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Items: 50

1.

Discovery of processive catalysis by an exo-hydrolase with a pocket-shaped active site.

Streltsov VA, Luang S, Peisley A, Varghese JN, Ketudat Cairns JR, Fort S, Hijnen M, Tvaroška I, Ardá A, Jiménez-Barbero J, Alfonso-Prieto M, Rovira C, Mendoza F, Tiessler-Sala L, Sánchez-Aparicio JE, Rodríguez-Guerra J, Lluch JM, Maréchal JD, Masgrau L, Hrmova M.

Nat Commun. 2019 May 20;10(1):2222. doi: 10.1038/s41467-019-09691-z.

2.

Naturally occurring polyphenolic inhibitors of amyloid beta aggregation.

Churches QI, Caine J, Cavanagh K, Epa VC, Waddington L, Tranberg CE, Meyer AG, Varghese JN, Streltsov V, Duggan PJ.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3108-12. doi: 10.1016/j.bmcl.2014.05.008. Epub 2014 May 13.

PMID:
24878198
3.

Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide.

Nisbet RM, Nuttall SD, Robert R, Caine JM, Dolezal O, Hattarki M, Pearce LA, Davydova N, Masters CL, Varghese JN, Streltsov VA.

Proteins. 2013 Oct;81(10):1748-58. doi: 10.1002/prot.24312. Epub 2013 Jul 22.

PMID:
23609990
4.

High-throughput production and structural characterization of libraries of self-assembly lipidic cubic phase materials.

Darmanin C, Conn CE, Newman J, Mulet X, Seabrook SA, Liang YL, Hawley A, Kirby N, Varghese JN, Drummond CJ.

ACS Comb Sci. 2012 Apr 9;14(4):247-52. doi: 10.1021/co2001718. Epub 2012 Mar 23.

PMID:
22428998
5.

Crystal structure of the amyloid-β p3 fragment provides a model for oligomer formation in Alzheimer's disease.

Streltsov VA, Varghese JN, Masters CL, Nuttall SD.

J Neurosci. 2011 Jan 26;31(4):1419-26. doi: 10.1523/JNEUROSCI.4259-10.2011.

6.

A new approach for structure analysis of two-dimensional membrane protein crystals using X-ray powder diffraction data.

Dilanian RA, Darmanin C, Varghese JN, Wilkins SW, Oka T, Yagi N, Quiney HM, Nugent KA.

Protein Sci. 2011 Feb;20(2):457-64. doi: 10.1002/pro.572. Epub 2011 Jan 18.

7.

Alzheimer's amyloid-beta rescues yeast from hydroxide toxicity.

Dubey AK, Bharadwaj PR, Varghese JN, Macreadie IG.

J Alzheimers Dis. 2009;18(1):31-3. doi: 10.3233/JAD-2009-1121.

PMID:
19542608
8.

Cardiovascular biology of interleukin-6.

Abeywardena MY, Leifert WR, Warnes KE, Varghese JN, Head RJ.

Curr Pharm Des. 2009;15(15):1809-21. Review.

PMID:
19442192
9.

The structure of the amyloid-beta peptide high-affinity copper II binding site in Alzheimer disease.

Streltsov VA, Titmuss SJ, Epa VC, Barnham KJ, Masters CL, Varghese JN.

Biophys J. 2008 Oct;95(7):3447-56. doi: 10.1529/biophysj.108.134429. Epub 2008 Jul 3.

10.

Substrate mediated reduction of copper-amyloid-beta complex in Alzheimer's disease.

Streltsov VA, Varghese JN.

Chem Commun (Camb). 2008 Jul 21;(27):3169-71. doi: 10.1039/b803911a. Epub 2008 May 14.

PMID:
18594731
11.

Structural rationale for low-nanomolar binding of transition state mimics to a family GH3 beta-D-glucan glucohydrolase from barley.

Hrmova M, Streltsov VA, Smith BJ, Vasella A, Varghese JN, Fincher GB.

Biochemistry. 2005 Dec 20;44(50):16529-39.

PMID:
16342944
12.

Oxidation of low-density lipoproteins induces amyloid-like structures that are recognized by macrophages.

Stewart CR, Tseng AA, Mok YF, Staples MK, Schiesser CH, Lawrence LJ, Varghese JN, Moore KJ, Howlett GJ.

Biochemistry. 2005 Jun 28;44(25):9108-16.

PMID:
15966734
13.

Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor.

Streltsov VA, Varghese JN, Carmichael JA, Irving RA, Hudson PJ, Nuttall SD.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12444-9. Epub 2004 Aug 10.

14.

Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III.

Lawrence MC, Borg NA, Streltsov VA, Pilling PA, Epa VC, Varghese JN, McKimm-Breschkin JL, Colman PM.

J Mol Biol. 2004 Jan 30;335(5):1343-57.

PMID:
14729348
15.

Three-dimensional structure of the barley beta-D-glucan glucohydrolase in complex with a transition state mimic.

Hrmova M, De Gori R, Smith BJ, Vasella A, Varghese JN, Fincher GB.

J Biol Chem. 2004 Feb 6;279(6):4970-80. Epub 2003 Nov 3.

16.

Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain.

Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15959-64. Epub 2002 Dec 2.

17.

Structural basis for broad substrate specificity in higher plant beta-D-glucan glucohydrolases.

Hrmova M, De Gori R, Smith BJ, Fairweather JK, Driguez H, Varghese JN, Fincher GB.

Plant Cell. 2002 May;14(5):1033-52.

18.

Structural studies of the resistance of influenza virus neuramindase to inhibitors.

Smith BJ, McKimm-Breshkin JL, McDonald M, Fernley RT, Varghese JN, Colman PM.

J Med Chem. 2002 May 23;45(11):2207-12.

PMID:
12014958
19.

Catalytic mechanisms and reaction intermediates along the hydrolytic pathway of a plant beta-D-glucan glucohydrolase.

Hrmova M, Varghese JN, De Gori R, Smith BJ, Driguez H, Fincher GB.

Structure. 2001 Nov;9(11):1005-16.

20.

Mutant barley (1-->3,1-->4)-beta-glucan endohydrolases with enhanced thermostability.

Stewart RJ, Varghese JN, Garrett TP, Høj PB, Fincher GB.

Protein Eng. 2001 Apr;14(4):245-53.

PMID:
11391016
21.

Analysis of inhibitor binding in influenza virus neuraminidase.

Smith BJ, Colman PM, Von Itzstein M, Danylec B, Varghese JN.

Protein Sci. 2001 Apr;10(4):689-96.

22.

Comparative modeling of the three-dimensional structures of family 3 glycoside hydrolases.

Harvey AJ, Hrmova M, De Gori R, Varghese JN, Fincher GB.

Proteins. 2000 Nov 1;41(2):257-69.

PMID:
10966578
23.

Three-dimensional structure of a barley beta-D-glucan exohydrolase, a family 3 glycosyl hydrolase.

Varghese JN, Hrmova M, Fincher GB.

Structure. 1999 Feb 15;7(2):179-90.

24.

Crystallization and preliminary X-ray analysis of beta-glucan exohydrolase isoenzyme ExoI from barley (Hordeum vulgare).

Hrmova M, Varghese JN, Høj PB, Fincher GB.

Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):687-9.

PMID:
9761876
25.

Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase.

Sahasrabudhe A, Lawrence L, Epa VC, Varghese JN, Colman PM, McKimm-Breschkin JL.

Virology. 1998 Jul 20;247(1):14-21.

26.

Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.

Varghese JN, Smith PW, Sollis SL, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL, Colman PM.

Structure. 1998 Jun 15;6(6):735-46.

27.

Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors.

McKimm-Breschkin JL, Sahasrabudhe A, Blick TJ, McDonald M, Colman PM, Hart GJ, Bethell RC, Varghese JN.

J Virol. 1998 Mar;72(3):2456-62.

28.

Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases.

Varghese JN, Colman PM, van Donkelaar A, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL.

Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11808-12.

29.

Polysaccharide hydrolases in germinated barley and their role in the depolymerization of plant and fungal cell walls.

Hrmova M, Banik M, Harvey AJ, Garrett TP, Varghese JN, Høj PB, Fincher GB.

Int J Biol Macromol. 1997 Aug;21(1-2):67-72. Review.

PMID:
9283018
30.

Protein Crystal Diffraction Patterns Using a Capillary-Focused Synchrotron X-ray Beam.

Balaic DX, Barnea Z, Nugent KA, Garrett RF, Varghese JN, Wilkins SW.

J Synchrotron Radiat. 1996 Nov 1;3(Pt 6):289-95.

PMID:
16702694
31.

Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en.

Blick TJ, Tiong T, Sahasrabudhe A, Varghese JN, Colman PM, Hart GJ, Bethell RC, McKimm-Breschkin JL.

Virology. 1995 Dec 20;214(2):475-84.

32.
33.

Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities.

Varghese JN, Garrett TP, Colman PM, Chen L, Høj PB, Fincher GB.

Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2785-9.

34.

Crystallization and preliminary X-ray analysis of (1,3)- and (1,3;1,4)-beta-D-glucanases from germinating barley.

Chen L, Garrett TJ, Varghese JN, Fincher GB, Høj PB.

J Mol Biol. 1993 Dec 5;234(3):888-9.

PMID:
8254681
35.

The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.

Varghese JN, McKimm-Breschkin JL, Caldwell JB, Kortt AA, Colman PM.

Proteins. 1992 Nov;14(3):327-32.

PMID:
1438172
36.

Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.

Tulip WR, Varghese JN, Webster RG, Laver WG, Colman PM.

J Mol Biol. 1992 Sep 5;227(1):149-59.

PMID:
1522584
37.

Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.

Tulip WR, Varghese JN, Laver WG, Webster RG, Colman PM.

J Mol Biol. 1992 Sep 5;227(1):122-48.

PMID:
1381757
38.

Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.

Tulip WR, Varghese JN, Baker AT, van Donkelaar A, Laver WG, Webster RG, Colman PM.

J Mol Biol. 1991 Sep 20;221(2):487-97.

PMID:
1920429
39.
40.

The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution.

Lawrence MC, Suzuki E, Varghese JN, Davis PC, Van Donkelaar A, Tulloch PA, Colman PM.

EMBO J. 1990 Jan;9(1):9-15.

41.

Three-dimensional structures of influenza virus neuraminidase-antibody complexes.

Colman PM, Tulip WR, Varghese JN, Tulloch PA, Baker AT, Laver WG, Air GM, Webster RG.

Philos Trans R Soc Lond B Biol Sci. 1989 Jun 12;323(1217):511-8.

PMID:
2569208
42.

Crystal structures of neuraminidase-antibody complexes.

Tulip WR, Varghese JN, Webster RG, Air GM, Laver WG, Colman PM.

Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:257-63. No abstract available.

PMID:
2484162
43.

Structure of an escape mutant of glycoprotein N2 neuraminidase of influenza virus A/Tokyo/3/67 at 3 A.

Varghese JN, Webster RG, Laver WG, Colman PM.

J Mol Biol. 1988 Mar 5;200(1):201-3.

PMID:
3379640
44.

Antigenic structure and variation in an influenza virus N9 neuraminidase.

Webster RG, Air GM, Metzger DW, Colman PM, Varghese JN, Baker AT, Laver WG.

J Virol. 1987 Sep;61(9):2910-6.

45.

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase.

Colman PM, Laver WG, Varghese JN, Baker AT, Tulloch PA, Air GM, Webster RG.

Nature. 1987 Mar 26-Apr 1;326(6111):358-63.

PMID:
2436051
46.

How antibodies recognize virus proteins.

Colman PM, Air GM, Webster RG, Varghese JN, Baker AT, Lentz MR, Tulloch PA, Laver WG.

Immunol Today. 1987;8(11):323-6. doi: 10.1016/0167-5699(87)90004-1.

PMID:
25291054
47.

Three-dimensional structure of neuraminidase of subtype N9 from an avian influenza virus.

Baker AT, Varghese JN, Laver WG, Air GM, Colman PM.

Proteins. 1987;2(2):111-7.

PMID:
3447170
48.

Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution.

Varghese JN, Laver WG, Colman PM.

Nature. 1983 May 5-11;303(5912):35-40.

PMID:
6843658
49.

Structure of the catalytic and antigenic sites in influenza virus neuraminidase.

Colman PM, Varghese JN, Laver WG.

Nature. 1983 May 5-11;303(5912):41-4.

PMID:
6188957
50.

Crystallization of phaseolin from Phaseolus vulgaris.

Suzuki E, Van Donkelaar A, Varghese JN, Lilley GG, Blagrove RJ, Colman PM.

J Biol Chem. 1983 Feb 25;258(4):2634-6.

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