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SGLT2 Inhibitors Increase the Risk of Diabetic Ketoacidosis Developing in the Community and During Hospital Admission.

Hamblin PS, Wong R, Ekinci EI, Fourlanos S, Shah S, Jones AR, Hare MJL, Calder GL, Epa DS, George EM, Giri R, Kotowicz MA, Kyi M, Lafontaine N, MacIsaac RJ, Nolan BJ, O'Neal DN, Renouf D, Varadarajan S, Wong J, Xu S, Bach LA.

J Clin Endocrinol Metab. 2019 Mar 5. pii: jc.2019-00139. doi: 10.1210/jc.2019-00139. [Epub ahead of print]


Subclinical Hypothyroidism During Pregnancy: The Melbourne Public Hospitals Consensus.

Hamblin PS, Sheehan PM, Allan C, Houlihan CA, Lu ZX, Forehan SP, Topliss DJ, Gilfillan C, Krishnamurthy B, Renouf D, Sztal-Mazer S, Varadarajan S.

Intern Med J. 2018 Dec 18. doi: 10.1111/imj.14210. [Epub ahead of print]


Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies.

Al-Zebeeby A, Vogler M, Milani M, Richards C, Alotibi A, Greaves G, Dyer MJS, Cohen GM, Varadarajan S.

Haematologica. 2019 May;104(5):1016-1025. doi: 10.3324/haematol.2018.204701. Epub 2018 Nov 22.


A high-throughput real-time in vitro assay using mitochondrial targeted roGFP for screening of drugs targeting mitochondria.

Chandrasekharan A, Varadarajan SN, Lekshmi A, Lupitha SS, Darvin P, Chandrasekhar L, Pillai PR, Santhoshkumar TR, Pillai MR.

Redox Biol. 2019 Jan;20:379-389. doi: 10.1016/j.redox.2018.10.013. Epub 2018 Oct 24.


Assembly and repair of eye-to-brain connections.

Varadarajan SG, Huberman AD.

Curr Opin Neurobiol. 2018 Dec;53:198-209. doi: 10.1016/j.conb.2018.10.001. Epub 2018 Oct 16. Review.


Connectome of the Suprachiasmatic Nucleus: New Evidence of the Core-Shell Relationship.

Varadarajan S, Tajiri M, Jain R, Holt R, Ahmed Q, LeSauter J, Silver R.

eNeuro. 2018 Oct 2;5(5). pii: ENEURO.0205-18.2018. doi: 10.1523/ENEURO.0205-18.2018. eCollection 2018 Sep-Oct.


BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL.

Greaves G, Milani M, Butterworth M, Carter RJ, Byrne DP, Eyers PA, Luo X, Cohen GM, Varadarajan S.

Cell Death Differ. 2019 Jun;26(6):1037-1047. doi: 10.1038/s41418-018-0183-7. Epub 2018 Sep 5.


Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations.

Henz K, Al-Zebeeby A, Basoglu M, Fulda S, Cohen GM, Varadarajan S, Vogler M.

Biol Chem. 2019 Jan 28;400(2):181-185. doi: 10.1515/hsz-2018-0233.


Systemic mastocytosis identified in two women developing fragility fractures during lactation.

Zhu JJ, Mahendran D, Lee MH, Seah J, Fourlanos S, Varadarajan S, Ghasem-Zadeh A, MacIsaac RJ, Seeman E.

Osteoporos Int. 2018 Jul;29(7):1671-1674. doi: 10.1007/s00198-018-4498-5. Epub 2018 Apr 4.


A Real-Time Image-Based Approach to Distinguish and Discriminate Apoptosis from Necrosis.

Lekshmi A, Varadarajan SN, Lupitha SS, Nair M, Chandrasekharan A, Santhoshkumar TR.

Curr Protoc Toxicol. 2018 Feb 21;75:2.27.1-2.27.16. doi: 10.1002/cptx.39.


Spinal dysraphism illustrated; Embroyology revisited.

Acharya UV, Pendharkar H, Varma DR, Pruthi N, Varadarajan S.

Indian J Radiol Imaging. 2017 Oct-Dec;27(4):417-426. doi: 10.4103/ijri.IJRI_451_16.


Uniformity from Diversity: Vast-Range Light Sensing in a Single Neuron Type.

Varadarajan SG, Huberman AD.

Cell. 2017 Nov 2;171(4):738-740. doi: 10.1016/j.cell.2017.10.028.


Strategies for imaging mitophagy in high-resolution and high-throughput.

Indira D, Varadarajan SN, Subhasingh Lupitha S, Lekshmi A, Mathew KA, Chandrasekharan A, Rajappan Pillai P, Pulikkal Kadamberi I, Ramachandran I, Sekar H, Kochucherukkan Gopalakrishnan A, Tr S.

Eur J Cell Biol. 2018 Jan;97(1):1-14. doi: 10.1016/j.ejcb.2017.10.003. Epub 2017 Oct 27.


Netrin1 establishes multiple boundaries for axon growth in the developing spinal cord.

Varadarajan SG, Butler SJ.

Dev Biol. 2017 Oct 1;430(1):177-187. doi: 10.1016/j.ydbio.2017.08.001. Epub 2017 Aug 3.


Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord.

Varadarajan SG, Kong JH, Phan KD, Kao TJ, Panaitof SC, Cardin J, Eltzschig H, Kania A, Novitch BG, Butler SJ.

Neuron. 2017 May 17;94(4):790-799.e3. doi: 10.1016/j.neuron.2017.03.007. Epub 2017 Apr 21.


Native valve endocarditis caused by Kocuria rosea complicated by peripheral mycotic aneurysm in an elderly host.

Gunaseelan P, Suresh G, Raghavan V, Varadarajan S.

J Postgrad Med. 2017 Apr-Jun;63(2):135-137. doi: 10.4103/jpgm.JPGM_441_16.


A quantitative real-time approach for discriminating apoptosis and necrosis.

Lekshmi A, Varadarajan SN, Lupitha SS, Indira D, Mathew KA, Chandrasekharan Nair A, Nair M, Prasad T, Sekar H, Gopalakrishnan AK, Murali A, Santhoshkumar TR.

Cell Death Discov. 2017 Jan 23;3:16101. doi: 10.1038/cddiscovery.2016.101. eCollection 2017.


DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.

Milani M, Byrne DP, Greaves G, Butterworth M, Cohen GM, Eyers PA, Varadarajan S.

Cell Death Dis. 2017 Jan 12;8(1):e2552. doi: 10.1038/cddis.2016.485.


Glycoconjugated Site-Selective DNA-Methylating Agent Targeting Glucose Transporters on Glioma Cells.

Buchanan MK, Needham CN, Neill NE, White MC, Kelly CB, Mastro-Kishton K, Chauvigne-Hines LM, Goodwin TJ, McIver AL, Bartolotti LJ, Frampton AR, Bourdelais AJ, Varadarajan S.

Biochemistry. 2017 Jan 17;56(2):421-440. doi: 10.1021/acs.biochem.6b01075. Epub 2017 Jan 3.


Evaluating the efficacy of memantine on improving cognitive functions in epileptic patients receiving anti-epileptic drugs: A double-blind placebo-controlled clinical trial (Phase IIIb pilot study).

Marimuthu P, Varadarajan S, Krishnan M, Shanmugam S, Kunjuraman G, Ravinder JR, Arumugam B, Alex D, Swaminathan P.

Ann Indian Acad Neurol. 2016 Jul-Sep;19(3):344-50. doi: 10.4103/0972-2327.179971.


High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia.

Lucas CM, Milani M, Butterworth M, Carmell N, Scott LJ, Clark RE, Cohen GM, Varadarajan S.

Leukemia. 2016 Jun;30(6):1273-81. doi: 10.1038/leu.2016.42. Epub 2016 Feb 29.


BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells.

Butterworth M, Pettitt A, Varadarajan S, Cohen GM.

Br J Cancer. 2016 Mar 15;114(6):638-41. doi: 10.1038/bjc.2016.49. Epub 2016 Mar 8.


Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.

Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G.

Immunity. 2016 Mar 15;44(3):647-658. doi: 10.1016/j.immuni.2016.02.006. Epub 2016 Mar 2.


Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction.

Negi SI, Jeong EM, Shukrullah I, Veleder E, Jones DP, Fan TH, Varadarajan S, Danilov SM, Fukai T, Dudley SC Jr.

Biomed Res Int. 2015;2015:825027. doi: 10.1155/2015/825027. Epub 2015 Oct 4.


Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model.

Gabbita SP, Johnson MF, Kobritz N, Eslami P, Poteshkina A, Varadarajan S, Turman J, Zemlan F, Harris-White ME.

PLoS One. 2015 Oct 5;10(10):e0137305. doi: 10.1371/journal.pone.0137305. eCollection 2015.


Invitro Anti-mycotic Activity of Hydro Alcoholic Extracts of Some Indian Medicinal Plants against Fluconazole Resistant Candida albicans.

Varadarajan S, Narasimhan M, Malaisamy M, Duraipandian C.

J Clin Diagn Res. 2015 Aug;9(8):ZC07-10. doi: 10.7860/JCDR/2015/14178.6273. Epub 2015 Aug 1.


Prevalence of Hepatitis B surface antigen in dental personnel.

Narasimhan M, Hazarey VK, Varadarajan S.

J Oral Maxillofac Pathol. 2015 Jan-Apr;19(1):34-6. doi: 10.4103/0973-029X.157198.


Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner.

Varadarajan S, Poornima P, Milani M, Gowda K, Amin S, Wang HG, Cohen GM.

Oncotarget. 2015 May 20;6(14):12668-81.


A No-Reference Texture Regularity Metric Based on Visual Saliency.

Varadarajan S, Karam LJ.

IEEE Trans Image Process. 2015 Sep;24(9):2784-96.


The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration.

Varadarajan S, Breda C, Smalley JL, Butterworth M, Farrow SN, Giorgini F, Cohen GM.

Cell Death Differ. 2015 Aug;22(8):1388-96. doi: 10.1038/cdd.2015.1. Epub 2015 Feb 6.


Nitroglycerin tolerance in caveolin-1 deficient mice.

Mao M, Varadarajan S, Fukai T, Bakhshi FR, Chernaya O, Dudley SC Jr, Minshall RD, Bonini MG.

PLoS One. 2014 Aug 26;9(8):e104101. doi: 10.1371/journal.pone.0104101. eCollection 2014.


A distributed Canny edge detector: algorithm and FPGA implementation.

Xu Q, Varadarajan S, Chakrabarti C, Karam LJ.

IEEE Trans Image Process. 2014 Jul;23(7):2944-60.


Notifying a doctor of a first hypoglycaemic episode is associated with a lower rate of recurrence among inpatients with diabetes.

De Alwis DT, Varadarajan S, Lim K.

Med J Aust. 2014 Feb 3;200(2):79. No abstract available.


3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.

He Y, Varadarajan S, Muñoz-Planillo R, Burberry A, Nakamura Y, Núñez G.

J Biol Chem. 2014 Jan 10;289(2):1142-50. doi: 10.1074/jbc.M113.515080. Epub 2013 Nov 21.


The role of immunohistochemistry in the analysis of the spectrum of small round cell tumours at a tertiary care centre.

D'cruze L, Dutta R, Rao S, R A, Varadarajan S, Kuruvilla S.

J Clin Diagn Res. 2013 Jul;7(7):1377-82. doi: 10.7860/JCDR/2013/5127.3132. Epub 2013 Jul 1.


Evaluation and critical assessment of putative MCL-1 inhibitors.

Varadarajan S, Vogler M, Butterworth M, Dinsdale D, Walensky LD, Cohen GM.

Cell Death Differ. 2013 Nov;20(11):1475-84. doi: 10.1038/cdd.2013.79. Epub 2013 Jul 5.


Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.

Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen GM.

Neoplasia. 2013 May;15(5):568-78.


Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.

Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM.

PLoS One. 2013;8(2):e56603. doi: 10.1371/journal.pone.0056603. Epub 2013 Feb 15.


An Endocrine Cause of Acute Post-partum Hypertension.

Bretherton I, Pattison D, Pattison S, Varadarajan S.

Obstet Med. 2013 Mar;6(1):30-32. Epub 2013 Mar 1.


The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export.

Lu L, Hannoush RN, Goess BC, Varadarajan S, Shair MD, Kirchhausen T.

Mol Biol Cell. 2013 Apr;24(7):1020-9. doi: 10.1091/mbc.E12-08-0575. Epub 2013 Feb 6.


Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity.

Yamauchi K, Varadarajan SG, Li JE, Butler SJ.

Development. 2013 Jan 15;140(2):333-42. doi: 10.1242/dev.089524.


A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, Dinsdale D, Cohen GM.

Cell Death Differ. 2012 Dec;19(12):1896-907. doi: 10.1038/cdd.2012.108. Epub 2012 Sep 7.


A novel regulator of angiogenesis in endothelial cells: 5-hydroxytriptamine 4 receptor.

Profirovic J, Strekalova E, Urao N, Krbanjevic A, Andreeva AV, Varadarajan S, Fukai T, Hen R, Ushio-Fukai M, Voyno-Yasenetskaya TA.

Angiogenesis. 2013 Jan;16(1):15-28. doi: 10.1007/s10456-012-9296-7. Epub 2012 Aug 18.


Hypocalcemia induced by raloxifene.

Vu TD, Varadarajan S, Seeman E, Jerums G, MacIsaac RJ.

Curr Drug Saf. 2012 Apr;7(2):176-8.


DNA site-specific N3-adenine methylation targeted to estrogen receptor-positive cells.

Kishton RJ, Miller SE, Perry H, Lynch T, Patel M, Gore VK, Akkaraju GR, Varadarajan S.

Bioorg Med Chem. 2011 Sep 1;19(17):5093-102. doi: 10.1016/j.bmc.2011.07.026. Epub 2011 Jul 22.


Phosphorylated HSP20 modulates the association of thin-filament binding proteins: caldesmon with tropomyosin in colonic smooth muscle.

Somara S, Gilmont RR, Varadarajan S, Bitar KN.

Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1164-76. doi: 10.1152/ajpgi.00479.2009. Epub 2010 Sep 9. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G676.


TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1.

Son JK, Varadarajan S, Bratton SB.

Cell Death Differ. 2010 Aug;17(8):1288-301. doi: 10.1038/cdd.2010.9. Epub 2010 Feb 19.


Hypercalcaemia in breast cancer patients: not always bony metastases.

Summers SH, Foo FJ, Varadarajan S.

BMJ Case Rep. 2009;2009. pii: bcr03.2009.1725. doi: 10.1136/bcr.03.2009.1725. Epub 2009 Jun 1.


Right receiver operating characteristic curves.

Pitani RS, Varadarajan S.

Am J Emerg Med. 2009 Jan;27(1):116. doi: 10.1016/j.ajem.2008.08.016. No abstract available.


Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.

Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB.

EMBO J. 2007 Jul 11;26(13):3144-56. Epub 2007 Jun 7.

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