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Items: 35


Development of an ELISA microarray assay for the sensitive and simultaneous detection of ten biodefense toxins.

Jenko KL, Zhang Y, Kostenko Y, Fan Y, Garcia-Rodriguez C, Lou J, Marks JD, Varnum SM.

Analyst. 2014 Oct 21;139(20):5093-102. doi: 10.1039/c4an01270d. Epub 2014 Aug 12.


A semiautomated framework for integrating expert knowledge into disease marker identification.

Wang J, Webb-Robertson BJ, Matzke MM, Varnum SM, Brown JN, Riensche RM, Adkins JN, Jacobs JM, Hoidal JR, Scholand MB, Pounds JG, Blackburn MR, Rodland KD, McDermott JE.

Dis Markers. 2013;35(5):513-23. doi: 10.1155/2013/613529. Epub 2013 Oct 10.


Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D.

Zhang Y, Gardberg AS, Edwards TE, Sankaran B, Robinson H, Varnum SM, Buchko GW.

Biochimie. 2013 Jul;95(7):1379-85. doi: 10.1016/j.biochi.2013.03.006. Epub 2013 Mar 21.


The effects of low-dose irradiation on inflammatory response proteins in a 3D reconstituted human skin tissue model.

Varnum SM, Springer DL, Chaffee ME, Lien KA, Webb-Robertson BJ, Waters KM, Sacksteder CA.

Radiat Res. 2012 Dec;178(6):591-9. doi: 10.1667/RR2976.1. Epub 2012 Oct 3.


Simultaneous and sensitive detection of six serotypes of botulinum neurotoxin using enzyme-linked immunosorbent assay-based protein antibody microarrays.

Zhang Y, Lou J, Jenko KL, Marks JD, Varnum SM.

Anal Biochem. 2012 Nov 15;430(2):185-92. doi: 10.1016/j.ab.2012.08.021. Epub 2012 Aug 27.


Structure determination and functional analysis of a chromate reductase from Gluconacetobacter hansenii.

Jin H, Zhang Y, Buchko GW, Varnum SM, Robinson H, Squier TC, Long PE.

PLoS One. 2012;7(8):e42432. doi: 10.1371/journal.pone.0042432. Epub 2012 Aug 6.


Proteomic analysis of bronchoalveolar lavage fluid proteins from mice infected with Francisella tularensis ssp. novicida.

Varnum SM, Webb-Robertson BJ, Pounds JG, Moore RJ, Smith RD, Frevert CW, Skerrett SJ, Wunschel D.

J Proteome Res. 2012 Jul 6;11(7):3690-703. doi: 10.1021/pr3001767. Epub 2012 Jun 22.


Plasma biomarkers for detecting Hodgkin's lymphoma in HIV patients.

Varnum SM, Webb-Robertson BJ, Hessol NA, Smith RD, Zangar RC.

PLoS One. 2011;6(12):e29263. doi: 10.1371/journal.pone.0029263. Epub 2011 Dec 15.


The receptor binding domain of botulinum neurotoxin serotype C binds phosphoinositides.

Zhang Y, Varnum SM.

Biochimie. 2012 Mar;94(3):920-3. doi: 10.1016/j.biochi.2011.11.004. Epub 2011 Nov 18.


High-level expression, purification, crystallization and preliminary X-ray crystallographic studies of the receptor-binding domain of botulinum neurotoxin serotype D.

Zhang Y, Gao X, Qin L, Buchko GW, Robinson H, Varnum SM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1610-3. doi: 10.1107/S1744309110039874. Epub 2010 Nov 25.


Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in mice.

Teeguarden JG, Webb-Robertson BJ, Waters KM, Murray AR, Kisin ER, Varnum SM, Jacobs JM, Pounds JG, Zanger RC, Shvedova AA.

Toxicol Sci. 2011 Mar;120(1):123-35. doi: 10.1093/toxsci/kfq363. Epub 2010 Dec 6.


Crystal structure of the receptor binding domain of the botulinum C-D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions.

Zhang Y, Buchko GW, Qin L, Robinson H, Varnum SM.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):407-12. doi: 10.1016/j.bbrc.2010.11.134. Epub 2010 Dec 3.


Structural analysis of the receptor binding domain of botulinum neurotoxin serotype D.

Zhang Y, Buchko GW, Qin L, Robinson H, Varnum SM.

Biochem Biophys Res Commun. 2010 Oct 29;401(4):498-503. doi: 10.1016/j.bbrc.2010.09.063. Epub 2010 Sep 19.


Combined statistical analyses of peptide intensities and peptide occurrences improves identification of significant peptides from MS-based proteomics data.

Webb-Robertson BJ, McCue LA, Waters KM, Matzke MM, Jacobs JM, Metz TO, Varnum SM, Pounds JG.

J Proteome Res. 2010 Nov 5;9(11):5748-56. doi: 10.1021/pr1005247. Epub 2010 Oct 8.


Proteomic biomarkers in plasma that differentiate rapid and slow decline in lung function in adult cigarette smokers with chronic obstructive pulmonary disease (COPD).

Rana GS, York TP, Edmiston JS, Zedler BK, Pounds JG, Adkins JN, Varnum SM, Smith RD, Liu Z, Li G, Webb BT, Murrelle EL, Flora JW.

Anal Bioanal Chem. 2010 Jul;397(5):1809-19. doi: 10.1007/s00216-010-3742-4. Epub 2010 May 5. Erratum in: Anal Bioanal Chem. 2010 Sep;398(2):1133. Varnum, Susan M [added].


A Bayesian integration model of high-throughput proteomics and metabolomics data for improved early detection of microbial infections.

Webb-Robertson BJ, McCue LA, Beagley N, McDermott JE, Wunschel DS, Varnum SM, Hu JZ, Isern NG, Buchko GW, Mcateer K, Pounds JG, Skerrett SJ, Liggitt D, Frevert CW.

Pac Symp Biocomput. 2009:451-63.


Predicting protein concentrations with ELISA microarray assays, monotonic splines and Monte Carlo simulation.

Daly DS, Anderson KK, White AM, Gonzalez RM, Varnum SM, Zangar RC.

Stat Appl Genet Mol Biol. 2008;7(1):Article21. doi: 10.2202/1544-6115.1364. Epub 2008 Jul 14.


Enhanced detection of low abundance human plasma proteins using a tandem IgY12-SuperMix immunoaffinity separation strategy.

Qian WJ, Kaleta DT, Petritis BO, Jiang H, Liu T, Zhang X, Mottaz HM, Varnum SM, Camp DG 2nd, Huang L, Fang X, Zhang WW, Smith RD.

Mol Cell Proteomics. 2008 Oct;7(10):1963-73. doi: 10.1074/mcp.M800008-MCP200. Epub 2008 Jul 15.


Human cytomegalovirus UL97 kinase activity is required for the hyperphosphorylation of retinoblastoma protein and inhibits the formation of nuclear aggresomes.

Prichard MN, Sztul E, Daily SL, Perry AL, Frederick SL, Gill RB, Hartline CB, Streblow DN, Varnum SM, Smith RD, Kern ER.

J Virol. 2008 May;82(10):5054-67. doi: 10.1128/JVI.02174-07. Epub 2008 Mar 5.


Enzyme-amplified protein microarray and a fluidic renewable surface fluorescence immunoassay for botulinum neurotoxin detection using high-affinity recombinant antibodies.

Varnum SM, Warner MG, Dockendorff B, Anheier NC Jr, Lou J, Marks JD, Smith LA, Feldhaus MJ, Grate JW, Bruckner-Lea CJ.

Anal Chim Acta. 2006 Jun 16;570(2):137-43. Epub 2006 May 2.


High dynamic range characterization of the trauma patient plasma proteome.

Liu T, Qian WJ, Gritsenko MA, Xiao W, Moldawer LL, Kaushal A, Monroe ME, Varnum SM, Moore RJ, Purvine SO, Maier RV, Davis RW, Tompkins RG, Camp DG 2nd, Smith RD; Inflammation and the Host Response to Injury Large Scale Collaborative Research Programm.

Mol Cell Proteomics. 2006 Oct;5(10):1899-913. Epub 2006 May 9.


ProMAT: protein microarray analysis tool.

White AM, Daly DS, Varnum SM, Anderson KK, Bollinger N, Zangar RC.

Bioinformatics. 2006 May 15;22(10):1278-9. Epub 2006 Apr 4.


Studying cellular processes and detecting disease with protein microarrays.

Zangar RC, Varnum SM, Bollinger N.

Drug Metab Rev. 2005;37(3):473-87. Review.


Evaluating concentration estimation errors in ELISA microarray experiments.

Daly DS, White AM, Varnum SM, Anderson KK, Zangar RC.

BMC Bioinformatics. 2005 Jan 26;6:17.


Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.

Varnum SM, Streblow DN, Monroe ME, Smith P, Auberry KJ, Pasa-Tolic L, Wang D, Camp DG 2nd, Rodland K, Wiley S, Britt W, Shenk T, Smith RD, Nelson JA.

J Virol. 2004 Oct;78(20):10960-6. Erratum in: J Virol. 2004 Dec;78(23):13395.


A protein microarray ELISA for screening biological fluids.

Varnum SM, Woodbury RL, Zangar RC.

Methods Mol Biol. 2004;264:161-72.


Proteomic characterization of nipple aspirate fluid: identification of potential biomarkers of breast cancer.

Varnum SM, Covington CC, Woodbury RL, Petritis K, Kangas LJ, Abdullah MS, Pounds JG, Smith RD, Zangar RC.

Breast Cancer Res Treat. 2003 Jul;80(1):87-97.


Elevated HGF levels in sera from breast cancer patients detected using a protein microarray ELISA.

Woodbury RL, Varnum SM, Zangar RC.

J Proteome Res. 2002 May-Jun;1(3):233-7.


Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.

Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG.

Mol Cell Proteomics. 2002 Dec;1(12):947-55.


Maturation-specific deadenylation in Xenopus oocytes requires nuclear and cytoplasmic factors.

Varnum SM, Hurney CA, Wormington WM.

Dev Biol. 1992 Oct;153(2):283-90.


The mRNA encoding elongation factor 1-alpha (EF-1 alpha) is a major transcript at the midblastula transition in Xenopus.

Krieg PA, Varnum SM, Wormington WM, Melton DA.

Dev Biol. 1989 May;133(1):93-100.


Specific DNA binding of GAL4, a positive regulatory protein of yeast.

Giniger E, Varnum SM, Ptashne M.

Cell. 1985 Apr;40(4):767-74.


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