusha VV.

Nat Commun. 2020 Jan 30;11(1):605. doi: 10.1038/s41467-020-14460-4.


Nuclear actin dynamics in gene expression and genome organization.

Kyheröinen S, Vartiainen MK.

Semin Cell Dev Biol. 2019 Nov 14. pii: S1084-9521(18)30314-8. doi: 10.1016/j.semcdb.2019.10.012. [Epub ahead of print] Review.


Nucleoskeletal regulation of transcription: Actin on MRTF.

Sidorenko E, Vartiainen MK.

Exp Biol Med (Maywood). 2019 Nov;244(15):1372-1381. doi: 10.1177/1535370219854669. Epub 2019 May 29. No abstract available.


Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

Viita T, Kyheröinen S, Prajapati B, Virtanen J, Frilander MJ, Varjosalo M, Vartiainen MK.

J Cell Sci. 2019 Apr 17;132(8). pii: jcs226852. doi: 10.1242/jcs.226852.


Nuclear Actin Is Required for Transcription during Drosophila Oogenesis.

Sokolova M, Moore HM, Prajapati B, Dopie J, Meriläinen L, Honkanen M, Matos RC, Poukkula M, Hietakangas V, Vartiainen MK.

iScience. 2018 Nov 30;9:63-70. doi: 10.1016/j.isci.2018.10.010. Epub 2018 Oct 15.


Myosin-1C uses a novel phosphoinositide-dependent pathway for nuclear localization.

Nevzorov I, Sidorenko E, Wang W, Zhao H, Vartiainen MK.

EMBO Rep. 2018 Feb;19(2):290-304. doi: 10.15252/embr.201744296. Epub 2018 Jan 12.


F-actin organizes the nucleus.

Moore HM, Vartiainen MK.

Nat Cell Biol. 2017 Nov 29;19(12):1386-1388. doi: 10.1038/ncb3650.


The actin binding cytoskeletal protein Moesin is involved in nuclear mRNA export.

Kristó I, Bajusz C, Borsos BN, Pankotai T, Dopie J, Jankovics F, Vartiainen MK, Erdélyi M, Vilmos P.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1589-1604. doi: 10.1016/j.bbamcr.2017.05.020. Epub 2017 May 27.


Diverse functions for different forms of nuclear actin.

Virtanen JA, Vartiainen MK.

Curr Opin Cell Biol. 2017 Jun;46:33-38. doi: 10.1016/ Epub 2017 Jan 13. Review.


Nuclear actin modulates cell motility via transcriptional regulation of adhesive and cytoskeletal genes.

Sharili AS, Kenny FN, Vartiainen MK, Connelly JT.

Sci Rep. 2016 Sep 21;6:33893. doi: 10.1038/srep33893.


From Cytoskeleton to Gene Expression: Actin in the Nucleus.

Viita T, Vartiainen MK.

Handb Exp Pharmacol. 2017;235:311-329. doi: 10.1007/164_2016_27. Review.


Genome-wide RNAi screen for nuclear actin reveals a network of cofilin regulators.

Dopie J, Rajakylä EK, Joensuu MS, Huet G, Ferrantelli E, Xie T, Jäälinoja H, Jokitalo E, Vartiainen MK.

J Cell Sci. 2015 Jul 1;128(13):2388-400. doi: 10.1242/jcs.169441. Epub 2015 May 28.


RNA export factor Ddx19 is required for nuclear import of the SRF coactivator MKL1.

Rajakylä EK, Viita T, Kyheröinen S, Huet G, Treisman R, Vartiainen MK.

Nat Commun. 2015 Jan 14;6:5978. doi: 10.1038/ncomms6978.


Directional cell migration, but not proliferation, drives hair placode morphogenesis.

Ahtiainen L, Lefebvre S, Lindfors PH, Renvoisé E, Shirokova V, Vartiainen MK, Thesleff I, Mikkola ML.

Dev Cell. 2014 Mar 10;28(5):588-602. doi: 10.1016/j.devcel.2014.02.003.


Rho, nuclear actin, and actin-binding proteins in the regulation of transcription and gene expression.

Rajakylä EK, Vartiainen MK.

Small GTPases. 2014;5:e27539. doi: 10.4161/sgtp.27539. Epub 2014 Mar 6. Review.


ER sheet persistence is coupled to myosin 1c-regulated dynamic actin filament arrays.

Joensuu M, Belevich I, Rämö O, Nevzorov I, Vihinen H, Puhka M, Witkos TM, Lowe M, Vartiainen MK, Jokitalo E.

Mol Biol Cell. 2014 Apr;25(7):1111-26. doi: 10.1091/mbc.E13-12-0712. Epub 2014 Feb 12.


To be or not to be assembled: progressing into nuclear actin filaments.

Grosse R, Vartiainen MK.

Nat Rev Mol Cell Biol. 2013 Nov;14(11):693-7. doi: 10.1038/nrm3681. Epub 2013 Oct 3. Review.


Actin as a model for the study of nucleocytoplasmic shuttling and nuclear dynamics.

Skarp KP, Vartiainen MK.

Methods Mol Biol. 2013;1042:245-55. doi: 10.1007/978-1-62703-526-2_18.


Steady-state nuclear actin levels are determined by export competent actin pool.

Skarp KP, Huet G, Vartiainen MK.

Cytoskeleton (Hoboken). 2013 Oct;70(10):623-34. doi: 10.1002/cm.21116. Epub 2013 Jul 11.


Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics.

Ho CY, Jaalouk DE, Vartiainen MK, Lammerding J.

Nature. 2013 May 23;497(7450):507-11. doi: 10.1038/nature12105. Epub 2013 May 5.


Actin-regulated feedback loop based on Phactr4, PP1 and cofilin maintains the actin monomer pool.

Huet G, Rajakylä EK, Viita T, Skarp KP, Crivaro M, Dopie J, Vartiainen MK.

J Cell Sci. 2013 Jan 15;126(Pt 2):497-507. doi: 10.1242/jcs.113241. Epub 2012 Nov 30.


Nuclear actin levels as an important transcriptional switch.

Huet G, Skarp KP, Vartiainen MK.

Transcription. 2012 Sep-Oct;3(5):226-30. doi: 10.4161/trns.21062. Epub 2012 Sep 1.


Nucleo-cytoplasmic actin relationships in Stockholm.

Vartiainen MK.

Nucleus. 2012 Mar 1;3(2):123-5. doi: 10.4161/nucl.19515. Epub 2012 Mar 1.


Active maintenance of nuclear actin by importin 9 supports transcription.

Dopie J, Skarp KP, Rajakylä EK, Tanhuanpää K, Vartiainen MK.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):E544-52. doi: 10.1073/pnas.1118880109. Epub 2012 Feb 9.


Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.

Rohn JL, Sims D, Liu T, Fedorova M, Schöck F, Dopie J, Vartiainen MK, Kiger AA, Perrimon N, Baum B.

J Cell Biol. 2011 Sep 5;194(5):789-805. doi: 10.1083/jcb.201103168.


Twinfilin-2a is dispensable for mouse development.

Nevalainen EM, Braun A, Vartiainen MK, Serlachius M, Andersson LC, Moser M, Lappalainen P.

PLoS One. 2011;6(8):e22894. doi: 10.1371/journal.pone.0022894. Epub 2011 Aug 18.


Nuclear transport of the serum response factor coactivator MRTF-A is downregulated at tensional homeostasis.

McGee KM, Vartiainen MK, Khaw PT, Treisman R, Bailly M.

EMBO Rep. 2011 Sep 1;12(9):963-70. doi: 10.1038/embor.2011.141.


An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A.

Pawłowski R, Rajakylä EK, Vartiainen MK, Treisman R.

EMBO J. 2010 Oct 20;29(20):3448-58. doi: 10.1038/emboj.2010.216. Epub 2010 Sep 3.


Actin on DNA-an ancient and dynamic relationship.

Skarp KP, Vartiainen MK.

Cytoskeleton (Hoboken). 2010 Aug;67(8):487-95. doi: 10.1002/cm.20464. Review.


Nuclear actin dynamics--from form to function.

Vartiainen MK.

FEBS Lett. 2008 Jun 18;582(14):2033-40. doi: 10.1016/j.febslet.2008.04.010. Epub 2008 Apr 16. Review.


RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding.

Guettler S, Vartiainen MK, Miralles F, Larijani B, Treisman R.

Mol Cell Biol. 2008 Jan;28(2):732-42. Epub 2007 Nov 19.


Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

Vartiainen MK, Guettler S, Larijani B, Treisman R.

Science. 2007 Jun 22;316(5832):1749-52.


Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells.

Hotulainen P, Paunola E, Vartiainen MK, Lappalainen P.

Mol Biol Cell. 2005 Feb;16(2):649-64. Epub 2004 Nov 17.


The WASP-Arp2/3 pathway: genetic insights.

Vartiainen MK, Machesky LM.

Curr Opin Cell Biol. 2004 Apr;16(2):174-81. Review.


Regulation of the actin cytoskeleton by PI(4,5)P2 and PI(3,4,5)P3.

Hilpelä P, Vartiainen MK, Lappalainen P.

Curr Top Microbiol Immunol. 2004;282:117-63. Review.


Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated.

Vartiainen MK, Sarkkinen EM, Matilainen T, Salminen M, Lappalainen P.

J Biol Chem. 2003 Sep 5;278(36):34347-55. Epub 2003 Jun 14.


Endogenous plasma membrane t-SNARE syntaxin 4 is present in rab11 positive endosomal membranes and associates with cortical actin cytoskeleton.

Band AM, Ali H, Vartiainen MK, Welti S, Lappalainen P, Olkkonen VM, Kuismanen E.

FEBS Lett. 2002 Nov 20;531(3):513-9.


The two ADF-H domains of twinfilin play functionally distinct roles in interactions with actin monomers.

Ojala PJ, Paavilainen VO, Vartiainen MK, Tuma R, Weeds AG, Lappalainen P.

Mol Biol Cell. 2002 Nov;13(11):3811-21.


The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics.

Vartiainen MK, Mustonen T, Mattila PK, Ojala PJ, Thesleff I, Partanen J, Lappalainen P.

Mol Biol Cell. 2002 Jan;13(1):183-94.

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