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J Cell Biol. 2018 Jan 2;217(1):11-13. doi: 10.1083/jcb.201712033. Epub 2017 Dec 19.

When E-cadherin is away, centrosomes can play.

Author information

1
Institut Curie, Paris Sciences et Lettres Research University, CNRS UMR144, Paris, France.
2
Institut Curie, Paris Sciences et Lettres Research University, CNRS UMR144, Paris, France renata.basto@curie.fr.

Abstract

Centrosome clustering is a process frequently used by cancer cells with extra centrosomes to avoid multipolar divisions. How cell-intrinsic properties influence clustering is not entirely known. In this issue, Rhys et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201704102) report an unexpected link between clustering capacity and cortical contractility through E-cadherin and DDR1 proteins.

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