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Items: 40

1.

Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer.

Kartha VK, Alamoud KA, Sadykov K, Nguyen BC, Laroche F, Feng H, Lee J, Pai SI, Varelas X, Egloff AM, Snyder-Cappione JE, Belkina AC, Bais MV, Monti S, Kukuruzinska MA.

Genome Med. 2018 Jul 20;10(1):54. doi: 10.1186/s13073-018-0569-7.

2.

Hsp70-Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation.

Meriin AB, Narayanan A, Meng L, Alexandrov I, Varelas X, Cissé II, Sherman MY.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7043-E7052. doi: 10.1073/pnas.1803130115. Epub 2018 Jul 9.

PMID:
29987014
3.

Glutamine-utilizing transaminases are a metabolic vulnerability of TAZ/YAP-activated cancer cells.

Yang CS, Stampouloglou E, Kingston NM, Zhang L, Monti S, Varelas X.

EMBO Rep. 2018 Jun;19(6). pii: e43577. doi: 10.15252/embr.201643577. Epub 2018 Apr 16.

PMID:
29661856
4.

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.

Lagares D, Santos A, Grasberger PE, Liu F, Probst CK, Rahimi RA, Sakai N, Kuehl T, Ryan J, Bhola P, Montero J, Kapoor M, Baron M, Varelas X, Tschumperlin DJ, Letai A, Tager AM.

Sci Transl Med. 2017 Dec 13;9(420). pii: eaal3765. doi: 10.1126/scitranslmed.aal3765.

PMID:
29237758
5.

Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis.

Alsaqer SF, Tashkandi MM, Kartha VK, Yang YT, Alkheriji Y, Salama A, Varelas X, Kukuruzinska M, Monti S, Bais MV.

Oncotarget. 2017 Jul 27;8(43):73372-73386. doi: 10.18632/oncotarget.19637. eCollection 2017 Sep 26.

6.

Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells.

Wasserman GA, Szymaniak AD, Hinds AC, Yamamoto K, Kamata H, Smith NM, Hilliard KL, Carrieri C, Labadorf AT, Quinton LJ, Ai X, Varelas X, Chen F, Mizgerd JP, Fine A, O'Carroll D, Jones MR.

J Clin Invest. 2017 Oct 2;127(10):3866-3876. doi: 10.1172/JCI94639. Epub 2017 Sep 18.

7.

Integrin-FAK-CDC42-PP1A signaling gnaws at YAP/TAZ activity to control incisor stem cells.

Hicks-Berthet J, Varelas X.

Bioessays. 2017 Oct;39(10). doi: 10.1002/bies.201700116. Epub 2017 Sep 11. Review.

PMID:
28891248
8.

Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis.

Toyama T, Looney AP, Baker BM, Stawski L, Haines P, Simms R, Szymaniak AD, Varelas X, Trojanowska M.

J Invest Dermatol. 2018 Jan;138(1):78-88. doi: 10.1016/j.jid.2017.08.024. Epub 2017 Sep 1.

PMID:
28870693
9.

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

Dieffenbach PB, Haeger CM, Coronata AMF, Choi KM, Varelas X, Tschumperlin DJ, Fredenburgh LE.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L628-L647. doi: 10.1152/ajplung.00173.2017. Epub 2017 Jun 22.

10.

The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.

Szymaniak AD, Mi R, McCarthy SE, Gower AC, Reynolds TL, Mingueneau M, Kukuruzinska M, Varelas X.

Elife. 2017 May 11;6. pii: e23499. doi: 10.7554/eLife.23499.

11.

Systematic morphological profiling of human gene and allele function via Cell Painting.

Rohban MH, Singh S, Wu X, Berthet JB, Bray MA, Shrestha Y, Varelas X, Boehm JS, Carpenter AE.

Elife. 2017 Mar 18;6. pii: e24060. doi: 10.7554/eLife.24060.

12.

TAZ activation drives fibroblast spheroid growth, expression of profibrotic paracrine signals, and context-dependent ECM gene expression.

Jorgenson AJ, Choi KM, Sicard D, Smith KM, Hiemer SE, Varelas X, Tschumperlin DJ.

Am J Physiol Cell Physiol. 2017 Mar 1;312(3):C277-C285. doi: 10.1152/ajpcell.00205.2016. Epub 2016 Nov 23.

13.

Altered RNA editing in 3' UTR perturbs microRNA-mediated regulation of oncogenes and tumor-suppressors.

Zhang L, Yang CS, Varelas X, Monti S.

Sci Rep. 2016 Mar 16;6:23226. doi: 10.1038/srep23226.

14.

Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap.

Szymaniak AD, Mahoney JE, Cardoso WV, Varelas X.

Dev Cell. 2015 Aug 10;34(3):283-96. doi: 10.1016/j.devcel.2015.06.020. Epub 2015 Jul 30.

15.

A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma.

Hiemer SE, Zhang L, Kartha VK, Packer TS, Almershed M, Noonan V, Kukuruzinska M, Bais MV, Monti S, Varelas X.

Mol Cancer Res. 2015 Jun;13(6):957-68. doi: 10.1158/1541-7786.MCR-14-0580. Epub 2015 Mar 20.

16.

Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling.

Narimatsu M, Samavarchi-Tehrani P, Varelas X, Wrana JL.

Dev Cell. 2015 Mar 9;32(5):652-6. doi: 10.1016/j.devcel.2015.02.019.

17.

Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors.

Mori M, Mahoney JE, Stupnikov MR, Paez-Cortez JR, Szymaniak AD, Varelas X, Herrick DB, Schwob J, Zhang H, Cardoso WV.

Development. 2015 Jan 15;142(2):258-67. doi: 10.1242/dev.116855.

18.

Head and neck cancer: from research to therapy and cure.

Varelas X, Kukuruzinska MA.

Ann N Y Acad Sci. 2014 Dec;1333:1-32. doi: 10.1111/nyas.12613.

PMID:
25532687
19.

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.

Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12.

20.

The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.

Mahoney JE, Mori M, Szymaniak AD, Varelas X, Cardoso WV.

Dev Cell. 2014 Jul 28;30(2):137-50. doi: 10.1016/j.devcel.2014.06.003. Epub 2014 Jul 17.

21.

Protein N-glycosylation in oral cancer: dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling.

Varelas X, Bouchie MP, Kukuruzinska MA.

Glycobiology. 2014 Jul;24(7):579-91. doi: 10.1093/glycob/cwu031. Epub 2014 Apr 17. Review.

22.

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.

Varelas X.

Development. 2014 Apr;141(8):1614-26. doi: 10.1242/dev.102376. Review.

23.

The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells.

Hiemer SE, Szymaniak AD, Varelas X.

J Biol Chem. 2014 May 9;289(19):13461-74. doi: 10.1074/jbc.M113.529115. Epub 2014 Mar 19.

24.

Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells.

Beyer TA, Weiss A, Khomchuk Y, Huang K, Ogunjimi AA, Varelas X, Wrana JL.

Cell Rep. 2013 Dec 26;5(6):1611-24. doi: 10.1016/j.celrep.2013.11.021. Epub 2013 Dec 12.

25.

The Hippo pathway effectors TAZ/YAP regulate dicer expression and microRNA biogenesis through Let-7.

Chaulk SG, Lattanzi VJ, Hiemer SE, Fahlman RP, Varelas X.

J Biol Chem. 2014 Jan 24;289(4):1886-91. doi: 10.1074/jbc.C113.529362. Epub 2013 Dec 9.

26.

The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome.

Enger TB, Samad-Zadeh A, Bouchie MP, Skarstein K, Galtung HK, Mera T, Walker J, Menko AS, Varelas X, Faustman DL, Jensen JL, Kukuruzinska MA.

Lab Invest. 2013 Nov;93(11):1203-18. doi: 10.1038/labinvest.2013.114. Epub 2013 Sep 30.

27.

N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration.

Liu G, Sengupta PK, Jamal B, Yang HY, Bouchie MP, Lindner V, Varelas X, Kukuruzinska MA.

J Biol Chem. 2013 Jul 12;288(28):20217-27. doi: 10.1074/jbc.M113.473785. Epub 2013 May 23.

28.

Stem cell regulation by the Hippo pathway.

Hiemer SE, Varelas X.

Biochim Biophys Acta. 2013 Feb;1830(2):2323-34. doi: 10.1016/j.bbagen.2012.07.005. Epub 2012 Jul 20. Review.

PMID:
22824335
29.

Coordinating developmental signaling: novel roles for the Hippo pathway.

Varelas X, Wrana JL.

Trends Cell Biol. 2012 Feb;22(2):88-96. doi: 10.1016/j.tcb.2011.10.002. Epub 2011 Dec 5. Review.

PMID:
22153608
30.

Integrating developmental signals: a Hippo in the (path)way.

Mauviel A, Nallet-Staub F, Varelas X.

Oncogene. 2012 Apr 5;31(14):1743-56. doi: 10.1038/onc.2011.363. Epub 2011 Aug 29. Review.

PMID:
21874053
31.

An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme.

Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, Cox S, Xu S, Lopez-Girona A, Mercurio F, Wrana J, Durocher D, Meloche S, Webb DR, Tyers M, Sicheri F.

Cell. 2011 Jun 24;145(7):1075-87. doi: 10.1016/j.cell.2011.05.039. Epub 2011 Jun 16.

32.

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

Varelas X, Samavarchi-Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen BG, Rossant J, Wrana JL.

Dev Cell. 2010 Dec 14;19(6):831-44. doi: 10.1016/j.devcel.2010.11.012.

33.

The Hippo pathway regulates Wnt/beta-catenin signaling.

Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L.

Dev Cell. 2010 Apr 20;18(4):579-91. doi: 10.1016/j.devcel.2010.03.007.

34.

The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates.

Ogunjimi AA, Wiesner S, Briant DJ, Varelas X, Sicheri F, Forman-Kay J, Wrana JL.

J Biol Chem. 2010 Feb 26;285(9):6308-15. doi: 10.1074/jbc.M109.044537. Epub 2009 Dec 21.

35.

Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown.

Sopko R, Silva E, Clayton L, Gardano L, Barrios-Rodiles M, Wrana J, Varelas X, Arbouzova NI, Shaw S, Saburi S, Matakatsu H, Blair S, McNeill H.

Curr Biol. 2009 Jul 14;19(13):1112-7. doi: 10.1016/j.cub.2009.05.049. Epub 2009 Jun 18.

36.

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.

Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL.

Nat Cell Biol. 2008 Jul;10(7):837-48. doi: 10.1038/ncb1748. Epub 2008 Jun 22.

PMID:
18568018
37.

The Cdc34/SCF ubiquitination complex mediates Saccharomyces cerevisiae cell wall integrity.

Varelas X, Stuart D, Ellison MJ, Ptak C.

Genetics. 2006 Dec;174(4):1825-39. Epub 2006 Oct 8.

38.

Purification and properties of the ubiquitin-conjugating enzymes Cdc34 and Ubc13.Mms2.

Ptak C, Varelas X, Moraes T, McKenna S, Ellison MJ.

Methods Enzymol. 2005;398:43-54.

PMID:
16275318
39.

[Conservative therapy adapted to findings of superficial chronic venous ulcers].

Billmann MK, Köhler Ch, Varelas X, Mayer D.

Vasa. 2004 May;33(2):97-101. German.

PMID:
15224464
40.

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