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Items: 41

1.

Host-directed therapies for parasitic diseases.

Singh B, Varikuti S, Halsey G, Volpedo G, Hamza OM, Satoskar AR.

Future Med Chem. 2019 Aug;11(15):1999-2018. doi: 10.4155/fmc-2018-0439. Epub 2019 Aug 8.

PMID:
31390889
2.

Cutting Edge: CXCR3 Escapes X Chromosome Inactivation in T Cells during Infection: Potential Implications for Sex Differences in Immune Responses.

Oghumu S, Varikuti S, Stock JC, Volpedo G, Saljoughian N, Terrazas CA, Satoskar AR.

J Immunol. 2019 Aug 15;203(4):789-794. doi: 10.4049/jimmunol.1800931. Epub 2019 Jun 28.

PMID:
31253729
3.

MicroRNA 155 Contributes to Host Immunity against Leishmania donovani but Is Not Essential for Resolution of Infection.

Varikuti S, Natarajan G, Volpedo G, Singh B, Hamza O, Messick GV, Guerau-de-Arellano M, Papenfuss TL, Oghumu S, Satoskar AR.

Infect Immun. 2019 Jul 23;87(8). pii: e00307-19. doi: 10.1128/IAI.00307-19. Print 2019 Aug.

PMID:
31182615
4.

Mannosylated thiolated paromomycin-loaded PLGA nanoparticles for the oral therapy of visceral leishmaniasis.

Afzal I, Sarwar HS, Sohail MF, Varikuti S, Jahan S, Akhtar S, Yasinzai M, Satoskar AR, Shahnaz G.

Nanomedicine (Lond). 2019 Feb;14(4):387-406. doi: 10.2217/nnm-2018-0038. Epub 2019 Jan 28.

PMID:
30688557
5.

Host-Directed Drug Therapies for Neglected Tropical Diseases Caused by Protozoan Parasites.

Varikuti S, Jha BK, Volpedo G, Ryan NM, Halsey G, Hamza OM, McGwire BS, Satoskar AR.

Front Microbiol. 2018 Nov 30;9:2655. doi: 10.3389/fmicb.2018.02655. eCollection 2018. Review.

6.

The Potent ITK/BTK Inhibitor Ibrutinib Is Effective for the Treatment of Experimental Visceral Leishmaniasis Caused by Leishmania donovani.

Varikuti S, Volpedo G, Saljoughian N, Hamza OM, Halsey G, Ryan NM, Sedmak BE, Seidler GR, Papenfuss TL, Oghumu S, Satoskar AR.

J Infect Dis. 2019 Jan 29;219(4):599-608. doi: 10.1093/infdis/jiy552.

PMID:
30239895
7.

STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.

Varikuti S, Oghumu S, Natarajan G, Kimble J, Sperling RH, Moretti E, Kaplan MH, Satoskar AR.

Int Immunol. 2018 Jul 24;30(8):385. doi: 10.1093/intimm/dxy037. No abstract available.

8.

Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation.

Ahirwar DK, Nasser MW, Ouseph MM, Elbaz M, Cuitiño MC, Kladney RD, Varikuti S, Kaul K, Satoskar AR, Ramaswamy B, Zhang X, Ostrowski MC, Leone G, Ganju RK.

Oncogene. 2018 Aug;37(32):4428-4442. doi: 10.1038/s41388-018-0263-7. Epub 2018 May 3.

PMID:
29720724
9.

Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG- and IgA-producing cells.

Attia Z, Rowe JC, Kim E, Varikuti S, Steiner HE, Zaghawa A, Hassan H, Cormet-Boyaka E, Satoskar AR, Boyaka PN.

Eur J Immunol. 2018 Aug;48(8):1295-1301. doi: 10.1002/eji.201747264. Epub 2018 Jul 5.

10.

IL-27 gene therapy induces depletion of Tregs and enhances the efficacy of cancer immunotherapy.

Zhu J, Liu JQ, Shi M, Cheng X, Ding M, Zhang JC, Davis JP, Varikuti S, Satoskar AR, Lu L, Pan X, Zheng P, Liu Y, Bai XF.

JCI Insight. 2018 Apr 5;3(7). pii: 98745. doi: 10.1172/jci.insight.98745. eCollection 2018 Apr 5.

11.

STAT1 gene deficient mice develop accelerated breast cancer growth and metastasis which is reduced by IL-17 blockade.

Varikuti S, Oghumu S, Elbaz M, Volpedo G, Ahirwar DK, Alarcon PC, Sperling RH, Moretti E, Pioso MS, Kimble J, Nasser MW, Ganju RK, Terrazas C, Satoskar AR.

Oncoimmunology. 2017 Aug 14;6(11):e1361088. doi: 10.1080/2162402X.2017.1361088. eCollection 2017.

12.

Ly6Chi inflammatory monocytes promote susceptibility to Leishmania donovani infection.

Terrazas C, Varikuti S, Oghumu S, Steinkamp HM, Ardic N, Kimble J, Nakhasi H, Satoskar AR.

Sci Rep. 2017 Oct 31;7(1):14693. doi: 10.1038/s41598-017-14935-3.

13.

Pentalinonsterol, a Constituent of Pentalinon andrieuxii, Possesses Potent Immunomodulatory Activity and Primes T Cell Immune Responses.

Oghumu S, Varikuti S, Saljoughian N, Terrazas C, Huntsman AC, Parinandi NL, Fuchs JR, Kinghorn AD, Satoskar AR.

J Nat Prod. 2017 Sep 22;80(9):2515-2523. doi: 10.1021/acs.jnatprod.7b00445. Epub 2017 Sep 6.

14.

Interleukin-27 signalling induces stem cell antigen-1 expression in T lymphocytes in vivo.

Liu Z, Wu L, Zhu J, Zhu X, Zhu J, Liu JQ, Zhang J, Davis JP, Varikuti S, Satoskar AR, Zhou J, Li MS, Bai XF.

Immunology. 2017 Dec;152(4):638-647. doi: 10.1111/imm.12805. Epub 2017 Aug 23.

15.

Topical treatment with nanoliposomal Amphotericin B reduces early lesion growth but fails to induce cure in an experimental model of cutaneous leishmaniasis caused by Leishmania mexicana.

Varikuti S, Oghumu S, Saljoughian N, Pioso MS, Sedmak BE, Khamesipour A, Satoskar AR.

Acta Trop. 2017 Sep;173:102-108. doi: 10.1016/j.actatropica.2017.06.004. Epub 2017 Jun 9.

16.

STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.

Varikuti S, Oghumu S, Natarajan G, Kimble J, Sperling RH, Moretti E, Kaplan MH, Satoskar AR.

Int Immunol. 2016 Nov;28(11):565-570. Epub 2016 Aug 30. Erratum in: Int Immunol. 2018 Jul 24;30(8):385.

17.

A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Gupta G, Peine KJ, Abdelhamid D, Snider H, Shelton AB, Rao L, Kotha SR, Huntsman AC, Varikuti S, Oghumu S, Naman CB, Pan L, Parinandi NL, Papenfuss TL, Kinghorn AD, Bachelder EM, Ainslie KM, Fuchs JR, Satoskar AR.

ACS Infect Dis. 2015 Oct 9;1(10):497-506. doi: 10.1021/acsinfecdis.5b00081. Epub 2015 Sep 21.

18.

Transgenic T cell-specific expression of CXCR3 enhances splenic and hepatic T cell accumulation but does not affect the outcome of visceral leishmaniasis.

Varikuti S, Natarajan G, Oghumu S, Sperling RH, Moretti E, Stock J, Papenfuss TL, Satoskar AR.

Cell Immunol. 2016 Nov;309:61-68. doi: 10.1016/j.cellimm.2016.08.016. Epub 2016 Sep 6.

19.

A Tec kinase BTK inhibitor ibrutinib promotes maturation and activation of dendritic cells.

Natarajan G, Oghumu S, Terrazas C, Varikuti S, Byrd JC, Satoskar AR.

Oncoimmunology. 2016 Mar 10;5(6):e1151592. doi: 10.1080/2162402X.2016.1151592. eCollection 2016 Jun.

20.

Deletion of macrophage migration inhibitory factor inhibits murine oral carcinogenesis: Potential role for chronic pro-inflammatory immune mediators.

Oghumu S, Knobloch TJ, Terrazas C, Varikuti S, Ahn-Jarvis J, Bollinger CE, Iwenofu H, Weghorst CM, Satoskar AR.

Int J Cancer. 2016 Sep 15;139(6):1379-90. doi: 10.1002/ijc.30177. Epub 2016 Jun 16.

21.

Ibrutinib enhances IL-17 response by modulating the function of bone marrow derived dendritic cells.

Natarajan G, Terrazas C, Oghumu S, Varikuti S, Dubovsky JA, Byrd JC, Satoskar AR.

Oncoimmunology. 2015 Jun 9;5(1):e1057385. eCollection 2016.

22.

Antileishmanial and Cytotoxic Activity of Some Highly Oxidized Abietane Diterpenoids from the Bald Cypress, Taxodium distichum.

Naman CB, Gromovsky AD, Vela CM, Fletcher JN, Gupta G, Varikuti S, Zhu X, Zywot EM, Chai H, Werbovetz KA, Satoskar AR, Kinghorn AD.

J Nat Prod. 2016 Mar 25;79(3):598-606. doi: 10.1021/acs.jnatprod.5b01131. Epub 2016 Feb 23.

23.

Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles.

Collier MA, Peine KJ, Gautam S, Oghumu S, Varikuti S, Borteh H, Papenfuss TL, Sataoskar AR, Bachelder EM, Ainslie KM.

Int J Pharm. 2016 Feb 29;499(1-2):186-194. doi: 10.1016/j.ijpharm.2016.01.004. Epub 2016 Jan 5.

24.

IL-17A promotes susceptibility during experimental visceral leishmaniasis caused by Leishmania donovani.

Terrazas C, Varikuti S, Kimble J, Moretti E, Boyaka PN, Satoskar AR.

FASEB J. 2016 Mar;30(3):1135-43. doi: 10.1096/fj.15-277202. Epub 2015 Nov 18.

25.

A Comparison of Demographic and Clinical Characteristics of Syrian and Turkish Patients with Cutaneous Leishmaniasis.

Turan E, Yeşilova Y, Sürücü HA, Ardic N, Doni N, Aksoy M, Yesilova A, Oghumu S, Varikuti S, Satoskar AR.

Am J Trop Med Hyg. 2015 Sep;93(3):559-63. doi: 10.4269/ajtmh.15-0090. Epub 2015 Jun 15.

26.

Uncovering Leishmania-macrophage interplay using imaging flow cytometry.

Terrazas C, Oghumu S, Varikuti S, Martinez-Saucedo D, Beverley SM, Satoskar AR.

J Immunol Methods. 2015 Aug;423:93-8. doi: 10.1016/j.jim.2015.04.022. Epub 2015 May 9.

27.

Immunomodulatory and Antileishmanial Activity of Phenylpropanoid Dimers Isolated from Nectandra leucantha.

da Costa-Silva TA, Grecco SS, de Sousa FS, Lago JH, Martins EG, Terrazas CA, Varikuti S, Owens KL, Beverley SM, Satoskar AR, Tempone AG.

J Nat Prod. 2015 Apr 24;78(4):653-7. doi: 10.1021/np500809a. Epub 2015 Apr 2.

28.

Northalrugosidine is a bisbenzyltetrahydroisoquinoline alkaloid from Thalictrum alpinum with in vivo antileishmanial activity.

Naman CB, Gupta G, Varikuti S, Chai H, Doskotch RW, Satoskar AR, Kinghorn AD.

J Nat Prod. 2015 Mar 27;78(3):552-6. doi: 10.1021/np501028u. Epub 2015 Jan 28.

29.

Signal transducer and activator of transcription 1 (STAT-1) plays a critical role in control of Trypanosoma cruzi infection.

Kulkarni MM, Varikuti S, Terrazas C, Kimble JL, Satoskar AR, McGwire BS.

Immunology. 2015 Jun;145(2):225-31. doi: 10.1111/imm.12438.

30.

CXCR3 expression defines a novel subset of innate CD8+ T cells that enhance immunity against bacterial infection and cancer upon stimulation with IL-15.

Oghumu S, Terrazas CA, Varikuti S, Kimble J, Vadia S, Yu L, Seveau S, Satoskar AR.

FASEB J. 2015 Mar;29(3):1019-28. doi: 10.1096/fj.14-264507. Epub 2014 Dec 2.

31.

Transgenic expression of CXCR3 on T cells enhances susceptibility to cutaneous Leishmania major infection by inhibiting monocyte maturation and promoting a Th2 response.

Oghumu S, Stock JC, Varikuti S, Dong R, Terrazas C, Edwards JA, Rappleye CA, Holovatyk A, Sharpe A, Satoskar AR.

Infect Immun. 2015 Jan;83(1):67-76. doi: 10.1128/IAI.02540-14. Epub 2014 Oct 13.

32.

Deficiency of p110δ isoform of the phosphoinositide 3 kinase leads to enhanced resistance to Leishmania donovani.

Khadem F, Mou Z, Liu D, Varikuti S, Satoskar A, Uzonna JE.

PLoS Negl Trop Dis. 2014 Jun 19;8(6):e2951. doi: 10.1371/journal.pntd.0002951. eCollection 2014 Jun.

33.

Effect of probiotic (VSL#3) and omega-3 on lipid profile, insulin sensitivity, inflammatory markers, and gut colonization in overweight adults: a randomized, controlled trial.

Rajkumar H, Mahmood N, Kumar M, Varikuti SR, Challa HR, Myakala SP.

Mediators Inflamm. 2014;2014:348959. doi: 10.1155/2014/348959. Epub 2014 Mar 26.

34.

CXCR3 deficiency enhances tumor progression by promoting macrophage M2 polarization in a murine breast cancer model.

Oghumu S, Varikuti S, Terrazas C, Kotov D, Nasser MW, Powell CA, Ganju RK, Satoskar AR.

Immunology. 2014 Sep;143(1):109-19. doi: 10.1111/imm.12293.

35.

STAT4 is critical for immunity but not for antileishmanial activity of antimonials in experimental visceral leishmaniasis.

Oghumu S, Gupta G, Snider HM, Varikuti S, Terrazas CA, Papenfuss TL, Kaplan MH, Satoskar AR.

Eur J Immunol. 2014 Feb;44(2):450-9. doi: 10.1002/eji.201343477. Epub 2013 Nov 15.

36.

Gr-1(high) CD11b+ cells suppress B cell differentiation and lupus-like disease in lupus-prone male mice.

Trigunaite A, Khan A, Der E, Song A, Varikuti S, Jørgensen TN.

Arthritis Rheum. 2013 Sep;65(9):2392-402. doi: 10.1002/art.38048.

37.

Multilocus microsatellite signature and identification of specific molecular markers for Leishmania aethiopica.

Kebede N, Oghumu S, Worku A, Hailu A, Varikuti S, Satoskar AR.

Parasit Vectors. 2013 Jun 4;6:160. doi: 10.1186/1756-3305-6-160.

38.

Molecular cloning, characterization and heterologous expression of bile salt hydrolase (Bsh) from Lactobacillus fermentum NCDO394.

Kumar R, Rajkumar H, Kumar M, Varikuti SR, Athimamula R, Shujauddin M, Ramagoni R, Kondapalli N.

Mol Biol Rep. 2013 Aug;40(8):5057-66. doi: 10.1007/s11033-013-2607-2. Epub 2013 May 15.

PMID:
23673477
39.

Leishmania donovani infection induces anemia in hamsters by differentially altering erythropoiesis in bone marrow and spleen.

Lafuse WP, Story R, Mahylis J, Gupta G, Varikuti S, Steinkamp H, Oghumu S, Satoskar AR.

PLoS One. 2013;8(3):e59509. doi: 10.1371/journal.pone.0059509. Epub 2013 Mar 22.

40.

Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse.

Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR.

J Immunol. 2013 Mar 1;190(5):2229-40. doi: 10.4049/jimmunol.1201170. Epub 2013 Jan 21.

41.

Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis.

Cummings HE, Barbi J, Reville P, Oghumu S, Zorko N, Sarkar A, Keiser TL, Lu B, Rückle T, Varikuti S, Lezama-Davila C, Wewers MD, Whitacre C, Radzioch D, Rommel C, Seveau S, Satoskar AR.

Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1251-6. doi: 10.1073/pnas.1110339109. Epub 2012 Jan 9.

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