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Items: 32


Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture.

Hadland BK, Varnum-Finney B, Nourigat-Mckay C, Flowers D, Bernstein ID.

J Vis Exp. 2018 May 8;(135). doi: 10.3791/56973.


A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells.

Hadland BK, Varnum-Finney B, Mandal PK, Rossi DJ, Poulos MG, Butler JM, Rafii S, Yoder MC, Yoshimoto M, Bernstein ID.

Stem Cell Reports. 2017 Jun 6;8(6):1563-1572. doi: 10.1016/j.stemcr.2017.04.007. Epub 2017 May 4.


The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.

Liu Z, Brunskill E, Varnum-Finney B, Zhang C, Zhang A, Jay PY, Bernstein I, Morimoto M, Kopan R.

Development. 2015 Jul 15;142(14):2452-63. doi: 10.1242/dev.125492. Epub 2015 Jun 10.


Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.

Hadland BK, Varnum-Finney B, Poulos MG, Moon RT, Butler JM, Rafii S, Bernstein ID.

J Clin Invest. 2015 May;125(5):2032-45. doi: 10.1172/JCI80137. Epub 2015 Apr 13.


SIRT1 is dispensable for function of hematopoietic stem cells in adult mice.

Leko V, Varnum-Finney B, Li H, Gu Y, Flowers D, Nourigat C, Bernstein ID, Bedalov A.

Blood. 2012 Feb 23;119(8):1856-60. doi: 10.1182/blood-2011-09-377077. Epub 2012 Jan 4.


Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells.

Varnum-Finney B, Halasz LM, Sun M, Gridley T, Radtke F, Bernstein ID.

J Clin Invest. 2011 Mar;121(3):1207-16. doi: 10.1172/JCI43868.


Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.

Butler JM, Nolan DJ, Vertes EL, Varnum-Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M, Witte L, May C, Shawber C, Kimura Y, Kitajewski J, Rosenwaks Z, Bernstein ID, Rafii S.

Cell Stem Cell. 2010 Mar 5;6(3):251-64. doi: 10.1016/j.stem.2010.02.001.


Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.

Laurenti E, Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose WE, Ehninger A, Knoepfler PS, Cheng PF, MacDonald HR, Eisenman RN, Bernstein ID, Trumpp A.

Cell Stem Cell. 2008 Dec 4;3(6):611-24. doi: 10.1016/j.stem.2008.09.005.


E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.

Yang Q, Kardava L, St Leger A, Martincic K, Varnum-Finney B, Bernstein ID, Milcarek C, Borghesi L.

J Immunol. 2008 Nov 1;181(9):5885-94.


Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.

Minella AC, Loeb KR, Knecht A, Welcker M, Varnum-Finney BJ, Bernstein ID, Roberts JM, Clurman BE.

Genes Dev. 2008 Jun 15;22(12):1677-89. doi: 10.1101/gad.1650208.


Notch target Hes5 ensures appropriate Notch induced T- versus B-cell choices in the thymus.

Varnum-Finney B, Dallas MH, Kato K, Bernstein ID.

Blood. 2008 Mar 1;111(5):2615-20. Epub 2007 Nov 29.


The interaction of the Wnt and Notch pathways modulates natural killer versus T cell differentiation.

Aoyama K, Delaney C, Varnum-Finney B, Kohn AD, Moon RT, Bernstein ID.

Stem Cells. 2007 Oct;25(10):2488-97. Epub 2007 Jul 19.


Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1.

Dallas MH, Varnum-Finney B, Martin PJ, Bernstein ID.

Blood. 2007 Apr 15;109(8):3579-87. Epub 2007 Jan 9.


Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells.

Delaney C, Varnum-Finney B, Aoyama K, Brashem-Stein C, Bernstein ID.

Blood. 2005 Oct 15;106(8):2693-9. Epub 2005 Jun 23.


Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells.

Dallas MH, Varnum-Finney B, Delaney C, Kato K, Bernstein ID.

J Exp Med. 2005 May 2;201(9):1361-6. Epub 2005 Apr 25.


Notch signalling in hematopoiesis.

Ohishi K, Katayama N, Shiku H, Varnum-Finney B, Bernstein ID.

Semin Cell Dev Biol. 2003 Apr;14(2):143-50. Review.


Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

Varnum-Finney B, Brashem-Stein C, Bernstein ID.

Blood. 2003 Mar 1;101(5):1784-9. Epub 2002 Oct 31.


Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells.

Ohishi K, Varnum-Finney B, Bernstein ID.

J Clin Invest. 2002 Oct;110(8):1165-74.


The notch pathway: modulation of cell fate decisions in hematopoiesis.

Ohishi K, Varnum-Finney B, Bernstein ID.

Int J Hematol. 2002 Jun;75(5):449-59. Review.


The Notch ligand, Delta-1, inhibits the differentiation of monocytes into macrophages but permits their differentiation into dendritic cells.

Ohishi K, Varnum-Finney B, Serda RE, Anasetti C, Bernstein ID.

Blood. 2001 Sep 1;98(5):1402-7.


Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling.

Varnum-Finney B, Wu L, Yu M, Brashem-Stein C, Staats S, Flowers D, Griffin JD, Bernstein ID.

J Cell Sci. 2000 Dec;113 Pt 23:4313-8.


Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling.

Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, Bakkour S, Pear WS, Bernstein ID.

Nat Med. 2000 Nov;6(11):1278-81.


Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1.

Ohishi K, Varnum-Finney B, Flowers D, Anasetti C, Myerson D, Bernstein ID.

Blood. 2000 May 1;95(9):2847-54.


The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells.

Varnum-Finney B, Purton LE, Yu M, Brashem-Stein C, Flowers D, Staats S, Moore KA, Le Roux I, Mann R, Gray G, Artavanis-Tsakonas S, Bernstein ID.

Blood. 1998 Jun 1;91(11):4084-91.


The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C.

Varnum-Finney B, Venstrom K, Muller U, Kypta R, Backus C, Chiquet M, Reichardt LF.

Neuron. 1995 Jun;14(6):1213-22.


Adaptation in the motility response to cAMP in Dictyostelium discoideum.

Varnum-Finney B, Schroeder NA, Soll DR.

Cell Motil Cytoskeleton. 1988;9(1):9-16.


Characterization of a timing mutant of Dictyostelium discoideum which exhibits "high frequency switching".

Soll DR, Mitchell L, Kraft B, Alexander S, Finney R, Varnum-Finney B.

Dev Biol. 1987 Mar;120(1):25-37.


HLAMP--a conjugate of hippuryllysine and AMP which contains a phosphoamide bond--stimulates chemotaxis in Dictyostelium discoideum.

Rossomando EF, Hadjimichael J, Varnum-Finney B, Soll DR.

Differentiation. 1987;35(2):88-93.


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