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Items: 1 to 50 of 235

1.

Imaging Sigma-1 Receptor (S1R) Expression Using Iodine-124-Labeled 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine ([124I]IPAG).

Gangangari KK, Váradi A, Majumdar S, Larson SM, Pasternak GW, Pillarsetty NK.

Mol Imaging Biol. 2019 Jun 4. doi: 10.1007/s11307-019-01369-8. [Epub ahead of print]

PMID:
31165385
2.

Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.

Cioffi CL, Racz B, Varadi A, Freeman EE, Conlon MP, Chen P, Zhu L, Kitchen DB, Barnes KD, Martin WH, Pearson PG, Johnson G, Blaner WS, Petrukhin K.

J Med Chem. 2019 Jun 13;62(11):5470-5500. doi: 10.1021/acs.jmedchem.9b00352. Epub 2019 May 28.

3.

Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (σ1) receptor selective ligands.

Uprety R, Váradi A, Allaoa A, Redel-Traub GN, Palmer TC, Feinberg EN, Ferris AC, Pande VS, Pasternak GW, Majumdar S.

Eur J Med Chem. 2019 Feb 15;164:241-251. doi: 10.1016/j.ejmech.2018.12.048. Epub 2018 Dec 22.

PMID:
30597325
4.

Dietary Pyrophosphate Modulates Calcification in a Mouse Model of Pseudoxanthoma Elasticum: Implication for Treatment of Patients.

Pomozi V, Julian CB, Zoll J, Pham K, Kuo S, Tőkési N, Martin L, Váradi A, Le Saux O.

J Invest Dermatol. 2019 May;139(5):1082-1088. doi: 10.1016/j.jid.2018.10.040. Epub 2018 Nov 20.

PMID:
30468740
5.

PXE, a Mysterious Inborn Error Clarified.

Borst P, Váradi A, van de Wetering K.

Trends Biochem Sci. 2019 Feb;44(2):125-140. doi: 10.1016/j.tibs.2018.10.005. Epub 2018 Nov 13. Review.

PMID:
30446375
6.

In vitro transport of methotrexate by Drosophila Multidrug Resistance-associated Protein.

Karasik A, Váradi A, Szeri F.

PLoS One. 2018 Oct 12;13(10):e0205657. doi: 10.1371/journal.pone.0205657. eCollection 2018.

7.

A non-retinoid antagonist of retinol-binding protein 4 rescues phenotype in a model of Stargardt disease without inhibiting the visual cycle.

Racz B, Varadi A, Kong J, Allikmets R, Pearson PG, Johnson G, Cioffi CL, Petrukhin K.

J Biol Chem. 2018 Jul 20;293(29):11574-11588. doi: 10.1074/jbc.RA118.002062. Epub 2018 Jun 5.

8.

Tissue-nonspecific alkaline phosphatase: a promising target for pseudoxanthoma elasticum therapy.

Váradi A, Fülöp K, Arányi T, Szeri F.

Ann Transl Med. 2017 Dec;5(24):489. doi: 10.21037/atm.2017.10.01. No abstract available.

9.

Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-β-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter.

Karasik A, Ledwitch KV, Arányi T, Váradi A, Roberts A, Szeri F.

FASEB J. 2018 Feb;32(2):669-680. doi: 10.1096/fj.201700606R. Epub 2018 Jan 4.

10.

14-O-Methylmorphine: A Novel Selective Mu-Opioid Receptor Agonist with High Efficacy and Affinity.

Zádor F, Balogh M, Váradi A, Zádori ZS, Király K, Szűcs E, Varga B, Lázár B, Hosztafi S, Riba P, Benyhe S, Fürst S, Al-Khrasani M.

Eur J Pharmacol. 2017 Nov 5;814:264-273. doi: 10.1016/j.ejphar.2017.08.034. Epub 2017 Aug 30.

PMID:
28864212
11.

Oral administration of pyrophosphate inhibits connective tissue calcification.

Dedinszki D, Szeri F, Kozák E, Pomozi V, Tőkési N, Mezei TR, Merczel K, Letavernier E, Tang E, Le Saux O, Arányi T, van de Wetering K, Váradi A.

EMBO Mol Med. 2017 Nov;9(11):1463-1470. doi: 10.15252/emmm.201707532.

12.

Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception.

Urai Á, Váradi A, Szőcs L, Komjáti B, Le Rouzic V, Hunkele A, Pasternak GW, Majumdar S, Hosztafi S.

Medchemcomm. 2017 Jan 1;8(1):152-157. doi: 10.1039/C6MD00450D. Epub 2016 Oct 18.

13.

New opioid receptor antagonist: Naltrexone-14-O-sulfate synthesis and pharmacology.

Zádor F, Király K, Váradi A, Balogh M, Fehér Á, Kocsis D, Erdei AI, Lackó E, Zádori ZS, Hosztafi S, Noszál B, Riba P, Benyhe S, Fürst S, Al-Khrasani M.

Eur J Pharmacol. 2017 Aug 15;809:111-121. doi: 10.1016/j.ejphar.2017.05.024. Epub 2017 May 11.

PMID:
28502630
14.

Pyrophosphate Supplementation Prevents Chronic and Acute Calcification in ABCC6-Deficient Mice.

Pomozi V, Brampton C, van de Wetering K, Zoll J, Calio B, Pham K, Owens JB, Marh J, Moisyadi S, Váradi A, Martin L, Bauer C, Erdmann J, Aherrahrou Z, Le Saux O.

Am J Pathol. 2017 Jun;187(6):1258-1272. doi: 10.1016/j.ajpath.2017.02.009. Epub 2017 Apr 14.

15.

Genetic dissociation of morphine analgesia from hyperalgesia in mice.

Marrone GF, Le Rouzic V, Varadi A, Xu J, Rajadhyaksha AM, Majumdar S, Pan YX, Pasternak GW.

Psychopharmacology (Berl). 2017 Jun;234(12):1891-1900. doi: 10.1007/s00213-017-4600-2. Epub 2017 Mar 25.

16.

Insights into Pathomechanisms and Treatment Development in Heritable Ectopic Mineralization Disorders: Summary of the PXE International Biennial Research Symposium-2016.

Uitto J, Li Q, van de Wetering K, Váradi A, Terry SF.

J Invest Dermatol. 2017 Apr;137(4):790-795. doi: 10.1016/j.jid.2016.12.014. Review.

17.

Variants of the EAAT2 Glutamate Transporter Gene Promoter Are Associated with Cerebral Palsy in Preterm Infants.

Rajatileka S, Odd D, Robinson MT, Spittle AC, Dwomoh L, Williams M, Harding D, Wagstaff M, Owen M, Crosby C, Ching J, Molnár E, Luyt K, Váradi A.

Mol Neurobiol. 2018 Mar;55(3):2013-2024. doi: 10.1007/s12035-017-0462-1. Epub 2017 Mar 7.

18.

Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice.

Pomozi V, Brampton C, Szeri F, Dedinszki D, Kozák E, van de Wetering K, Hopkins H, Martin L, Váradi A, Le Saux O.

J Invest Dermatol. 2017 Mar;137(3):595-602. doi: 10.1016/j.jid.2016.10.035. Epub 2016 Nov 5.

20.

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.

Váradi A, Marrone GF, Palmer TC, Narayan A, Szabó MR, Le Rouzic V, Grinnell SG, Subrath JJ, Warner E, Kalra S, Hunkele A, Pagirsky J, Eans SO, Medina JM, Xu J, Pan YX, Borics A, Pasternak GW, McLaughlin JP, Majumdar S.

J Med Chem. 2016 Sep 22;59(18):8381-97. doi: 10.1021/acs.jmedchem.6b00748. Epub 2016 Sep 2.

21.

New Morphine Analogs Produce Peripheral Antinociception within a Certain Dose Range of Their Systemic Administration.

Lackó E, Riba P, Giricz Z, Váradi A, Cornic L, Balogh M, Király K, Csekő K, Mousa SA, Hosztafi S, Schäfer M, Zádori ZS, Helyes Z, Ferdinandy P, Fürst S, Al-Khrasani M.

J Pharmacol Exp Ther. 2016 Oct;359(1):171-81. doi: 10.1124/jpet.116.233551. Epub 2016 Jul 19.

PMID:
27435180
22.

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.

Kruegel AC, Gassaway MM, Kapoor A, Váradi A, Majumdar S, Filizola M, Javitch JA, Sames D.

J Am Chem Soc. 2016 Jun 1;138(21):6754-64. doi: 10.1021/jacs.6b00360. Epub 2016 May 18.

23.

Association between neonatal resuscitation and a single nucleotide polymorphism rs1835740.

Odd D, Váradi A, Rajatileka S, Molnár E, Luyt K.

Acta Paediatr. 2016 Jul;105(7):e307-12. doi: 10.1111/apa.13421. Epub 2016 May 13.

PMID:
27059438
24.

New perspectives on rare connective tissue calcifying diseases.

Rashdan NA, Rutsch F, Kempf H, Váradi A, Lefthériotis G, MacRae VE.

Curr Opin Pharmacol. 2016 Jun;28:14-23. doi: 10.1016/j.coph.2016.02.002. Epub 2016 Feb 27. Review.

25.

Research Progress in Pseudoxanthoma Elasticum and Related Ectopic Mineralization Disorders.

Li Q, Arányi T, Váradi A, Terry SF, Uitto J.

J Invest Dermatol. 2016 Mar;136(3):550-556. doi: 10.1016/j.jid.2015.10.065. Review.

26.

Isocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles.

Váradi A, Palmer TC, Notis Dardashti R, Majumdar S.

Molecules. 2015 Dec 23;21(1):E19. doi: 10.3390/molecules21010019. Review.

28.

Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior.

Váradi A, Marrone GF, Eans SO, Ganno ML, Subrath JJ, Le Rouzic V, Hunkele A, Pasternak GW, McLaughlin JP, Majumdar S.

ACS Chem Neurosci. 2015 Nov 18;6(11):1813-24. doi: 10.1021/acschemneuro.5b00153. Epub 2015 Sep 14.

29.

Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction.

Váradi A, Palmer TC, Haselton N, Afonin D, Subrath JJ, Le Rouzic V, Hunkele A, Pasternak GW, Marrone GF, Borics A, Majumdar S.

ACS Chem Neurosci. 2015 Sep 16;6(9):1570-7. doi: 10.1021/acschemneuro.5b00137. Epub 2015 Jul 21.

30.

Mild, Pd-catalyzed stannylation of radioiodination targets.

Pickett JE, Váradi A, Palmer TC, Grinnell SG, Schrock JM, Pasternak GW, Karimov RR, Majumdar S.

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1761-1764. doi: 10.1016/j.bmcl.2015.02.055. Epub 2015 Mar 2.

31.

It is all about calcification.

Váradi A.

Cell Cycle. 2014;13(24):3793. doi: 10.4161/15384101.2014.980706. No abstract available.

32.

Hungary: Research agency will lose autonomy.

Váradi A, Kertész J.

Nature. 2014 Dec 18;516(7531):329. doi: 10.1038/516329c. No abstract available.

PMID:
25519120
33.

Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter.

Gál Z, Hegedüs C, Szakács G, Váradi A, Sarkadi B, Özvegy-Laczka C.

Biochim Biophys Acta. 2015 Feb;1848(2):477-87. doi: 10.1016/j.bbamem.2014.11.006. Epub 2014 Nov 14.

34.

PSEUDOXANTHOMA ELASTICUM: DIAGNOSTIC FEATURES, CLASSIFICATION, AND TREATMENT OPTIONS.

Uitto J, Jiang Q, Váradi A, Bercovitch LG, Terry SF.

Expert Opin Orphan Drugs. 2014 Jun 1;2(6):567-577.

35.
36.

ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report.

Jansen RS, Duijst S, Mahakena S, Sommer D, Szeri F, Váradi A, Plomp A, Bergen AA, Oude Elferink RP, Borst P, van de Wetering K.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1985-9. doi: 10.1161/ATVBAHA.114.304017. Epub 2014 Jun 26.

37.

[E-health developments in the system of health services in Hungary and the European Union].

Váradi Á.

Orv Hetil. 2014 May 25;155(21):822-7. doi: 10.1556/OH.2014.29913. Review. Hungarian.

PMID:
24836317
38.

Hb Fontainebleau (HBA2: c.64G > C) in the United Arab Emirates.

Turner A, Sasse J, Varadi A.

Hemoglobin. 2014;38(3):216-20. doi: 10.3109/03630269.2014.912221.

PMID:
24826794
39.

[Pneumococcal meningitis in a pregnant woman].

Scharek P, Jekkel C, Budai J, Szilasi Z, Helferich F, Arva I, Váradi A, Létay E, Katona K, Rókusz L.

Ideggyogy Sz. 2014 Jan 30;67(1-2):56-8. Hungarian.

PMID:
24654448
40.

Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping.

Váradi A, Palmer TC, Notis PR, Redel-Traub GN, Afonin D, Subrath JJ, Pasternak GW, Hu C, Sharma I, Majumdar S.

Org Lett. 2014 Mar 21;16(6):1668-71. doi: 10.1021/ol500328t. Epub 2014 Feb 28.

41.

The level of hepatic ABCC6 expression determines the severity of calcification after cardiac injury.

Brampton C, Aherrahrou Z, Chen LH, Martin L, Bergen AA, Gorgels TG, Erdmann J, Schunkert H, Szabó Z, Váradi A, Le Saux O.

Am J Pathol. 2014 Jan;184(1):159-70. Erratum in: Am J Pathol. 2014 Mar;184(3):878. Erdfdi, Jeannette [corrected to Erdmann, Jeannette].

42.

Regulation of the function of the human ABCG2 multidrug transporter by cholesterol and bile acids: effects of mutations in potential substrate and steroid binding sites.

Telbisz Á, Hegedüs C, Váradi A, Sarkadi B, Özvegy-Laczka C.

Drug Metab Dispos. 2014 Apr;42(4):575-85. doi: 10.1124/dmd.113.055731. Epub 2014 Jan 2.

43.

Analysis of pseudoxanthoma elasticum-causing missense mutants of ABCC6 in vivo; pharmacological correction of the mislocalized proteins.

Pomozi V, Brampton C, Fülöp K, Chen LH, Apana A, Li Q, Uitto J, Le Saux O, Váradi A.

J Invest Dermatol. 2014 Apr;134(4):946-953. doi: 10.1038/jid.2013.482. Epub 2013 Nov 11.

44.

Isolation of human genomic DNA for genetic analysis from premature neonates: a comparison between newborn dried blood spots, whole blood and umbilical cord tissue.

Rajatileka S, Luyt K, El-Bokle M, Williams M, Kemp H, Molnár E, Váradi A.

BMC Genet. 2013 Oct 29;14:105. doi: 10.1186/1471-2156-14-105.

45.

Novel 6β-acylaminomorphinans with analgesic activity.

Váradi A, Hosztafi S, Le Rouzic V, Tóth G, Urai Á, Noszál B, Pasternak GW, Grinnell SG, Majumdar S.

Eur J Med Chem. 2013 Nov;69:786-9. doi: 10.1016/j.ejmech.2013.09.031. Epub 2013 Sep 22.

46.

Synthetic and quantum chemical study on the regioselective addition of amines to methyl maleamate.

Rácz A, Váradi A, Mazák K, Kökösi J, Noszál B.

J Mol Model. 2013 Sep;19(9):3683-94. doi: 10.1007/s00894-013-1905-x. Epub 2013 Jun 19.

PMID:
23780347
47.

Bone mineral density (BMD) and computer tomographic measurements of the equine proximal phalanx in correlation with breaking strength.

Tóth P, Horváth C, Ferencz V, Tóth B, Váradi A, Szenci O, Bodó G.

Pol J Vet Sci. 2013;16(1):3-8.

48.

Pseudoxanthoma elasticum: progress in research toward treatment: summary of the 2012 PXE international research meeting.

Uitto J, Váradi A, Bercovitch L, Terry PF, Terry SF.

J Invest Dermatol. 2013 Jun;133(6):1444-9. doi: 10.1038/jid.2013.20. No abstract available.

49.

ABCC6 is a basolateral plasma membrane protein.

Pomozi V, Le Saux O, Brampton C, Apana A, Iliás A, Szeri F, Martin L, Monostory K, Paku S, Sarkadi B, Szakács G, Váradi A.

Circ Res. 2013 May 24;112(11):e148-51. doi: 10.1161/CIRCRESAHA.111.300194. Epub 2013 Apr 26.

50.

Transcriptional regulation of the ABCC6 gene and the background of impaired function of missense disease-causing mutations.

Arányi T, Bacquet C, de Boussac H, Ratajewski M, Pomozi V, Fülöp K, Brampton CN, Pulaski L, Le Saux O, Váradi A.

Front Genet. 2013 Mar 11;4:27. doi: 10.3389/fgene.2013.00027. eCollection 2013.

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