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Items: 21

1.

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.

Kunova Bosakova M, Nita A, Gregor T, Varecha M, Gudernova I, Fafilek B, Barta T, Basheer N, Abraham SP, Balek L, Tomanova M, Fialova Kucerova J, Bosak J, Potesil D, Zieba J, Song J, Konik P, Park S, Duran I, Zdrahal Z, Smajs D, Jansen G, Fu Z, Ko HW, Hampl A, Trantirek L, Krakow D, Krejci P.

Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 201800338. doi: 10.1073/pnas.1800338116. [Epub ahead of print]

2.

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases.

Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M, Jonatova L, Cernohorsky NH, Zieba JT, Kostas M, Haugsten EM, Wesche J, Erneux C, Trantirek L, Krakow D, Krejci P.

Sci Signal. 2018 Sep 18;11(548). pii: eaap8608. doi: 10.1126/scisignal.aap8608.

PMID:
30228226
3.

Nanodiamonds as "artificial proteins": Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals.

Balek L, Buchtova M, Kunova Bosakova M, Varecha M, Foldynova-Trantirkova S, Gudernova I, Vesela I, Havlik J, Neburkova J, Turner S, Krzyscik MA, Zakrzewska M, Klimaschewski L, Claus P, Trantirek L, Cigler P, Krejci P.

Biomaterials. 2018 Sep;176:106-121. doi: 10.1016/j.biomaterials.2018.05.030. Epub 2018 May 21.

4.

Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.

Kunova Bosakova M, Varecha M, Hampl M, Duran I, Nita A, Buchtova M, Dosedelova H, Machat R, Xie Y, Ni Z, Martin JH, Chen L, Jansen G, Krakow D, Krejci P.

Hum Mol Genet. 2018 Mar 15;27(6):1093-1105. doi: 10.1093/hmg/ddy031.

5.

Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480.

Gudernova I, Balek L, Varecha M, Kucerova JF, Kunova Bosakova M, Fafilek B, Palusova V, Uldrijan S, Trantirek L, Krejci P.

Oncotarget. 2017 Nov 27;8(65):109319-109331. doi: 10.18632/oncotarget.22674. eCollection 2017 Dec 12.

6.

Proteomic analyses of signalling complexes associated with receptor tyrosine kinase identify novel members of fibroblast growth factor receptor 3 interactome.

Balek L, Nemec P, Konik P, Kunova Bosakova M, Varecha M, Gudernova I, Medalova J, Krakow D, Krejci P.

Cell Signal. 2018 Jan;42:144-154. doi: 10.1016/j.cellsig.2017.10.003. Epub 2017 Oct 13.

PMID:
29030113
7.

ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3.

Balek L, Gudernova I, Vesela I, Hampl M, Oralova V, Kunova Bosakova M, Varecha M, Nemec P, Hall T, Abbadessa G, Hatch N, Buchtova M, Krejci P.

Bone. 2017 Dec;105:57-66. doi: 10.1016/j.bone.2017.08.016. Epub 2017 Aug 18.

PMID:
28826843
8.

Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion.

Vanova T, Konecna Z, Zbonakova Z, La Venuta G, Zoufalova K, Jelinkova S, Varecha M, Rotrekl V, Krejci P, Nickel W, Dvorak P, Kunova Bosakova M.

Stem Cells. 2017 Sep;35(9):2050-2059. doi: 10.1002/stem.2660. Epub 2017 Jul 6.

9.

Statins do not inhibit the FGFR signaling in chondrocytes.

Fafilek B, Hampl M, Ricankova N, Vesela I, Balek L, Kunova Bosakova M, Gudernova I, Varecha M, Buchtova M, Krejci P.

Osteoarthritis Cartilage. 2017 Sep;25(9):1522-1530. doi: 10.1016/j.joca.2017.05.014. Epub 2017 Jun 3.

10.

One reporter for in-cell activity profiling of majority of protein kinase oncogenes.

Gudernova I, Foldynova-Trantirkova S, Ghannamova BE, Fafilek B, Varecha M, Balek L, Hruba E, Jonatova L, Jelinkova I, Kunova Bosakova M, Trantirek L, Mayer J, Krejci P.

Elife. 2017 Feb 15;6. pii: e21536. doi: 10.7554/eLife.21536.

11.

Stage-specific roles of FGF2 signaling in human neural development.

Grabiec M, Hříbková H, Vařecha M, Střítecká D, Hampl A, Dvořák P, Sun YM.

Stem Cell Res. 2016 Sep;17(2):330-341. doi: 10.1016/j.scr.2016.08.012. Epub 2016 Aug 27.

12.

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.

Paige Taylor S, Kunova Bosakova M, Varecha M, Balek L, Barta T, Trantirek L, Jelinkova I, Duran I, Vesela I, Forlenza KN, Martin JH, Hampl A; University of Washington Center for Mendelian Genomics, Bamshad M, Nickerson D, Jaworski ML, Song J, Ko HW, Cohn DH, Krakow D, Krejci P.

Hum Mol Genet. 2016 Sep 15;25(18):3998-4011. doi: 10.1093/hmg/ddw240. Epub 2016 Jul 27.

13.

Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage.

Buchtova M, Oralova V, Aklian A, Masek J, Vesela I, Ouyang Z, Obadalova T, Konecna Z, Spoustova T, Pospisilova T, Matula P, Varecha M, Balek L, Gudernova I, Jelinkova I, Duran I, Cervenkova I, Murakami S, Kozubik A, Dvorak P, Bryja V, Krejci P.

Biochim Biophys Acta. 2015 May;1852(5):839-50. doi: 10.1016/j.bbadis.2014.12.020. Epub 2015 Jan 2.

14.

Knockdown of apoptosis-inducing factor disrupts function of respiratory complex I.

Varecha M, Páclová D, Procházková J, Matula P, Cmarko D, Kozubek M.

Biocell. 2012 Dec;36(3):121-6.

PMID:
23682427
15.

Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis.

Vařecha M, Potěšilová M, Matula P, Kozubek M.

Mol Cell Biochem. 2012 Apr;363(1-2):301-7. doi: 10.1007/s11010-011-1182-x. Epub 2011 Dec 8.

PMID:
22160858
16.

SUV39h- and A-type lamin-dependent telomere nuclear rearrangement.

Uhlírová R, Horáková AH, Galiová G, Legartová S, Matula P, Fojtová M, Varecha M, Amrichová J, Vondrácek J, Kozubek S, Bártová E.

J Cell Biochem. 2010 Apr 1;109(5):915-26. doi: 10.1002/jcb.22466.

PMID:
20069564
17.

Prediction of localization and interactions of apoptotic proteins.

Varecha M, Zimmermann M, Amrichová J, Ulman V, Matula P, Kozubek M.

J Biomed Sci. 2009 Jul 6;16:59. doi: 10.1186/1423-0127-16-59.

18.

Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells.

Varecha M, Amrichová J, Zimmermann M, Ulman V, Lukásová E, Kozubek M.

Apoptosis. 2007 Jul;12(7):1155-71.

PMID:
17347867
19.
20.

How do uncoupling proteins uncouple?

Garlid KD, Jabůrek M, Jezek P, Varecha M.

Biochim Biophys Acta. 2000 Aug 15;1459(2-3):383-9. Review.

21.

Transport function and regulation of mitochondrial uncoupling proteins 2 and 3.

Jabůrek M, Varecha M, Gimeno RE, Dembski M, Jezek P, Zhang M, Burn P, Tartaglia LA, Garlid KD.

J Biol Chem. 1999 Sep 10;274(37):26003-7.

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