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Items: 1 to 50 of 428

1.

Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms.

Kawanishi K, Dhar C, Do R, Varki N, Gordts PLSM, Varki A.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16036-16045. doi: 10.1073/pnas.1902902116. Epub 2019 Jul 22.

PMID:
31332008
2.

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells.

Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H.

Mol Cell. 2019 Jul 25;75(2):394-407.e5. doi: 10.1016/j.molcel.2019.05.017. Epub 2019 Jun 18.

PMID:
31227230
3.

Updates to the Symbol Nomenclature For Glycans (SNFG) Guidelines.

Neelamegham S, Aoki-Kinoshita K, Bolton E, Frank M, Lisacek F, Lütteke T, O'Boyle N, Packer N, Stanley P, Toukach P, Varki A, Woods RJ; SNFG Discussion group.

Glycobiology. 2019 Jun 11. pii: cwz045. doi: 10.1093/glycob/cwz045. [Epub ahead of print]

PMID:
31184695
4.

Nontypeable Haemophilus influenzae Has Evolved Preferential Use of N-Acetylneuraminic Acid as a Host Adaptation.

Ng PSK, Day CJ, Atack JM, Hartley-Tassell LE, Winter LE, Marshanski T, Padler-Karavani V, Varki A, Barenkamp SJ, Apicella MA, Jennings MP.

MBio. 2019 May 7;10(3). pii: e00422-19. doi: 10.1128/mBio.00422-19.

5.

From "Serum Sickness" to "Xenosialitis": Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc.

Dhar C, Sasmal A, Varki A.

Front Immunol. 2019 Apr 17;10:807. doi: 10.3389/fimmu.2019.00807. eCollection 2019. Review.

6.

Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.

Uchiyama S, Sun J, Fukahori K, Ando N, Wu M, Schwarz F, Siddiqui SS, Varki A, Marth JD, Nizet V.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7465-7470. doi: 10.1073/pnas.1815572116. Epub 2019 Mar 25.

PMID:
30910970
7.

Redox-Controlled Site-Specific α2-6-Sialylation.

Lu N, Ye J, Cheng J, Sasmal A, Liu CC, Yao W, Yan J, Khan N, Yi W, Varki A, Cao H.

J Am Chem Soc. 2019 Mar 20;141(11):4547-4552. doi: 10.1021/jacs.9b00044. Epub 2019 Mar 11.

PMID:
30843692
8.

Evolution of the exclusively human pathogen Neisseria gonorrhoeae: Human-specific engagement of immunoregulatory Siglecs.

Landig CS, Hazel A, Kellman BP, Fong JJ, Schwarz F, Agarwal S, Varki N, Massari P, Lewis NE, Ram S, Varki A.

Evol Appl. 2019 Jan 3;12(2):337-349. doi: 10.1111/eva.12744. eCollection 2019 Feb.

9.

Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells.

Fong JJ, Tsai CM, Saha S, Nizet V, Varki A, Bui JD.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10410-10415. doi: 10.1073/pnas.1804108115. Epub 2018 Sep 25.

10.

Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution.

Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC.

Proc Biol Sci. 2018 Sep 12;285(1886). pii: 20181656. doi: 10.1098/rspb.2018.1656.

PMID:
30209232
11.

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.

Stanczak MA, Siddiqui SS, Trefny MP, Thommen DS, Boligan KF, von Gunten S, Tzankov A, Tietze L, Lardinois D, Heinzelmann-Schwarz V, von Bergwelt-Baildon M, Zhang W, Lenz HJ, Han Y, Amos CI, Syedbasha M, Egli A, Stenner F, Speiser DE, Varki A, Zippelius A, Läubli H.

J Clin Invest. 2018 Nov 1;128(11):4912-4923. doi: 10.1172/JCI120612. Epub 2018 Sep 24.

12.

Human evolutionary loss of epithelial Neu5Gc expression and species-specific susceptibility to cholera.

Alisson-Silva F, Liu JZ, Diaz SL, Deng L, Gareau MG, Marchelletta R, Chen X, Nizet V, Varki N, Barrett KE, Varki A.

PLoS Pathog. 2018 Jun 18;14(6):e1007133. doi: 10.1371/journal.ppat.1007133. eCollection 2018 Jun.

13.

Polyclonal human antibodies against glycans bearing red meat-derived non-human sialic acid N-glycolylneuraminic acid are stable, reproducible, complex and vary between individuals: Total antibody levels are associated with colorectal cancer risk.

Samraj AN, Bertrand KA, Luben R, Khedri Z, Yu H, Nguyen D, Gregg CJ, Diaz SL, Sawyer S, Chen X, Eliassen H, Padler-Karavani V, Wu K, Khaw KT, Willett W, Varki A.

PLoS One. 2018 Jun 18;13(6):e0197464. doi: 10.1371/journal.pone.0197464. eCollection 2018.

14.

A Novel Sialylation Site on Neisseria gonorrhoeae Lipooligosaccharide Links Heptose II Lactose Expression with Pathogenicity.

Ram S, Gulati S, Lewis LA, Chakraborti S, Zheng B, DeOliveira RB, Reed GW, Cox AD, Li J, St Michael F, Stupak J, Su XH, Saha S, Landig CS, Varki A, Rice PA.

Infect Immun. 2018 Jul 23;86(8). pii: e00285-18. doi: 10.1128/IAI.00285-18. Print 2018 Aug.

15.

Chemoenzymatic Assembly of Mammalian O-Mannose Glycans.

Meng C, Sasmal A, Zhang Y, Gao T, Liu CC, Khan N, Varki A, Wang F, Cao H.

Angew Chem Int Ed Engl. 2018 Jul 16;57(29):9003-9007. doi: 10.1002/anie.201804373. Epub 2018 Jun 25.

16.

Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus.

Owen CD, Tailford LE, Monaco S, Šuligoj T, Vaux L, Lallement R, Khedri Z, Yu H, Lecointe K, Walshaw J, Tribolo S, Horrex M, Bell A, Chen X, Taylor GL, Varki A, Angulo J, Juge N.

Nat Commun. 2017 Dec 19;8(1):2196. doi: 10.1038/s41467-017-02109-8.

17.

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates.

Hayakawa T, Khedri Z, Schwarz F, Landig C, Liang SY, Yu H, Chen X, Fujito NT, Satta Y, Varki A, Angata T.

BMC Evol Biol. 2017 Nov 23;17(1):228. doi: 10.1186/s12862-017-1075-z.

18.

Author Correction: Evolution of host adaptation in the Salmonella typhoid toxin.

Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE.

Nat Microbiol. 2017 Dec;2(12):1697. doi: 10.1038/s41564-017-0070-x.

PMID:
29093550
19.

Evolution of host adaptation in the Salmonella typhoid toxin.

Gao X, Deng L, Stack G, Yu H, Chen X, Naito-Matsui Y, Varki A, Galán JE.

Nat Microbiol. 2017 Dec;2(12):1592-1599. doi: 10.1038/s41564-017-0033-2. Epub 2017 Oct 9. Erratum in: Nat Microbiol. 2017 Dec;2(12 ):1697.

20.

New and updated glycoscience-related resources at NCBI.

Varki A.

Glycobiology. 2017 Nov 1;27(11):993. doi: 10.1093/glycob/cwx077. No abstract available.

PMID:
28973256
21.

Distribution of O-Acetylated Sialic Acids among Target Host Tissues for Influenza Virus.

Wasik BR, Barnard KN, Ossiboff RJ, Khedri Z, Feng KH, Yu H, Chen X, Perez DR, Varki A, Parrish CR.

mSphere. 2017 Sep 6;2(5). pii: e00379-16. doi: 10.1128/mSphere.00379-16. eCollection 2017 Sep-Oct.

22.

N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils.

Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG, Varki A.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8155-E8164. doi: 10.1073/pnas.1706306114. Epub 2017 Sep 11.

23.

Glycosylation Changes in Cancer.

Varki A, Kannagi R, Toole B, Stanley P.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 47.
2017.

24.

P-Type Lectins.

Varki A, Kornfeld S.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 33.
2017.

25.

Biological Functions of Glycans.

Varki A, Gagneux P.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 7.
2017.

26.

Historical Background and Overview.

Varki A, Kornfeld S.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 1.
2017.

27.

Sialic Acids and Other Nonulosonic Acids.

Varki A, Schnaar RL, Schauer R.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 15.
2017.

28.

Glycans in Acquired Human Diseases.

Freeze HH, Kinoshita T, Varki A.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 46.
2017.

29.

Evolution of Glycan Diversity.

Gagneux P, Aebi M, Varki A.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 20.
2017.

30.

Future Directions in Glycosciences.

Hart GW, Varki A.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 60.
2017.

31.

I-Type Lectins.

Varki A, Schnaar RL, Crocker PR.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 35.
2017.

32.

Glycans in Systemic Physiology.

Freeze HH, Baum L, Varki A.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 41.
2017.

33.

Microbial Lectins: Hemagglutinins, Adhesins, and Toxins.

Nizet V, Varki A, Aebi M.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 37.
2017.

34.

Discovery and Classification of Glycan-Binding Proteins.

Taylor ME, Drickamer K, Schnaar RL, Etzler ME, Varki A.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 28.
2017.

35.

Cellular Organization of Glycosylation.

Colley KJ, Varki A, Kinoshita T.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 4.
2017.

36.

Scientific journals: Rename the impact factor.

Varki A.

Nature. 2017 Aug 23;548(7668):393. doi: 10.1038/548393c. No abstract available.

PMID:
28836596
37.

Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract.

Patras KA, Coady A, Olson J, Ali SR, RamachandraRao SP, Kumar S, Varki A, Nizet V.

Immunol Cell Biol. 2017 Nov;95(10):960-965. doi: 10.1038/icb.2017.63. Epub 2017 Aug 22.

38.

Are humans prone to autoimmunity? Implications from evolutionary changes in hominin sialic acid biology.

Varki A.

J Autoimmun. 2017 Sep;83:134-142. doi: 10.1016/j.jaut.2017.07.011. Epub 2017 Jul 26. Review.

PMID:
28755952
39.

The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool.

Siddiqui SS, Springer SA, Verhagen A, Sundaramurthy V, Alisson-Silva F, Jiang W, Ghosh P, Varki A.

J Biol Chem. 2017 Sep 15;292(37):15312-15320. doi: 10.1074/jbc.M117.799346. Epub 2017 Jul 26.

40.

The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes.

Graustein AD, Horne DJ, Fong JJ, Schwarz F, Mefford HC, Peterson GJ, Wells RD, Musvosvi M, Shey M, Hanekom WA, Hatherill M, Scriba TJ, Thuong NTT, Mai NTH, Caws M, Bang ND, Dunstan SJ, Thwaites GE, Varki A, Angata T, Hawn TR.

Tuberculosis (Edinb). 2017 May;104:38-45. doi: 10.1016/j.tube.2017.02.005. Epub 2017 Feb 21.

PMID:
28454648
41.

Biochemical, Cellular, Physiological, and Pathological Consequences of Human Loss of N-Glycolylneuraminic Acid.

Okerblom J, Varki A.

Chembiochem. 2017 Jul 4;18(13):1155-1171. doi: 10.1002/cbic.201700077. Epub 2017 Jun 9. Review.

PMID:
28423240
42.

Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation.

Lizcano A, Secundino I, Döhrmann S, Corriden R, Rohena C, Diaz S, Ghosh P, Deng L, Nizet V, Varki A.

Blood. 2017 Jun 8;129(23):3100-3110. doi: 10.1182/blood-2016-11-751636. Epub 2017 Apr 17.

43.

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

Dharmadhikari G, Stolz K, Hauke M, Morgan NG, Varki A, de Koning E, Kelm S, Maedler K.

Sci Rep. 2017 Apr 5;7:45319. doi: 10.1038/srep45319.

44.

Loss of CMAH during Human Evolution Primed the Monocyte-Macrophage Lineage toward a More Inflammatory and Phagocytic State.

Okerblom JJ, Schwarz F, Olson J, Fletes W, Ali SR, Martin PT, Glass CK, Nizet V, Varki A.

J Immunol. 2017 Mar 15;198(6):2366-2373. doi: 10.4049/jimmunol.1601471. Epub 2017 Feb 1.

45.

Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.

Schwarz F, Landig CS, Siddiqui S, Secundino I, Olson J, Varki N, Nizet V, Varki A.

EMBO J. 2017 Mar 15;36(6):751-760. doi: 10.15252/embj.201695581. Epub 2017 Jan 18.

46.

Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain.

Naito-Matsui Y, Davies LR, Takematsu H, Chou HH, Tangvoranuntakul P, Carlin AF, Verhagen A, Heyser CJ, Yoo SW, Choudhury B, Paton JC, Paton AW, Varki NM, Schnaar RL, Varki A.

J Biol Chem. 2017 Feb 17;292(7):2557-2570. doi: 10.1074/jbc.M116.768531. Epub 2017 Jan 3.

47.

A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9-O-Acetyl Sialic Acids.

Khedri Z, Xiao A, Yu H, Landig CS, Li W, Diaz S, Wasik BR, Parrish CR, Wang LP, Varki A, Chen X.

ACS Chem Biol. 2017 Jan 20;12(1):214-224. doi: 10.1021/acschembio.6b00928. Epub 2016 Dec 12.

48.

Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E.

Siddiqui S, Schwarz F, Springer S, Khedri Z, Yu H, Deng L, Verhagen A, Naito-Matsui Y, Jiang W, Kim D, Zhou J, Ding B, Chen X, Varki N, Varki A.

J Biol Chem. 2017 Jan 20;292(3):1029-1037. doi: 10.1074/jbc.M116.738351. Epub 2016 Dec 5.

49.

Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR.

Hentrich K, Löfling J, Pathak A, Nizet V, Varki A, Henriques-Normark B.

Cell Host Microbe. 2016 Sep 14;20(3):307-317. doi: 10.1016/j.chom.2016.07.019. Epub 2016 Sep 1.

50.

Biological roles of glycans.

Varki A.

Glycobiology. 2017 Jan;27(1):3-49. doi: 10.1093/glycob/cww086. Epub 2016 Aug 24. Review.

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