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Items: 28

1.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2019 Jun;93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. Epub 2019 Jun 27.

PMID:
31250071
2.

Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis.

Damle-Vartak A, Begher-Tibbe B, Gunther G, Geisler F, Vartak N, Hengstler JG.

Methods Mol Biol. 2019;1981:25-53. doi: 10.1007/978-1-4939-9420-5_3.

PMID:
31016646
3.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R.

Hepatology. 2019 Feb;69(2):666-683. doi: 10.1002/hep.30213. Epub 2018 Nov 19.

4.

Single cell polarity in liquid phase facilitates tumour metastasis.

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M.

Nat Commun. 2018 Feb 28;9(1):887. doi: 10.1038/s41467-018-03139-6.

5.

The ascending pathophysiology of cholestatic liver disease.

Jansen PL, Ghallab A, Vartak N, Reif R, Schaap FG, Hampe J, Hengstler JG.

Hepatology. 2017 Feb;65(2):722-738. doi: 10.1002/hep.28965. Review.

PMID:
27981592
6.

Activated ErbB3 Translocates to the Nucleus via Clathrin-independent Endocytosis, Which Is Associated with Proliferating Cells.

Reif R, Adawy A, Vartak N, Schröder J, Günther G, Ghallab A, Schmidt M, Schormann W, Hengstler JG.

J Biol Chem. 2016 Feb 19;291(8):3837-47. doi: 10.1074/jbc.M115.686782. Epub 2015 Dec 30.

7.

Cholestasis-induced adaptive remodeling of interlobular bile ducts.

Vartak N, Damle-Vartak A, Richter B, Dirsch O, Dahmen U, Hammad S, Hengstler JG.

Hepatology. 2016 Mar;63(3):951-64. doi: 10.1002/hep.28373. Epub 2016 Jan 14.

8.

miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL.

Berg V, Rusch M, Vartak N, Jüngst C, Schauss A, Waldmann H, Hedberg C, Pallasch CP, Bastiaens PI, Hallek M, Wendtner CM, Frenzel LP.

Blood. 2015 May 7;125(19):2948-57. doi: 10.1182/blood-2014-07-586511. Epub 2015 Feb 10.

9.

KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport.

Schmick M, Vartak N, Papke B, Kovacevic M, Truxius DC, Rossmannek L, Bastiaens PIH.

Cell. 2014 Apr 10;157(2):459-471. doi: 10.1016/j.cell.2014.02.051.

10.

The autodepalmitoylating activity of APT maintains the spatial organization of palmitoylated membrane proteins.

Vartak N, Papke B, Grecco HE, Rossmannek L, Waldmann H, Hedberg C, Bastiaens PI.

Biophys J. 2014 Jan 7;106(1):93-105. doi: 10.1016/j.bpj.2013.11.024.

11.

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling.

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H.

Nature. 2013 May 30;497(7451):638-42. doi: 10.1038/nature12205. Epub 2013 May 22.

PMID:
23698361
12.

Chemical-biological exploration of the limits of the Ras de- and repalmitoylating machinery.

Görmer K, Bürger M, Kruijtzer JA, Vetter I, Vartak N, Brunsveld L, Bastiaens PI, Liskamp RM, Triola G, Waldmann H.

Chembiochem. 2012 May 7;13(7):1017-23. doi: 10.1002/cbic.201200078. Epub 2012 Apr 5.

PMID:
22488913
13.

Novel anti-cancer compounds for developing combinatorial therapies to target anoikis-resistant tumors.

Nagaprashantha L, Vartak N, Awasthi S, Awasthi S, Singhal SS.

Pharm Res. 2012 Mar;29(3):621-36. doi: 10.1007/s11095-011-0645-9. Epub 2011 Dec 28. Review.

PMID:
22203324
14.

Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design.

Hedberg C, Dekker FJ, Rusch M, Renner S, Wetzel S, Vartak N, Gerding-Reimers C, Bon RS, Bastiaens PI, Waldmann H.

Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9832-7. doi: 10.1002/anie.201102965. Epub 2011 Sep 9.

PMID:
21905185
15.

Regulation of Ras localization by acylation enables a mode of intracellular signal propagation.

Lorentzen A, Kinkhabwala A, Rocks O, Vartak N, Bastiaens PI.

Sci Signal. 2010 Sep 21;3(140):ra68. doi: 10.1126/scisignal.20001370.

16.

Spatial cycles in G-protein crowd control.

Vartak N, Bastiaens P.

EMBO J. 2010 Aug 18;29(16):2689-99. doi: 10.1038/emboj.2010.184. Review.

17.

Small-molecule inhibition of APT1 affects Ras localization and signaling.

Dekker FJ, Rocks O, Vartak N, Menninger S, Hedberg C, Balamurugan R, Wetzel S, Renner S, Gerauer M, Schölermann B, Rusch M, Kramer JW, Rauh D, Coates GW, Brunsveld L, Bastiaens PI, Waldmann H.

Nat Chem Biol. 2010 Jun;6(6):449-56. doi: 10.1038/nchembio.362. Epub 2010 Apr 25.

PMID:
20418879
18.

The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins.

Rocks O, Gerauer M, Vartak N, Koch S, Huang ZP, Pechlivanis M, Kuhlmann J, Brunsveld L, Chandra A, Ellinger B, Waldmann H, Bastiaens PI.

Cell. 2010 Apr 30;141(3):458-71. doi: 10.1016/j.cell.2010.04.007. Epub 2010 Apr 22.

19.

GelStar nucleic acid gel stain: high sensitivity detection in gels.

White HW, Vartak NB, Burland TG, Curtis FP, Kusukawa N.

Biotechniques. 1999 May;26(5):984-8.

PMID:
10337492
20.

Glucose metabolism in 'Sphingomonas elodea': pathway engineering via construction of a glucose-6-phosphate dehydrogenase insertion mutant.

Vartak NB, Lin CC, Cleary JM, Fagan MJ, Saier MH Jr.

Microbiology. 1995 Sep;141 ( Pt 9):2339-50.

PMID:
7496544
21.

In vitro asymmetric binding of the pleiotropic regulatory protein, FruR, to the ace operator controlling glyoxylate shunt enzyme synthesis.

Cortay JC, Nègre D, Scarabel M, Ramseier TM, Vartak NB, Reizer J, Saier MH Jr, Cozzone AJ.

J Biol Chem. 1994 May 27;269(21):14885-91.

22.

Mevalonate kinase is predominantly localized in peroxisomes and is defective in patients with peroxisome deficiency disorders.

Biardi L, Sreedhar A, Zokaei A, Vartak NB, Bozeat RL, Shackelford JE, Keller GA, Krisans SK.

J Biol Chem. 1994 Jan 14;269(2):1197-205.

23.

The m gamma delta-1 element, a small gamma delta (Tn1000) derivative useful for plasmid mutagenesis, allele replacement and DNA sequencing.

Berg CM, Vartak NB, Wang G, Xu X, Liu L, MacNeil DJ, Gewain KM, Wiater LA, Berg DE.

Gene. 1992 Apr 1;113(1):9-16.

PMID:
1314210
25.
26.

pBR322-derived multicopy plasmids harboring large inserts are often dimers in Escherichia coli K-12.

Berg CM, Liu L, Coon M, Strausbaugh LD, Gray P, Vartak NB, Brown M, Talbot D, Berg DE.

Plasmid. 1989 Mar;21(2):138-41.

PMID:
2544913
28.

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