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Items: 43


MAIT cells promote tumor initiation, growth and metastases via tumor MR1.

Yan J, Allen S, McDonald E, Das I, Mak JYW, Liu L, Fairlie DP, Meehan BS, Chen Z, Corbett AJ, Varelias A, Smyth MJ, Teng MWL.

Cancer Discov. 2019 Dec 11. pii: CD-19-0569. doi: 10.1158/2159-8290.CD-19-0569. [Epub ahead of print]


Pegylated interferon-2α invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation.

Henden AS, Varelias A, Leach J, Sturgeon E, Avery J, Kelly J, Olver S, Samson L, Hartel G, Durrant S, Butler J, Morton AJ, Misra A, Tey SK, Subramoniapillai E, Curley C, Kennedy G, Hill GR.

Blood Adv. 2019 Oct 22;3(20):3013-3019. doi: 10.1182/bloodadvances.2019000453.


Pilot study investigating the effect of enteral and parenteral nutrition on the gastrointestinal microbiome post-allogeneic transplantation.

Andersen S, Staudacher H, Weber N, Kennedy G, Varelias A, Banks M, Bauer J.

Br J Haematol. 2019 Oct 14. doi: 10.1111/bjh.16218. [Epub ahead of print]


IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling.

Wilkinson AN, Chang K, Kuns RD, Henden AS, Minnie SA, Ensbey KS, Clouston AD, Zhang P, Koyama M, Hidalgo J, Rose-John S, Varelias A, Vuckovic S, Gartlan KH, Hill GR.

Blood. 2019 Dec 5;134(23):2092-2106. doi: 10.1182/blood.2019000396.


MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.

Koyama M, Mukhopadhyay P, Schuster IS, Henden AS, Hülsdünker J, Varelias A, Vetizou M, Kuns RD, Robb RJ, Zhang P, Blazar BR, Thomas R, Begun J, Waddell N, Trinchieri G, Zeiser R, Clouston AD, Degli-Esposti MA, Hill GR.

Immunity. 2019 Nov 19;51(5):885-898.e7. doi: 10.1016/j.immuni.2019.08.011. Epub 2019 Sep 18.


PAG1 limits allergen-induced type 2 inflammation in the murine lung.

Ullah MA, Vicente CT, Collinson N, Curren B, Sikder MAA, Sebina I, Simpson J, Varelias A, Lindquist JA, Ferreira MAR, Phipps S.

Allergy. 2019 Jul 18. doi: 10.1111/all.13991. [Epub ahead of print]


Expansion of IL-17A-secreting CD8+ mucosa-associated invariant T cells in peripheral blood following stem cell mobilization.

Varelias A, Gartlan KH, Wilkinson AN, Olver SD, Samson LD, Tey SK, MacDonald KPA, Hill GR.

Blood Adv. 2019 Mar 12;3(5):718-723. doi: 10.1182/bloodadvances.2018025601. No abstract available.


Phase I Trial of Inducible Caspase 9 T Cells in Adult Stem Cell Transplant Demonstrates Massive Clonotypic Proliferative Potential and Long-term Persistence of Transgenic T Cells.

Zhang P, Raju J, Ullah MA, Au R, Varelias A, Gartlan KH, Olver SD, Samson LD, Sturgeon E, Zomerdijk N, Avery J, Gargett T, Brown MP, Coin LJ, Ganesamoorthy D, Hutchins C, Pratt GR, Kennedy GA, Morton AJ, Curley CI, Hill GR, Tey SK.

Clin Cancer Res. 2019 Mar 15;25(6):1749-1755. doi: 10.1158/1078-0432.CCR-18-3069. Epub 2019 Feb 14.


Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation.

Martins JP, Andoniou CE, Fleming P, Kuns RD, Schuster IS, Voigt V, Daly S, Varelias A, Tey SK, Degli-Esposti MA, Hill GR.

Science. 2019 Jan 18;363(6424):288-293. doi: 10.1126/science.aat0066.


Bone marrow transplantation generates T cell-dependent control of myeloma in mice.

Vuckovic S, Minnie SA, Smith D, Gartlan KH, Watkins TS, Markey KA, Mukhopadhyay P, Guillerey C, Kuns RD, Locke KR, Pritchard AL, Johansson PA, Varelias A, Zhang P, Huntington ND, Waddell N, Chesi M, Miles JJ, Smyth MJ, Hill GR.

J Clin Invest. 2019 Jan 2;129(1):106-121. doi: 10.1172/JCI98888. Epub 2018 Nov 19.


Recipient mucosal-associated invariant T cells control GVHD within the colon.

Varelias A, Bunting MD, Ormerod KL, Koyama M, Olver SD, Straube J, Kuns RD, Robb RJ, Henden AS, Cooper L, Lachner N, Gartlan KH, Lantz O, Kjer-Nielsen L, Mak JY, Fairlie DP, Clouston AD, McCluskey J, Rossjohn J, Lane SW, Hugenholtz P, Hill GR.

J Clin Invest. 2018 May 1;128(5):1919-1936. doi: 10.1172/JCI91646. Epub 2018 Apr 9.


Early Blood Stream Infections after BMT are Associated with Cytokine Dysregulation and Poor Overall Survival.

Catchpoole EM, Thirunavukarasu CE, Varelias A, Schlebusch S, Olver S, Zomerdijk N, Osland E, Kennedy GA, Tey SK, Hill GR, Markey KA.

Biol Blood Marrow Transplant. 2018 Jul;24(7):1360-1366. doi: 10.1016/j.bbmt.2018.02.025. Epub 2018 Mar 5.


Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT.

Gartlan KH, Varelias A, Koyama M, Robb RJ, Markey KA, Chang K, Wilkinson AN, Smith D, Ullah MA, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Teal BE, Cheong M, Teng MWL, Smyth MJ, Tey SK, MacDonald KPA, Hill GR.

Blood Adv. 2017 Jan 26;1(6):341-351. doi: 10.1182/bloodadvances.2016002980. eCollection 2017 Feb 14.


A critical role for donor-derived IL-22 in cutaneous chronic GVHD.

Gartlan KH, Bommiasamy H, Paz K, Wilkinson AN, Owen M, Reichenbach DK, Banovic T, Wehner K, Buchanan F, Varelias A, Kuns RD, Chang K, Fedoriw Y, Shea T, Coghill J, Zaiken M, Plank MW, Foster PS, Clouston AD, Blazar BR, Serody JS, Hill GR.

Am J Transplant. 2018 Apr;18(4):810-820. doi: 10.1111/ajt.14513. Epub 2017 Oct 24.


Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.

Zhang P, Lee JS, Gartlan KH, Schuster IS, Comerford I, Varelias A, Ullah MA, Vuckovic S, Koyama M, Kuns RD, Locke KR, Beckett KJ, Olver SD, Samson LD, Montes de Oca M, de Labastida Rivera F, Clouston AD, Belz GT, Blazar BR, MacDonald KP, McColl SR, Thomas R, Engwerda CR, Degli-Esposti MA, Kallies A, Tey SK, Hill GR.

Sci Immunol. 2017 Apr 7;2(10). pii: eaah7152. doi: 10.1126/sciimmunol.aah7152.


Acute graft-versus-host disease is regulated by an IL-17-sensitive microbiome.

Varelias A, Ormerod KL, Bunting MD, Koyama M, Gartlan KH, Kuns RD, Lachner N, Locke KR, Lim CY, Henden AS, Zhang P, Clouston AD, Hasnain SZ, McGuckin MA, Blazar BR, MacDonald KP, Hugenholtz P, Hill GR.

Blood. 2017 Apr 13;129(15):2172-2185. doi: 10.1182/blood-2016-08-732628. Epub 2017 Jan 30.


GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity.

Bunting MD, Varelias A, Souza-Fonseca-Guimaraes F, Schuster IS, Lineburg KE, Kuns RD, Fleming P, Locke KR, Huntington ND, Blazar BR, Lane SW, Tey SK, MacDonald KP, Smyth MJ, Degli-Esposti MA, Hill GR.

Blood. 2017 Feb 2;129(5):630-642. doi: 10.1182/blood-2016-08-734020. Epub 2016 Dec 7.


Pharmacokinetics and immunological outcomes of alemtuzumab-based treatment for steroid-refractory acute GvHD.

Tey SK, Vuckovic S, Varelias A, Martins JP, Olver S, Samson L, Sturgeon E, Leach J, Avery J, Nakagaki M, Butler JP, Curley C, Morton AJ, Durrant ST, Kennedy GA, Hill GR.

Bone Marrow Transplant. 2016 Aug;51(8):1153-5. doi: 10.1038/bmt.2016.83. Epub 2016 Apr 4. No abstract available.


IL-17A-Producing γδ T Cells Suppress Early Control of Parasite Growth by Monocytes in the Liver.

Sheel M, Beattie L, Frame TC, de Labastida Rivera F, Faleiro RJ, Bunn PT, Montes de Oca M, Edwards CL, Ng SS, Kumar R, Amante FH, Best SE, McColl SR, Varelias A, Kuns RD, MacDonald KP, Smyth MJ, Haque A, Hill GR, Engwerda CR.

J Immunol. 2015 Dec 15;195(12):5707-17. doi: 10.4049/jimmunol.1501046. Epub 2015 Nov 4.


Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects.

Gartlan KH, Markey KA, Varelias A, Bunting MD, Koyama M, Kuns RD, Raffelt NC, Olver SD, Lineburg KE, Cheong M, Teal BE, Lor M, Comerford I, Teng MW, Smyth MJ, McCluskey J, Rossjohn J, Stockinger B, Boyle GM, Lane SW, Clouston AD, McColl SR, MacDonald KP, Hill GR.

Blood. 2015 Sep 24;126(13):1609-20. doi: 10.1182/blood-2015-01-622662. Epub 2015 Jul 23.


Donor colonic CD103+ dendritic cells determine the severity of acute graft-versus-host disease.

Koyama M, Cheong M, Markey KA, Gartlan KH, Kuns RD, Locke KR, Lineburg KE, Teal BE, Leveque-El Mouttie L, Bunting MD, Vuckovic S, Zhang P, Teng MW, Varelias A, Tey SK, Wockner LF, Engwerda CR, Smyth MJ, Belz GT, McColl SR, MacDonald KP, Hill GR.

J Exp Med. 2015 Jul 27;212(8):1303-21. doi: 10.1084/jem.20150329. Epub 2015 Jul 13.


Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation.

Ullah MA, Revez JA, Loh Z, Simpson J, Zhang V, Bain L, Varelias A, Rose-John S, Blumenthal A, Smyth MJ, Hill GR, Sukkar MB, Ferreira MA, Phipps S.

J Allergy Clin Immunol. 2015 Oct;136(4):1065-73. doi: 10.1016/j.jaci.2015.02.032. Epub 2015 Apr 28.


Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation.

Varelias A, Gartlan KH, Kreijveld E, Olver SD, Lor M, Kuns RD, Lineburg KE, Teal BE, Raffelt NC, Cheong M, Alexander KA, Koyama M, Markey KA, Sturgeon E, Leach J, Reddy P, Kennedy GA, Yanik GA, Blazar BR, Tey SK, Clouston AD, MacDonald KP, Cooke KR, Hill GR.

Blood. 2015 Apr 9;125(15):2435-44. doi: 10.1182/blood-2014-07-590232. Epub 2015 Feb 11.


Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial.

Kennedy GA, Varelias A, Vuckovic S, Le Texier L, Gartlan KH, Zhang P, Thomas G, Anderson L, Boyle G, Cloonan N, Leach J, Sturgeon E, Avery J, Olver SD, Lor M, Misra AK, Hutchins C, Morton AJ, Durrant ST, Subramoniapillai E, Butler JP, Curley CI, MacDonald KPA, Tey SK, Hill GR.

Lancet Oncol. 2014 Dec;15(13):1451-1459. doi: 10.1016/S1470-2045(14)71017-4. Epub 2014 Nov 14.


CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease.

Alexander KA, Flynn R, Lineburg KE, Kuns RD, Teal BE, Olver SD, Lor M, Raffelt NC, Koyama M, Leveque L, Le Texier L, Melino M, Markey KA, Varelias A, Engwerda C, Serody JS, Janela B, Ginhoux F, Clouston AD, Blazar BR, Hill GR, MacDonald KP.

J Clin Invest. 2014 Oct;124(10):4266-80. doi: 10.1172/JCI75935. Epub 2014 Aug 26.


Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity.

Haque A, Best SE, Montes de Oca M, James KR, Ammerdorffer A, Edwards CL, de Labastida Rivera F, Amante FH, Bunn PT, Sheel M, Sebina I, Koyama M, Varelias A, Hertzog PJ, Kalinke U, Gun SY, Rénia L, Ruedl C, MacDonald KP, Hill GR, Engwerda CR.

J Clin Invest. 2014 Jun;124(6):2483-96. doi: 10.1172/JCI70698. Epub 2014 May 1.


Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo.

Zhang P, Tey SK, Koyama M, Kuns RD, Olver SD, Lineburg KE, Lor M, Teal BE, Raffelt NC, Raju J, Leveque L, Markey KA, Varelias A, Clouston AD, Lane SW, MacDonald KP, Hill GR.

J Immunol. 2013 Nov 15;191(10):5291-303. doi: 10.4049/jimmunol.1301181. Epub 2013 Oct 11.


Promoting regulation via the inhibition of DNAM-1 after transplantation.

Koyama M, Kuns RD, Olver SD, Lineburg KE, Lor M, Teal BE, Raffelt NC, Leveque L, Chan CJ, Robb RJ, Markey KA, Alexander KA, Varelias A, Clouston AD, Smyth MJ, MacDonald KP, Hill GR.

Blood. 2013 Apr 25;121(17):3511-20. doi: 10.1182/blood-2012-07-444026. Epub 2013 Feb 21.


Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.

Robb RJ, Lineburg KE, Kuns RD, Wilson YA, Raffelt NC, Olver SD, Varelias A, Alexander KA, Teal BE, Sparwasser T, Hammerling GJ, Markey KA, Koyama M, Clouston AD, Engwerda CR, Hill GR, MacDonald KP.

Blood. 2012 Jun 14;119(24):5898-908. doi: 10.1182/blood-2011-12-396119. Epub 2012 Apr 26.


Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets.

Markey KA, Koyama M, Kuns RD, Lineburg KE, Wilson YA, Olver SD, Raffelt NC, Don AL, Varelias A, Robb RJ, Cheong M, Engwerda CR, Steptoe RJ, Ramshaw HS, Lopez AF, Vega-Ramos J, Lew AM, Villadangos JA, Hill GR, MacDonald KP.

Blood. 2012 Jun 14;119(24):5918-30. doi: 10.1182/blood-2011-12-398164. Epub 2012 Mar 13.


Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease.

Koyama M, Kuns RD, Olver SD, Raffelt NC, Wilson YA, Don AL, Lineburg KE, Cheong M, Robb RJ, Markey KA, Varelias A, Malissen B, Hämmerling GJ, Clouston AD, Engwerda CR, Bhat P, MacDonald KP, Hill GR.

Nat Med. 2011 Nov 29;18(1):135-42. doi: 10.1038/nm.2597.


Type I-IFNs control GVHD and GVL responses after transplantation.

Robb RJ, Kreijveld E, Kuns RD, Wilson YA, Olver SD, Don AL, Raffelt NC, De Weerd NA, Lineburg KE, Varelias A, Markey KA, Koyama M, Clouston AD, Hertzog PJ, Macdonald KP, Hill GR.

Blood. 2011 Sep 22;118(12):3399-409. doi: 10.1182/blood-2010-12-325746. Epub 2011 Jun 30.


Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma.

Hill GR, Olver SD, Kuns RD, Varelias A, Raffelt NC, Don AL, Markey KA, Wilson YA, Smyth MJ, Iwakura Y, Tocker J, Clouston AD, Macdonald KP.

Blood. 2010 Aug 5;116(5):819-28. doi: 10.1182/blood-2009-11-256495. Epub 2010 Apr 30.


T-lymphocyte-induced, Fas-mediated apoptosis is associated with early keratinocyte differentiation.

Daehn IS, Varelias A, Rayner TE.

Exp Dermatol. 2010 Apr;19(4):372-80. doi: 10.1111/j.1600-0625.2009.00917.x. Epub 2009 Jul 23.


Hematopoietic growth factor mimetics: from concept to clinic.

Perugini M, Varelias A, Sadlon T, D'Andrea RJ.

Cytokine Growth Factor Rev. 2009 Feb;20(1):87-94. doi: 10.1016/j.cytogfr.2009.01.002. Epub 2009 Feb 14. Review.


Donor treatment with a multipegylated G-CSF maximizes graft-versus-leukemia effects.

Banovic T, MacDonald KP, Markey KA, Morris ES, Kuns RD, Varelias A, Hill GR.

Biol Blood Marrow Transplant. 2009 Jan;15(1):126-30. doi: 10.1016/j.bbmt.2008.11.019.


Statins inhibit neutrophil infiltration in skeletal muscle reperfusion injury.

Cowled PA, Khanna A, Laws PE, Field JB, Varelias A, Fitridge RA.

J Surg Res. 2007 Aug;141(2):267-76. Epub 2007 Jun 7.


Sodium butyrate induced keratinocyte apoptosis.

Daehn IS, Varelias A, Rayner TE.

Apoptosis. 2006 Aug;11(8):1379-90.


Th2 immunological inflammation in allergic fungal sinusitis, nonallergic eosinophilic fungal sinusitis, and chronic rhinosinusitis.

Carney AS, Tan LW, Adams D, Varelias A, Ooi EH, Wormald PJ.

Am J Rhinol. 2006 Mar-Apr;20(2):145-9.


Mitogenic bovine whey extract modulates matrix metalloproteinase-2, -9, and tissue inhibitor of matrix metalloproteinase-2 levels in chronic leg ulcers.

Varelias A, Cowin AJ, Adams D, Harries RH, Cooter RD, Belford DA, Fitridge RA, Rayner TE.

Wound Repair Regen. 2006 Jan-Feb;14(1):28-37. Erratum in: Wound Repair Regen. 2007 Jan-Feb;15(1):163.


Regulation of MAPK activation, AP-1 transcription factor expression and keratinocyte differentiation in wounded fetal skin.

Gangnuss S, Cowin AJ, Daehn IS, Hatzirodos N, Rothnagel JA, Varelias A, Rayner TE.

J Invest Dermatol. 2004 Mar;122(3):791-804.


Human osteosarcoma expresses specific ephrin profiles: implications for tumorigenicity and prognosis.

Varelias A, Koblar SA, Cowled PA, Carter CD, Clayer M.

Cancer. 2002 Aug 15;95(4):862-9.


Up-regulation of MMP-2 and MMP-9 leads to degradation of type IV collagen during skeletal muscle reperfusion injury; protection by the MMP inhibitor, doxycycline.

Roach DM, Fitridge RA, Laws PE, Millard SH, Varelias A, Cowled PA.

Eur J Vasc Endovasc Surg. 2002 Mar;23(3):260-9.

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