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Items: 1 to 50 of 75

1.

Dominant TOM1 mutation associated with combined immunodeficiency and autoimmune disease.

Keskitalo S, Haapaniemi EM, Glumoff V, Liu X, Lehtinen V, Fogarty C, Rajala H, Chiang SC, Mustjoki S, Kovanen P, Lohi J, Bryceson YT, Seppänen M, Kere J, Heiskanen K, Varjosalo M.

NPJ Genom Med. 2019 Jun 27;4:14. doi: 10.1038/s41525-019-0088-5. eCollection 2019.

2.

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.

Göös H, Fogarty CL, Sahu B, Plagnol V, Rajamäki K, Nurmi K, Liu X, Einarsdottir E, Jouppila A, Pettersson T, Vihinen H, Krjutskov K, Saavalainen P, Järvinen A, Muurinen M, Greco D, Scala G, Curtis J, Nordström D, Flaumenhaft R, Vaarala O, Kovanen PE, Keskitalo S, Ranki A, Kere J, Lehto M, Notarangelo LD, Nejentsev S, Eklund KK, Varjosalo M, Taipale J, Seppänen MRJ.

J Allergy Clin Immunol. 2019 Jun 13. pii: S0091-6749(19)30762-6. doi: 10.1016/j.jaci.2019.06.003. [Epub ahead of print]

3.

ER-Targeted Beclin 1 Supports Autophagosome Biogenesis in the Absence of ULK1 and ULK2 Kinases.

Anwar T, Liu X, Suntio T, Marjamäki A, Biazik J, Chan EYW, Varjosalo M, Eskelinen EL.

Cells. 2019 May 17;8(5). pii: E475. doi: 10.3390/cells8050475.

4.

Pool-seq driven proteogenomic database for Group G Streptococcus.

Weldatsadik RG, Datta N, Kolmeder C, Vuopio J, Kere J, Wilkman SV, Flatt JW, Vuento R, Haapasalo KJ, Keskitalo S, Varjosalo M, Jokiranta TS.

J Proteomics. 2019 Jun 15;201:84-92. doi: 10.1016/j.jprot.2019.04.015. Epub 2019 Apr 20.

PMID:
31015036
5.

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis.

Turunen SP, von Nandelstadh P, Öhman T, Gucciardo E, Seashore-Ludlow B, Martins B, Rantanen V, Li H, Höpfner K, Östling P, Varjosalo M, Lehti K.

Cell Death Differ. 2019 Mar 22. doi: 10.1038/s41418-019-0321-x. [Epub ahead of print]

PMID:
30903103
6.

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

Viita T, Kyheröinen S, Prajapati B, Virtanen J, Frilander MJ, Varjosalo M, Vartiainen MK.

J Cell Sci. 2019 Apr 17;132(8). pii: jcs226852. doi: 10.1242/jcs.226852.

7.

Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling.

Rahikainen R, Öhman T, Turkki P, Varjosalo M, Hytönen VP.

J Cell Sci. 2019 Apr 3;132(7). pii: jcs226514. doi: 10.1242/jcs.226514.

PMID:
30837291
8.

MKRN3 Interacts With Several Proteins Implicated in Puberty Timing but Does Not Influence GNRH1 Expression.

Yellapragada V, Liu X, Lund C, Känsäkoski J, Pulli K, Vuoristo S, Lundin K, Tuuri T, Varjosalo M, Raivio T.

Front Endocrinol (Lausanne). 2019 Feb 8;10:48. doi: 10.3389/fendo.2019.00048. eCollection 2019.

9.

Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion.

Brix DM, Tvingsholm SA, Hansen MB, Clemmensen KB, Ohman T, Siino V, Lambrughi M, Hansen K, Puustinen P, Gromova I, James P, Papaleo E, Varjosalo M, Moreira J, Jäättelä M, Kallunki T.

Oncogene. 2019 Apr;38(17):3170-3184. doi: 10.1038/s41388-018-0653-x. Epub 2019 Jan 8.

PMID:
30622337
10.

Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles.

Jiu Y, Kumari R, Fenix AM, Schaible N, Liu X, Varjosalo M, Krishnan R, Burnette DT, Lappalainen P.

Curr Biol. 2019 Jan 7;29(1):81-92.e5. doi: 10.1016/j.cub.2018.11.045. Epub 2018 Dec 20.

11.

Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival.

Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K, Lee DA, Okada-Hatakeyama M, Varjosalo MT, Del Río Hernández AE.

EMBO Rep. 2019 Jan;20(1). pii: e46557. doi: 10.15252/embr.201846557. Epub 2018 Dec 11.

12.

Anagrelide for Gastrointestinal Stromal Tumor.

Pulkka OP, Gebreyohannes YK, Wozniak A, Mpindi JP, Tynninen O, Icay K, Cervera A, Keskitalo S, Murumägi A, Kulesskiy E, Laaksonen M, Wennerberg K, Varjosalo M, Laakkonen P, Lehtonen R, Hautaniemi S, Kallioniemi O, Schöffski P, Sihto H, Joensuu H.

Clin Cancer Res. 2019 Mar 1;25(5):1676-1687. doi: 10.1158/1078-0432.CCR-18-0815. Epub 2018 Dec 7.

PMID:
30530703
13.

Assembly of the β4-Integrin Interactome Based on Proximal Biotinylation in the Presence and Absence of Heterodimerization.

Myllymäki SM, Kämäräinen UR, Liu X, Cruz SP, Miettinen S, Vuorela M, Varjosalo M, Manninen A.

Mol Cell Proteomics. 2019 Feb;18(2):277-293. doi: 10.1074/mcp.RA118.001095. Epub 2018 Nov 7.

PMID:
30404858
14.

Haploinsufficiency of A20 impairs protein-protein interactome and leads into caspase-8-dependent enhancement of NLRP3 inflammasome activation.

Rajamäki K, Keskitalo S, Seppänen M, Kuismin O, Vähäsalo P, Trotta L, Väänänen A, Glumoff V, Keskitalo P, Kaarteenaho R, Jartti A, Hautala N, Jackson P, Nordström DC, Saarela J, Hautala T, Eklund KK, Varjosalo M.

RMD Open. 2018 Oct 17;4(2):e000740. doi: 10.1136/rmdopen-2018-000740. eCollection 2018.

15.

Ribosome profiles and riboproteomes of healthy and Potato virus A- and Agrobacterium-infected Nicotiana benthamiana plants.

Eskelin K, Varjosalo M, Ravantti J, Mäkinen K.

Mol Plant Pathol. 2019 Mar;20(3):392-409. doi: 10.1111/mpp.12764. Epub 2018 Dec 6.

PMID:
30375150
16.

Molecular Atlas of Postnatal Mouse Heart Development.

Talman V, Teppo J, Pöhö P, Movahedi P, Vaikkinen A, Karhu ST, Trošt K, Suvitaival T, Heikkonen J, Pahikkala T, Kotiaho T, Kostiainen R, Varjosalo M, Ruskoaho H.

J Am Heart Assoc. 2018 Oct 16;7(20):e010378. doi: 10.1161/JAHA.118.010378.

17.

Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants.

Korpela K, Salonen A, Vepsäläinen O, Suomalainen M, Kolmeder C, Varjosalo M, Miettinen S, Kukkonen K, Savilahti E, Kuitunen M, de Vos WM.

Microbiome. 2018 Oct 16;6(1):182. doi: 10.1186/s40168-018-0567-4.

18.

Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease.

Paakkola T, Salokas K, Miinalainen I, Lehtonen S, Manninen A, Kaakinen M, Ruddock LW, Varjosalo M, Kaarteenaho R, Uusimaa J, Hinttala R.

Hum Mol Genet. 2018 Dec 15;27(24):4288-4302. doi: 10.1093/hmg/ddy298.

PMID:
30239752
19.

Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer.

Kondelin J, Salokas K, Saarinen L, Ovaska K, Rauanheimo H, Plaketti RM, Hamberg J, Liu X, Yadav L, Gylfe AE, Cajuso T, Hänninen UA, Palin K, Ristolainen H, Katainen R, Kaasinen E, Tanskanen T, Aavikko M, Taipale M, Taipale J, Renkonen-Sinisalo L, Lepistö A, Koskensalo S, Böhm J, Mecklin JP, Ongen H, Dermitzakis ET, Kilpivaara O, Vahteristo P, Turunen M, Hautaniemi S, Tuupanen S, Karhu A, Välimäki N, Varjosalo M, Pitkänen E, Aaltonen LA.

EMBO Mol Med. 2018 Sep;10(9). pii: e8552. doi: 10.15252/emmm.201708552.

20.

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone.

Konovalova S, Liu X, Manjunath P, Baral S, Neupane N, Hilander T, Yang Y, Balboa D, Terzioglu M, Euro L, Varjosalo M, Tyynismaa H.

Redox Biol. 2018 Oct;19:37-45. doi: 10.1016/j.redox.2018.07.024. Epub 2018 Aug 4.

21.

Systems pathology analysis identifies neurodegenerative nature of age-related vitreoretinal interface diseases.

Öhman T, Tamene F, Göös H, Loukovaara S, Varjosalo M.

Aging Cell. 2018 Oct;17(5):e12809. doi: 10.1111/acel.12809. Epub 2018 Jul 2.

22.

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

Liu X, Salokas K, Tamene F, Jiu Y, Weldatsadik RG, Öhman T, Varjosalo M.

Nat Commun. 2018 Mar 22;9(1):1188. doi: 10.1038/s41467-018-03523-2.

23.

Candidate proteins from predegenerated nerve exert time-specific protection of retinal ganglion cells in glaucoma.

Pietrucha-Dutczak M, Smedowski A, Liu X, Matuszek I, Varjosalo M, Lewin-Kowalik J.

Sci Rep. 2017 Nov 6;7(1):14540. doi: 10.1038/s41598-017-14860-5.

24.

Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure.

Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):296-306. doi: 10.1016/j.bbadis.2017.10.030. Epub 2017 Oct 28.

25.

Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis.

Tommiska J, Känsäkoski J, Skibsbye L, Vaaralahti K, Liu X, Lodge EJ, Tang C, Yuan L, Fagerholm R, Kanters JK, Lahermo P, Kaunisto M, Keski-Filppula R, Vuoristo S, Pulli K, Ebeling T, Valanne L, Sankila EM, Kivirikko S, Lääperi M, Casoni F, Giacobini P, Phan-Hug F, Buki T, Tena-Sempere M, Pitteloud N, Veijola R, Lipsanen-Nyman M, Kaunisto K, Mollard P, Andoniadou CL, Hirsch JA, Varjosalo M, Jespersen T, Raivio T.

Nat Commun. 2017 Nov 3;8(1):1289. doi: 10.1038/s41467-017-01429-z.

26.

PWP1 Mediates Nutrient-Dependent Growth Control through Nucleolar Regulation of Ribosomal Gene Expression.

Liu Y, Mattila J, Ventelä S, Yadav L, Zhang W, Lamichane N, Sundström J, Kauko O, Grénman R, Varjosalo M, Westermarck J, Hietakangas V.

Dev Cell. 2017 Oct 23;43(2):240-252.e5. doi: 10.1016/j.devcel.2017.09.022.

27.

UNC-45a promotes myosin folding and stress fiber assembly.

Lehtimäki JI, Fenix AM, Kotila TM, Balistreri G, Paavolainen L, Varjosalo M, Burnette DT, Lappalainen P.

J Cell Biol. 2017 Dec 4;216(12):4053-4072. doi: 10.1083/jcb.201703107. Epub 2017 Oct 20.

28.

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

Lempiäinen JK, Niskanen EA, Vuoti KM, Lampinen RE, Göös H, Varjosalo M, Palvimo JJ.

Mol Cell Proteomics. 2017 Aug;16(8):1462-1474. doi: 10.1074/mcp.M117.067488. Epub 2017 Jun 13.

29.

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation.

Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, Grym H, Ustinov J, Wartiovaara K, Hawkins RD, Silvennoinen O, Varjosalo M, Morgan NG, Otonkoski T.

Cell Rep. 2017 Apr 11;19(2):281-294. doi: 10.1016/j.celrep.2017.03.055.

30.

Role for formin-like 1-dependent acto-myosin assembly in lipid droplet dynamics and lipid storage.

Pfisterer SG, Gateva G, Horvath P, Pirhonen J, Salo VT, Karhinen L, Varjosalo M, Ryhänen SJ, Lappalainen P, Ikonen E.

Nat Commun. 2017 Mar 31;8:14858. doi: 10.1038/ncomms14858.

31.

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

Yadav L, Tamene F, Göös H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M.

Cell Syst. 2017 Apr 26;4(4):430-444.e5. doi: 10.1016/j.cels.2017.02.011. Epub 2017 Mar 18.

32.

Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes.

Kaustio M, Haapaniemi E, Göös H, Hautala T, Park G, Syrjänen J, Einarsdottir E, Sahu B, Kilpinen S, Rounioja S, Fogarty CL, Glumoff V, Kulmala P, Katayama S, Tamene F, Trotta L, Morgunova E, Krjutškov K, Nurmi K, Eklund K, Lagerstedt A, Helminen M, Martelius T, Mustjoki S, Taipale J, Saarela J, Kere J, Varjosalo M, Seppänen M.

J Allergy Clin Immunol. 2017 Sep;140(3):782-796. doi: 10.1016/j.jaci.2016.10.054. Epub 2017 Jan 21.

PMID:
28115215
33.

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry.

Heikkinen T, Kämpjärvi K, Keskitalo S, von Nandelstadh P, Liu X, Rantanen V, Pitkänen E, Kinnunen M, Kuusanmäki H, Kontro M, Turunen M, Mäkinen N, Taipale J, Heckman C, Lehti K, Mustjoki S, Varjosalo M, Vahteristo P.

Hum Mutat. 2017 Mar;38(3):269-274. doi: 10.1002/humu.23157. Epub 2017 Jan 11.

PMID:
28054750
34.

Several Hfq-dependent alterations in physiology of Yersinia enterocolitica O:3 are mediated by derepression of the transcriptional regulator RovM.

Leskinen K, Pajunen MI, Varjosalo M, Fernández-Carrasco H, Bengoechea JA, Skurnik M.

Mol Microbiol. 2017 Mar;103(6):1065-1091. doi: 10.1111/mmi.13610. Epub 2017 Jan 23.

35.

Combined immunodeficiency and hypoglycemia associated with mutations in hypoxia upregulated 1.

Haapaniemi EM, Fogarty CL, Keskitalo S, Katayama S, Vihinen H, Ilander M, Mustjoki S, Krjutškov K, Lehto M, Hautala T, Eriksson O, Jokitalo E, Velagapudi V, Varjosalo M, Seppänen M, Kere J.

J Allergy Clin Immunol. 2017 Apr;139(4):1391-1393.e11. doi: 10.1016/j.jaci.2016.09.050. Epub 2016 Nov 29. No abstract available.

36.

A proteomics view on integrin-mediated adhesions.

Manninen A, Varjosalo M.

Proteomics. 2017 Feb;17(3-4). doi: 10.1002/pmic.201600022. Epub 2016 Dec 14. Review.

PMID:
27723259
37.

HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix.

Paveliev M, Fenrich KK, Kislin M, Kuja-Panula J, Kulesskiy E, Varjosalo M, Kajander T, Mugantseva E, Ahonen-Bishopp A, Khiroug L, Kulesskaya N, Rougon G, Rauvala H.

Sci Rep. 2016 Sep 27;6:33916. doi: 10.1038/srep33916.

38.

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.

Santio NM, Landor SK, Vahtera L, Ylä-Pelto J, Paloniemi E, Imanishi SY, Corthals G, Varjosalo M, Manoharan GB, Uri A, Lendahl U, Sahlgren C, Koskinen PJ.

Oncotarget. 2016 Jul 12;7(28):43220-43238. doi: 10.18632/oncotarget.9215.

39.

Predegenerated Schwann cells--a novel prospect for cell therapy for glaucoma: neuroprotection, neuroregeneration and neuroplasticity.

Smedowski A, Liu X, Pietrucha-Dutczak M, Matuszek I, Varjosalo M, Lewin-Kowalik J.

Sci Rep. 2016 Apr 1;6:23187. doi: 10.1038/srep23187.

40.

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication.

Balistreri G, Viiliäinen J, Turunen M, Diaz R, Lyly L, Pekkonen P, Rantala J, Ojala K, Sarek G, Teesalu M, Denisova O, Peltonen K, Julkunen I, Varjosalo M, Kainov D, Kallioniemi O, Laiho M, Taipale J, Hautaniemi S, Ojala PM.

PLoS Pathog. 2016 Feb 18;12(2):e1005424. doi: 10.1371/journal.ppat.1005424. eCollection 2016 Feb.

41.

Molecular insights into the function of the viral RNA silencing suppressor HCPro.

Ivanov KI, Eskelin K, Bašić M, De S, Lõhmus A, Varjosalo M, Mäkinen K.

Plant J. 2016 Jan;85(1):30-45. doi: 10.1111/tpj.13088.

42.

Protein composition of 6K2-induced membrane structures formed during Potato virus A infection.

Lõhmus A, Varjosalo M, Mäkinen K.

Mol Plant Pathol. 2016 Aug;17(6):943-58. doi: 10.1111/mpp.12341. Epub 2016 Feb 17.

PMID:
26574906
43.

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients.

Loukovaara S, Nurkkala H, Tamene F, Gucciardo E, Liu X, Repo P, Lehti K, Varjosalo M.

J Proteome Res. 2015 Dec 4;14(12):5131-43. doi: 10.1021/acs.jproteome.5b00900. Epub 2015 Oct 30.

PMID:
26490944
44.

Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.

Haapasalo K, van Kessel K, Nissilä E, Metso J, Johansson T, Miettinen S, Varjosalo M, Kirveskari J, Kuusela P, Chroni A, Jauhiainen M, van Strijp J, Jokiranta TS.

J Biol Chem. 2015 Nov 27;290(48):28977-87. doi: 10.1074/jbc.M115.669226. Epub 2015 Oct 14.

45.

Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.

Kämpjärvi K, Kim NH, Keskitalo S, Clark AD, von Nandelstadh P, Turunen M, Heikkinen T, Park MJ, Mäkinen N, Kivinummi K, Lintula S, Hotakainen K, Nevanlinna H, Hokland P, Böhling T, Bützow R, Böhm J, Mecklin JP, Järvinen H, Kontro M, Visakorpi T, Taipale J, Varjosalo M, Boyer TG, Vahteristo P.

Prostate. 2016 Jan;76(1):22-31. doi: 10.1002/pros.23092. Epub 2015 Sep 18.

PMID:
26383637
46.

Colonic metaproteomic signatures of active bacteria and the host in obesity.

Kolmeder CA, Ritari J, Verdam FJ, Muth T, Keskitalo S, Varjosalo M, Fuentes S, Greve JW, Buurman WA, Reichl U, Rapp E, Martens L, Palva A, Salonen A, Rensen SS, de Vos WM.

Proteomics. 2015 Oct;15(20):3544-52. doi: 10.1002/pmic.201500049. Epub 2015 Sep 11.

PMID:
26255997
47.

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers.

Jiu Y, Lehtimäki J, Tojkander S, Cheng F, Jäälinoja H, Liu X, Varjosalo M, Eriksson JE, Lappalainen P.

Cell Rep. 2015 Jun 16;11(10):1511-8. doi: 10.1016/j.celrep.2015.05.008. Epub 2015 May 28.

48.

Rho-kinase inhibitor Y-27632 increases cellular proliferation and migration in human foreskin fibroblast cells.

Piltti J, Varjosalo M, Qu C, Häyrinen J, Lammi MJ.

Proteomics. 2015 Sep;15(17):2953-65. doi: 10.1002/pmic.201400417. Epub 2015 Jun 15.

PMID:
25951301
49.

Navigating through metaproteomics data: a logbook of database searching.

Muth T, Kolmeder CA, Salojärvi J, Keskitalo S, Varjosalo M, Verdam FJ, Rensen SS, Reichl U, de Vos WM, Rapp E, Martens L.

Proteomics. 2015 Oct;15(20):3439-53. doi: 10.1002/pmic.201400560. Epub 2015 Apr 27.

PMID:
25778831
50.

Expression of the Yersinia enterocolitica O:3 LPS O-antigen and outer core gene clusters is RfaH-dependent.

Leskinen K, Varjosalo M, Li Z, Li CM, Skurnik M.

Microbiology. 2015 Jun;161(6):1282-94. doi: 10.1099/mic.0.000076. Epub 2015 Jun 23.

PMID:
25767108

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