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Items: 1 to 50 of 204

1.

High olive oil diets enhance cervical tumour growth in mice: transcriptome analysis for potential candidate genes and pathways.

Zhang X, Yang P, Luo X, Su C, Chen Y, Zhao L, Wei L, Zeng H, Varghese Z, Moorhead JF, Ruan XZ, Chen Y.

Lipids Health Dis. 2019 Mar 28;18(1):76. doi: 10.1186/s12944-019-1023-6.

2.

CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway.

Li Y, Yang P, Zhao L, Chen Y, Zhang X, Zeng S, Wei L, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.

J Lipid Res. 2019 Apr;60(4):844-855. doi: 10.1194/jlr.M090969. Epub 2019 Jan 20.

PMID:
30662007
3.

SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE-/- mice.

Li D, Chen A, Lan T, Zou Y, Zhao L, Yang P, Qu H, Wei L, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.

FASEB J. 2019 Mar;33(3):3437-3450. doi: 10.1096/fj.201800975RRR. Epub 2018 Nov 21.

PMID:
30462530
4.

Dietary oleic acid-induced CD36 promotes cervical cancer cell growth and metastasis via up-regulation Src/ERK pathway.

Yang P, Su C, Luo X, Zeng H, Zhao L, Wei L, Zhang X, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.

Cancer Lett. 2018 Dec 1;438:76-85. doi: 10.1016/j.canlet.2018.09.006. Epub 2018 Sep 11.

PMID:
30213558
5.

CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis.

Zhao L, Zhang C, Luo X, Wang P, Zhou W, Zhong S, Xie Y, Jiang Y, Yang P, Tang R, Pan Q, Hall AR, Luong TV, Fan J, Varghese Z, Moorhead JF, Pinzani M, Chen Y, Ruan XZ.

J Hepatol. 2018 Sep;69(3):705-717. doi: 10.1016/j.jhep.2018.04.006. Epub 2018 Apr 27.

PMID:
29705240
6.

CD36 and lipid metabolism in the evolution of atherosclerosis.

Zhao L, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.

Br Med Bull. 2018 Jun 1;126(1):101-112. doi: 10.1093/bmb/ldy006. Review.

PMID:
29534172
7.

CD36 in chronic kidney disease: novel insights and therapeutic opportunities.

Yang X, Okamura DM, Lu X, Chen Y, Moorhead J, Varghese Z, Ruan XZ.

Nat Rev Nephrol. 2017 Dec;13(12):769-781. doi: 10.1038/nrneph.2017.126. Epub 2017 Sep 18. Review.

PMID:
28919632
8.

Association between reductions in low-density lipoprotein cholesterol with statin therapy and the risk of new-onset diabetes: a meta-analysis.

Wang S, Cai R, Yuan Y, Varghese Z, Moorhead J, Ruan XZ.

Sci Rep. 2017 Jan 10;7:39982. doi: 10.1038/srep39982.

9.

Cluster of Differentiation 36 Deficiency Aggravates Macrophage Infiltration and Hepatic Inflammation by Upregulating Monocyte Chemotactic Protein-1 Expression of Hepatocytes Through Histone Deacetylase 2-Dependent Pathway.

Zhong S, Zhao L, Wang Y, Zhang C, Liu J, Wang P, Zhou W, Yang P, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.

Antioxid Redox Signal. 2017 Aug 1;27(4):201-214. doi: 10.1089/ars.2016.6808. Epub 2017 Jan 10.

PMID:
27967209
10.

Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice.

Wu W, Zhao L, Yang P, Zhou W, Li B, Moorhead JF, Varghese Z, Ruan XZ, Chen Y.

PLoS One. 2016 Jul 18;11(7):e0159512. doi: 10.1371/journal.pone.0159512. eCollection 2016.

11.

Paradoxical effect of rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo.

Yang P, Zhao Y, Zhao L, Yuan J, Chen Y, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.

Sci Rep. 2015 Oct 9;5:14959. doi: 10.1038/srep14959.

12.

Chronic inflammation aggravates metabolic disorders of hepatic fatty acids in high-fat diet-induced obese mice.

Zhao L, Zhong S, Qu H, Xie Y, Cao Z, Li Q, Yang P, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.

Sci Rep. 2015 May 14;5:10222. doi: 10.1038/srep10222.

13.

Inflammatory Stress Exacerbated Mesangial Foam Cell Formation and Renal Injury via Disrupting Cellular Cholesterol Homeostasis.

Zhong S, Zhao L, Li Q, Yang P, Varghese Z, Moorhead JF, Chen Y, Ruan XZ.

Inflammation. 2015;38(3):959-71. doi: 10.1007/s10753-014-0058-0.

PMID:
25387652
14.

The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis.

Chen Y, Varghese Z, Ruan XZ.

Genes Dis. 2014 Jul 27;1(1):106-112. doi: 10.1016/j.gendis.2014.07.007. eCollection 2014 Sep. Review.

15.

Inflammatory stress increases hepatic CD36 translational efficiency via activation of the mTOR signalling pathway.

Wang C, Hu L, Zhao L, Yang P, Moorhead JF, Varghese Z, Chen Y, Ruan XZ.

PLoS One. 2014 Jul 21;9(7):e103071. doi: 10.1371/journal.pone.0103071. eCollection 2014.

16.

Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation.

Chen Y, Zhao L, Li Q, Wheeler DC, Varghese Z, Moorhead JF, Powis SH, Ruan XZ.

Nephrol Dial Transplant. 2014 Oct;29(10):1864-78. doi: 10.1093/ndt/gfu203. Epub 2014 Jun 3.

PMID:
24895437
17.

Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis.

Wang C, Yan Y, Hu L, Zhao L, Yang P, Moorhead JF, Varghese Z, Chen Y, Ruan XZ.

Biochem Biophys Res Commun. 2014 Apr 25;447(1):57-63. doi: 10.1016/j.bbrc.2014.03.103. Epub 2014 Mar 28.

PMID:
24685479
18.

Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation.

Chen Y, Ku H, Zhao L, Wheeler DC, Li LC, Li Q, Varghese Z, Moorhead JF, Powis SH, Huang A, Ruan XZ.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):365-76. doi: 10.1161/ATVBAHA.113.301301. Epub 2013 Nov 14.

PMID:
24233489
19.

Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation.

Zhou C, Lei H, Chen Y, Liu Q, Li LC, Moorhead JF, Varghese Z, Ruan XZ.

PLoS One. 2013 Oct 16;8(10):e75650. doi: 10.1371/journal.pone.0075650. eCollection 2013.

20.

Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet.

Wu Y, Wu T, Wu J, Zhao L, Li Q, Varghese Z, Moorhead JF, Powis SH, Chen Y, Ruan XZ.

J Endocrinol. 2013 Oct 28;219(3):195-204. doi: 10.1530/JOE-13-0160. Print 2013 Dec.

PMID:
24029730
21.

Cross-talk between TLR4-MyD88-NF-κB and SCAP-SREBP2 pathways mediates macrophage foam cell formation.

Li LC, Varghese Z, Moorhead JF, Lee CT, Chen JB, Ruan XZ.

Am J Physiol Heart Circ Physiol. 2013 Mar 15;304(6):H874-84. doi: 10.1152/ajpheart.00096.2012. Epub 2013 Jan 18.

22.

Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export.

Chen Y, Chen Y, Zhao L, Chen Y, Mei M, Li Q, Huang A, Varghese Z, Moorhead JF, Ruan XZ.

J Gastroenterol Hepatol. 2012 May;27(5):974-84. doi: 10.1111/j.1440-1746.2011.06986.x.

PMID:
22098164
23.

Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice.

Xu ZE, Chen Y, Huang A, Varghese Z, Moorhead JF, Yan F, Powis SH, Li Q, Ruan XZ.

Am J Physiol Renal Physiol. 2011 Oct;301(4):F713-22. doi: 10.1152/ajprenal.00341.2010. Epub 2011 Jul 27.

24.

Inflammatory stress exacerbates ectopic lipid deposition in C57BL/6J mice.

Mei M, Zhao L, Li Q, Chen Y, Huang A, Varghese Z, Moorhead JF, Zhang S, Powis SH, Li Q, Ruan XZ.

Lipids Health Dis. 2011 Jun 30;10:110. doi: 10.1186/1476-511X-10-110.

25.

Murine gamma herpes virus 68 infection promotes fatty liver formation and hepatic insulin resistance in C57BL/6J mice.

Zhao L, Chen YX, Varghese Z, Huang AL, Tang RK, Jia B, Moorhead JF, Gong JP, Ruan XZ.

Hepatol Int. 2012 Apr;6(2):520-30. doi: 10.1007/s12072-011-9283-x. Epub 2011 Jun 24.

PMID:
21701901
26.

Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro.

Yuan Y, Zhao L, Chen Y, Moorhead JF, Varghese Z, Powis SH, Minogue S, Sun Z, Ruan XZ.

Am J Physiol Renal Physiol. 2011 Jul;301(1):F236-43. doi: 10.1152/ajprenal.00646.2010. Epub 2011 Apr 20.

27.

Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis.

Zhao L, Chen Y, Tang R, Chen Y, Li Q, Gong J, Huang A, Varghese Z, Moorhead JF, Ruan XZ.

J Gastroenterol Hepatol. 2011 May;26(5):875-83. doi: 10.1111/j.1440-1746.2010.06560.x.

PMID:
21488946
28.

Sirolimus inhibits endogenous cholesterol synthesis induced by inflammatory stress in human vascular smooth muscle cells.

Ma KL, Varghese Z, Ku Y, Powis SH, Chen Y, Moorhead JF, Ruan XZ.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1646-51. doi: 10.1152/ajpheart.00492.2009. Epub 2010 Mar 26.

29.

An update on the lipid nephrotoxicity hypothesis.

Ruan XZ, Varghese Z, Moorhead JF.

Nat Rev Nephrol. 2009 Dec;5(12):713-21. doi: 10.1038/nrneph.2009.184. Epub 2009 Oct 27. Review.

PMID:
19859071
30.

Endoplasmic reticulum stress is involved in acetylated low-density lipoprotein induced apoptosis in THP-1 differentiated macrophages.

Tao JL, Ruan XZ, Li H, Li XM, Moorhead JF, Varghese Z, Li XW.

Chin Med J (Engl). 2009 Aug 5;122(15):1794-9.

PMID:
19781328
31.

Inflammatory stress increases unmodified LDL uptake via LDL receptor: an alternative pathway for macrophage foam-cell formation.

Ye Q, Chen Y, Lei H, Liu Q, Moorhead JF, Varghese Z, Ruan XZ.

Inflamm Res. 2009 Nov;58(11):809-18. doi: 10.1007/s00011-009-0052-4. Epub 2009 Jun 17.

PMID:
19533020
32.

Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice.

Ma KL, Ruan XZ, Powis SH, Chen Y, Moorhead JF, Varghese Z.

Hepatology. 2008 Sep;48(3):770-81. doi: 10.1002/hep.22423.

PMID:
18752326
33.

Lipid redistribution in renal dysfunction.

Ruan XZ, Moorhead JF, Varghese Z.

Kidney Int. 2008 Aug;74(4):407-9. doi: 10.1038/ki.2008.226.

34.

Mesangial matrix-activated monocytes express functional scavenger receptors and accumulate intracellular lipid.

Rahman EU, Ruan XZ, Chana RS, Brunskill NJ, Gaya J, Powis SH, Varghese Z, Moorhead JF, Wheeler DC.

Nephrol Dial Transplant. 2008 Jun;23(6):1876-85. doi: 10.1093/ndt/gfm901. Epub 2008 Feb 14.

PMID:
18281317
35.

Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines.

Chen YX, Ruan XZ, Huang AL, Li Q, Moorhead JF, Varghese Z.

Chin Med J (Engl). 2007 Dec 20;120(24):2185-90.

PMID:
18167199
36.

Sirolimus modifies cholesterol homeostasis in hepatic cells: a potential molecular mechanism for sirolimus-associated dyslipidemia.

Ma KL, Ruan XZ, Powis SH, Chen Y, Moorhead JF, Varghese Z.

Transplantation. 2007 Oct 27;84(8):1029-36.

PMID:
17989609
37.

Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: a comparative study in human hepatic cells and mesangial cells.

Chen Y, Ruan XZ, Li Q, Huang A, Moorhead JF, Powis SH, Varghese Z.

Am J Physiol Renal Physiol. 2007 Sep;293(3):F680-7. Epub 2007 Jul 18.

38.

Anti-atherosclerotic effects of sirolimus on human vascular smooth muscle cells.

Ma KL, Ruan XZ, Powis SH, Moorhead JF, Varghese Z.

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2721-8. Epub 2007 Feb 23.

39.

Platelet-activating factor (PAF) increase intracellular lipid accumulation by increasing both LDL and scavenger receptors in human mesangial cells.

Fragopoulou E, Iatrou C, Antonopoulou S, Ruan XZ, Fernando RL, Powis SH, Moorhead JF, Varghese Z.

J Lab Clin Med. 2006 Jun;147(6):281-9.

PMID:
16750665
40.

The PPARalpha ligand fenofibrate: meeting multiple targets in diabetic nephropathy.

Varghese Z, Moorhead JF, Ruan XZ.

Kidney Int. 2006 May;69(9):1490-1.

41.

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines.

Ruan XZ, Moorhead JF, Tao JL, Ma KL, Wheeler DC, Powis SH, Varghese Z.

Arterioscler Thromb Vasc Biol. 2006 May;26(5):1150-5. Epub 2006 Mar 16.

PMID:
16543490
42.

Nuclear receptors and their coregulators in kidney.

Ruan XZ, Varghese Z, Powis SH, Moorhead JF.

Kidney Int. 2005 Dec;68(6):2444-61. Review.

43.

Effects of sirolimus on mesangial cell cholesterol homeostasis: a novel mechanism for its action against lipid-mediated injury in renal allografts.

Varghese Z, Fernando R, Moorhead JF, Powis SH, Ruan XZ.

Am J Physiol Renal Physiol. 2005 Jul;289(1):F43-8. Epub 2005 Mar 15.

44.

EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism.

Li H, Ruan XZ, Powis SH, Fernando R, Mon WY, Wheeler DC, Moorhead JF, Varghese Z.

Kidney Int. 2005 Mar;67(3):867-74.

45.

Acute transplant rejection induced by blood transfusion reaction to the Kidd blood group system.

Holt S, Donaldson H, Hazlehurst G, Varghese Z, Contreras M, Kingdon E, Sweny P, Burns A.

Nephrol Dial Transplant. 2004 Sep;19(9):2403-6.

PMID:
15299103
46.

Renovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10.

George S, Ruan XZ, Navarrete C, Turner D, Reynard M, Sweny P, Hamilton G, Wheeler DC, Powis SH, Moorhead JF, Varghese Z.

Tissue Antigens. 2004 May;63(5):470-5.

PMID:
15104679
47.

Intraperitoneal nitric oxide production in patients treated by continuous ambulatory peritonal dialysis.

Davenport A, Fernando RL, Varghese Z.

Blood Purif. 2004;22(2):216-23.

PMID:
15044821
48.

Nitric oxide production by human peritoneal mesothelial cells.

Davenport A, Fernando RL, Robson R, Varghese Z.

Int J Artif Organs. 2004 Jan;27(1):15-23.

PMID:
14984179
49.

Regulation of lipoprotein trafficking in the kidney: role of inflammatory mediators and transcription factors.

Ruan XZ, Moorhead JF, Fernando R, Wheeler DC, Powis SH, Varghese Z.

Biochem Soc Trans. 2004 Feb;32(Pt 1):88-91.

PMID:
14748720
50.

PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway.

Ruan XZ, Moorhead JF, Fernando R, Wheeler DC, Powis SH, Varghese Z.

J Am Soc Nephrol. 2003 Mar;14(3):593-600.

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