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Differentiation of human colon tissue in culture: Effects of calcium on trans-epithelial electrical resistance and tissue cohesive properties.

McClintock SD, Attili D, Dame MK, Richter A, Silvestri SS, Berner MM, Bohm MS, Karpoff K, McCarthy CL, Spence JR, Varani J, Aslam MN.

PLoS One. 2020 Mar 5;15(3):e0222058. doi: 10.1371/journal.pone.0222058. eCollection 2020.


A Calcium-Rich Multimineral Intervention to Modulate Colonic Microbial Communities and Metabolomic Profiles in Humans: Results from a 90-Day Trial.

Aslam MN, Bassis CM, Bergin IL, Knuver K, Zick SM, Sen A, Turgeon DK, Varani J.

Cancer Prev Res (Phila). 2020 Jan;13(1):101-116. doi: 10.1158/1940-6207.CAPR-19-0325. Epub 2019 Nov 26.


Calcium-induced differentiation in normal human colonoid cultures: Cell-cell / cell-matrix adhesion, barrier formation and tissue integrity.

Attili D, McClintock SD, Rizvi AH, Pandya S, Rehman H, Nadeem DM, Richter A, Thomas D, Dame MK, Turgeon DK, Varani J, Aslam MN.

PLoS One. 2019 Apr 17;14(4):e0215122. doi: 10.1371/journal.pone.0215122. eCollection 2019.


Atrophic and hypertrophic photoaging: Clinical, histologic, and molecular features of 2 distinct phenotypes of photoaged skin.

Sachs DL, Varani J, Chubb H, Fligiel SEG, Cui Y, Calderone K, Helfrich Y, Fisher GJ, Voorhees JJ.

J Am Acad Dermatol. 2019 Aug;81(2):480-488. doi: 10.1016/j.jaad.2019.03.081. Epub 2019 Apr 5.


Pro-inflammatory agents released by pathogens, dying host cells, and neutrophils act synergistically to destroy host tissues: a working hypothesis.

Ginsburg I, Korem M, Koren E, Varani J.

J Inflamm Res. 2019 Jan 23;12:35-47. doi: 10.2147/JIR.S190007. eCollection 2019. Review.


Calcium-Induced Differentiation of Human Colon Adenomas in Colonoid Culture: Calcium Alone versus Calcium with Additional Trace Elements.

McClintock SD, Colacino JA, Attili D, Dame MK, Richter A, Reddy AR, Basrur V, Rizvi AH, Turgeon DK, Varani J, Aslam MN.

Cancer Prev Res (Phila). 2018 Jul;11(7):413-428. doi: 10.1158/1940-6207.CAPR-17-0308. Epub 2018 Apr 10.


Identification, isolation and characterization of human LGR5-positive colon adenoma cells.

Dame MK, Attili D, McClintock SD, Dedhia PH, Ouillette P, Hardt O, Chin AM, Xue X, Laliberte J, Katz EL, Newsome GM, Hill DR, Miller AJ, Tsai YH, Agorku D, Altheim CH, Bosio A, Simon B, Samuelson LC, Stoerker JA, Appelman HD, Varani J, Wicha MS, Brenner DE, Shah YM, Spence JR, Colacino JA.

Development. 2018 Mar 14;145(6). pii: dev153049. doi: 10.1242/dev.153049.


Correction: Calcium Reduces Liver Injury in Mice on a High-Fat Diet: Alterations in Microbial and Bile Acid Profiles.

Aslam MN, Bassis CM, Zhang L, Zaidi S, Varani J, Bergin IL.

PLoS One. 2017 Jan 9;12(1):e0170136. doi: 10.1371/journal.pone.0170136. eCollection 2017.


Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar Collagen Deposition and Tensile Strength due to Impaired Transforming Growth Factor-β1 to -β3 Translation.

Cheng T, Yue M, Aslam MN, Wang X, Shekhawat G, Varani J, Schuger L.

Am J Pathol. 2017 Feb;187(2):292-303. doi: 10.1016/j.ajpath.2016.10.004. Epub 2016 Dec 8.


Calcium Reduces Liver Injury in Mice on a High-Fat Diet: Alterations in Microbial and Bile Acid Profiles.

Nadeem Aslam M, Bassis CM, Zhang L, Zaidi S, Varani J, Bergin IL.

PLoS One. 2016 Nov 16;11(11):e0166178. doi: 10.1371/journal.pone.0166178. eCollection 2016. Erratum in: PLoS One. 2017 Jan 9;12 (1):e0170136.


Nuclear histones: major virulence factors or just additional early sepsis markers? A comment.

Ginsburg I, Koren E, Varani J, Kohen R.

Inflammopharmacology. 2016 Oct;24(5):287-289. Epub 2016 Sep 9. Review.


Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.

Xue X, Ramakrishnan SK, Weisz K, Triner D, Xie L, Attili D, Pant A, Győrffy B, Zhan M, Carter-Su C, Hardiman KM, Wang TD, Dame MK, Varani J, Brenner D, Fearon ER, Shah YM.

Cell Metab. 2016 Sep 13;24(3):447-461. doi: 10.1016/j.cmet.2016.07.015. Epub 2016 Aug 18.


Balanced regulation of the CCN family of matricellular proteins: a novel approach to the prevention and treatment of fibrosis and cancer.

Riser BL, Barnes JL, Varani J.

J Cell Commun Signal. 2015 Dec;9(4):327-39. doi: 10.1007/s12079-015-0309-3. Epub 2015 Dec 23.


Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1.

Zhang H, Ramakrishnan SK, Triner D, Centofanti B, Maitra D, Győrffy B, Sebolt-Leopold JS, Dame MK, Varani J, Brenner DE, Fearon ER, Omary MB, Shah YM.

Sci Signal. 2015 Oct 6;8(397):ra98. doi: 10.1126/scisignal.aac5418.


Ulcerative Dermatitis in C57BL/6NCrl Mice on a Low-Fat or High-Fat Diet With or Without a Mineralized Red-Algae Supplement.

Hampton AL, Aslam MN, Naik MK, Bergin IL, Allen RM, Craig RA, Kunkel SL, Veerapaneni I, Paruchuri T, Patterson KA, Rothman ED, Hish GA, Varani J, Rush HG.

J Am Assoc Lab Anim Sci. 2015 Sep;54(5):487-96.


Induction of calcium sensing receptor in human colon cancer cells by calcium, vitamin D and aquamin: Promotion of a more differentiated, less malignant and indolent phenotype.

Singh N, Aslam MN, Varani J, Chakrabarty S.

Mol Carcinog. 2015 Jul;54(7):543-53. doi: 10.1002/mc.22123. Epub 2013 Dec 17.


MDI 301 suppresses myeloid leukemia cell growth in vitro and in vivo without the toxicity associated with all-trans retinoic acid therapy.

Aslam MN, McClintock S, Khan SP, Perone P, Allen R, Ouillette PD, Dame MK, Cheng JX, Kunkel SL, Varani J.

Anticancer Drugs. 2015 Aug;26(7):763-73. doi: 10.1097/CAD.0000000000000248.


Monoclonal antibodies specific for oncofetal antigen--immature laminin receptor protein: Effects on tumor growth and spread in two murine models.

McClintock SD, Warner RL, Ali S, Chekuri A, Dame MK, Attili D, Knibbs RK, Aslam MN, Sinkule J, Morgan AC, Barsoum A, Smith LB, Beer DG, Johnson KJ, Varani J.

Cancer Biol Ther. 2015;16(5):724-32. doi: 10.1080/15384047.2015.1026484.


Clinical, Histologic, and Molecular Analysis of Differences Between Erythematotelangiectatic Rosacea and Telangiectatic Photoaging.

Helfrich YR, Maier LE, Cui Y, Fisher GJ, Chubb H, Fligiel S, Sachs D, Varani J, Voorhees J.

JAMA Dermatol. 2015 Aug;151(8):825-36. doi: 10.1001/jamadermatol.2014.4728.


Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture.

Ward NL, Bhagathavula N, Johnston A, Dawes SM, Fu W, Lambert S, Dame MK, Warner RL, Gudjonsson JE, Varani J, Elder JT.

J Invest Dermatol. 2015 Mar;135(3):910-913. doi: 10.1038/jid.2014.445. Epub 2014 Oct 13. No abstract available.


Human colonic crypts in culture: segregation of immunochemical markers in normal versus adenoma-derived.

Dame MK, Jiang Y, Appelman HD, Copley KD, McClintock SD, Aslam MN, Attili D, Elmunzer BJ, Brenner DE, Varani J, Turgeon DK.

Lab Invest. 2014 Feb;94(2):222-34. doi: 10.1038/labinvest.2013.145. Epub 2013 Dec 23.


Preservation of bone structure and function by Lithothamnion sp. derived minerals.

Aslam MN, Bergin I, Jepsen K, Kreider JM, Graf KH, Naik M, Goldstein SA, Varani J.

Biol Trace Elem Res. 2013 Dec;156(1-3):210-20. doi: 10.1007/s12011-013-9820-7. Epub 2013 Oct 6.


Role of calcium sensing receptor (CaSR) in tumorigenesis.

Singh N, Promkan M, Liu G, Varani J, Chakrabarty S.

Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):455-63. doi: 10.1016/j.beem.2013.04.001. Epub 2013 May 6. Review.


Progression of ulcerative dermatitis lesions in C57BL/6Crl mice and the development of a scoring system for dermatitis lesions.

Hampton AL, Hish GA, Aslam MN, Rothman ED, Bergin IL, Patterson KA, Naik M, Paruchuri T, Varani J, Rush HG.

J Am Assoc Lab Anim Sci. 2012;51(5):586-93.


A multimineral natural product from red marine algae reduces colon polyp formation in C57BL/6 mice.

Aslam MN, Bergin I, Naik M, Paruchuri T, Hampton A, Rehman M, Dame MK, Rush H, Varani J.

Nutr Cancer. 2012;64(7):1020-8. doi: 10.1080/01635581.2012.713160. Epub 2012 Oct 4.


Growth control in colon epithelial cells: gadolinium enhances calcium-mediated growth regulation.

Attili D, Jenkins B, Aslam MN, Dame MK, Varani J.

Biol Trace Elem Res. 2012 Dec;150(1-3):467-76. doi: 10.1007/s12011-012-9503-9. Epub 2012 Sep 19.


Gadolinium-induced fibrosis is counter-regulated by CCN3 in human dermal fibroblasts: a model for potential treatment of nephrogenic systemic fibrosis.

Riser BL, Bhagavathula N, Perone P, Garchow K, Xu Y, Fisher GJ, Najmabadi F, Attili D, Varani J.

J Cell Commun Signal. 2012 Jun;6(2):97-105. doi: 10.1007/s12079-012-0164-4. Epub 2012 May 31.


A multi-mineral natural product inhibits liver tumor formation in C57BL/6 mice.

Aslam MN, Bergin I, Naik M, Hampton A, Allen R, Kunkel SL, Rush H, Varani J.

Biol Trace Elem Res. 2012 Jun;147(1-3):267-74. doi: 10.1007/s12011-011-9316-2. Epub 2012 Jan 6.


Effects of a synthetic retinoid on skin structure, matrix metalloproteinases, and procollagen in healthy and high-risk subjects with diabetes.

Zeng W, Tahrani A, Shakher J, Varani J, Hughes S, Dubb K, Stevens MJ.

J Diabetes Complications. 2011 Nov-Dec;25(6):398-404. doi: 10.1016/j.jdiacomp.2011.10.002. Epub 2011 Nov 4.


Stimulation of fibroblast proliferation by insoluble gadolinium salts.

Bleavins K, Perone P, Naik M, Rehman M, Aslam MN, Dame MK, Meshinchi S, Bhagavathula N, Varani J.

Biol Trace Elem Res. 2012 Feb;145(2):257-67. doi: 10.1007/s12011-011-9176-9. Epub 2011 Sep 1.


Fibroblast response to lanthanoid metal ion stimulation: potential contribution to fibrotic tissue injury.

Jenkins W, Perone P, Walker K, Bhagavathula N, Aslam MN, DaSilva M, Dame MK, Varani J.

Biol Trace Elem Res. 2011 Dec;144(1-3):621-35. doi: 10.1007/s12011-011-9041-x. Epub 2011 Apr 12.


Calcium, calcium-sensing receptor and growth control in the colonic mucosa.

Varani J.

Histol Histopathol. 2011 Jun;26(6):769-79. doi: 10.14670/HH-26.769. Review.


Human colon tissue in organ culture: calcium and multi-mineral-induced mucosal differentiation.

Dame MK, Veerapaneni I, Bhagavathula N, Naik M, Varani J.

In Vitro Cell Dev Biol Anim. 2011 Jan;47(1):32-8. doi: 10.1007/s11626-010-9358-3. Epub 2010 Nov 20.


IL-1RL2 and its ligands contribute to the cytokine network in psoriasis.

Blumberg H, Dinh H, Dean C Jr, Trueblood ES, Bailey K, Shows D, Bhagavathula N, Aslam MN, Varani J, Towne JE, Sims JE.

J Immunol. 2010 Oct 1;185(7):4354-62. doi: 10.4049/jimmunol.1000313. Epub 2010 Sep 10.


Fibroblast response to gadolinium: role for platelet-derived growth factor receptor.

Bhagavathula N, Dame MK, DaSilva M, Jenkins W, Aslam MN, Perone P, Varani J.

Invest Radiol. 2010 Dec;45(12):769-77. doi: 10.1097/RLI.0b013e3181e943d2.


Responses of human skin in organ culture and human skin fibroblasts to a gadolinium-based MRI contrast agent: comparison of skin from patients with end-stage renal disease and skin from healthy subjects.

DaSilva M, O'Brien Deming M, Fligiel SE, Dame MK, Johnson KJ, Swartz RD, Varani J.

Invest Radiol. 2010 Nov;45(11):733-9. doi: 10.1097/RLI.0b013e3181e9436b.


A multi-component herbal preparation (PADMA 28) improves structure/function of corticosteroid-treated skin, leading to improved wound healing of subsequently induced abrasion wounds in rats.

Aslam MN, Warner RL, Bhagavathula N, Ginsburg I, Varani J.

Arch Dermatol Res. 2010 Nov;302(9):669-77. doi: 10.1007/s00403-010-1066-z. Epub 2010 Jul 7.


A mineral-rich extract from the red marine algae Lithothamnion calcareum preserves bone structure and function in female mice on a Western-style diet.

Aslam MN, Kreider JM, Paruchuri T, Bhagavathula N, DaSilva M, Zernicke RF, Goldstein SA, Varani J.

Calcif Tissue Int. 2010 Apr;86(4):313-24. doi: 10.1007/s00223-010-9340-9. Epub 2010 Feb 24.


A mineral-rich red algae extract inhibits polyp formation and inflammation in the gastrointestinal tract of mice on a high-fat diet.

Aslam MN, Paruchuri T, Bhagavathula N, Varani J.

Integr Cancer Ther. 2010 Mar;9(1):93-9. doi: 10.1177/1534735409360360. Epub 2010 Feb 11.


Collagenolytic activity is suppressed in organ-cultured human skin exposed to a gadolinium-based MRI contrast agent.

Perone PA, Weber SL, DaSilva M, Paruchuri T, Bhagavathula N, Aslam MN, Dame MK, Johnson KJ, Swartz RD, Varani J.

Invest Radiol. 2010 Jan;45(1):42-8. doi: 10.1097/RLI.0b013e3181bf95eb.


Human colon tissue in organ culture: preservation of normal and neoplastic characteristics.

Dame MK, Bhagavathula N, Mankey C, DaSilva M, Paruchuri T, Aslam MN, Varani J.

In Vitro Cell Dev Biol Anim. 2010 Feb;46(2):114-22. doi: 10.1007/s11626-009-9247-9.


A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin.

Bhagavathula N, Warner RL, DaSilva M, McClintock SD, Barron A, Aslam MN, Johnson KJ, Varani J.

Wound Repair Regen. 2009 May-Jun;17(3):360-6. doi: 10.1111/j.1524-475X.2009.00483.x.


Regulation of collagen turnover in human skin fibroblasts exposed to a gadolinium-based contrast agent.

Bhagavathula N, DaSilva M, Aslam MN, Dame MK, Warner RL, Xu Y, Fisher GJ, Johnson KJ, Swartz R, Varani J.

Invest Radiol. 2009 Aug;44(8):433-9. doi: 10.1097/RLI.0b013e3181a4d7e9.


The Göttingen minipig for assessment of retinoid efficacy in the skin: comparison of results from topically treated animals with results from organ-cultured skin.

Dame MK, Paruchuri T, DaSilva M, Bhagavathula N, Ridder W, Varani J.

In Vitro Cell Dev Biol Anim. 2009 Oct;45(9):551-7. doi: 10.1007/s11626-009-9221-6. Epub 2009 Jun 18.


Growth-inhibitory effects of a mineralized extract from the red marine algae, Lithothamnion calcareum, on Ca(2+)-sensitive and Ca(2+)-resistant human colon carcinoma cells.

Aslam MN, Bhagavathula N, Paruchuri T, Hu X, Chakrabarty S, Varani J.

Cancer Lett. 2009 Oct 8;283(2):186-92. doi: 10.1016/j.canlet.2009.03.037. Epub 2009 Apr 24.


Impaired keratinocyte function on matrix metalloproteinase-1 (MMP-1) damaged collagen.

Varani J, Perone P, Deming MO, Warner RL, Aslam MN, Bhagavathula N, Dame MK, Voorhees JJ.

Arch Dermatol Res. 2009 Aug;301(7):497-506. doi: 10.1007/s00403-009-0948-4. Epub 2009 Apr 8.


Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin.

Fisher GJ, Quan T, Purohit T, Shao Y, Cho MK, He T, Varani J, Kang S, Voorhees JJ.

Am J Pathol. 2009 Jan;174(1):101-14. doi: 10.2353/ajpath.2009.080599. Epub 2008 Dec 30.


Effects of gadolinium-based magnetic resonance imaging contrast agents on human skin in organ culture and human skin fibroblasts.

Varani J, DaSilva M, Warner RL, Deming MO, Barron AG, Johnson KJ, Swartz RD.

Invest Radiol. 2009 Feb;44(2):74-81. doi: 10.1097/RLI.0b013e31818f76b5.


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