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Items: 1 to 50 of 94

1.

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB.

Cancer Cell. 2019 May 13;35(5):816. doi: 10.1016/j.ccell.2019.04.011. No abstract available.

PMID:
31085179
2.

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Ma J, Benitez JA, Li J, Miki S, Ponte de Albuquerque C, Galatro T, Orellana L, Zanca C, Reed R, Boyer A, Koga T, Varki NM, Fenton TR, Nagahashi Marie SK, Lindahl E, Gahman TC, Shiau AK, Zhou H, DeGroot J, Sulman EP, Cavenee WK, Kolodner RD, Chen CC, Furnari FB.

Cancer Cell. 2019 Mar 18;35(3):504-518.e7. doi: 10.1016/j.ccell.2019.01.020. Epub 2019 Feb 28. Erratum in: Cancer Cell. 2019 May 13;35(5):816.

PMID:
30827889
3.

The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation.

Miles LA, Baik N, Bai H, Makarenkova HP, Kiosses WB, Krajewski S, Castellino FJ, Valenzuela A, Varki NM, Mueller BM, Parmer RJ.

J Thromb Haemost. 2018 May;16(5):919-932. doi: 10.1111/jth.13988. Epub 2018 Apr 1.

4.

Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions.

Lee J, Liao R, Wang G, Yang BH, Luo X, Varki NM, Qiu SJ, Ren B, Fu W, Feng GS.

Cell Rep. 2017 Nov 14;21(7):1870-1882. doi: 10.1016/j.celrep.2017.10.064.

5.

Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain.

Naito-Matsui Y, Davies LR, Takematsu H, Chou HH, Tangvoranuntakul P, Carlin AF, Verhagen A, Heyser CJ, Yoo SW, Choudhury B, Paton JC, Paton AW, Varki NM, Schnaar RL, Varki A.

J Biol Chem. 2017 Feb 17;292(7):2557-2570. doi: 10.1074/jbc.M116.768531. Epub 2017 Jan 3.

6.

Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.

Luo X, Liao R, Hanley KL, Zhu HH, Malo KN, Hernandez C, Wei X, Varki NM, Alderson N, Chu C, Li S, Fan J, Loomba R, Qiu SJ, Feng GS.

Cell Rep. 2016 Dec 13;17(11):2979-2993. doi: 10.1016/j.celrep.2016.11.048.

7.

Deficiency of plasminogen receptor, Plg-RKT , causes defects in plasminogen binding and inflammatory macrophage recruitment in vivo.

Miles LA, Baik N, Lighvani S, Khaldoyanidi S, Varki NM, Bai H, Mueller BM, Parmer RJ.

J Thromb Haemost. 2017 Jan;15(1):155-162. doi: 10.1111/jth.13532. Epub 2016 Nov 28.

8.

Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness.

Springer SA, Schwarz F, Altheide TK, Varki NM, Varki A, Gagneux P.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):E1591-2. doi: 10.1073/pnas.1601419113. Epub 2016 Mar 1. No abstract available.

9.

Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity.

Hartmann P, Seebauer CT, Mazagova M, Horvath A, Wang L, Llorente C, Varki NM, Brandl K, Ho SB, Schnabl B.

Am J Physiol Gastrointest Liver Physiol. 2016 Mar 1;310(5):G310-22. doi: 10.1152/ajpgi.00094.2015. Epub 2015 Dec 23.

10.

Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline.

Schwarz F, Springer SA, Altheide TK, Varki NM, Gagneux P, Varki A.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):74-9. doi: 10.1073/pnas.1517951112. Epub 2015 Nov 30.

11.

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14.

Fong JJ, Sreedhara K, Deng L, Varki NM, Angata T, Liu Q, Nizet V, Varki A.

EMBO J. 2015 Nov 12;34(22):2775-88. doi: 10.15252/embj.201591407. Epub 2015 Oct 12.

12.

On the apparent rarity of epithelial cancers in captive chimpanzees.

Varki NM, Varki A.

Philos Trans R Soc Lond B Biol Sci. 2015 Jul 19;370(1673). pii: 20140225. doi: 10.1098/rstb.2014.0225. Review.

13.

Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens.

Pearce OM, Samraj AN, Läubli H, Varki NM, Varki A.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1405. doi: 10.1073/pnas.1500880112. Epub 2015 Feb 20. No abstract available.

14.

A red meat-derived glycan promotes inflammation and cancer progression.

Samraj AN, Pearce OM, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A.

Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):542-7. doi: 10.1073/pnas.1417508112. Epub 2014 Dec 29.

15.

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer.

Läubli H, Pearce OM, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Deng L, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD, Varki A.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14211-6. doi: 10.1073/pnas.1409580111. Epub 2014 Sep 15.

16.

Risk of breast cancer recurrence associated with carbohydrate intake and tissue expression of IGFI receptor.

Emond JA, Pierce JP, Natarajan L, Gapuz LR, Nguyen J, Parker BA, Varki NM, Patterson RE.

Cancer Epidemiol Biomarkers Prev. 2014 Jul;23(7):1273-9. doi: 10.1158/1055-9965.EPI-13-1218. Epub 2014 Apr 22.

17.

Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies.

Pearce OM, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD, Varki A.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5998-6003. doi: 10.1073/pnas.1209067111. Epub 2014 Apr 7.

18.

Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor.

Grewal PK, Aziz PV, Uchiyama S, Rubio GR, Lardone RD, Le D, Varki NM, Nizet V, Marth JD.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20218-23. doi: 10.1073/pnas.1313905110. Epub 2013 Nov 27.

19.

Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase.

Cohen M, Zhang XQ, Senaati HP, Chen HW, Varki NM, Schooley RT, Gagneux P.

Virol J. 2013 Nov 22;10:321. doi: 10.1186/1743-422X-10-321.

20.

Using unfixed, frozen tissues to study natural mucin distribution.

Cohen M, Varki NM, Jankowski MD, Gagneux P.

J Vis Exp. 2012 Sep 21;(67):e3928. doi: 10.3791/3928.

21.

Metabolism of vertebrate amino sugars with N-glycolyl groups: mechanisms underlying gastrointestinal incorporation of the non-human sialic acid xeno-autoantigen N-glycolylneuraminic acid.

Banda K, Gregg CJ, Chow R, Varki NM, Varki A.

J Biol Chem. 2012 Aug 17;287(34):28852-64. doi: 10.1074/jbc.M112.364182. Epub 2012 Jun 12.

22.

Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.

Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki NM, Wang H, Feng GS.

Cancer Cell. 2011 May 17;19(5):629-39. doi: 10.1016/j.ccr.2011.03.023.

23.

Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology.

Varki NM, Strobert E, Dick EJ Jr, Benirschke K, Varki A.

Annu Rev Pathol. 2011;6:365-93. doi: 10.1146/annurev-pathol-011110-130315. Review.

PMID:
21073341
24.

The ROCK inhibitor Y-27632 improves recovery of human embryonic stem cells after fluorescence-activated cell sorting with multiple cell surface markers.

Emre N, Vidal JG, Elia J, O'Connor ED, Paramban RI, Hefferan MP, Navarro R, Goldberg DS, Varki NM, Marsala M, Carson CT.

PLoS One. 2010 Aug 13;5(8):e12148. doi: 10.1371/journal.pone.0012148.

25.

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium.

Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A.

Blood. 2009 Dec 10;114(25):5225-35. doi: 10.1182/blood-2009-05-220400.

26.

A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome.

Löfling JC, Paton AW, Varki NM, Paton JC, Varki A.

Kidney Int. 2009 Jul;76(2):140-4. doi: 10.1038/ki.2009.131. Epub 2009 Apr 22. Review.

27.

Molecular basis of metastasis.

Varki A, Varki NM, Borsig L.

N Engl J Med. 2009 Apr 16;360(16):1678-9; author reply 1679-80. doi: 10.1056/NEJMc090143. No abstract available.

PMID:
19369678
28.

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.

Diaz SL, Padler-Karavani V, Ghaderi D, Hurtado-Ziola N, Yu H, Chen X, Brinkman-Van der Linden EC, Varki A, Varki NM.

PLoS One. 2009;4(1):e4241. doi: 10.1371/journal.pone.0004241. Epub 2009 Jan 21.

29.

Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression.

Hedlund M, Padler-Karavani V, Varki NM, Varki A.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18936-41. doi: 10.1073/pnas.0803943105. Epub 2008 Nov 18.

30.

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.

Byres E, Paton AW, Paton JC, Löfling JC, Smith DF, Wilce MC, Talbot UM, Chong DC, Yu H, Huang S, Chen X, Varki NM, Varki A, Rossjohn J, Beddoe T.

Nature. 2008 Dec 4;456(7222):648-52. doi: 10.1038/nature07428. Epub 2008 Oct 29.

31.

alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.

Hedlund M, Ng E, Varki A, Varki NM.

Cancer Res. 2008 Jan 15;68(2):388-94. doi: 10.1158/0008-5472.CAN-07-1340.

32.

Diversity in cell surface sialic acid presentations: implications for biology and disease.

Varki NM, Varki A.

Lab Invest. 2007 Sep;87(9):851-7. Epub 2007 Jul 16. Review.

33.

Expression of the human copper influx transporter 1 in normal and malignant human tissues.

Holzer AK, Varki NM, Le QT, Gibson MA, Naredi P, Howell SB.

J Histochem Cytochem. 2006 Sep;54(9):1041-9. Epub 2006 May 18.

PMID:
16709730
34.

L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest.

Läubli H, Stevenson JL, Varki A, Varki NM, Borsig L.

Cancer Res. 2006 Feb 1;66(3):1536-42.

35.

A human-specific gene in microglia.

Hayakawa T, Angata T, Lewis AL, Mikkelsen TS, Varki NM, Varki A.

Science. 2005 Sep 9;309(5741):1693.

36.

Combining parenting and a science career.

Lewis AL, Altheide TK, Varki A, Arden K, Varki NM.

Science. 2005 Mar 18;307(5716):1720-1. No abstract available.

PMID:
15779114
37.

Combining Parenting and a Science Career.

Djerassi C, Lewis AL, Altheide TK, Varki A, Arden K, Varki NM, Peekna A.

Science. 2005 Mar 18;307(5716):1720b-1721b. No abstract available.

PMID:
15778202
38.

A fluorescent orthotopic mouse model for reliable measurement and genetic modulation of human neuroblastoma metastasis.

Henriksson KC, Almgren MA, Thurlow R, Varki NM, Chang CL.

Clin Exp Metastasis. 2004;21(6):563-70.

PMID:
15679054
39.

Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies.

Maaser C, Housley MP, Iimura M, Smith JR, Vallance BA, Finlay BB, Schreiber JR, Varki NM, Kagnoff MF, Eckmann L.

Infect Immun. 2004 Jun;72(6):3315-24.

40.

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification.

Hosaka T, Biggs WH 3rd, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2975-80. Epub 2004 Feb 20.

41.

Increase in expression of the copper transporter ATP7A during platinum drug-based treatment is associated with poor survival in ovarian cancer patients.

Samimi G, Varki NM, Wilczynski S, Safaei R, Alberts DS, Howell SB.

Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):5853-9.

42.

Human-specific regulation of alpha 2-6-linked sialic acids.

Gagneux P, Cheriyan M, Hurtado-Ziola N, van der Linden EC, Anderson D, McClure H, Varki A, Varki NM.

J Biol Chem. 2003 Nov 28;278(48):48245-50. Epub 2003 Sep 18.

43.
44.
46.
47.

Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis.

Wang Y, Tan J, Sutton-Smith M, Ditto D, Panico M, Campbell RM, Varki NM, Long JM, Jaeken J, Levinson SR, Wynshaw-Boris A, Morris HR, Le D, Dell A, Schachter H, Marth JD.

Glycobiology. 2001 Dec;11(12):1051-70.

PMID:
11805078
48.
49.

A second uniquely human mutation affecting sialic acid biology.

Angata T, Varki NM, Varki A.

J Biol Chem. 2001 Oct 26;276(43):40282-7. Epub 2001 Aug 23.

50.

Pictures in molecular medicine: three-dimensional visualization of intravascular tumor cells in mice.

Borsig L, Wong R, Feramisco J, Nadeau DR, Varki NM, Varki A.

Trends Mol Med. 2001 Aug;7(8):377. No abstract available.

PMID:
11517000

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