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Items: 1 to 50 of 62

1.

Arming Tumor-Associated Macrophages to Reverse Epithelial Cancer Progression.

Wettersten HI, Weis SM, Pathria P, Von Schalscha T, Minami T, Varner JA, Cheresh DA.

Cancer Res. 2019 Oct 1;79(19):5048-5059. doi: 10.1158/0008-5472.CAN-19-1246. Epub 2019 Aug 15.

PMID:
31416839
2.

Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide-Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNA.

Kim B, Sun S, Varner JA, Howell SB, Ruoslahti E, Sailor MJ.

Adv Mater. 2019 Aug;31(35):e1902952. doi: 10.1002/adma.201902952. Epub 2019 Jul 3.

PMID:
31267590
3.

MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages.

Babicky ML, Harper MM, Chakedis J, Cazes A, Mose ES, Jaquish DV, French RP, Childers B, Alakus H, Schmid MC, Foubert P, Miyamoto J, Holman PJ, Walterscheid ZJ, Tang CM, Varki N, Sicklick JK, Messer K, Varner JA, Waltz SE, Lowy AM.

Oncogene. 2019 Jul;38(28):5599-5611. doi: 10.1038/s41388-019-0811-9. Epub 2019 Apr 9.

4.

Targeting Tumor-Associated Macrophages in Cancer.

Pathria P, Louis TL, Varner JA.

Trends Immunol. 2019 Apr;40(4):310-327. doi: 10.1016/j.it.2019.02.003. Epub 2019 Mar 17. Review.

PMID:
30890304
5.

Integrin CD11b activation drives anti-tumor innate immunity.

Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, Anand S, Woo G, Leem C, Faridi MH, Geraghty T, Rajagopalan A, Gupta S, Ahmed M, Vazquez-Padron RI, Cheresh DA, Gupta V, Varner JA.

Nat Commun. 2018 Dec 19;9(1):5379. doi: 10.1038/s41467-018-07387-4.

6.

PI3Kγ Activates Integrin α4 and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.

Foubert P, Kaneda MM, Varner JA.

Cancer Immunol Res. 2017 Nov;5(11):957-968. doi: 10.1158/2326-6066.CIR-17-0143. Epub 2017 Sep 28.

7.

Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.

Sato-Kaneko F, Yao S, Ahmadi A, Zhang SS, Hosoya T, Kaneda MM, Varner JA, Pu M, Messer KS, Guiducci C, Coffman RL, Kitaura K, Matsutani T, Suzuki R, Carson DA, Hayashi T, Cohen EE.

JCI Insight. 2017 Sep 21;2(18). pii: 93397. doi: 10.1172/jci.insight.93397. eCollection 2017 Sep 21.

8.

Corrigendum: PI3Kγ is a molecular switch that controls immune suppression.

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA.

Nature. 2017 Feb 2;542(7639):124. doi: 10.1038/nature21026. Epub 2016 Dec 14. No abstract available.

PMID:
27974794
9.

PI3Kγ is a molecular switch that controls immune suppression.

Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA.

Nature. 2016 Nov 17;539(7629):437-442. doi: 10.1038/nature19834. Epub 2016 Sep 19. Erratum in: Nature. 2017 Feb 2;542(7639):124.

10.

Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.

Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA.

Cancer Discov. 2016 Aug;6(8):870-85. doi: 10.1158/2159-8290.CD-15-1346. Epub 2016 May 13.

11.

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.

Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, Chang BY, Varner JA, Coussens LM.

Cancer Discov. 2016 Mar;6(3):270-85. doi: 10.1158/2159-8290.CD-15-0827. Epub 2015 Dec 29. Erratum in: Cancer Discov. 2016 Jul;6(7):802.

12.

Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma.

Young SA, McCabe KE, Bartakova A, Delaney J, Pizzo DP, Newbury RO, Varner JA, Schlaepfer DD, Stupack DG.

PLoS One. 2015 May 14;10(5):e0120815. doi: 10.1371/journal.pone.0120815. eCollection 2015.

13.

PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growth.

Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA.

PLoS One. 2013;8(4):e60226. doi: 10.1371/journal.pone.0060226. Epub 2013 Apr 2.

14.

The primacy of β1 integrin activation in the metastatic cascade.

Kato H, Liao Z, Mitsios JV, Wang HY, Deryugina EI, Varner JA, Quigley JP, Shattil SJ.

PLoS One. 2012;7(10):e46576. doi: 10.1371/journal.pone.0046576. Epub 2012 Oct 3.

15.

Myeloid cells in tumor inflammation.

Schmid MC, Varner JA.

Vasc Cell. 2012 Sep 3;4(1):14. doi: 10.1186/2045-824X-4-14.

16.

Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growth.

Schmid MC, Avraamides CJ, Foubert P, Shaked Y, Kang SW, Kerbel RS, Varner JA.

Cancer Res. 2011 Nov 15;71(22):6965-75. doi: 10.1158/0008-5472.CAN-11-0588. Epub 2011 Sep 23.

17.

Integrins in tumor angiogenesis and lymphangiogenesis.

Foubert P, Varner JA.

Methods Mol Biol. 2012;757:471-86. doi: 10.1007/978-1-61779-166-6_27.

18.

Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.

Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA.

Cancer Cell. 2011 Jun 14;19(6):715-27. doi: 10.1016/j.ccr.2011.04.016.

19.

Lymphatic endothelial heparan sulfate deficiency results in altered growth responses to vascular endothelial growth factor-C (VEGF-C).

Yin X, Johns SC, Lawrence R, Xu D, Reddi K, Bishop JR, Varner JA, Fuster MM.

J Biol Chem. 2011 Apr 29;286(17):14952-62. doi: 10.1074/jbc.M110.206664. Epub 2011 Feb 22.

20.

A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting.

Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA.

Blood. 2010 Dec 16;116(25):5773-83. doi: 10.1182/blood-2010-07-296210. Epub 2010 Sep 8.

21.

Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation.

Schmid MC, Varner JA.

J Oncol. 2010;2010:201026. doi: 10.1155/2010/201026. Epub 2010 May 16.

22.

Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis.

Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA.

Cancer Res. 2010 Apr 15;70(8):3042-51. doi: 10.1158/0008-5472.CAN-09-3761. Epub 2010 Apr 13.

23.

Circulating endothelial progenitor cells.

Schmid MC, Varner JA.

Methods Mol Biol. 2009;467:139-55.

PMID:
19301669
24.

Roles of integrins in tumor angiogenesis and lymphangiogenesis.

Garmy-Susini B, Varner JA.

Lymphat Res Biol. 2008;6(3-4):155-63. doi: 10.1089/lrb.2008.1011. Review.

25.

Chapter 15. Methods to study myeloid cell roles in angiogenesis.

Schmid MC, Varner JA.

Methods Enzymol. 2008;445:343-71. doi: 10.1016/S0076-6879(08)03015-2.

PMID:
19022067
26.

Fluorescent LYVE-1 antibody to image dynamically lymphatic trafficking of cancer cells in vivo.

McElroy M, Hayashi K, Garmy-Susini B, Kaushal S, Varner JA, Moossa AR, Hoffman RM, Bouvet M.

J Surg Res. 2009 Jan;151(1):68-73. doi: 10.1016/j.jss.2007.12.769. Epub 2008 Jan 18.

27.

Integrins in angiogenesis and lymphangiogenesis.

Avraamides CJ, Garmy-Susini B, Varner JA.

Nat Rev Cancer. 2008 Aug;8(8):604-17. doi: 10.1038/nrc2353. Epub 2008 May 22. Review.

28.

Methods to study lymphatic vessel integrins.

Garmy-Susini B, Makale M, Fuster M, Varner JA.

Methods Enzymol. 2007;426:415-38. Review.

PMID:
17697894
29.

Stem cells and neurogenesis in tumors.

Varner JA.

Prog Exp Tumor Res. 2007;39:122-129. doi: 10.1159/000100072. Review.

PMID:
17314505
30.

The sticky truth about angiogenesis and thrombospondins.

Varner JA.

J Clin Invest. 2006 Dec;116(12):3111-3.

31.

Myeloid cell trafficking and tumor angiogenesis.

Schmid MC, Varner JA.

Cancer Lett. 2007 May 18;250(1):1-8. Epub 2006 Oct 17. Review.

32.

Validation of the revised Patient Perception of Migraine Questionnaire: measuring satisfaction with acute migraine treatment.

Revicki DA, Kimel M, Beusterien K, Kwong JW, Varner JA, Ames MH, Mahajan S, Cady RK.

Headache. 2006 Feb;46(2):240-52.

PMID:
16492233
33.

Circulating endothelial progenitor cells.

Garmy-Susini B, Varner JA.

Br J Cancer. 2005 Oct 17;93(8):855-8. Review.

34.
35.

Inhibition of angiogenesis and tumor growth by murine 7E3, the parent antibody of c7E3 Fab (abciximab; ReoPro).

Varner JA, Nakada MT, Jordan RE, Coller BS.

Angiogenesis. 1999;3(1):53-60.

PMID:
14517444
36.

Lamotrigine as adjunctive therapy in patients with refractory epilepsy and mental retardation.

McKee JR, Sunder TR, FineSmith R, Vuong A, Varner JA, Hammer AE, Barrett PS.

Epilepsy Behav. 2003 Aug;4(4):386-94.

PMID:
12899858
37.

Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1.

Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA.

J Clin Invest. 2003 Jul;112(1):30-41.

38.

Inhibition of endothelial cell survival and angiogenesis by protein kinase A.

Kim S, Bakre M, Yin H, Varner JA.

J Clin Invest. 2002 Oct;110(7):933-41.

39.

Parathyroid hormone-related peptide is a naturally occurring, protein kinase A-dependent angiogenesis inhibitor.

Bakre MM, Zhu Y, Yin H, Burton DW, Terkeltaub R, Deftos LJ, Varner JA.

Nat Med. 2002 Sep;8(9):995-1003. Epub 2002 Aug 19.

PMID:
12185361
40.

Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action.

Ojo-Amaize EA, Nchekwube EJ, Cottam HB, Bai R, Verdier-Pinard P, Kakkanaiah VN, Varner JA, Leoni L, Okogun JI, Adesomoju AA, Oyemade OA, Hamel E.

Cancer Res. 2002 Jul 15;62(14):4007-14.

41.

The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation.

Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T.

Microvasc Res. 2002 Jul;64(1):148-61.

PMID:
12074641
43.
44.

Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3.

Penta K, Varner JA, Liaw L, Hidai C, Schatzman R, Quertermous T.

J Biol Chem. 1999 Apr 16;274(16):11101-9.

45.

Immunohistological markers of cerebrovascular integrity.

Jensen KF, Olin JK, Varner JA, Isaacson RL.

Methods Mol Med. 1999;22:271-88. doi: 10.1385/0-89603-612-X:271.

PMID:
21380842
46.
47.

Toxin-induced blood vessel inclusions caused by the chronic administration of aluminum and sodium fluoride and their implications for dementia.

Isaacson RL, Varner JA, Jensen KF.

Ann N Y Acad Sci. 1997 Oct 15;825:152-66. Review. No abstract available.

PMID:
9369984
48.

The role of vascular cell integrins alpha v beta 3 and alpha v beta 5 in angiogenesis.

Varner JA.

EXS. 1997;79:361-90. Review. No abstract available.

PMID:
9002227
49.

Integrins and cancer.

Varner JA, Cheresh DA.

Curr Opin Cell Biol. 1996 Oct;8(5):724-30. Review.

PMID:
8939661
50.

Isolation of a sponge-derived extracellular matrix adhesion protein.

Varner JA.

J Biol Chem. 1996 Jul 5;271(27):16119-25.

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