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Items: 1 to 50 of 208

1.

High rates of variation in HLA-DQ2/DQ8 testing for coeliac disease: results from an RCPAQAP pilot program.

Horan MP, Chai SY, Munusamy N, Tay KH, Wienholt L, Tye-Din JA, Daveson J, Varney M, Badrick T.

J Clin Pathol. 2018 May 15. pii: jclinpath-2018-205209. doi: 10.1136/jclinpath-2018-205209. [Epub ahead of print]

PMID:
29764931
2.

Effects of the Serotonin 5-HT1A Receptor Biased Agonists, F13714 and F15599, on Striatal Neurotransmitter Levels Following L-DOPA Administration in Hemi-Parkinsonian Rats.

Newman-Tancredi A, Varney MA, McCreary AC.

Neurochem Res. 2018 May;43(5):1035-1046. doi: 10.1007/s11064-018-2514-y. Epub 2018 Mar 23.

PMID:
29572645
3.

NLX-112, a highly selective 5-HT1A receptor agonist, mediates analgesia and antidepressant-like activity in rats via spinal cord and prefrontal cortex 5-HT1A receptors, respectively.

Newman-Tancredi A, Bardin L, Auclair A, Colpaert F, Depoortère R, Varney MA.

Brain Res. 2018 Jun 1;1688:1-7. doi: 10.1016/j.brainres.2018.03.016. Epub 2018 Mar 16.

PMID:
29555239
4.

Preclinical investigation of a potent geranylgeranyl diphosphate synthase inhibitor.

Haney SL, Chhonker YS, Varney ML, Talmon G, Murry DJ, Holstein SA.

Invest New Drugs. 2018 Mar 2. doi: 10.1007/s10637-018-0571-3. [Epub ahead of print]

PMID:
29497895
5.

Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis.

Saxena S, Hayashi Y, Wu L, Awaji M, Atri P, Varney ML, Purohit A, Rachagani S, Batra SK, Singh RK.

Oncotarget. 2017 Dec 23;9(5):5931-5943. doi: 10.18632/oncotarget.23644. eCollection 2018 Jan 19.

6.

Rapid, Loop-Mediated Isothermal Amplification Detection of Celiac Disease Risk Alleles.

Erlichster M, Tye-Din JA, Varney MD, Skafidas E, Kwan P.

J Mol Diagn. 2018 May;20(3):307-315. doi: 10.1016/j.jmoldx.2018.01.005. Epub 2018 Feb 17.

PMID:
29458095
7.

Resolving incomplete single nucleotide polymorphism tagging of HLA-DQ2.2 for coeliac disease genotyping using digital droplet PCR.

Hardy MY, Ontiveros N, Varney MD, Tye-Din JA.

HLA. 2018 Apr;91(4):280-288. doi: 10.1111/tan.13219. Epub 2018 Feb 26.

PMID:
29364577
8.

Neurophysiological effects in cortico-basal ganglia-thalamic circuits of antidyskinetic treatment with 5-HT1A receptor biased agonists.

Brys I, Halje P, Scheffer-Teixeira R, Varney M, Newman-Tancredi A, Petersson P.

Exp Neurol. 2018 Apr;302:155-168. doi: 10.1016/j.expneurol.2018.01.010. Epub 2018 Jan 13.

PMID:
29339052
9.

Activity of Serotonin 5-HT1A Receptor Biased Agonists in Rat: Anxiolytic and Antidepressant-like properties.

Jastrzębska-Więsek M, Partyka A, Rychtyk J, Śniecikowska J, Kołaczkowski M, Wesołowska A, Varney MA, Newman-Tancredi A.

ACS Chem Neurosci. 2018 May 16;9(5):1040-1050. doi: 10.1021/acschemneuro.7b00443. Epub 2018 Jan 11.

PMID:
29266914
10.

CXCR1/2 Chemokine Network Regulates Melanoma Resistance to Chemotherapies Mediated by NF-κB.

Wu S, Saxena S, Varney ML, Singh RK.

Curr Mol Med. 2017;17(6):436-449. doi: 10.2174/1566524018666171219100158.

PMID:
29256349
11.

α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.

Matthiesen RA, Varney ML, Xu PC, Rier AS, Wiemer DF, Holstein SA.

Bioorg Med Chem. 2018 Jan 15;26(2):376-385. doi: 10.1016/j.bmc.2017.10.023. Epub 2017 Oct 19.

PMID:
29248353
12.

NLX-112, a highly selective 5-HT1A receptor agonist: Effects on body temperature and plasma corticosterone levels in rats.

Newman-Tancredi A, Depoortère R, Carilla-Durand E, Tarayre JP, Kleven M, Koek W, Bardin L, Varney MA.

Pharmacol Biochem Behav. 2018 Feb;165:56-62. doi: 10.1016/j.pbb.2017.11.002. Epub 2017 Nov 7.

PMID:
29126856
13.

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells.

Haney SL, Allen C, Varney ML, Dykstra KM, Falcone ER, Colligan SH, Hu Q, Aldridge AM, Wright DL, Wiemer AJ, Holstein SA.

Oncotarget. 2017 Jun 16;8(44):76085-76098. doi: 10.18632/oncotarget.18543. eCollection 2017 Sep 29.

14.

Discrepancies in genetic testing results for coeliac disease: call for standardised testing and reporting.

Daveson AJM, Varney M, Jackson KE, Tye-Din JA.

Med J Aust. 2017 Aug 21;207(4):179-180. No abstract available.

PMID:
28814223
15.

Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain.

Sałat K, Kołaczkowski M, Furgała A, Rojek A, Śniecikowska J, Varney MA, Newman-Tancredi A.

Neuropharmacology. 2017 Oct;125:181-188. doi: 10.1016/j.neuropharm.2017.07.022. Epub 2017 Jul 24.

PMID:
28751195
16.

Distinctive in vitro signal transduction profile of NLX-112, a potent and efficacious serotonin 5-HT1A receptor agonist.

Newman-Tancredi A, Martel JC, Cosi C, Heusler P, Lestienne F, Varney MA, Cussac D.

J Pharm Pharmacol. 2017 Sep;69(9):1178-1190. doi: 10.1111/jphp.12762. Epub 2017 Jun 14.

PMID:
28612503
17.

Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome.

Varney ME, Choi K, Bolanos L, Christie S, Fang J, Grimes HL, Maciejewski JP, Inoue JI, Starczynowski DT.

Leukemia. 2017 Jul;31(7):1659. doi: 10.1038/leu.2017.95. Epub 2017 Apr 7.

18.

Characterizing the differential roles of striatal 5-HT1A auto- and hetero-receptors in the reduction of l-DOPA-induced dyskinesia.

Meadows SM, Chambers NE, Conti MM, Bossert SC, Tasber C, Sheena E, Varney M, Newman-Tancredi A, Bishop C.

Exp Neurol. 2017 Jun;292:168-178. doi: 10.1016/j.expneurol.2017.03.013. Epub 2017 Mar 23.

PMID:
28342749
19.

Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.

Wills VS, Metzger JI, Allen C, Varney ML, Wiemer DF, Holstein SA.

Bioorg Med Chem. 2017 Apr 15;25(8):2437-2444. doi: 10.1016/j.bmc.2017.02.066. Epub 2017 Mar 4.

20.

Self-assembly of colloidal particles in deformation landscapes of electrically driven layer undulations in cholesteric liquid crystals.

Varney MC, Zhang Q, Senyuk B, Smalyukh II.

Phys Rev E. 2016 Oct;94(4-1):042709. Epub 2016 Oct 28.

PMID:
27841645
21.

Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome.

Varney ME, Choi K, Bolanos L, Christie S, Fang J, Grimes HL, Maciejewski JP, Inoue JI, Starczynowski DT.

Leukemia. 2017 Feb;31(2):491-495. doi: 10.1038/leu.2016.276. Epub 2016 Oct 3. No abstract available. Erratum in: Leukemia. 2017 Jul;31(7):1659.

22.

Elaeophora in the meninges of a Malayan sambar (Rusa unicolor equina).

Bernard J, Grunenwald C, Stalis IH, Varney M, Zuba J, Gerhold R.

J Vet Diagn Invest. 2016 Nov;28(6):735-738. Epub 2016 Sep 23.

PMID:
27664097
23.

Modulation of p73 isoforms expression induces anti-proliferative and pro-apoptotic activity in mantle cell lymphoma independent of p53 status.

Hassan HM, Varney ML, Chaturvedi NK, Joshi SS, Weisenburger DD, Singh RK, Dave BJ.

Leuk Lymphoma. 2016 Dec;57(12):2874-2889. Epub 2016 Apr 13.

24.

Induction of CXCR2 ligands, stem cell-like phenotype, and metastasis in chemotherapy-resistant breast cancer cells.

Sharma B, Varney ML, Saxena S, Wu L, Singh RK.

Cancer Lett. 2016 Mar 28;372(2):192-200. doi: 10.1016/j.canlet.2015.12.011. Epub 2016 Jan 12.

25.

The novel 5-HT1A receptor agonist, NLX-112 reduces l-DOPA-induced abnormal involuntary movements in rat: A chronic administration study with microdialysis measurements.

McCreary AC, Varney MA, Newman-Tancredi A.

Neuropharmacology. 2016 Jun;105:651-660. doi: 10.1016/j.neuropharm.2016.01.013. Epub 2016 Jan 9.

PMID:
26777281
26.

CXCR2 signaling regulates KRAS(G¹²D)-induced autocrine growth of pancreatic cancer.

Purohit A, Varney M, Rachagani S, Ouellette MM, Batra SK, Singh RK.

Oncotarget. 2016 Feb 9;7(6):7280-96. doi: 10.18632/oncotarget.6906.

27.

Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.

Varney ME, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, Akiyama T, Christie S, Fang J, Miller D, Jerez A, Karsan A, Maciejewski JP, Meetei RA, Inoue J, Starczynowski DT.

J Exp Med. 2015 Oct 19;212(11):1967-85. doi: 10.1084/jem.20141898. Epub 2015 Oct 12.

28.

Deconstructing innate immune signaling in myelodysplastic syndromes.

Varney ME, Melgar K, Niederkorn M, Smith M, Barreyro L, Starczynowski DT.

Exp Hematol. 2015 Aug;43(8):587-598. doi: 10.1016/j.exphem.2015.05.016. Epub 2015 Jul 2. Review.

29.

Stick-slip motion of surface point defects prompted by magnetically controlled colloidal-particle dynamics in nematic liquid crystals.

Varney MC, Zhang Q, Smalyukh II.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 May;91(5):052503. Epub 2015 May 11.

PMID:
26066187
30.

NLX-112, a novel 5-HT1A receptor agonist for the treatment of L-DOPA-induced dyskinesia: Behavioral and neurochemical profile in rat.

Iderberg H, McCreary AC, Varney MA, Kleven MS, Koek W, Bardin L, Depoortère R, Cenci MA, Newman-Tancredi A.

Exp Neurol. 2015 Sep;271:335-50. doi: 10.1016/j.expneurol.2015.05.021. Epub 2015 May 30.

PMID:
26037043
31.

VEGF-C-VEGFR3/Flt4 axis regulates mammary tumor growth and metastasis in an autocrine manner.

Varney ML, Singh RK.

Am J Cancer Res. 2015 Jan 15;5(2):616-28. eCollection 2015.

32.

Appropriate clinical use of human leukocyte antigen typing for coeliac disease: an Australasian perspective.

Tye-Din JA, Cameron DJ, Daveson AJ, Day AS, Dellsperger P, Hogan C, Newnham ED, Shepherd SJ, Steele RH, Wienholt L, Varney MD.

Intern Med J. 2015 Apr;45(4):441-50. doi: 10.1111/imj.12716.

33.

Mike Varney.

Varney M, Mullard A.

Nat Rev Drug Discov. 2015 Mar;14(3):158-9. doi: 10.1038/nrd4566. Epub 2015 Feb 13. No abstract available.

PMID:
25677359
34.

Activity of serotonin 5-HT(1A) receptor 'biased agonists' in rat models of Parkinson's disease and L-DOPA-induced dyskinesia.

Iderberg H, McCreary AC, Varney MA, Cenci MA, Newman-Tancredi A.

Neuropharmacology. 2015 Jun;93:52-67. doi: 10.1016/j.neuropharm.2015.01.012. Epub 2015 Jan 31.

PMID:
25645393
35.

Periodic dynamics, localization metastability, and elastic interaction of colloidal particles with confining surfaces and helicoidal structure of cholesteric liquid crystals.

Varney MC, Zhang Q, Tasinkevych M, Silvestre NM, Bertness KA, Smalyukh II.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Dec;90(6):062502. Epub 2014 Dec 4.

PMID:
25615114
36.

Divergent effects of the 'biased' 5-HT1 A receptor agonists F15599 and F13714 in a novel object pattern separation task.

van Goethem NP, Schreiber R, Newman-Tancredi A, Varney M, Prickaerts J.

Br J Pharmacol. 2015 May;172(10):2532-43. doi: 10.1111/bph.13071. Epub 2015 Feb 27.

37.

Host Cxcr2-dependent regulation of mammary tumor growth and metastasis.

Sharma B, Nannuru KC, Varney ML, Singh RK.

Clin Exp Metastasis. 2015 Jan;32(1):65-72. doi: 10.1007/s10585-014-9691-0. Epub 2014 Dec 16.

38.

Topological switching and orbiting dynamics of colloidal spheres dressed with chiral nematic solitons.

Porenta T, Copar S, Ackerman PJ, Pandey MB, Varney MC, Smalyukh II, Žumer S.

Sci Rep. 2014 Dec 5;4:7337. doi: 10.1038/srep07337.

39.

Geometrically unrestricted, topologically constrained control of liquid crystal defects using simultaneous holonomic magnetic and holographic optical manipulation.

Varney MC, Jenness NJ, Smalyukh II.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Feb;89(2):022505. Epub 2014 Feb 13.

PMID:
25353487
40.

Magnetically responsive gourd-shaped colloidal particles in cholesteric liquid crystals.

Senyuk B, Varney MC, Lopez JA, Wang S, Wu N, Smalyukh II.

Soft Matter. 2014 Aug 28;10(32):6014-23. doi: 10.1039/c4sm00878b.

PMID:
24994521
41.

Higher body mass index in adults at diagnosis of the slowly progressive form of type 1 diabetes mellitus is associated with lower risk HLA genes.

Fourlanos S, Elkassaby S, Varney MD, Colman PG, Harrison LC.

Diabetes Res Clin Pract. 2014 Jun;104(3):e69-71. doi: 10.1016/j.diabres.2014.03.009. Epub 2014 Mar 18.

PMID:
24698405
42.

Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression in follicular lymphoma.

Hassan HM, Varney ML, Jain S, Weisenburger DD, Singh RK, Dave BJ.

Leuk Lymphoma. 2014 Dec;55(12):2924-31. doi: 10.3109/10428194.2014.900759. Epub 2014 May 6.

43.

Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness.

Jami MS, Hou J, Liu M, Varney ML, Hassan H, Dong J, Geng L, Wang J, Yu F, Huang X, Peng H, Fu K, Li Y, Singh RK, Ding SJ.

BMC Cancer. 2014 Mar 15;14:194. doi: 10.1186/1471-2407-14-194.

44.

Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.

Hopkins SC, Campbell UC, Heffernan ML, Spear KL, Jeggo RD, Spanswick DC, Varney MA, Large TH.

Pharmacol Res Perspect. 2013 Oct;1(1):e00007. doi: 10.1002/prp2.7. Epub 2013 Oct 1.

45.

Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis.

Guo F, Zhang S, Grogg M, Cancelas JA, Varney ME, Starczynowski DT, Du W, Yang JQ, Liu W, Thomas G, Kozma S, Pang Q, Zheng Y.

Haematologica. 2013 Sep;98(9):1353-8. doi: 10.3324/haematol.2012.080424. Epub 2013 May 28.

46.

Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.

Hopkins SC, Heffernan ML, Saraswat LD, Bowen CA, Melnick L, Hardy LW, Orsini MA, Allen MS, Koch P, Spear KL, Foglesong RJ, Soukri M, Chytil M, Fang QK, Jones SW, Varney MA, Panatier A, Oliet SH, Pollegioni L, Piubelli L, Molla G, Nardini M, Large TH.

J Med Chem. 2013 May 9;56(9):3710-24. doi: 10.1021/jm4002583. Epub 2013 Apr 30.

PMID:
23631755
47.

Receiver operating characteristic analysis of HLA, CTLA4, and insulin genotypes for type 1 diabetes.

Valdes AM, Varney MD, Erlich HA, Noble JA.

Diabetes Care. 2013 Sep;36(9):2504-7. doi: 10.2337/dc12-2284. Epub 2013 Apr 29.

48.

Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.

Hopkins SC, Zhao FY, Bowen CA, Fang X, Wei H, Heffernan ML, Spear KL, Spanswick DC, Varney MA, Large TH.

J Pharmacol Exp Ther. 2013 Jun;345(3):502-11. doi: 10.1124/jpet.113.204016. Epub 2013 Mar 21.

49.

Common and well-documented HLA alleles: 2012 update to the CWD catalogue.

Mack SJ, Cano P, Hollenbach JA, He J, Hurley CK, Middleton D, Moraes ME, Pereira SE, Kempenich JH, Reed EF, Setterholm M, Smith AG, Tilanus MG, Torres M, Varney MD, Voorter CE, Fischer GF, Fleischhauer K, Goodridge D, Klitz W, Little AM, Maiers M, Marsh SG, Müller CR, Noreen H, Rozemuller EH, Sanchez-Mazas A, Senitzer D, Trachtenberg E, Fernandez-Vina M.

Tissue Antigens. 2013 Apr;81(4):194-203. doi: 10.1111/tan.12093.

50.

Targeting CXCR2 enhances chemotherapeutic response, inhibits mammary tumor growth, angiogenesis, and lung metastasis.

Sharma B, Nawandar DM, Nannuru KC, Varney ML, Singh RK.

Mol Cancer Ther. 2013 May;12(5):799-808. doi: 10.1158/1535-7163.MCT-12-0529. Epub 2013 Mar 6.

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