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Items: 1 to 50 of 317

1.

Toward a Shared Vision for Cancer Genomic Data.

Grossman RL, Heath AP, Ferretti V, Varmus HE, Lowy DR, Kibbe WA, Staudt LM.

N Engl J Med. 2016 Sep 22;375(12):1109-12. doi: 10.1056/NEJMp1607591. No abstract available.

PMID:
27653561
2.

Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.

Maity TK, Venugopalan A, Linnoila I, Cultraro CM, Giannakou A, Nemati R, Zhang X, Webster JD, Ritt D, Ghosal S, Hoschuetzky H, Simpson RM, Biswas R, Politi K, Morrison DK, Varmus HE, Guha U.

Cancer Discov. 2015 May;5(5):534-49. doi: 10.1158/2159-8290.CD-14-0750. Epub 2015 Mar 3.

3.

DOK2 inhibits EGFR-mutated lung adenocarcinoma.

Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE, Pandolfi PP.

PLoS One. 2013 Nov 8;8(11):e79526. doi: 10.1371/journal.pone.0079526. eCollection 2013.

4.

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.

Somwar R, Erdjument-Bromage H, Larsson E, Shum D, Lockwood WW, Yang G, Sander C, Ouerfelli O, Tempst PJ, Djaballah H, Varmus HE.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16375-80. doi: 10.1073/pnas.1113554108. Epub 2011 Sep 19.

5.

Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.

Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Fa├ža VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM.

Cancer Cell. 2011 Sep 13;20(3):289-99. doi: 10.1016/j.ccr.2011.08.007.

6.

The Interactions of Retroviruses and their Hosts.

Coffin JM, Hughes SH, Varmus HE.

In: Coffin JM, Hughes SH, Varmus HE, editors. Retroviruses. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1997.

7.

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.

Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, Beroukhim R, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofrio RC, Saito T, Shukla N, Lau C, Nelander S, Silver SJ, Sougnez C, Viale A, Winckler W, Maki RG, Garraway LA, Lash A, Greulich H, Root DE, Sellers WR, Schwartz GK, Antonescu CR, Lander ES, Varmus HE, Ladanyi M, Sander C, Meyerson M, Singer S.

Nat Genet. 2010 Aug;42(8):715-21. doi: 10.1038/ng.619. Epub 2010 Jul 4.

8.

Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B.

Asimakopoulos F, Varmus HE.

J Virol. 2009 May;83(10):4835-43. doi: 10.1128/JVI.02254-08. Epub 2009 Mar 11.

9.

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family.

Beverly LJ, Varmus HE.

Oncogene. 2009 Mar 5;28(9):1274-9. doi: 10.1038/onc.2008.466. Epub 2009 Jan 12.

10.

Somatic mutations affect key pathways in lung adenocarcinoma.

Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK.

Nature. 2008 Oct 23;455(7216):1069-75. doi: 10.1038/nature07423.

11.

Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.

Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, Harsha HC, Sato M, Bader JS, Lash AE, Minna JD, Pandey A, Varmus HE.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14112-7. doi: 10.1073/pnas.0806158105. Epub 2008 Sep 5.

12.

The classic: integration of deoxyribonucleic acid specific for Rous sarcoma virus after infection of permissive and nonpermissive hosts: (RNA tumor viruses/reassociation kinetics/duck cells). 1973.

Varmus HE, Vogt PK, Bishop JM.

Clin Orthop Relat Res. 2008 Sep;466(9):2031-8. doi: 10.1007/s11999-008-0355-8. Epub 2008 Jul 3. No abstract available. Erratum in: Clin Orthop Relat Res. 2009 Jul;467(7):1927.

13.

Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras.

Podsypanina K, Politi K, Beverly LJ, Varmus HE.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5242-7. doi: 10.1073/pnas.0801197105. Epub 2008 Mar 20.

14.

Characterizing the cancer genome in lung adenocarcinoma.

Weir BA, Woo MS, Getz G, Perner S, Ding L, Beroukhim R, Lin WM, Province MA, Kraja A, Johnson LA, Shah K, Sato M, Thomas RK, Barletta JA, Borecki IB, Broderick S, Chang AC, Chiang DY, Chirieac LR, Cho J, Fujii Y, Gazdar AF, Giordano T, Greulich H, Hanna M, Johnson BE, Kris MG, Lash A, Lin L, Lindeman N, Mardis ER, McPherson JD, Minna JD, Morgan MB, Nadel M, Orringer MB, Osborne JR, Ozenberger B, Ramos AH, Robinson J, Roth JA, Rusch V, Sasaki H, Shepherd F, Sougnez C, Spitz MR, Tsao MS, Twomey D, Verhaak RG, Weinstock GM, Wheeler DA, Winckler W, Yoshizawa A, Yu S, Zakowski MF, Zhang Q, Beer DG, Wistuba II, Watson MA, Garraway LA, Ladanyi M, Travis WD, Pao W, Rubin MA, Gabriel SB, Gibbs RA, Varmus HE, Wilson RK, Lander ES, Meyerson M.

Nature. 2007 Dec 6;450(7171):893-8. Epub 2007 Nov 4.

15.

Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models.

Du Z, Podsypanina K, Huang S, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck M, Allred DC, Lewis MT, Varmus HE, Li Y.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17396-401. Epub 2006 Nov 7.

16.

Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.

Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE.

Genes Dev. 2006 Jun 1;20(11):1496-510. Epub 2006 May 16.

17.

Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice.

Huang S, Li Y, Chen Y, Podsypanina K, Chamorro M, Olshen AB, Desai KV, Tann A, Petersen D, Green JE, Varmus HE.

Genome Biol. 2005;6(10):R84. Epub 2005 Sep 30.

18.

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.

Pao W, Wang TY, Riely GJ, Miller VA, Pan Q, Ladanyi M, Zakowski MF, Heelan RT, Kris MG, Varmus HE.

PLoS Med. 2005 Jan;2(1):e17. Epub 2005 Jan 25.

19.

The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma.

Lewis BC, Klimstra DS, Socci ND, Xu S, Koutcher JA, Varmus HE.

Mol Cell Biol. 2005 Feb;25(4):1228-37.

20.

FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.

Chamorro MN, Schwartz DR, Vonica A, Brivanlou AH, Cho KR, Varmus HE.

EMBO J. 2005 Jan 12;24(1):73-84. Epub 2004 Dec 9.

21.
22.

The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.

Lewis BC, Klimstra DS, Varmus HE.

Genes Dev. 2003 Dec 15;17(24):3127-38. Epub 2003 Dec 17.

23.

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.

Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, Rowlands T, Egeblad M, Cowin P, Werb Z, Tan LK, Rosen JM, Varmus HE.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15853-8. Epub 2003 Dec 10.

24.

Why PLoS became a publisher.

Brown PO, Eisen MB, Varmus HE.

PLoS Biol. 2003 Oct;1(1):E36. Epub 2003 Oct 13. No abstract available.

25.

Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance.

Pao W, Klimstra DS, Fisher GH, Varmus HE.

Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8764-9. Epub 2003 Jul 11.

26.

Public-access group supports PubMed Central.

Eisen MB, Brown PO, Varmus HE.

Nature. 2002 Sep 12;419(6903):111. No abstract available.

PMID:
12226637
27.

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.

Orsulic S, Li Y, Soslow RA, Vitale-Cross LA, Gutkind JS, Varmus HE.

Cancer Cell. 2002 Feb;1(1):53-62.

28.

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.

Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, Lizak MJ, Whitsett JA, Koretsky A, Varmus HE.

Genes Dev. 2001 Dec 15;15(24):3249-62.

29.

Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector.

Lewis BC, Chinnasamy N, Morgan RA, Varmus HE.

J Virol. 2001 Oct;75(19):9339-44.

30.

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.

Chamorro M, Czar MJ, Debnath J, Cheng G, Lenardo MJ, Varmus HE, Schwartzberg PL.

BMC Immunol. 2001;2:3. Epub 2001 May 8.

31.

Information access. Building a "GenBank" of the published literature.

Roberts RJ, Varmus HE, Ashburner M, Brown PO, Eisen MB, Khosla C, Kirschner M, Nusse R, Scott M, Wold B.

Science. 2001 Mar 23;291(5512):2318-9. No abstract available.

PMID:
11269300
32.

The challenge of making laws on the shifting terrain of science.

Varmus HE.

J Law Med Ethics. 2000 Winter;28(4 Suppl):46-53. No abstract available.

PMID:
11244844
33.

Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice.

Li Y, Podsypanina K, Liu X, Crane A, Tan LK, Parsons R, Varmus HE.

BMC Mol Biol. 2001;2:2. Epub 2001 Jan 23.

34.

Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.

Xing L, Venegas AM, Chen A, Garrett-Beal L, Boyce BF, Varmus HE, Schwartzberg PL.

Genes Dev. 2001 Jan 15;15(2):241-53.

35.

A comparative evaluation of beta-catenin and plakoglobin signaling activity.

Williams BO, Barish GD, Klymkowsky MW, Varmus HE.

Oncogene. 2000 Nov 23;19(50):5720-8.

36.

The National Institutes of Health and clinical research: a progress report.

Nathan DG, Varmus HE.

Nat Med. 2000 Nov;6(11):1201-4. No abstract available.

PMID:
11062519
37.

Use of MMTV-Wnt-1 transgenic mice for studying the genetic basis of breast cancer.

Li Y, Hively WP, Varmus HE.

Oncogene. 2000 Feb 21;19(8):1002-9. Review.

38.

Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin.

Zorn AM, Barish GD, Williams BO, Lavender P, Klymkowsky MW, Varmus HE.

Mol Cell. 1999 Oct;4(4):487-98.

39.

Membrane-anchored plakoglobins have multiple mechanisms of action in Wnt signaling.

Klymkowsky MW, Williams BO, Barish GD, Varmus HE, Vourgourakis YE.

Mol Biol Cell. 1999 Oct;10(10):3151-69.

40.

Development of a flexible and specific gene delivery system for production of murine tumor models.

Fisher GH, Orsulic S, Holland E, Hively WP, Li Y, Lewis BC, Williams BO, Varmus HE.

Oncogene. 1999 Sep 20;18(38):5253-60. Review.

41.

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity.

Schaeffer EM, Debnath J, Yap G, McVicar D, Liao XC, Littman DR, Sher A, Varmus HE, Lenardo MJ, Schwartzberg PL.

Science. 1999 Apr 23;284(5414):638-41.

42.

A mouse mammary tumor virus-Wnt-1 transgene induces mammary gland hyperplasia and tumorigenesis in mice lacking estrogen receptor-alpha.

Bocchinfuso WP, Hively WP, Couse JF, Varmus HE, Korach KS.

Cancer Res. 1999 Apr 15;59(8):1869-76.

43.

rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases.

Debnath J, Chamorro M, Czar MJ, Schaeffer EM, Lenardo MJ, Varmus HE, Schwartzberg PL.

Mol Cell Biol. 1999 Feb;19(2):1498-507.

46.

National Institutes of Health in the tropics.

Varmus HE.

Am J Trop Med Hyg. 1998 Jul;59(1):24-8. No abstract available.

PMID:
9684621
47.

Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus.

Bates P, Rong L, Varmus HE, Young JA, Crittenden LB.

J Virol. 1998 Mar;72(3):2505-8.

48.
49.

Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a.

Saint-Jeannet JP, He X, Varmus HE, Dawid IB.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13713-8.

50.

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.

Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE.

Genes Dev. 1997 Nov 1;11(21):2835-44.

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